Biocompatibility and Degradation of Fe-Mn-5Si Alloy after Equal-Channel Angular Pressing: In Vitro and In Vivo Study
Source abstract
Abstract
An attempt to improve the functional characteristics of a degradable Fe-Mn-5Si shape memory alloy by means of structure refinement by equal-channel angular pressing (ECAP) was made. In the course of ECAP, an austenitic ultrafine-grained structure was obtained. In shear bands with a thickness of 301 ± 31 nm, twins 11 ± 1 nm in size were formed. Due to the resulting structure, the tensile strength was doubled up to 1419 MPa, and the yield strength was increased up to 1352 MPa, four times higher compared with the annealed state. Dynamic indentation tests revealed a decrease in Young’s modulus by more than 2.5 times after ECAP compared to values measured in the annealed state. The results of the study of hemolytic and cytotoxic activity in vitro, as well as the local and systemic reactivity of the body of laboratory animals after implantation of the test samples indicate the biocompatibility of the alloy after ECAP. Biocompatibility, high specific strength and low modulus of elasticity open prospects for Fe-Mn-5Si alloy after ECAP to be used for the production of degradable implants that can effectively provide the fastening function in osteoreconstruction.
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Research context
OpenAlex topics: Magnesium Alloys: Properties and Applications · Titanium Alloys Microstructure and Properties · Microstructure and mechanical properties
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
A.A. Baikov Institute of Metallurgy and Materials Science of the Russian Academy of Sciences, 119334 Moscow, Russia
N.N. Blokhin National Medical Research Center of Oncology (N.N. Blokhin NMRCO) of the Ministry of Health of the Russian Federation, 115478 Moscow, Russia
Center for Biomedical Engineering, National University of Science and Technology “MISIS”, 119049 Moscow, Russia
P.N. Lebedev Physical Institute of the Russian Academy of Sciences, 119991 Moscow, Russia
Laboratory of Mechanical Properties of Nanostructured Materials and Superalloys, Belgorod State University, 308015 Belgorod, Russia
Department of Physical Materials Science, National University of Science and Technology “MISIS”, 119049 Moscow, Russia
Institute of Physics of Advanced Materials, Ufa University of Science and Technology, 450000 Ufa, Russia
Limited Liability Company “Veterinary Oncological Scientific Center”, 115211 Moscow, Russia
Research Institute of Molecular and Cellular Medicine, RUDN University, 117198 Moscow, Russia
Funding
Russian Science Foundation
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