journal article·2023-12-12Open access

New Insights into Bioactive Compounds of Wild-Growing Medicinal Plants

Omar Salem, Lidia Szwajkowska-Michałek, Anna Przybylska-Balcerek, Tomasz Szablewski, Renata Cegielska-Radziejewska, Dariusz Świerk, Kinga Stuper-Szablewska

Applied Sciences· Volume 13· Issue 24

Abstract

Plants contain bioactive substances and secondary metabolites that have a variety of functions, including antibacterial, antioxidant, anti-inflammatory, and anticancer activities. In this study, the content of bioactive compounds in five medicinal plants was determined, i.e., Plantago major L., Armoracia rusticana, Hypericum perforatum L., Rumex acetosa L., and Urtica dioica L., from 38 locations. Additionally, the antimicrobial effect of extracts of bioactive compounds from the above-mentioned plants was checked. The experiment used an original method of extracting bioactive compounds. Purpose of the research: the assessment of antimicrobial activity and chemical characterization of extracts obtained using our own method of isolating bioactive compounds from green parts of medical plants in Poland. Based on the research, the presence of bioactive compounds, i.e., phenolic acids and flavonoids, was found in the tested plant extracts. The results of this study suggest that the geographic parameters of the locations where these plants grow have different effects on their biochemical composition and biological activity. The results showed that all tested plants had significant antibacterial activities. Rumex acetose L. showed the highest antimicrobial activity against Escherichia coli and Salmonella enteritidis. These studies supplement the existing literature on the subject with information about the antimicrobial properties of the tested plant extracts that can be used in herbal medicine. The results have significant implications for the pharmaceutical, nutraceutical, and cosmetic sectors, establishing a foundation for future research in this area.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Medicinal plant effects and applications · Phytochemicals and Antioxidant Activities · Phytochemistry and Biological Activities

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry, Poznań University of Life Sciences, 60-637 Poznan, Poland

Department of Management of Food Quality and Safety, Poznań University of Life Sciences, 60-637 Poznan, Poland

Department of Landscape Architecture, Poznań University of Life Sciences, 60-637 Poznan, Poland

References (49)

