journal article·2023-08-11Open access

Marine-Originated Materials and Their Potential Use in Biomedicine

Nefeli Lagopati, Natassa Pippa, Maria-Anna Gatou, Nefeli Papadopoulou-Fermeli, Vassilis G. Gorgoulis, Maria Gazouli, Evangelia A. Pavlatou

Applied Sciences· Volume 13· Issue 16

Abstract

Aquatic habitats cover almost 70% of the Earth, containing several species contributing to marine biodiversity. Marine and aquatic organisms are rich in chemical compounds that can be widely used in biomedicine (dentistry, pharmacy, cosmetology, etc.) as alternative raw biomaterials or in food supplements. Their structural characteristics make them promising candidates for tissue engineering approaches in regenerative medicine. Thus, seaweeds, marine sponges, arthropods, cnidaria, mollusks, and the biomaterials provided by them, such as alginate, vitamins, laminarin, collagen, chitin, chitosan, gelatin, hydroxyapatite, biosilica, etc., are going to be discussed focusing on the biomedical applications of these marine-originated biomaterials. The ultimate goal is to highlight the sustainability of the use of these biomaterials instead of conventional ones, mainly due to the antimicrobial, anti-inflammatory, anti-aging and anticancer effect.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Seaweed-derived Bioactive Compounds · Protein Hydrolysis and Bioactive Peptides · Bone Tissue Engineering Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Laboratory of Biology, Department of Basic Medical Sciences, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece

Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece

Section of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, 15771 Athens, Greece

Laboratory of General Chemistry, School of Chemical Engineering, National Technical University of Athens, Zografou Campus, 15772 Athens, Greece

Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 11527 Athens, Greece

Clinical Molecular Pathology, Medical School, University of Dundee, Dundee DD1 9SY, UK

Molecular and Clinical Cancer Sciences, Manchester Cancer Research Centre, Manchester Academic Health Sciences Centre, University of Manchester, Manchester M20 4GJ, UK

Center for New Biotechnologies and Precision Medicine, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece

Faculty of Health and Medical Sciences, University of Surrey, Surrey GU2 7YH, UK

School of Science and Technology, Hellenic Open University, 26335 Patra, Greece

References (94)

