Composition, Bioactivities, Microbiome, Safety Concerns, and Impact of Essential Oils on the Health Status of Domestic Animals
Source abstract
Abstract
Essential oils (EOs) are highly concentrated and volatile blends of nonpolar substances that are derived from aromatic plant components and comprise terpenes, terpenoids, and phenylpropanoids, exhibiting diverse biological and pharmacological properties. The burgeoning pet industry is interested in EOs as a potential solution for common health issues in domestic animals, particularly in addressing antimicrobial resistance. The present literature review summarizes the composition, properties, benefits, safety considerations, and effects of EOs on domestic animals. The applications of EOs range from antimicrobial effects to antioxidant, anti-inflammatory, and anticancer activities, etc. The chemical constituents of EOs, exemplified by eucalyptus EO and rosemary EO, highlight their distinct aromatic profiles and potential benefits. Nevertheless, understanding the chemical makeup of EOs is fundamental to assessing their potential impacts on biological systems. The gut microbiota plays a crucial role in regulating various metabolic processes in the host, including energy homeostasis, glucose metabolism, and lipid metabolism. Safety considerations, including potential toxicity risk awareness, are essential when incorporating EOs into animal care routines. The feed additives incorporating EOs have shown promise in influencing gut microbiota balance, reducing inflammation, and acting as antioxidants. However, considering the potential risks associated with high doses or multiple administrations, cautious application is paramount. Preliminary studies suggest low toxicity levels, but further research is required to evaluate the safety of EOs. Though studies have reported the beneficial effects of EOs on pets and animals, further research is needed to validate the findings in real-world conditions. The paper also discussed the regulatory considerations and future perspectives on applying EOs in veterinary medicine.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Essential Oils and Antimicrobial Activity · Bee Products Chemical Analysis · Insect Pest Control Strategies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Office of Research Administration, Chiang Mai University, Chiang Mai 50200, Thailand
Innovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand
References (100+)
Show source-provided references
1. In Vitro bacteriostatic activity of Origanum vulgare, Cymbopogon citratus, and Lippia alba essential oils in cat food bacterial isolates10.5433/1679-0359.2019v40n6Supl2p3107 ↗
2. Exposure assessment of cattle via roughages to plants producing compounds of concern10.1016/j.foodchem.2015.02.050 ↗
3. Effects of Litsea cubeba (Lour.) Persoon essential oil aromatherapy on mood states and salivary cortisol levels in healthy volunteers10.1155/2020/4389239 ↗
4. Do recent research studies validate the medicinal plants used in British Columbia, Canada for pet diseases and wild animals taken into temporary care?10.1016/j.jep.2019.02.030 ↗
5. de Sousa, D.P., Damasceno, R.O.S., Amorati, R., Elshabrawy, H.A., de Castro, R.D., Bezerra, D.P., Nunes, V.R.V., Gomes, R.C., and Lima, T.C. (2023). Essential Oils: Chemistry and Pharmacological Activities. Biomolecules, 13.10.3390/biom13071144 ↗
6. Secondary metabolites of plants
7. Botanical control of parasites in veterinary medicine
8. Thangaleela, S., Sivamaruthi, B.S., Kesika, P., Tiyajamorn, T., Bharathi, M., and Chaiyasut, C. (2022). A narrative review on the bioactivity and health benefits of alpha-phellandrene. Sci. Pharm., 90.10.3390/scipharm90040057 ↗
