Metabolic Periparturient Diseases in Small Ruminants: An Update
Source abstract
Abstract
Metabolic diseases are significant diseases that affect the welfare, health, and production of small ruminant flocks raised for dairy and meat purposes. In breeding females, they mainly occur from six to eight weeks before and after parturition, respectively. Pregnancy toxemia and lactational ketosis are manifestations of hyperketonemia, primarily due to energetic deficit. Hypocalcemia and hypomagnesemia are related to the metabolic unavailability of calcium and magnesium, respectively. This review aimed to identify and discuss the current and most relevant aspects related to individual and herd health management of these interrelated metabolic diseases with impact on the sheep and goats’ farm sustainability. These diseases are primarily due to nutritional deficits, but homeostatic and homeorhetic disruptions are responsible for clinical signs and forms. Currently, their clinical diagnosis and monitoring are mainly assessed by biochemistry of body fluids and feed bromatological evaluation. Epidemiological studies and measuring risk factors also contribute to their prevention. Nevertheless, research on specific biomarkers and composite indices related to these diseases, in the context of herd health management and precision medicine, are new pathways driven to suitable and efficient animal production.
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Research context
OpenAlex topics: Reproductive Physiology in Livestock
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Veterinary Sciences, Veterinary and Animal Research Centre (CECAV), AL4AnimalS, School of Agricultural and Veterinary Sciences, University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal
References (100+)
Show source-provided references
1. Models for Estimating Feed Intake in Small Ruminants10.1590/S1516-35982013000900010 ↗
2. Partitioning of Nutrients During Pregnancy and Lactation: A Review of Mechanisms Involving Homeostasis and Homeorhesis10.3168/jds.S0022-0302(80)83111-0 ↗
3. Endocrine and Metabolic Status of Commercial Dairy Goats during the Transition Period10.3168/jds.2019-18040 ↗
4. Simões, J., and Gutiérrez, C. (2017). Nutritional and Metabolic Disorders in Dairy Goats. Sustainable Goat Production in Adverse Environments: Volume I, Springer International Publishing.10.1007/978-3-319-71855-2_11 ↗
5. How Can Nutrition Models Increase the Production Efficiency of Sheep and Goat Operations?10.1093/af/vfz005 ↗
6. Review: Managing Sheep and Goats for Sustainable High Yield Production10.1016/j.animal.2021.100293 ↗
7. Dunière, L., Esparteiro, D., Lebbaoui, Y., Ruiz, P., Bernard, M., Thomas, A., Durand, D., Forano, E., and Chaucheyras-Durand, F. (2021). Changes in Digestive Microbiota, Rumen Fermentations and Oxidative Stress around Parturition Are Alleviated by Live Yeast Feed Supplementation to Gestating Ewes. JoF, 7.10.3390/jof7060447 ↗
8. Huang, Y., Wen, J., Kong, Y., Zhao, C., Liu, S., Liu, Y., Li, L., Yang, J., Zhu, X., and Zhao, B. (2021). Oxidative Status in Dairy Goats: Periparturient Variation and Changes in Subclinical Hyperketonemia and Hypocalcemia. BMC Vet. Res., 17.10.1186/s12917-021-02947-1 ↗
9. The Effect of Parity Number on the Metabolism, Inflammation, and Oxidative Status of Dairy Sheep during the Transition Period10.3168/jds.2019-18114 ↗
10. Lisuzzo, A., Fiore, F., Harvatine, K., Mazzotta, E., Berlanda, M., Spissu, N., Badon, T., Contiero, B., Moscati, L., and Fiore, E. (2022). Changes in Plasma Fatty Acids Profile in Hyperketonemic Ewes during Early Lactation: A Preliminary Study. Sci. Rep., 12.10.1038/s41598-022-21088-5 ↗
11. Edmondson, M.A., Roberts, J.F., Baird, A.N., Bychawski, S., and Pugh, D.G. (2012). Theriogenology of Sheep and Goats. Sheep and Goat Medicine, Elsevier.10.1016/B978-1-4377-2353-3.10008-3 ↗
12. Clinical Findings, Blood Chemistry Values, and Epidemiologic Data from Dairy Goats with Pregnancy Toxemia10.21423/bovine-vol46no2p102-110 ↗
13. Pregnancy Toxemia in Sheep and Goats10.1016/j.cvfa.2023.02.010 ↗
14. Pregnancy Toxemia of Ewes, Does, and Beef Cows10.1016/S0749-0720(15)30107-9 ↗
15. Prevalence of Pregnancy Toxemia Due to Inadequate Feeding of Goats in Kancheepuram, Tamil Nadu, India
16. Correlations among Serum Beta Hydroxyl Butyrate, Energy Indices and Trace Minerals in Late Pregnant Ewes
17. Bousquet, C. (2005). Pathologies Caprines En Deux-Sèvres: Etat Des Lieux et Impact Sur Les Niveaux de Réforme et de Mortalité. [Ph.D. Thesis, Ecole Nationale Vétérinaire de Toulouse].
