Stimuli-Responsive Polymeric Nanosystems for Controlled Drug Delivery
Source abstract
Abstract
Biocompatible nanosystems based on polymeric materials are promising drug delivery nanocarrier candidates for antitumor therapy. However, the efficacy is unsatisfying due to nonspecific accumulation and drug release of the nanoparticles in normal tissue. Recently, the nanosystems that can be triggered by tumor-specific stimuli have drawn great interest for drug delivery applications due to their controllable drug release properties. In this review, various polymers and external stimuli that can be employed to develop stimuli-responsive polymeric nanosystems are discussed, and finally, we delineate the challenges in designing this kind of Nanomedicine to improve the therapeutic efficacy.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Nanoplatforms for cancer theranostics · Graphene and Nanomaterials Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
College of Food Engineering and Biotechnology, Hanshan Normal University, Chaozhou 521041, China
Center for Biomedical Optics and Photonics (CBOP) & College of Physics and Optoelectronic Engineering, Key Laboratory of Optoelectronic Devices and Systems, Shenzhen University, Shenzhen 518060, China
CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China
References (100+)
Show source-provided references
1. Biodegradable nanoparticles for drug and gene delivery to cells and tissue10.1016/S0169-409X(02)00228-4 ↗
2. Recent advances with liposomes as pharmaceutical carriers10.1038/nrd1632 ↗
3. Nanoparticle therapeutics: An emerging treatment modality for cancer10.1038/nrd2614 ↗
4. Theranostic nanomedicine10.1021/ar200019c ↗
5. Cancer nanomedicine: Progress, challenges and opportunities10.1038/nrc.2016.108 ↗
6. Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier
7. Hybrid poly(lactic-co-glycolic acid) nanoparticles: Design and delivery prospectives10.1016/j.drudis.2014.09.018 ↗
8. Generation of porous microcellular 85/15 poly (DL-lactide-co-glycolide) foams for biomedical applications10.1016/j.biomaterials.2003.09.040 ↗
9. Biologically responsive polymeric nanoparticles for drug delivery10.1002/adma.201200420 ↗
10. Residual polyvinyl alcohol associated with poly (D,L-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake10.1016/S0168-3659(02)00127-X ↗
11. Biodegradable polymeric micelles for targeted and controlled anticancer drug delivery: Promises, progress and prospects10.1016/j.nantod.2012.08.005 ↗
12. A review of stimuli-responsive nanocarriers for drug and gene delivery10.1016/j.jconrel.2007.12.017 ↗
13. pH-responsive polymer nanoparticles for drug delivery10.1002/marc.201800917 ↗
14. Recent progress of redox-responsive polymeric nanomaterials for controlled release10.1039/D0TB02190C ↗
15. Peptides in cancer nanomedicine: Drug carriers, targeting ligands and protease substrates10.1016/j.jconrel.2011.10.023 ↗
16. Protease-activated nanomaterials for targeted cancer theranostics10.2217/nnm-2017-0068 ↗
17. Phototriggering of liposomal drug delivery systems10.1016/S0169-409X(01)00232-0 ↗
18. Targeted drug delivery by thermally responsive polymers10.1016/S0169-409X(02)00041-8 ↗
19. Liposomes in ultrasonic drug and gene delivery10.1016/j.addr.2008.03.003 ↗
20. Hyaluronic acid-targeted and pH-responsive drug delivery system based on metal-organic frameworks for efficient antitumor therapy10.1016/j.biomaterials.2019.119473 ↗
21. pH-Responsive nanoparticles for drug delivery10.1021/mp100253e ↗
