RETRACTED: A Si-αTCP Scaffold for Biomedical Applications: An Experimental Study Using the Rabbit Tibia Model
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Source abstract
Abstract
We herein hypothesize that bioceramics with an appropriate architecture made of Si-αtricalcium phosphate (Si-αTCP) meet the biocompatibility and biological safety requirements for bone grafting applications. Polyurethane sponges were used as templates, soaked with ceramic slurry at different ratios and sintered at 1400 °C for 3 h at heating and cooling rates of 5 °C/min. Four critical size defects of 6 mm Ø were created in 15 NZ tibias. Three working times were established as 15, 30 and 60 days. A highly porous Si-αTCP scaffold with micro and macropores and pore interconnectivity was produced by the polymer replication method. Considerably more bone formation took place in the pores and the periphery of the implant for the Si-αTCP scaffolds than for the control group. The ceramic scaffold (68.32% ± 1.21) generated higher bone-to-implant contact (BIC) percentage values (higher quality, closer contact) than the control group, according to the histomorphometric analysis, and defect closure was significant compared with the control group. The highest percentages of BIC and bone formation were found after 60 days of implantation. These results suggest that the Si-αTCP scaffold is advantageous for initial bone regeneration.
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Research context
OpenAlex topics: Bone Tissue Engineering Materials · Dental materials and restorations · biodegradable polymer synthesis and properties
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Affiliations
Instituto de Bioingenieria, Universidad Miguel Hernandez, Avda. Ferrocarril s/n 03202-Elche, Alicante, Spain
Instituto de Cerámica y Vidrio, ICV-CSIC, C/Kelsen 5, 28049 Madrid, Spain
Biotecnos Research Center, Rua Dr. Bonazo nº 57 Santa Maria (RS), 97015-001, Brasil
Cátedra Internacional de Investigación en Odontología, Universidad Católica San Antonio de Murcia, Avda. Jerónimos, 135, 30107 Guadalupe, Murcia, Spain
Funding
Ministerio de Economía y Competitividad · Ministerio de Economia y Competitividad
References (51)
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