18. Glycaemia as a Sign of the Viability of the Foetuses in the Last Days of Gestation in Dairy Goats with Pregnancy Toxaemia10.1186/2046-0481-65-1 ↗
19. Dystocia in Sheep and Goats: Outcome and Fertility Following Surgical and Non-Surgical Management10.1515/macvetrev-2017-0012 ↗
20. Pregnancy Toxaemia in the Ewe10.1136/inpract.19.6.306 ↗
21. Clinical and Haematological Studies on Subclinical Lactational Ketosis in Dairy Goats
22. Ketonemia in Dairy Goats: Effect of Dry Period Length and Effect on Lying Behavior10.3168/jds.2014-9136 ↗
23. Chartier, C. (2009). Pathologie Caprine: Du Diagnostic à la Prévention, Les Éditions du Point Vétérinaire. [1st ed.].
24. Treatment and Control of Peri-Parturient Metabolic Diseases: Pregnancy Toxemia, Hypocalcemia, Hypomagnesemia10.1016/j.cvfa.2010.10.004 ↗
25. Hematobiochemical Profile of Pregnant and Experimentally Pregnancy toxemic goats
26. Treatment of Emergency Conditions in Sheep and Goats10.1016/j.cvfa.2010.10.005 ↗
27. Ji, X., Liu, N., Wang, Y., Ding, K., Huang, S., and Zhang, C. (2023). Pregnancy Toxemia in Ewes: A Review of Molecular Metabolic Mechanisms and Management Strategies. Metabolites, 13.10.3390/metabo13020149 ↗
28. Radostits, O.M., Gay, C.C., Hinchcliff, K.W., and Constable, P.D. (2007). Pregnancy toxemia in sheep. Veterinary Medicine: A Textbook of the Diseases of Cattle, Sheep, Pigs, Goats and Horses, Saunders Elsevier. [10th ed.].
29. Xue, Y., Guo, C., Hu, F., Liu, J., and Mao, S. (2018). Hepatic Metabolic Profile Reveals the Adaptive Mechanisms of Ewes to Severe Undernutrition during Late Gestation. Metabolites, 8.10.3390/metabo8040085 ↗
30. Dietary Selection by Goats and the Implications for Range Management in the Chihuahuan Desert: A Review10.1071/RJ16002 ↗
31. Maternal Undernutrition Induces Fetal Hepatic Lipid Metabolism Disorder and Affects the Development of Fetal Liver in a Sheep Model10.1096/fj.201900406R ↗
32. Hepatic Ketogenesis and Peripheral Ketone Body Utilization in the Ruminant10.1093/jn/117.6.1174 ↗
33. Energy Metabolite Concentrations and Net Fluxes across Splanchnic and Peripheral Tissues in Pregnant Ewes
34. Metabolism of Sheep Adipose Tissue during Pregnancy and Lactation. Adaptation and Regulation10.1042/bj2000307 ↗
35. Board-invited review: The Hepatic Oxidation Theory of the Control of Feed Intake and Its Application to Ruminants10.2527/jas.2009-1779 ↗
36. Triglyceride Accumulation and Very Low Density Lipoprotein Secretion by Rat and Goat Hepatocytes In Vitro10.3168/jds.S0022-0302(88)79750-7 ↗