22. Tumor-acidity-cleavable maleic acid amide (TACMAA): A powerful tool for designing smart nanoparticles to overcome delivery barriers in cancer nanomedicine10.1021/acs.accounts.8b00195 ↗
23. A glutathione-responsive sulfur dioxide polymer prodrug as a nanocarrier for combating drug-resistance in cancer chemotherapy10.1016/j.biomaterials.2018.02.011 ↗
24. Cationic vesicles based on amphiphilic pillar arene capped with ferrocenium: A redox-responsive system for drug/siRNA co-delivery10.1002/anie.201407272 ↗
25. Ultrasensitive GSH-responsive ditelluride-containing poly(ether-urethane) nanoparticles for controlled drug release10.1021/acsami.6b14639 ↗
26. GSH-Responsive supramolecular nanoparticles constructed by β-d-galactose-modified pillar arene and camptothecin prodrug for targeted anticancer drug delivery10.1039/C7CC04932C ↗
27. Targeting proteases: Successes, failures and future prospects10.1038/nrd2092 ↗
28. Cathepsin-sensitive nanoscale drug delivery systems for cancer therapy and other diseases10.1016/j.addr.2019.01.010 ↗
29. Matrix metalloproteases-responsive nanomaterials for tumor targeting diagnosis and treatment10.1080/02652048.2017.1343873 ↗
30. Stimuli-responsive nanocarriers for drug delivery10.1038/nmat3776 ↗
31. A light-responsive, self-immolative linker for controlled drug delivery via peptide- and protein-drug conjugates10.1039/C9SC03016F ↗
32. Red and NIR light-responsive polymeric nanocarriers for on-demand drug delivery10.2174/0929867326666190215113522 ↗
33. Remote light-responsive nanocarriers for controlled drug delivery: Advances and perspectives10.1002/smll.201903060 ↗
34. Light-responsive polymersomes with a charge-switch for targeted drug delivery10.1039/C9TB02411E ↗
35. Thermo-responsive drug delivery from polymeric micelles constructed using block copolymers of poly(N-isopropylacrylamide) and poly(butylmethacrylate)10.1016/S0168-3659(99)00029-2 ↗
36. Thermo-sensitive dual-functional nanospheres with enhanced lubrication and drug delivery for the treatment of osteoarthritis10.1002/chem.202001372 ↗
37. Chatterjee, S., and Chi-Leung Hui, P. (2019). Review of stimuli-responsive polymers in drug delivery and textile application. Molecules, 24.10.3390/molecules24142547 ↗
38. Ultrasound-responsive carriers for therapeutic applications10.1021/acsbiomaterials.9b01979 ↗
39. Ultrasound-mediated polymeric micelle drug delivery10.1007/978-3-319-22536-4_20 ↗
40. Ultrasound-responsive lipid microbubbles for drug delivery: A review of preparation techniques to optimise formulation size, stability and drug loading10.1016/j.ijpharm.2020.119559 ↗
41. Poly-є-caprolactone based formulations for drug delivery and tissue engineering: A review10.1016/j.jconrel.2011.09.064 ↗
42. Polymeric modification and its implication in drug delivery: Poly-ε-caprolactone (PCL) as a model polymer10.1021/mp3001952 ↗
43. Formulation and immunological evaluation of novel vaccine delivery systems based on bioresorbable poly(ethylene glycol)-block-poly(lactide-co-epsilon-caprolactone)10.1002/jbm.b.31352 ↗
44. Self-assembled star-shaped chlorin-core poly(epsilon-caprolactone)-poly(ethylene glycol) diblock copolymer micelles for dual chemo-photodynamic therapies10.1016/j.biomaterials.2008.05.018 ↗
45. cRGD-functionalized polymer micelles for targeted doxorubicin delivery10.1002/anie.200460800 ↗
46. Biodegradable poly(epsilon-caprolactone)-poly(ethylene glycol) copolymers as drug delivery system10.1016/j.ijpharm.2009.07.033 ↗