9. Castagna, F., Palma, E., Cringoli, G., Bosco, A., Nisticò, N., Caligiuri, G., Britti, D., and Musella, V. (2019). Use of Complementary Natural Feed for Gastrointestinal Nematodes Control in Sheep: Effectiveness and Benefits for Animals. Animals, 9.10.3390/ani9121037 ↗
10. Vijayakumar, R., and Raja, S. (2022). Plant Secondary Metabolites: Therapeutic Potential and Pharmacological Properties. Secondary Metabolites-Trends and Reviews, IntechOpen. [1st ed.].10.5772/intechopen.98129 ↗
11. Thangaleela, S., Sivamaruthi, B.S., Kesika, P., Bharathi, M., Kunaviktikul, W., Klunklin, A., Chanthapoon, C., and Chaiyasut, C. (2022). Essential oils, phytoncides, aromachology, and aromatherapy—A review. Appl. Sci., 12.10.3390/app12094495 ↗
12. The composition, pharmacological and economic importance of essential oil of Litsea cubeba (Lour.) Pers10.1590/fst.35720 ↗
13. Sivamaruthi, B.S., Kesika, P., and Chaiyasut, C. (2021). Influence of Probiotic Supplementation on Health Status of the Dogs: A Review. Appl. Sci., 11.10.3390/app112311384 ↗
14. Diet–Microbiota Interactions as Moderators of Human Metabolism10.1038/nature18846 ↗
15. Odamaki, T., Kato, K., Sugahara, H., Hashikura, N., Takahashi, S., Xiao, J., Abe, F., and Osawa, R. (2016). Age-Related Changes in Gut Microbiota Composition from Newborn to Centenarian: A Cross-Sectional Study. BMC Microbiol., 16.10.1186/s12866-016-0708-5 ↗
16. Factors Affecting the Composition of the Gut Microbiota, and Its Modulation10.7717/peerj.7502 ↗
17. Gorczyca, K., Obuchowska, A., Kimber-Trojnar, Z., Wierzchowska-Opoka, M., and Leszczy´nska-Gorzelak, B. (2022). Changes in the Gut Microbiome and Pathologies in Pregnancy. Int. J. Environ. Res. Public Health, 19.10.3390/ijerph19169961 ↗
18. Host Remodeling of the Gut Microbiome and Metabolic Changes during Pregnancy10.1016/j.cell.2012.07.008 ↗
19. Stages of Pregnancy and Weaning Influence the Gut Microbiota Diversity and Function in Sows10.1111/jam.14344 ↗
20. Miko, E., Csaszar, A., Bodis, J., and Kovacs, K. (2022). The Maternal–Fetal Gut Microbiota Axis: Physiological Changes, Dietary Influence, and Modulation Possibilities. Life, 12.10.3390/life12030424 ↗
21. The Developing Gut Microbiota and Its Consequences for Health10.1017/S2040174418000119 ↗
22. Unveiling Bifidobacterial Biogeography across the Mammalian Branch of the Tree of Life10.1038/ismej.2017.138 ↗
23. Adverse reactions from essential oil-containing natural flea products exempted from Environmental Protection Agency regulations in dogs and cats10.1111/j.1476-4431.2012.00780.x ↗
24. Khan, S., Abdo, A.A.A., Shu, Y., Zhang, Z., and Liang, T. (2023). The Extraction and Impact of Essential Oils on Bioactive Films and Food Preservation, with Emphasis on Antioxidant and Antibacterial Activities—A Review. Foods, 12.10.3390/foods12224169 ↗
25. Decrypting solvent-free microwave as a dual green extraction: Studying simultaneous extraction of essential oil and phenolics from the same biomass-valorization and outperforming traditional approaches10.1002/jctb.7597 ↗
26. Optimization of Eucalyptus essential oil extraction by applying response surface methodology in traditional distillation and its adaption to solar thermal process10.1186/s40807-024-00118-y ↗
27. Application of response surface methodology to optimize the extraction of essential oil from Rosmarinus officinalis using microwave-assisted hydrodistillation
