Zn Doping Improves the Anticancer Efficacy of SnO2 Nanoparticles
Source abstract
Abstract
Tin dioxide (SnO2) nanoparticles (NPs) can be applied in several ways due to their low cost, high surface-to-volume ratio, facile synthesis, and chemical stability. There is limited research on the biomedical application of SnO2-based nanostructures. This study aimed to investigate the role of Zn doping in relation to the anticancer potential of SnO2 NPs and to enhance the anticancer potential of SnO2 NPs through Z doping. Pure SnO2 and Zn-doped SnO2 NPs (1% and 5%) were prepared using a modified sol–gel route. XRD, TEM, SEM, EDX, UV-Vis, FTIR, and PL techniques were used to characterize the physicochemical properties of produced NPs. XRD analysis revealed that the crystalline size and phase composition of pure SnO2 increased after the addition of Zn. The spherical shape and homogenous distribution of these NPs were confirmed using TEM and SEM techniques. EDX analysis confirmed the Sn, Zn, and O elements in Zn-SnO2 NPs without impurities. Zn doping decreased the band gap energy of SnO2 NPs. The PL study indicated a reduction in the recombination rate of charges (electrons/holes) in SnO2 NPs after Zn doping. In vitro studies showed that the anticancer efficacy of SnO2 NPs increased with increasing levels of Zn doping in breast cancer MCF-7 cells. Moreover, pure and Zn-doped SnO2 NPs showed good cytocompatibility in HUVECs. This study emphasizes the need for additional investigation into the anticancer properties of Zn-SnO2 nanoparticles in various cancer cell lines and appropriate animal models.
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Research context
OpenAlex topics: Gas Sensing Nanomaterials and Sensors · Nanoparticles: synthesis and applications · Advanced Nanomaterials in Catalysis
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Physics, College of Science, Imam Mohammad Ibn Saud Islamic University, Riyadh 11642, Saudi Arabia
Department of Physics and Astronomy, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
Department of Biochemistry, School of Life and Basic Sciences, Jaipur National University, Jaipur 302017, Rajasthan, India
Microelectronics and Semiconductors Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 11442, Saudi Arabia
King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia
Funding
Deputyship for Research and Innovation at the Ministry of Education in Saudi Arabia
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