Show source-provided references
1. Importance of ethnopharmacological studies in drug discovery: Role of medicinal plants10.1007/s11101-019-09629-9 ↗
2. Xiong, Y., and Long, C. (2020). An ethnoveterinary study on medicinal plants used by the Buyi people in Southwest Guizhou, China. J. Ethnobiol. Ethnomed., 16.10.1186/s13002-020-00396-y ↗
3. Lowe, H., Steele, B., Bryant, J., Fouad, E., Toyang, N., and Ngwa, W. (2021). Antiviral activity of Jamaican medicinal plants and isolated bioactiv compounds. Molecules, 26.10.3390/molecules26030607 ↗
4. Tran, N., Pham, B., and Le, L. (2020). Bioactive Compounds in Anti-Diabetic Plants. Biology, 9.10.3390/biology9090252 ↗
5. Screening techniques for the identification of bioactive compounds in natural products10.1016/j.jpba.2019.02.027 ↗
6. Evaluation of antibacterial activity and synergistic effect between antibiotic and the essential oils of some medicinal plants10.1016/j.apjtb.2015.09.024 ↗
7. Mechanochemical solid acid/base reactions for obtaining biologically active preparations and extracting plant materials10.1080/17518253.2017.1339832 ↗
8. Kowalska-Krochmal, B., and Dudek-Wicher, R. (2021). The minimum inhibitory concentration of antibiotics: Methods, interpretation, clinical relevance. Pathogens, 10.10.3390/pathogens10020165 ↗
9. Chemical constituents and medical benefits of Plantago major10.1016/j.biopha.2017.09.152 ↗
10. Green-based methods to obtain bioactive extracts from Plantago major and Plantago lanceolata10.1016/j.supflu.2016.09.018 ↗
11. Armoracia rusticana Gaertn., Mey. & Scherb. A neglected multiuseful species
12. Altitudinal impacts on chemical content and composition of Hypericum perforatum, a prominent medicinal herb10.1016/j.sajb.2020.09.034 ↗
13. Sorrel (Rumex acetosa L.): Not Only a Weed but a Promising Vegetable and Medicinal Plant10.1007/s12229-020-09225-z ↗
14. Chitosan films incorporated with nettle (Urtica dioica L.) extract-loaded nanoliposomes: II. Antioxidant activity and release properties10.1080/02652048.2016.1208295 ↗
15. Kurasiak-Popowska, D., Graczyk, M., Przybylska-Balcerek, A., Stuper-Szablewska, K., and Szwajkowska-Michałek, L. (2022). An Analysis of Variability in the Content of Phenolic Acids and Flavonoids in Camelina Seeds Depending on Weather Conditions, Functional Form, and Genotypes. Molecules, 27.10.3390/molecules27113364 ↗
16. P Przybylska-Balcerek, A., Szablewski, T., Szwajkowska-Michałek, L., Świerk, D., Cegielska-Radziejewska, R., Krejpcio, Z., Suchowilska, E., Tomczyk, Ł., and Stuper-Szablewska, K. (2021). Sambucus nigra Extracts—Natural Antioxidants and Antimicrobial Compounds. Molecules, 26.10.3390/molecules26102910 ↗
17. Bioactive compounds in sorghum10.1007/s00217-018-3207-0 ↗
18. Dziedzinski, M., Kobus-Cisowska, J., Szymanowska, D., Stuper-Szablewska, K., and Baranowska, M. (2020). Identification of Polyphenols from Coniferous Shoots as Natural Antioxidants and Antimicrobial Compounds. Molecules, 25.10.3390/molecules25153527 ↗
19. Stuper-Szablewska, K., Szablewski, T., Przybylska-Balcerek, A., Szwajkowska-Michałek, L., Krzyżaniak, M., Świerk, D., Cegielska-Radziejewska, R., and Krejpcio, Z. (2023). Antimicrobial Activities Evaluation and Phytochemical Screening of Some Selected Plant Materials Used in Traditional Medicine. Molecules, 28.10.3390/molecules28010244 ↗
20. Przybylska-Balcerek, A., Szablewski, T., Cegielska-Radziejewska, R., Góral, T., Kurasiak-Popowska, D., and Stuper-Szablewska, K. (2022). Assessment of Antimicrobial Properties of Phenolic Acid Extracts from Grain Infected with Fungi from the Genus Fusarium. Molecules, 27.10.3390/molecules27051741 ↗
21. Biochemical studies on Plantago major L.
22. Ferulic acid. Properties, determination and application in cosmetics
23. Comparison of different solvents for isolation of phenolic compounds from horseradish (Armoracia rusticana L.) leaves
24. Variation in total polyphenolic contents, DNA protective potential and antioxidant capacity from aqueous and ethanol extracts in different plant parts of Hypericum perforatum L.10.5530/ijper.51.2s.43 ↗
25. Puccinelli, M., Pezzarossa, B., Pintimalli, L., and Malorgio, F. (2021). Selenium Biofortification of Three Wild Species, Rumex acetosa L., Plantago coronopus L., and Portulaca oleracea L., Grown as Microgreens. Agronomy, 11.10.3390/agronomy11061155 ↗
26. Antioxidant Capacity and Total Phenolic and Flavonoid Contents of Methanolic Extracts of Urtica dioica L. by Different Extraction Techniques
27. Antioxidant activity, phenol and flavonoid contents of some selected Iranian medicinal plants
28. Mickymaray, S., and Al Aboody, M.S. (2019). In vitro antioxidant and bactericidal efficacy of 15 common spices: Novel therapeutics for urinary tract infections?. Medicina, 55.10.3390/medicina55060289 ↗
29. Antimicrobial properties of selected essential oils in vapour phase against foodborne bacteria10.1016/j.foodcont.2008.03.007 ↗
30. Antibacterial activities of isothiocyanates extracted from horseradish (Armoracia rusticana) root against Antibiotic-resistant bacteria10.1007/s10068-015-0131-y ↗
31. The Biological Activities of Hypericum perforatum L.10.21010/ajtcam.v14i1.23 ↗
32. A review of the antibacterial activity of Hypericum perforatum L.10.1016/j.jep.2010.07.034 ↗
33. The profile of bioactive compounds in the grain of various x Tritordeum genotypes10.1016/j.jcs.2021.103352 ↗
34. Osman, K., Mohamed, J., and Hing, H. (2023, April 13). Effects of Methanol, Ethanol and Aqueous Extract of Plantago major on Gram Positive Bacteria, Gram Negative Bacteria and Yeast Biomedicine View Project Protective Effect of Palm Vitamin E on Streptozotocin Induced Diabetic Rats. Available online: https://www.researchgate.net/publication/308597277.
35. Antibacterial effects of ethanol and acetone extract of Plantago major L. on gram positive and gram negative bacteria
36. Antioxidant and antimicrobial activities of Plantago major
37. Antimicrobial activity of the extracts from fruits of Rumex L. species
38. Screening antimicrobial activity of various extracts of Urtica Dioica
39. Sabzar Antibacterial Activity
40. Assessment and comparison of phytochemical constituents and biological activities of bitter bean (Parkia speciosa Hassk.) collected from different locations in Malaysia10.1186/s13065-018-0377-6 ↗
41. Effects of Plantago major L. leaf extracts on oral epithelial cells in a scratch assay10.1016/j.jep.2012.03.016 ↗
42. Detection of genetic and phytochemical differences between and within populations of Plantago major L. (plantain)10.1016/j.scienta.2012.01.002 ↗
43. Study of dynamic accumulation of secondary metabolites in three subspecies of Hypericum perforatum10.1016/j.fitote.2009.08.002 ↗
44. Estimation of some plant secondary products in Urtica dioica L., Viola odorata L. and Melissa officinalis L. Naturally Grown in Hawraman-Kurdistan Region of Iraq
45. Karimi, E., Jaafar, H.Z.E., and Ahmad, S. (2013). Antifungal, anti-inflammatory and cytotoxicity activities of three varieties of labisia pumila benth: From microwave obtained extracts. BMC Complement. Altern. Med., 13.10.1186/1472-6882-13-20 ↗
46. Light intensity effects on production and antioxidant activity of flavonoids and phenolic compounds in leaves, stems and roots of three varieties of Labisia pumila Benth
47. Influence of environmental factors on the active substance production and antioxidant activity in Potentilla fruticosa L. and its quality assessment10.1038/srep28591 ↗
48. Phytochemical variation: How to resolve the quality controversies of herbal medicinal products?10.1016/j.hermed.2015.04.002 ↗
49. Plant cell cultures: Bioreactors for industrial production10.1007/978-1-4419-7347-4_15 ↗