28. Mukherjee, S., Chouhan, K.B., Khan, A., Meshram, S., Srivastava, S.C., Das, S., Yadav, V., Patra, A., and Mandal, V. (2024). An eco-extraction protocol based on blended mode microwave hydrodiffusion and gravity (MHG) principle for floral biomass valorisation through simultaneous recovery of volatile and non-volatile principles: The case of Tagetes erecta. Biomass Convers. Biorefin.10.1007/s13399-024-05654-7 ↗
29. Optimization of Process Parameters Using Response Surface Methodology for Essential Oil Extraction from Canarium odontophyllum Kernels by Subcritical Water Treatment10.1007/s12161-024-02624-7 ↗
30. Čmiková, N., Galovičová, L., Schwarzová, M., Vukic, M.D., Vukovic, N.L., Kowalczewski, P.Ł., Bakay, L., Kluz, M.I., Puchalski, C., and Kačániová, M. (2023). Chemical Composition and Biological Activities of Eucalyptus globulus Essential Oil. Plants, 12.10.3390/plants12051076 ↗
31. Chemical composition and comparative analysis of lavender essential oil samples from Bulgaria in relation to the pharmacological effects10.3897/pharmacia.70.e104404 ↗
32. Comparing two different extraction techniques on chemical composition and antioxidant property of three essential oils of Ferulago contracta, Rosmarinus officinalis and Lavendula sublepoidota10.1007/s11694-023-01859-y ↗
33. Assessment of chemical compositions and antibacterial activity of the essential oil of Mentha piperita in response to salicylic acid10.1080/14786419.2023.2256020 ↗
34. Dangol, S., Poudel, D.K., Ojha, P.K., Maharjan, S., Poudel, A., Satyal, R., Rokaya, A., Timsina, S., Dosoky, N.S., and Satyal, P. (2023). Essential Oil Composition Analysis of Cymbopogon Species from Eastern Nepal by GC-MS and Chiral GC-MS, and Antimicrobial Activity of Some Major Compounds. Molecules, 28.10.3390/molecules28020543 ↗
35. Chemical Composition of Essential Oils of Thymus and Mentha Species and Their Antifungal Activities10.3390/molecules14010238 ↗
36. Chemical composition and antimicrobial activity of the essential oil of Rosemary10.1016/j.etap.2011.03.011 ↗
37. Essential oil content and composition of Indian sandalwood (Santalum album) in Sri Lanka10.1007/s11676-013-0331-3 ↗
38. Chemical composition of neem and lavender essential oils and their antifungal activity against pathogenic fungi causing ginseng root rot
39. EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Bampidis, V., Azimonti, G., Bastos, M.L., Christensen, H., Kos Durjava, M., Kouba, M., López-Alonso, M., López Puente, S., and Marcon, F. (2020). Safety and efficacy of essential oil, oleoresin and tincture from Zingiber officinale Roscoe when used as sensory additives in feed for all animal species. EFSA J., 18, e06147.10.2903/j.efsa.2020.6147 ↗
40. Effect of Galangal (Alpinia galanga) essential oil supplementation on milk production, composition, and characteristics of fatty acids in dairy cows
41. Ruiz-Cano, D., Sánchez-Carrasco, G., El-Mihyaoui, A.B., and Arnao, M. (2022). Essential Oils and Melatonin as Functional Ingredients in Dogs. Animals, 12.10.3390/ani12162089 ↗
42. Ibrahium, S.M., Wahba, A.A., Farghali, A.A., Abdel-Baki, A.-A.S., Mohamed, S.A.A., Al-Quraishy, S., Hassan, A.O., and Aboelhadid, S.M. (2022). Acaricidal Activity of Tea Tree and Lemon Oil Nanoemulsions against Rhipicephalus annulatus. Pathogens, 11.10.3390/pathogens11121506 ↗
43. EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Bampidis, V., Azimonti, G., Bastos, M.L., Christensen, H., Fašmon Durjava, M., Kouba, M., López-Alonso, M., López Puente, S., and Marcon, F. (2022). Safety and efficacy of feed additives consisting of essential oils from the bark and the leaves of Cinnamomum verum J. Presl (Cinnamon Bark Oil Cinnamon Leaf Oil) Use All Anim. Species (FEFANA asbl). EFSA J., 20, e07601.10.2903/j.efsa.2022.7601 ↗
44. EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Bampidis, V., Azimonti, G., Bastos, M.L., Christensen, H., Durjava, M., Kouba, M., López-Alonso, M., López Puente, S., and Marcon, F. (2023). Safety and efficacy of a feed additive consisting of an essential oil from the seeds of Myristica fragrans Houtt. (nutmeg oil) for all animal species (FEFANA asbl). EFSA J., 21, e08066.10.2903/j.efsa.2023.8066 ↗
45. Lupia, C., Castagna, F., Bava, R., Naturale, M.D., Zicarelli, L., Marrelli, M., Statti, G., Tilocca, B., Roncada, P., and Britti, D. (2024). Use of Essential Oils to Counteract the Phenomena of Antimicrobial Resistance in Livestock Species. Antibiotics, 13.10.3390/antibiotics13020163 ↗
46. Toxicity and therapeutic applications of citrus essential oils (CEOs): A review10.1080/10942912.2022.2158864 ↗
47. In Vitro effects of cinnamon, oregano, and thyme essential oils against Escherichia coli and Trueperella pyogenes isolated from dairy cows with clinical endometritis10.1016/j.theriogenology.2022.11.010 ↗
48. Ebani, V.V., Najar, B., Bertelloni, F., Pistelli, L., Mancianti, F., and Nardoni, S. (2018). Chemical Composition and In Vitro Antimicrobial Efficacy of Sixteen Essential Oils against Escherichia coli and Aspergillus fumigatus Isolated from Poultry. Vet. Sci., 5.10.3390/vetsci5030062 ↗
49. Ebani, V.V., Nardoni, S., Bertelloni, F., Tosi, G., Massi, P., Pistelli, L., and Mancianti, F. (2019). In Vitro Antimicrobial Activity of Essential Oils against Salmonella enterica Serotypes Enteritidis and Typhimurium Strains Isolated from Poultry. Molecules, 24.10.3390/molecules24050900 ↗
50. Ebani, V.V., Nardoni, S., Bertelloni, F., Najar, B., Pistelli, L., and Mancianti, F. (2017). Antibacterial and Antifungal Activity of Essential Oils against Pathogens Responsible for Otitis Externa in Dogs and Cats. Medicines, 4.10.3390/medicines4020021 ↗
51. Ebani, V.V., Nardoni, S., Bertelloni, F., Pistelli, L., and Mancianti, F. (2018). Antimicrobial Activity of Five Essential Oils against Bacteria and Fungi Responsible for Urinary Tract Infections. Molecules, 23.10.3390/molecules23071668 ↗
52. Synergistic, antidermatophytic activity and chemical composition of essential oils against zoonotic dermatophytosis10.1134/S1068162022060218 ↗
53. Stringaro, A., Colone, M., Cecchetti, S., Zeppetella, E., Spadaro, F., and Angiolella, L. (2022). “In Vivo” and “In Vitro” antimicrobial activity of Origanum vulgare essential oil and its two phenolic compounds on clinical isolates of Candida spp.. Arch. Microbiol., 205.10.1007/s00203-022-03355-1 ↗
54. Chemical composition and antifungal activity of essential oil from Origanum vulgare against Botrytis cinerea10.1016/j.foodchem.2021.130506 ↗
55. Antifungal In Vitro Activity of Essential Oils against Clinical Isolates of Malassezia pachydermatis from Canine Ears: A Report from a Practice Laboratory10.1159/000504316 ↗
56. Phytochemical analysis and in vitro antiviral activities of the essential oils of seven Lebanon species10.1002/cbdv.200890045 ↗
57. Senthil Kumar, K.J., Gokila Vani, M., Wang, C.-S., Chen, C.-C., Chen, Y.-C., Lu, L.-P., Huang, C.-H., Lai, C.-S., and Wang, S.-Y. (2020). Geranium and Lemon Essential Oils and Their Active Compounds Downregulate Angiotensin-Converting Enzyme 2 (ACE2), a SARS-CoV-2 Spike Receptor-Binding Domain, in Epithelial Cells. Plants, 9.10.3390/plants9060770 ↗
58. Antiviral Activity of Essential Oils Against Hepatitis A Virus in Soft Fruits10.1007/s12560-019-09367-3 ↗
59. Essential oils of Citrus aurantifolia, Anthemis nobile and Lavandula officinalis: In vitro anthelmintic activities against Haemonchus contortus10.1186/s13071-018-2849-x ↗