37. Invited Review: Pathology, Etiology, Prevention, and Treatment of Fatty Liver in Dairy Cows10.3168/jds.S0022-0302(04)73446-3 ↗
38. Fatty Liver in Dairy Cows10.1016/S0749-0720(15)31048-3 ↗
39. Tufarelli, V., Puvača, N., Glamočić, D., Pugliese, G., and Colonna, M.A. (2024). The Most Important Metabolic Diseases in Dairy Cattle during the Transition Period. Animals, 14.10.3390/ani14050816 ↗
40. Insulin Sensitivity during Late Gestation in Ewes Affected by Pregnancy Toxemia and in Ewes with High and Low Susceptibility to This Disorder10.1111/jvim.12035 ↗
41. Qiao, K., Jiang, R., Contreras, G.A., Xie, L., Pascottini, O.B., Opsomer, G., and Dong, Q. (2024). The Complex Interplay of Insulin Resistance and Metabolic Inflammation in Transition Dairy Cows. Animals, 14.10.3390/ani14060832 ↗
42. The Etiology of Oxidative Stress in Insulin Resistance10.1016/j.bj.2017.06.007 ↗
43. Effects of Body Condition on the Insulin Resistance, Lipid Metabolism and Oxidative Stress of Lactating Dairy Cows10.1186/s12944-020-01233-7 ↗
44. Association of Vitamin D Status with Redox Balance and Insulin Resistance and Its Predicting Ability for Subclinical Pregnancy Toxemia in Pregnant Sheep10.1016/j.domaniend.2023.106823 ↗
45. Usefulness of Clinical Observations and Blood Chemistry Values for Predicting Clinical Outcomes in Dairy Goats with Pregnancy Toxaemia10.1186/s13620-016-0075-4 ↗
46. Menzies, P., and Bailey, D. (1997). Diseases of the Periparturient Ewe. Current Therapy in Large Animal Theriogenology, WB Saunders Company. [1st ed.].
47. Evaluation of Metabolic and Oxidative Profile in Ovine Pregnancy Toxemia and to Determine Their Association with Diagnosis and Prognosis of Disease10.1007/s11250-022-03339-9 ↗
48. Selected Serum Biochemical Parameters and Acute Phase Protein Levels in a Herd of Saanen Goats Showing Signs of Pregnancy Toxaemia10.17221/7620-VETMED ↗
49. Definition of Prepartum Hyperketonemia in Dairy Goats10.3168/jds.2014-9172 ↗
50. Variations of Energy Biochemical Metabolites in Periparturient Dairy Saanen Goats10.1007/s00580-012-1431-8 ↗
51. Blood Inflammatory Indices in Goats around Kidding10.4081/ijas.2005.2s.404 ↗
52. Achados Bioquímicos, Eletrolíticos e Hormonais de Cabras Acometidas Com Toxemia Da Prenhez10.1590/S0100-736X2013001000002 ↗
53. Biochemical, Endocrine, and Histopathological Profile of Liver and Kidneys of Sheep with Pregnancy Toxemia10.1590/1678-5150-pvb-6400 ↗
54. Kaneko, J.J., Harvey, J.W., and Bruss, M. (2008). Clinical Biochemistry of Domestic Animals, Academic Press/Elsevier. [6th ed.].