Show source-provided references
1. Freshwater biodiversity and aquatic insect diversification10.1146/annurev-ento-011613-161958 ↗
2. The contribution of fisheries and aquaculture to the global protein supply10.1007/s12571-021-01246-9 ↗
3. Potential of sponges and microalgae for marine biotechnology10.1016/j.tibtech.2007.10.002 ↗
4. Casadidio, C., Peregrina, D.V., Gigliobianco, M.R., Deng, S., Censi, R., and Di Martino, P. (2019). Chitin and Chitosans: Characteristics, Eco-Friendly Processes, and Applications in Cosmetic Science. Mar. Drugs, 17.10.20944/preprints201905.0066.v1 ↗
5. A sustainable hydrophobic luffa sponge for efficient removal of oils from water
6. Khalifa, S.A.M., Elias, N., Farag, M.A., Chen, L., Saeed, A., Hegazy, M.F., Moustafa, M.S., Abd El-Wahed, A., Al-Mousawi, S.M., and Musharraf, S.G. (2019). Marine Natural Products: A Source of Novel Anticancer Drugs. Mar. Drugs, 17.10.3390/md17090491 ↗
7. Lomartire, S., and Gonçalves, A.M.M. (2022). An Overview of Potential Seaweed-Derived Bioactive Compounds for Pharmaceutical Applications. Mar. Drugs, 20.10.3390/md20020141 ↗
8. Antioxidant, Anti-inflammatory and Antiproliferative Effects of Aqueous Extracts of Three Mediterranean Brown Seaweeds of the Genus Cystoseira
9. Seaweed as bioindicators of organic micropollutants polycyclic aromatic hydrocarbons (PAHs) and organochlorine pesticides (OCPs)10.1007/s11356-022-18634-z ↗
10. Seaweed for climate mitigation, wastewater treatment, bioenergy, bioplastic, biochar, food, pharmaceuticals, and cosmetics: A review10.1007/s10311-022-01520-y ↗
11. Sponge-associated microorganisms: Evolution, ecology, and biotechnological potential10.1128/MMBR.00040-06 ↗
12. Varijakzhan, D., Loh, J.Y., Yap, W.S., Yusoff, K., Seboussi, R., Lim, S.E., Lai, K.S., and Chong, C.M. (2021). Bioactive Compounds from Marine Sponges: Fundamentals and Applications. Mar. Drugs, 219.10.3390/md19050246 ↗
13. Gonadal ecdysteroidogenesis in arthropoda: Occurrence and regulation10.1146/annurev.ento.53.103106.093334 ↗
14. Calcium phosphate mineralization is widely applied in crustacean mandibles10.1038/srep22118 ↗
15. Zhang, H., Wu, X., Quan, L., and Ao, Q. (2022). Characteristics of Marine Biomaterials and Their Applications in Biomedicine. Mar. Drugs, 20.10.3390/md20060372 ↗
16. Haematopoiesis in molluscs: A review of haemocyte development and function in gastropods, cephalopods and bivalves10.1016/j.dci.2015.11.010 ↗
17. Hydroxyapatite Scaffolds Produced from Cuttlefish Bone via Hydrothermal Transformation for Application in Tissue Engineering and Drug Delivery Systems10.1007/978-981-13-8855-2_9 ↗
18. Preparation and characterization of pure natural hydroxyapatite derived from seashells for controlled drug delivery10.1007/s41779-022-00739-w ↗
19. Hydroxyapatite Derived from Marine Resources and their Potential Biomedical Applications10.1007/s12257-020-0359-0 ↗
20. Hydroxyapatite, a multifunctional material for air, water and soil pollution control: A review10.1016/j.jhazmat.2019.121139 ↗
21. Salehi, B., Sharifi-Rad, J., Seca, A.M.L., Pinto, D.C.G.A., Michalak, I., Trincone, A., Mishra, A.P., Nigam, M., Zam, W., and Martins, N. (2019). Current Trends on Seaweeds: Looking at Chemical Composition, Phytopharmacology, and Cosmetic Applications. Molecules, 24.10.3390/molecules24224182 ↗
22. Assessment of nutrient composition and antioxidant potential of Caulerpaceae seaweeds10.1016/j.jfca.2010.07.007 ↗
23. Peñalver, R., Lorenzo, J.M., Ros, G., Amarowicz, R., Pateiro, M., and Nieto, G. (2020). Seaweeds as a Functional Ingredient for a Healthy Diet. Mar. Drugs, 18.10.3390/md18060301 ↗
24. Seaweeds as nutritional supplements: Analysis of nutritional profile, physicochemical properties and proximate composition of G. acerosa and S. wightii10.1016/j.bionut.2012.12.002 ↗