47. PLGA: A unique polymer for drug delivery10.4155/tde.14.91 ↗
48. Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy PEG-PLGA copolymer nanoparticles10.1016/j.biomaterials.2011.07.032 ↗
49. Pharmacokinetics of curcumin-loaded PLGA and PLGA-PEG blend nanoparticles after oral administration in rats10.1016/j.colsurfb.2012.06.024 ↗
50. Poly(lactic acid)-poly(ethylene oxide) block copolymers: New directions in self-assembly and biomedical applications10.2174/092986711798347324 ↗
51. ABA-triblock copolymers from biodegradable polyester A-blocks and hydrophilic poly(ethylene oxide) B-blocks as a candidate for in situ forming hydrogel delivery systems for proteins10.1016/S0169-409X(01)00244-7 ↗
52. Maeda, T., Kitagawa, M., Hotta, A., and Koizumi, S. (2019). Thermo-responsive nanocomposite hydrogels based on PEG-b-PLGA diblock copolymer and laponite. Polymers, 11.10.3390/polym11020250 ↗
53. Biodegradable polymers derived from amino acids10.1002/mabi.201100324 ↗
54. Degradable controlled-release polymers and polymeric nanoparticles: Mechanisms of controlling drug release10.1021/acs.chemrev.5b00346 ↗
55. Peptide-based Biomaterials for protease-enhanced drug delivery10.1021/bm050920f ↗
56. Dendritic alpha, epsilon-poly(L-lysine)s as delivery agents for antisense oligonucleotides10.1007/s11095-006-9231-y ↗
57. Biomedical applications of chemically and microbiologically synthesized poly(glutamic acid) and poly(lysine)10.2174/1389557043487420 ↗
58. Synthesis, characterization, and blood compatibility of polyamidoamines copolymers10.1016/S0142-9612(03)00122-4 ↗
59. Poly (γ-glutamic acid) based combination of water-insoluble paclitaxel and TLR7 agonist for chemo-immunotherapy10.1016/j.biomaterials.2014.05.076 ↗
60. Agmatine-grafted bioreducible poly(l-lysine) for gene delivery with low cytotoxicity and high efficiency10.1039/C9TB02641J ↗
61. Thomas, T.J., Tajmir-Riahi, H.A., and Pillai, C.K.S. (2019). Biodegradable polymers for gene delivery. Molecules, 24.10.3390/molecules24203744 ↗
62. Dendritic poly(L-lysine)-b-Poly(L-lactide)-b-dendritic poly(L-lysine) amphiphilic gene delivery vectors: Roles of PLL dendritic generation and enhanced transgene efficacies via termini modification10.1021/bm900456x ↗
63. Polyethylenimine-grafted copolymer of poly(l-lysine) and poly(ethylene glycol) for gene delivery10.1016/j.biomaterials.2010.10.044 ↗
64. Metabolite-based modification of poly(l-lysine) for improved gene delivery10.1021/acs.biomac.0c00614 ↗
65. Polycation-based gene therapy: Current knowledge and new perspectives10.2174/156652311796150408 ↗
66. Drug delivery of oligonucleotides by peptides10.1016/j.ejpb.2004.03.031 ↗
67. Polyglutamic acid-PEG nanocapsules as long circulating carriers for the delivery of docetaxel10.1016/j.ejpb.2014.02.004 ↗
68. Self-assembling stereocomplex nanoparticles by enantiomeric poly(γ-glutamic acid)-poly(lactide) graft copolymers as a protein delivery carrier10.1002/mabi.201300434 ↗
69. Preparation of pixantrone/poly(γ-glutamic acid) nanoparticles through complex self-assembly for oral chemotherapy10.1002/mabi.201200137 ↗
70. Poly(ortho esters)—From concept to reality10.1021/bm040049n ↗
71. Poly(ortho esters): Synthesis, characterization, properties and uses10.1016/S0169-409X(02)00055-8 ↗
72. Electrospun fibers of acid-labile biodegradable polymers containing ortho ester groups for controlled release of paracetamol10.1016/j.ejpb.2008.05.003 ↗
