Analysis of Chronic Periodontitis in Tonsillectomy Patients: A Longitudinal Follow-Up Study Using a National Health Screening Cohort
Source abstract
Abstract
This study aimed to compare the risk of chronic periodontitis (CP) between participants who underwent tonsillectomy and those who did not (control participants) using a national cohort dataset. Patients who underwent tonsillectomy were selected from a total of 514,866 participants. A control group was included if participants had not undergone tonsillectomy from 2002 to 2015. The number of CP treatments was counted from the date of the tonsillectomy treatment. Patients who underwent tonsillectomy were matched 1:4 with control participants who were categorized based on age, sex, income, and region of residence. Finally, 1044 patients who underwent tonsillectomy were matched 1:4 with 4176 control participants. The adjusted estimated value of the number of post-index date (ID) CP did not reach statistical significance in any post-ID year (each of p > 0.05). In another subgroup analysis according to the number of pre- ID CP, it did not show statistical significance. This study revealed that tonsillectomy was not strongly associated with reducing the risk of CP. Even though the tonsils and periodontium are located adjacently, and tonsillectomy and CP may be related to bacterial inflammation, there was no significant risk of CP in patients undergoing tonsillectomy.
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Research context
OpenAlex topics: Oral microbiology and periodontitis research · Obstructive Sleep Apnea Research · Oral Health Pathology and Treatment
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Oral & Maxillofacial Surgery, Dentistry, Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Korea
Hallym Data Science Laboratory, Hallym University College of Medicine, 14068 Anyang, Korea
Graduate School of Public Health, Seoul National University, Seoul 03080, Korea
Department of Otorhinolaryngology-Head & Neck Surgery, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Dongtan 18450, Korea
Department of Biomedical Sciences, College of Medicine, Hallym University, Chuncheon 24252, Korea
Department of Otorhinolaryngology-Head & Neck Surgery, Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Korea
Funding
Hallym University Research Fund 2016
References (33)
Show source-provided references
1. Principles of periodontology10.1111/j.1600-0757.2011.00397.x ↗
2. Microbiology of periodontal disease—Present status and future considerations10.1902/jop.1977.48.9.497 ↗
3. Microbial profile of patients with periodontitis compared with healthy subjects
4. Microbial complexes in subgingival plaque10.1111/j.1600-051X.1998.tb02419.x ↗
5. Influence of tobacco smoking on dental periapical condition in a sample of Croatian adults10.1007/s00508-015-0910-8 ↗
6. Smoking, Smoking Cessation, and Risk of Tooth Loss: The EPIC-Potsdam Study10.1177/0022034515598961 ↗
7. The relationship between diabetes mellitus and destructive periodontal disease: A meta-analysis
8. Jensen, A., Fago-Olsen, H., Sorensen, C.H., and Kilian, M. (2013). Molecular mapping to species level of the tonsillar crypt microbiota associated with health and recurrent tonsillitis. PLoS ONE, 8.10.1371/journal.pone.0056418 ↗
9. Kim, E.K., Lee, S.G., Choi, Y.H., Won, K.C., Moon, J.S., Merchant, A.T., and Lee, H.-K. (2013). Association between diabetes-related factors and clinical periodontal parameters in type-2 diabetes mellitus. BMC Oral Health, 13.10.1186/1472-6831-13-64 ↗
10. Nagasawa, Y., Iio, K., Fukuda, S., Date, Y., Iwatani, H., Yamamoto, R., Horii, A., Inohara, H., Imai, E., and Nakanishi, T. (2014). Periodontal disease bacteria specific to tonsil in IgA nephropathy patients predicts the remission by the treatment. PLoS ONE, 9.10.1371/journal.pone.0081636 ↗
11. Isola, G., Matarese, G., Ramaglia, L., Pedulla, E., Rapisarda, E., and Iorio-Siciliano, V. (2019). Association between periodontitis and glycosylated haemoglobin before diabetes onset: A cross-sectional study. Clin. Oral Investig.10.1007/s00784-019-03143-0 ↗
12. Isola, G., Alibrandi, A., Curro, M., Matarese, M., Ricca, S., Matarese, G., Ientile, R., and Kocher, T. (2020). Evaluation of salivary and serum ADMA levels in patients with periodontal and cardiovascular disease as subclinical marker of cardiovascular risk. J. Periodontol.10.1002/JPER.19-0446 ↗
13. Isola, G., Alibrandi, A., Rapisarda, E., Matarese, G., Williams, R.C., and Leonardi, R. (2020). Association of vitamin D in patients with periodontitis: A cross-sectional study. J. Periodontal Res.10.1111/jre.12746 ↗
14. Isola, G. (2020). Current Evidence of Natural Agents in Oral and Periodontal Health. Nutrients, 12.10.3390/nu12020585 ↗
15. Low-cost periodontal therapy10.1111/j.1600-0757.2011.00429.x ↗
16. Consensus Report: 2nd European Workshop on Tobacco Use Prevention and Cessation for Oral Health Professionals
17. Systematic review on the effect of rinsing with povidone-iodine during nonsurgical periodontal therapy10.1111/j.1600-0765.2009.01232.x ↗
18. Full- vs. partial-mouth disinfection in the treatment of periodontal infections: Short-term clinical and microbiological observations10.1177/00220345950740080501 ↗
19. Clinical Practice Guideline: Tonsillectomy in Children (Update)
20. The effect of tonsillectomy on the immune system: A systematic review and meta-analysis10.1016/j.ijporl.2015.05.016 ↗
21. Toward Adenotonsillectomy in Children: A Review for the General Pediatrician10.1001/jamapediatrics.2015.2016 ↗
22. The intra-oral translocation of periodontopathogens jeopardises the outcome of periodontal therapy. A review of the literature10.1034/j.1600-051x.2001.028006499.x ↗
23. Microcosm biofilms cultured from different oral niches in periodontitis patients10.1080/20022727.2018.1551596 ↗
24. Relationship of clinical and microbiological variables in patients with type 1 diabetes mellitus and periodontitis10.12659/MSM.890879 ↗
25. Bacteriological evaluation of tonsillar microbial flora according to age and tonsillar size in recurrent tonsillitis10.1007/s00405-014-2898-5 ↗
26. Diener, V.N., Gay, A., Soyka, M.B., Attin, T., Schmidlin, P.R., and Sahrmann, P. (2018). What is the influence of tonsillectomy on the level of periodontal pathogens on the tongue dorsum and in periodontal pockets. BMC Oral Health, 18.10.1186/s12903-018-0521-7 ↗
27. Tobacco Smoking and Alcohol Consumption Are Related to Benign Parotid Tumor: A Nested Case-Control Study Using a National Health Screening Cohort10.21053/ceo.2018.01774 ↗
28. Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries10.1093/aje/kwq433 ↗
29. The association between periodontal disease and peritonsillar infection: A prospective study10.1067/mhn.2002.121318 ↗
30. The otologic microbiome: A study of the bacterial microbiota in a pediatric patient with chronic serous otitis media using 16SrRNA gene-based pyrosequencing10.1001/archoto.2011.116 ↗
31. Tonsillectomy or tonsillotomy? A systematic review for paediatric sleep-disordered breathing10.1016/j.ijporl.2017.10.008 ↗
32. Influence of mouth breathing on outcome of scaling and root planing in chronic periodontitis10.1038/s41405-018-0007-3 ↗
33. A randomized clinical trial of salivary substitute as an adjunct to scaling and root planing for management of periodontal inflammation in mouth breathing patients10.2334/josnusd.57.241 ↗