25. Agars of Gelidiella acerosa of west and southeast coasts of India10.1016/j.biortech.2006.07.028 ↗
26. Dietary fibre and physicochemical properties of edible Spanish seaweeds10.1007/s002170000264 ↗
27. An overview on the nutritional and bioactive components of green seaweeds10.1186/s43014-023-00132-5 ↗
28. Machado, M., Machado, S., Pimentel, F.B., Freitas, V., Alves, R.C., and Oliveira, M.B.P.P. (2020). Amino Acid Profile and Protein Quality Assessment of Macroalgae Produced in an Integrated Multi-Trophic Aquaculture System. Foods, 9.10.3390/foods9101382 ↗
29. Syakilla, N., George, R., Chye, F.Y., Pindi, W., Mantihal, S., Wahab, N.A., Fadzwi, F.M., Gu, P.H., and Matanjun, P. (2022). A Review on Nutrients, Phytochemicals, and Health Benefits of Green Seaweed, Caulerpa lentillifera. Foods, 11.10.3390/foods11182832 ↗
30. Circuncisão, A.R., Catarino, M.D., Cardoso, S.M., and Silva, A.M.S. (2018). Minerals from Macroalgae Origin: Health Benefits and Risks for Consumers. Mar. Drugs, 16.10.3390/md16110400 ↗
31. Advance research in biomedical applications on marine sulfated polysaccharide10.1016/j.ijbiomac.2021.11.142 ↗
32. Nutritional value of edible seaweeds10.1111/j.1753-4887.2007.tb00278.x ↗
33. Etraprenyltoluquinols as chemotaxonomic markers in the genus Cystoseira: C. barbarula and C. barbata, Gazz
34. Fucoidan: Structure and bioactivity10.3390/molecules13081671 ↗
35. Pozharitskaya, O.N., Shikov, A.N., Faustova, N.M., Obluchinskaya, E.D., Kosman, V.M., Vuorela, H., and Makarov, V.G. (2018). Pharmacokinetic and tissue distribution of fucoidan from Fucus vesiculosus after oral administration to rats. Mar. Drugs, 16.10.3390/md16040132 ↗
36. Krylova, N.V., Ermakova, S.P., Lavrov, V.F., Leneva, I.A., Kompanets, G.G., Iunikhina, O.V., Nosik, M.N., Ebralidze, L.K., Falynskova, I.N., and Silchenko, A.S. (2020). The comparative analysis of antiviral activity of native and modified fucoidans from brown algae Fucus evanescens in Vitro and in Vivo. Mar. Drugs, 18.10.3390/md18040224 ↗
37. Antiviral activity of lambda-carrageenan prepared from red seaweed (Gigartina skottsbergii) against BoHV-1 and SuHV-110.1016/j.rvsc.2014.11.010 ↗
38. Potent antibacterial activity of halogenated metabolites from Red algae Laurencia majuscule (Rhodomelaceae, Ceramiales)10.1016/S1389-0344(03)00067-4 ↗
39. Immunostimulatory effect of laminarin on RAW 264.7 mouse macrophages10.3390/molecules17055404 ↗
40. Structural feature and antioxidant activity of low molecular weight laminarin degraded by gamma irradiation10.1016/j.foodchem.2011.03.078 ↗
41. Advanced Applications of Biomaterials Based on Alginic Acid10.34297/AJBSR.2020.09.001350 ↗
42. Cervino, G., Fiorillo, L., Herford, A.S., Laino, L., Troiano, G., Amoroso, G., Crimi, S., Matarese, M., D’Amico, C., and Nastro Siniscalchi, E. (2018). Alginate Materials and Dental Impression Technique: A Current State of the Art and Application to Dental Practice. Mar. Drugs, 17.10.3390/md17010018 ↗
43. Kaliampakou, C., Lagopati, N., and Charitidis, C.A. (2023). Direct Ink Writing of Alginate–Gelatin Hydrogel: An Optimization of Ink Property Design and Printing Process Efficacy. Appl. Sci., 13.10.3390/app13148261 ↗
44. Kamran, S., Sinniah, A., Abdulghani, M.A.M., and Alshawsh, M.A. (2022). Therapeutic Potential of Certain Terpenoids as Anticancer Agents: A Scoping Review. Cancers, 14.10.3390/cancers14051100 ↗
45. Phytosterols of marine algae: Insights into the potential health benefits and molecular pharmacology10.1016/j.phymed.2020.153201 ↗
46. Extracting and purifying R-phycoerythrin from Mediterranean red algae Corallina elongata Ellis & Solander10.1016/S0168-1656(03)00002-6 ↗
47. Bioproducts from seaweeds: A review with special focus on the iberian peninsula10.2174/138527281807140515154116 ↗
