Ciclopirox and Ciclopirox Olamine: Antifungal Agents in Dermatology with Expanding Therapeutic Potential
Source abstract
Abstract
Ciclopirox (CPX) and its ethanolamine salt, ciclopirox olamine (CPO), are synthetic hydroxypyridone derivatives with a wide range of antimicrobial activity, making them valuable in dermatology for treating fungal infections. Their mechanism of action is multifaceted, impacting iron-dependent enzymes and disrupting mitochondrial function, cellular energy production, and membrane integrity. The compounds’ favorable physicochemical properties allow effective skin absorption, while the olamine salt enhances solubility and bioavailability. Research is ongoing to explore therapeutic uses beyond dermatology, including applications in autoimmune diseases, cancer, and neurodegenerative disorders. In cosmetics, ciclopirox is used primarily in anti-dandruff and skincare products, combining therapeutic effects with minimal side effects.
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Research context
OpenAlex topics: Nail Diseases and Treatments · Insect and Pesticide Research · Bee Products Chemical Analysis
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of the Chemistry of Cosmetic Raw Materials, Faculty of Pharmacy, Medical University of Łódź, Muszyńskiego 1 Street, 91-151 Łódź, Poland
Research and Development Department, Pharmaceutical Works POLPHARMA S.A. Medana Branch in Sieradz, 10 Władysława Łokietka, 98-200 Sieradz, Poland
Department of Cosmetology and Aesthetic Dermatology, Faculty of Pharmacy, Medical University of Łódź, Muszyńskiego 1 Street, 91-151 Łódź, Poland
Funding
Department of Cosmetic Raw Material Chemistry, Faculty of Pharmacy, Medical University of Łódź
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