73. Synthesis and characterization of biodegradable poly(ester amide)s with pendant amine functional groups and in vitro cellular response10.1021/bm9006437 ↗
74. Poly(ester amide) blend microspheres for oral insulin delivery10.1016/j.ijpharm.2013.07.022 ↗
75. Poly(ester amide) particles for controlled delivery of celecoxib10.1002/jbm.a.36632 ↗
76. Biodegradable arginine-based poly(ester-amide)s as non-viral gene delivery reagents10.1016/j.biomaterials.2008.04.026 ↗
77. Monitoring the in vitro enzyme-mediated degradation of degradable poly(ester amide) for controlled drug delivery by LC-ToF-MS10.1021/bm200709r ↗
78. Parallel synthesis and biophysical characterization of a degradable polymer library for gene delivery10.1021/ja034429c ↗
79. Combinatorial synthesis of chemically diverse core-shell nanoparticles for intracellular delivery10.1073/pnas.1106379108 ↗
80. Development of a vinyl ether-functionalized polyphosphoester as a template for multiple postpolymerization conjugation chemistries and study of core degradable polymeric nanoparticles10.1021/ma402480a ↗
81. Supramolecular micellar drug delivery system based on multi-arm block copolymer for highly effective encapsulation and sustained-release chemotherapy10.1039/C9TB01221D ↗
82. Improving paclitaxel delivery: In vitro and in vivo characterization of PEGylated polyphosphoester-based nanocarriers10.1021/ja512616s ↗
83. Polyphosphoesters in drug and gene delivery10.1016/S0169-409X(03)00040-1 ↗
84. Hyperbranched polyphosphates for drug delivery application: Design, synthesis, and in vitro evaluation10.1021/bm100188h ↗
85. Preparation and in vitro antimicrobial activity of silver-bearing degradable polymeric nanoparticles of polyphosphoester-block-poly(L-lactide)10.1021/nn507046h ↗
86. Polymers in drug delivery10.1016/S1367-5931(00)00227-1 ↗
87. Trimethylated chitosans as non-viral gene delivery vectors: Cytotoxicity and transfection efficiency10.1016/j.jconrel.2005.01.001 ↗
88. Polymer-based nanoparticles for oral insulin delivery: Revisited approaches10.1016/j.biotechadv.2015.02.010 ↗
89. Polyethylenimine and chitosan carriers for the delivery of RNA interference effectors10.1517/17425247.2013.840286 ↗
90. Challenges in evaluation of chitosan and trimethylated chitosan (TMC) as mucosal permeation enhancers: From synthesis to in vitro application10.1016/j.jconrel.2013.10.022 ↗
91. Advances in chitosan-based drug delivery vehicles10.1039/c3nr00338h ↗
92. Chitosan-based siRNA delivery systems10.1016/j.jconrel.2013.08.005 ↗
93. Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules10.1016/j.addr.2012.10.010 ↗
94. Hyaluronic acid: A natural biopolymer with a broad range of biomedical and industrial applications10.1007/s10529-006-9219-z ↗
95. Hyaluronic acid for anticancer drug and nucleic acid delivery10.1016/j.addr.2015.11.011 ↗
96. Application of hyaluronic acid as carriers in drug delivery10.1080/10717544.2018.1450910 ↗
97. Hyaluronic acid-based biopharmaceutical delivery and tumor-targeted drug delivery system10.1016/j.jconrel.2018.04.015 ↗
98. A hydrogel-based tumor model for the evaluation of nanoparticle-based cancer therapeutics10.1016/j.biomaterials.2013.12.080 ↗
99. Trombino, S., Servidio, C., Curcio, F., and Cassano, R. (2019). Strategies for hyaluronic acid-based hydrogel design in drug delivery. Pharmaceutics, 11.10.3390/pharmaceutics11080407 ↗
100. Stimuli responsive nanoparticles for controlled anti-cancer drug release10.2174/0929867325666180111095913 ↗