48. Biomass soaking treatments to reduce potentially undesirable compounds in the edible seaweeds sugar kelp (Saccharina latissima) and winged kelp (Alaria esculenta) and health risk estimation for human consumption10.1007/s10811-017-1343-8 ↗
49. Santos, C.P.G., Prado, J.P.S., Fernandes, K.R., Kido, H.W., Dorileo, B.P., Parisi, J.R., Silva, J.A., Cruz, M.A., Custódio, M.R., and Rennó, A.C.M. (2023). Different Species of Marine Sponges Diverge in Osteogenic Potential When Therapeutically Applied as Natural Scaffolds for Bone Regeneration in Rats. J. Funct. Biomater., 14.10.3390/jfb14030122 ↗
50. Commercial Sponges as A Novel Technology for Crude Oil Removal from Seawater and Industrial Wastewater: A Review
51. Biomaterials from the sea: Future building blocks for biomedical applications10.1016/j.bioactmat.2021.04.028 ↗
52. Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei10.1073/pnas.0405976101 ↗
53. Monoalide, an Antibiotic Sesterterpenoid from the MArine Sponge Luffariella variabilis10.1016/S0040-4039(00)77766-5 ↗
54. Molecular Model of the Interaction of Bee Venom Phospholipase A2 with Manoalide10.1021/jm00065a010 ↗
55. A New Triterpenoid Pigment from the MArine Sponge Stelletta tenuis10.1021/np50112a017 ↗
56. Manzamine alkaloids: Isolation, cytotoxicity, antimalarial activity and SAR studies10.1016/j.drudis.2014.06.010 ↗
57. Marine Peptides as Anticancer Agents: A Remedy To Mankind By Nature10.2174/1389203717666160724200849 ↗
58. Bicyclic C21 terpenoids from the marine sponge Clathria compressa10.1021/np300265p ↗
59. Motualevic Acids A–F, Antimicrobial Acids from the Sponge Siliquariaspongia sp.10.1021/ol802890b ↗
60. Inhibitory effects of metachromin A on hepatitis B virus production via impairment of the viral promoter activity10.1016/j.antiviral.2017.08.001 ↗
61. Karpiński, T.M. (2019). Marine Macrolides with Antibacterial and/or Antifungal Activity. Mar. Drugs, 17.10.3390/md17040241 ↗
62. Isolation and Synthesis of Misszrtine A: A Novel Indole Alkaloid From Marine Sponge-Associated Aspergillus sp. SCSIO XWS03F0310.3389/fchem.2018.00212 ↗
63. Shubina, L.K., Makarieva, T.N., Denisenko, V.A., Popov, R.S., Dyshlovoy, S.A., Grebnev, B.B., Dmitrenok, P.S., von Amsberg, G., and Stonik, V.A. (2020). Gracilosulfates, A–G, Monosulfated Polyoxygenated Steroids from the Marine Sponge Haliclona gracilis. Mar. Drugs, 18.10.3390/md18090454 ↗
64. A Novel Apoptosis-Inducing Metabolite Isolated from Marine Sponge Symbiont: Monascus sp. NMK7 Attenuates Cell Proliferation, Migration and ROS Stress-Mediated Apoptosis in Breast Cancer Cells10.1039/C8RA09886G ↗
65. Biosilica: Molecular Biology, Biochemistry and Function in Demosponges as well as its Applied Aspects for Tissue Engineering10.1016/B978-0-12-394283-8.00005-9 ↗
66. Diatom Biosilica in Targeted Drug Delivery and Biosensing Applications: Recent Studies10.3390/micro2020023 ↗
67. Götz, W., Tobiasch, E., Witzleben, S., and Schulze, M. (2019). Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation. Pharmaceutics, 11.10.3390/pharmaceutics11030117 ↗
68. Preparation and characterization of chitosan-natural nano hydroxyapatite-fucoidan nanocomposites for bone tissue engineering10.1016/j.ijbiomac.2016.02.054 ↗
69. Complications of posterior iliac crest bone grafting in spine surgery in children10.1097/00007632-200009150-00021 ↗
70. Tziveleka, L.A., Ioannou, E., Tsiourvas, D., Berillis, P., Foufa, E., and Roussis, V. (2017). Collagen from the Marine Sponges Axinella cannabina and Suberites carnosus: Isolation and Morphological, Biochemical, and Biophysical Characterization. Mar. Drugs, 15.10.3390/md15060152 ↗
71. Three-dimensional scaffolds for tissue engineering applications: Role of porosity and pore size10.1089/ten.teb.2012.0437 ↗