60. Addition of a blend of essential oils (cloves, rosemary and oregano) and vitamin E to replace conventional chemical antioxidants in dog feed: Effects on food quality and health of beagles10.1080/1745039X.2021.1960091 ↗
61. Antimicrobial Activity of Essential Oils Extracted from Clove and Lemongrass against Pathogenic Bacteria Isolated from Bovine, Swine and Poultry Feces10.5433/1679-0359.2019v40n5p1937 ↗
62. Antimicrobial agents from plants: Antibacterial activity of plant volatile oils10.1046/j.1365-2672.2000.00969.x ↗
63. Chemical composition and antimicrobial activity of leaf, ripe and unripe peel of bitter orange (Citrus aurantium) essential oils10.18869/acadpub.nfsr.3.1.43 ↗
64. Chemical constituents, antibacterial activity and mechanism of action of the essential oil from Cinnamomum cassia bark against four food-related bacteria10.1134/S0026261714040067 ↗
65. Hyldgaard, M., Mygind, T., and Meyer, R.L. (2012). Essential oils in food preservation: Mode of action, synergies, and interactions with food matrix components. Front. Microbiol., 3.10.3389/fmicb.2012.00012 ↗
66. The mode of antimicrobial action of the essential oil of Melaleuca alternifolia (Tea tree oil)10.1046/j.1365-2672.2000.00943.x ↗
67. Antibacterial mode of action of Cudrania tricuspidata fruit essential oil, affecting membrane permeability and surface characteristics of food-borne pathogens10.1016/j.foodcont.2013.01.032 ↗
68. In vitro antimicrobial effects and mechanism of action of selected plant essential oil combinations against four food-related microorganisms10.1016/j.foodres.2011.07.030 ↗
69. Antimicrobial activity and mechanisms of Salvia sclarea essential oil10.1186/s40529-015-0096-4 ↗
70. Essential Oils of Herbs and Spices: Their Antimicrobial Activity and Application in Preservation of Food10.20546/ijcmas.2016.505.092 ↗
71. Effects of oregano essential oil as an antibiotic growth promoter alternative on growth performance, antioxidant status, and intestinal health of broilers10.1016/j.psj.2021.101163 ↗
72. Johnson, A.M., Anderson, G., Arguelles-Ramos, M., and Ali, A.A.B. (2022). Effect of dietary essential oil of oregano on performance parameters, gastrointestinal traits, blood lipid profile, and antioxidant capacity of laying hens during the pullet phase. Front. Anim. Sci., 3.10.3389/fanim.2022.1072712 ↗
73. Effects of dietary thyme and rosemary essential oils on biochemical parameters, antioxidant metabolism, small intestinal morphology and myofiber structure of superficial pectoral and biceps femoris muscles in broilers
74. Chemical composition and in vivo/in silico anti-inflammatory activity of an antioxidant, non-toxic essential oil from Thymus algeriensis Boiss & Reut10.1016/j.sajb.2023.03.050 ↗
75. Blend of essential oils can reduce diarrheal disorders and improve liver antioxidant status in weaning piglets10.5713/ab.22.0072 ↗
76. Anti-inflammatory mechanisms of eucalyptol rich Eucalyptus globulus essential oil alone and in combination with flurbiprofen10.1007/s10787-023-01237-6 ↗
77. Analgesic and anti-inflammatory effects of essential oils of Eucalyptus10.1016/j.jep.2003.09.007 ↗
78. Zhang, W., Shi, R., Gao, T., Hu, Y., Zhou, J., Li, C., Wang, P., Yang, H., Xing, W., and Dong, L. (2023). Repeated Inhalation of Peppermint Essential Oil Improves Exercise Performance in Endurance-Trained Rats. Nutrients, 15.10.3390/nu15112480 ↗
79. Larvicidal activity in vitro of essential oils against Cochliomyia hominivorax10.1016/j.vetpar.2023.110020 ↗
80. A review on the occurrence of Cochliomyia hominivorax (Diptera: Calliphoridae) in Brazil10.1590/s1984-29612019059 ↗
81. Thymol bioactivity: A review focusing on practical applications10.1016/j.arabjc.2020.11.009 ↗