55. Insulin Resistance: Relationship between Indices during Late Gestation in Dairy Cows and Effects on Newborn Metabolism10.1111/asj.13300 ↗
56. Liu, S., Kong, Y., Wen, J., Huang, Y., Liu, Y., Zhu, X., Zhao, B., Cao, B., and Wang, J. (2021). Surrogate Indexes of Insulin Resistance in Dairy Goats: Transitional Variation in Subclinical Hyperketonemia. Vet. Sci., 8.10.3390/vetsci8060102 ↗
57. Malagón-Soriano, V.A., Ledezma-Forero, A.J., Espinel-Pachon, C.F., Burgos-Cárdenas, Á.J., Garces, M.F., Ortega-Ramírez, G.E., Franco-Vega, R., Peralta-Franco, J.J., Maldonado-Acosta, L.M., and Rubio-Romero, J.A. (2024). Surrogate Indices of Insulin Resistance Using the Matsuda Index as Reference in Adult Men—A Computational Approach. Front. Endocrinol., 15.10.3389/fendo.2024.1343641 ↗
58. Studies on Clinical Signs and Biochemical Alteration in Pregnancy Toxemic Goats10.14202/vetworld.2016.869-874 ↗
59. Changes in Cardiac Biomarkers in Goats Naturally Affected by Pregnancy Toxemia10.1016/j.rvsc.2020.02.016 ↗
60. Influence of Calcium Concentrations on the Metabolic Profile of Dairy Goats during the Transitional Period10.33448/rsd-v10i11.19462 ↗
61. Hyperketonemia Impairs Glucose Metabolism in Pregnant and Nonpregnant Ewes10.3168/jds.S0022-0302(04)73174-4 ↗
62. Cardiac Biomarkers Troponin I And CK-MB In Ewes Affected by Pregnancy Toxemia10.1016/j.smallrumres.2019.06.020 ↗
63. Oxidant and Antioxidant Profile of Hyperketonemic Ewes Affected by Pregnancy Toxemia10.1111/j.1939-165X.2011.00284.x ↗
64. Intrauterine Infusion of a Pathogenic Bacterial Cocktail Is Associated with the Development of Clinical Metritis in Postpartum Multiparous Holstein Cows10.3168/jds.2022-21954 ↗
65. Novel Biomarkers for Pregnancy Toxemia in Ewes: Acute Phase Proteins and Pro-Inflammatory Cytokines
66. Some Biochemical Parameters and Acute Phase Proteins in Goats with Pregnancy Toxemia
67. Some Acute Phase Proteins, Oxidative Stress Biomarkers and Antioxidant Enzyme Activities in Ewes with Pregnancy Toxemia
68. Clinical and Biochemical Study of Pregnancy Toxemia in Iraqi Ewes
69. Spontaneous Pregnancy Toxaemia (Ketosis) in Sheep and the Role of Insulin10.1111/j.1439-0442.1998.tb00825.x ↗
70. Evaluation of Prognostic Indicators for Goats with Pregnancy Toxemia10.2460/javma.254.7.859 ↗
71. Characterization of Short- and Long-term Morbidity and Mortality of Goat Kids Born to Does with Pregnancy Toxemia10.1111/jvim.16069 ↗
72. Sargison, N. (1995). Recent Advances in the Diagnosis, Prognosis and Treatment of Ovine Pregnancy Toxaemia, The Sheep Veterinary Society.
73. Evaluation of Three Therapeutic Alternatives for the Early Treatment of Ovine Pregnancy Toxaemia10.1186/s13620-015-0053-2 ↗
74. Oral Sugar and Vasopressin: Possible Alternative in the Management of Ovine Pregnancy Toxemia10.1016/j.smallrumres.2023.107087 ↗
75. The Distinctive Short-Term Response of Late-Pregnant Prolific Ewes to Propylene Glycol or Glycerol Drenching10.3168/jds.2020-18227 ↗
76. Pregnancy Toxemia Therapeutic Options10.1016/j.cvfa.2023.02.003 ↗
77. Beetal Keçilerinde Gebelik Toksemisi İçin Hemato-Biyokimyasal Biyobelirteçlerin, İlgili Risk Faktörlerinin ve Terapötik Protokollerin Belirlenmesi/Determination of Hemato-Biochemical Biomarkers, Associated Risk Factors and Therapeutic Protocols for Pregnancy Toxemia in Beetal Goats
78. Potential Prophylactic Effect of Recombinant Bovine Somatotropin (rbST) in Sheep with Experimentally Induced Hyperketonemia10.1016/j.rvsc.2018.06.005 ↗
79. L-Carnitine Ameliorates Immune-Metabolic Response and Improves Antioxidant Status in Goats with Pregnancy Toxemia