72. Zdarta, J., Norman, M., Smułek, W., Moszyński, D., Kaczorek, E., Stelling, A.L., Ehrlich, H., and Jesionowski, T. (2017). Spongin-Based Scaffolds from Hippospongia communis Demosponge as an Effective Support for Lipase Immobilization. Catalysts, 7.10.3390/catal7050147 ↗
73. Chitin and Chitosan: Production and Application of Versatile Biomedical Nanomaterials
74. de Sousa Victor, R., Marcelo da Cunha Santos, A., Viana de Sousa, B., de Araújo Neves, G., Navarro de Lima Santana, L., and Rodrigues Menezes, R. (2020). A Review on Chitosan’s Uses as Biomaterial: Tissue Engineering, Drug Delivery Systems and Cancer Treatment. Materials, 13.10.3390/ma13214995 ↗
75. Thambiliyagodage, C., Jayanetti, M., Mendis, A., Ekanayake, G., Liyanaarachchi, H., and Vigneswaran, S. (2023). Recent Advances in Chitosan-Based Applications—A Review. Materials, 16.10.3390/ma16052073 ↗
76. Editorial: Silk-Based Functional Biomaterials10.3389/fbioe.2021.721761 ↗
77. Biomineralizations: Insights and prospects from crustaceans10.3897/zookeys.176.2318 ↗
78. Kim, Y., Zharkinbekov, Z., Raziyeva, K., Tabyldiyeva, L., Berikova, K., Zhumagul, D., Temirkhanova, K., and Saparov, A. (2023). Chitosan-Based Biomaterials for Tissue Regeneration. Pharmaceutics, 15.10.3390/pharmaceutics15030807 ↗
79. Sethmann, I., Luft, C., and Kleebe, H.-J. (2018). Development of Phosphatized Calcium Carbonate Biominerals as Bioactive Bone Graft Substitute Materials, Part I: Incorporation of Magnesium and Strontium Ions. J. Funct. Biomater., 9.10.3390/jfb9040069 ↗
80. Silva, A.S., Costa, E.C., Reis, S., Spencer, C., Calhelha, R.C., Miguel, S.P., Ribeiro, M.P., Barros, L., Vaz, J.A., and Coutinho, P. (2022). Silk Sericin: A Promising Sustainable Biomaterial for Biomedical and Pharmaceutical Applications. Polymers, 14.10.3390/polym14224931 ↗
82. 3D Silk Fiber Construct Embedded Dual-Layer PEG Hydrogel for Articular Cartilage Repair—In vitro Assessment10.3389/fbioe.2021.653509 ↗
83. Fabrication of Silk-Hyaluronan Composite as a Potential Scaffold for Tissue Repair10.3389/fbioe.2020.578988 ↗
84. Development of Small-Diameter Elastin-Silk Fibroin Vascular Grafts10.3389/fbioe.2020.622220 ↗
85. Enhancing Osseointegration of TC4 Alloy by Surficial Activation Through Biomineralization Method10.3389/fbioe.2021.639835 ↗
86. Comprehensive Transcriptome Sequencing of Tanaidacea with Proteomic Evidences for Their Silk10.1093/gbe/evab281 ↗
87. Siddiqui, H.A., Pickering, K.L., and Mucalo, M.R. (2018). A Review on the Use of Hydroxyapatite-Carbonaceous Structure Composites in Bone Replacement Materials for Strengthening Purposes. Materials, 11.10.3390/ma11101813 ↗
88. Radulescu, D.-E., Neacsu, I.A., Grumezescu, A.-M., and Andronescu, E. (2022). Novel Trends into the Development of Natural Hydroxyapatite-Based Polymeric Composites for Bone Tissue Engineering. Polymers, 14.10.3390/polym14050899 ↗
89. Chen, L., Al-Bayatee, S., Khurshid, Z., Shavandi, A., Brunton, P., and Ratnayake, J. (2021). Hydroxyapatite in Oral Care Products-A Review. Materials, 14.10.3390/ma14174865 ↗
90. Lueyot, A., Rungsardthong, V., Vatanyoopaisarn, S., Hutangura, P., Wonganu, B., Wongsa-Ngasri, P., Charoenlappanit, S., Roytrakul, S., and Thumthanaruk, B. (2021). Influence of collagen and some proteins on gel properties of jellyfish gelatin. PLoS ONE, 16.10.1371/journal.pone.0253254 ↗
91. Naomi, R., Bahari, H., Ridzuan, P.M., and Othman, F. (2021). Natural-Based Biomaterial for Skin Wound Healing (Gelatin vs. Collagen): Expert Review. Polymers, 13.10.3390/polym13142319 ↗
92. Al-Nimry, S., Dayah, A.A., Hasan, I., and Daghmash, R. (2021). Cosmetic, Biomedical and Pharmaceutical Applications of Fish Gelatin/Hydrolysates. Mar. Drugs, 19.10.3390/md19030145 ↗
93. Squid Gelatin Hydrolysates with Antihypertensive, Anticancer and Antioxidant Activity10.1016/j.foodres.2011.03.010 ↗
94. Fish Gelatin: The Novel Potential Applications10.1016/j.jff.2019.103581 ↗