82. In vitro activity of essential oils against adult and immature stages of Ctenocephalides felis felis10.1017/S0031182019001641 ↗
83. Insecticidal potential of Ajwain essential oil and its major components against Chilo suppressalis Walker10.1007/s41348-023-00762-4 ↗
84. Effects of Rosmarinus officinalis L. (Laminaceae) essential oil on adult and larvae of Drosophila melanogaster10.1093/toxres/tfad081 ↗
85. Traditional Mediterranean plants: Characterization and use of an essential oils mixture to treat Malassezia otitis externa in atopic dogs10.1080/14786419.2016.1263853 ↗
86. Soares, N.M.M., Bastos, T.S., Kaelle, G.C.B., de Souza, R.B.M.d.S., de Oliveira, S.G., and Félix, A.P. (2023). Digestibility and palatability of the diet and intestinal functionality of dogs fed a blend of yeast cell wall and oregano essential oil. Animals, 13.10.3390/ani13152527 ↗
87. The influence of olfactory stimulation on the behaviour of dogs housed in a rescue shelter10.1016/j.applanim.2004.08.024 ↗
88. The effect of a spot-on formulation containing polyunsaturated fatty acids and essential oils on dogs with atopic dermatitis10.1016/j.tvjl.2013.10.024 ↗
89. Evaluation of a topical gel containing a novel combination of essential oils and antioxidants for reducing oral malodor in dogs10.2460/ajvr.75.7.653 ↗
90. Preventing tick attachment to dogs using essential oils10.1016/j.ttbdis.2018.03.029 ↗
91. Thymol and eugenol microemulsion for Rhiphicephalus sanguineus sensu lato control: Formulation development, field efficacy, and safety on dogs10.1016/j.vetpar.2021.109501 ↗
92. In vitro efficacy of essential oils and extracts of Schinus molle L. against Ctenocephalides felis felis10.1017/S0031182016000081 ↗
93. Open-field study comparing an essential oil-based shampoo with miconazole/chlorhexidine for haircoat disinfection in cats with spontaneous microsporiasis10.1177/1098612X15625709 ↗
94. In vitro and in vivo antifungal activity of some essential oils against feline isolates of Microsporum canis10.1016/j.mycmed.2012.04.003 ↗
95. The influence of olfactory stimulation on the behaviour of cats housed in a rescue shelter10.1016/j.applanim.2009.12.011 ↗
96. Štrbac, F., Krnjajić, S., Stojanović, D., Ratajac, R., Simin, N., Orčić, D., Rinaldi, L., Ciccone, E., Maurelli, M.P., and Cringoli, G. (2023). In vitro and in vivo anthelmintic efficacy of peppermint (Mentha x piperita L.) essential oil against gastrointestinal nematodes of sheep. Front. Vet. Sci., 10.10.3389/fvets.2023.1232570 ↗
97. Hassan, M.A., Abo-Elmaaty, A.M.A., Zaglool, A.W., Mohamed, S.A.M., Abou-Zeid, S.M., Farag, M.R., Alagawany, M., Di Cerbo, A., Azzam, M.M., and Alhotan, R. (2023). Origanum vulgare Essential Oil Modulates the AFB1-Induced Oxidative Damages, Nephropathy, and Altered Inflammatory Responses in Growing Rabbits. Toxins, 15.10.3390/toxins15010069 ↗
98. El-Sayed, Y., Khalil, W., Fayez, N., and Mohamed Abdel-Fattah, A.F. (2024). Enhancing effect of oregano essential oil and Bacillus subtilis on broiler immune function, intestinal morphology and growth performance. BMC Vet. Res., 20.10.1186/s12917-024-03960-w ↗
99. Uyarlar, C., Rahman, A., Gultepe, E.E., Cetingul, I.S., and Bayram, I. (2024). Effect of a Dietary Essential Oil Blend in Dairy Cows during the Dry and Transition Period on Blood and Metabolic Parameters of Dams and Their Calves. Animals, 14.10.3390/ani14010150 ↗
100. Research Note: Effects of the intermittent feeding of microencapsulation essential oil on laying performance, egg quality, immune response, intestinal morphology, and oxidation status of laying hens10.1016/j.psj.2024.103600 ↗