80. Chen, J., Wang, S., Yin, X., Duan, C., Li, J., Liu, Y., and Zhang, Y. (2024). Relationship between Rumen Microbiota and Pregnancy Toxemia in Ewes. Front. Vet. Sci., 11.10.3389/fvets.2024.1472334 ↗
81. Jin, B., Wang, R., Hu, J., Wang, Y., Cheng, P., Zhang, J., Zhang, J., Xue, G., Zhu, Y., and Zhang, Y. (2024). Analysis of Fecal Microbiome and Metabolome Changes in Goats with Pregnant Toxemia. BMC Vet. Res., 20.10.1186/s12917-023-03849-0 ↗
82. Impact of Subacute Ruminal Acidosis on the Diversity of Liquid and Solid-Associated Bacteria in the Rumen of Goats10.1007/s11274-013-1489-8 ↗
83. High Concentrate-Induced Subacute Ruminal Acidosis (SARA) Increases Plasma Acute Phase Proteins (APPs) and Cortisol in Goats10.1017/S1751731114001128 ↗
84. The Association of Serum β-Hydroxybutyrate Concentration with Fetal Number and Health Indicators in Late-Gestation Ewes in Commercial Meat Flocks in Prince Edward Island10.1016/j.prevetmed.2018.03.009 ↗
85. Validation of a Handheld β-Hydroxybutyrate Acid Meter to Identify Hyperketonaemia in Ewes10.7717/peerj.8933 ↗
86. Evaluation of 2 Electronic Handheld Devices for Diagnosis of Ketonemia and Glycemia in Dairy Goats10.3168/jds.2014-8198 ↗
87. Evaluation of Freestyle Optium Neo H and T Ai D Oc- TD4 235 Point-of-care Meters for Measuring Blood Β-hydroxybutyrate Concentration in Sheep10.1111/vcp.13223 ↗
88. Comparison of Blood ΒHBA Measurement Devices for Diagnosis of Subclinical Pregnancy Toxaemia in Sheep: A Field Study10.1111/rda.14589 ↗
89. Evaluation of a Continuous Glucose Monitoring System in Healthy Dairy Calves and Adult Goats10.2460/ajvr.24.03.0076 ↗
90. Evaluation of the Accuracy of an Electronic Point-of-care Analyzer to Quantify Blood Creatinine Concentration in Goats10.1111/jvim.16059 ↗
91. Sturm, V., Efrosinin, D., Öhlschuster, M., Gusterer, E., Drillich, M., and Iwersen, M. (2020). Combination of Sensor Data and Health Monitoring for Early Detection of Subclinical Ketosis in Dairy Cows. Sensors, 20.10.3390/s20051484 ↗
92. Intelligent Wearable Devices and Biosensors for Monitoring Cattle Health Conditions: A Review and Classification10.1016/j.smhl.2022.100369 ↗
93. Autonomous On-Animal Sensors in Sheep Research: A Systematic Review10.1016/j.compag.2018.04.017 ↗
94. Schneidewind, S.J., Al Merestani, M.R., Schmidt, S., Schmidt, T., Thöne-Reineke, C., and Wiegard, M. (2023). Rumination Detection in Sheep: A Systematic Review of Sensor-Based Approaches. Animals, 13.10.3390/ani13243756 ↗
95. On-Farm Welfare Monitoring System for Goats Based on Internet of Things and Machine Learning10.1177/1550147720944030 ↗
96. Hollevoet, A., De Waele, T., Peralta, D., Tuyttens, F., De Poorter, E., and Shahid, A. (2024). Goats on the Move: Evaluating Machine Learning Models for Goat Activity Analysis Using Accelerometer Data. Animals, 14.10.3390/ani14131977 ↗
97. A Systematic Review of IoT Technology and Applications in Animals
98. Lutz, B., Zwygart, S., Thomann, B., Stucki, D., and Burla, J.-B. (2022). The Relationship between Common Data-Based Indicators and the Welfare of Swiss Dairy Herds. Front. Vet. Sci., 9.10.3389/fvets.2022.991363 ↗
99. Mariottini, F., Giuliotti, L., Gracci, M., Benvenuti, M.N., Salari, F., Arzilli, L., Martini, M., Roncoroni, C., and Brajon, G. (2022). The ClassyFarm System in Tuscan Beef Cattle Farms and the Association between Animal Welfare Level and Productive Performance. Animals, 12.10.3390/ani12151924 ↗
100. Animal Board Invited Review: Improving Animal Health and Welfare in the Transition of Livestock Farming Systems: Towards Social Acceptability and Sustainability10.1016/j.animal.2024.101100 ↗