Evaluation of an Early Regression Index (ERITCP) as Predictor of Pathological Complete Response in Cervical Cancer: A Pilot-Study
Source abstract
Abstract
Background: Recent studies have highlighted the potentialities of a radiobiological parameter, the early regression index (ERITCP), in the treatment response prediction for rectal cancer patients treated with chemoradiotherapy followed by surgery. The aim of this study is to evaluate the performance of this parameter in predicting pathological complete response (pCR) in the context of low field MR guided radiotherapy (MRgRT) for cervical cancer (CC). Methods: A total of 16 patients affected by CC were enrolled. All patients underwent a MRgRT treatment, with prescription of 50.6 Gy in 22 fractions. A daily MR acquisition was performed at simulation and on each treatment fraction. Gross tumor volume (GTV) was delineated on the MR images acquired at the following biological effective dose (BED) levels: 14, 28, 42, 54 and 62 Gy. The ERITCP was calculated at the different BED levels and its predictive performance was quantified in terms of receiver operating characteristic (ROC) curve. Results: pCR was observed in 11/16 cases. The highest discriminative power of ERITCP was reported when a BED value of 28 Gy is reached, obtaining an area under curve (AUC) of 0.84. Conclusion: This study confirmed ERITCP as a promising response biomarker also for CC, although further studies with larger cohort of patients are recommended.
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Research context
OpenAlex topics: Radiomics and Machine Learning in Medical Imaging · Endometrial and Cervical Cancer Treatments · Cervical Cancer and HPV Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Fondazione Policlinico Universitario “Agostino Gemelli” IRCCS, 00168 Rome, Italy
UO Radioterapia Oncologica, Villa Santa Teresa, 90011 Bagheria, Palermo, Italy
Medical Physics, San Raffaele Scientific Institute, 20132 Milano, Italy
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