Protective Activity against Oxidative Stress in Dermal Papillae with Extracted Herbal Essential Oils
Source abstract
Abstract
Dermal papilla cells (DPCs) are a rich source of nutrients and secrete multiple growth factors that can affect hair growth. As oxidative stress leads to hair loss in humans, it is considered to be one of the factors that can impair the function of DPCs. Herb-derived phytochemicals exhibit potent antioxidant activities; therefore, this study investigated whether a set of essential oils (lavender, lemongrass, rosemary, and chamomile oils) promote the hair-growth activity of DPCs. Intracellular reactive oxygen species (ROS) increased markedly in ultraviolet B-irradiated DPCs (50 mJ/cm2) and were efficiently blocked by essential oils. Essential oils upregulated the mRNA and protein levels of phase II enzymes (detoxifying and antioxidant), including heme oxygenase-1, NAD(P)H quinone oxidoreductase-1, and glutathione S-transferase pi. They also upregulated and activated nuclear factor E2-related factor 2, an essential transcription factor for phase II enzymes. Regarding biomarkers for hair growth, essential oils significantly increased vascular endothelial cell growth factor and insulin-like growth factor-1 mRNA levels. In conclusion, phytochemicals in essential oils enhance hair growth through ROS-scavenging activity in DPCs.
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Research context
OpenAlex topics: Hair Growth and Disorders · Dermatologic Treatments and Research · Skin Protection and Aging
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Smart Medical Convergence Technology Support Center, Chosun University, 208 Cheomdangwagi-ro, Buk-gu, Gwangju 61012, Republic of Korea
Hospital-Based Business Innovation Center, Chonnam National University Medical School, 160 Baekseo-ro, Dong-gu, Gwangju 61469, Republic of Korea
Department of Dermatology, Chonnam National University Medical School, 160 Baekseo-ro, Dong-gu, Gwangju 61469, Republic of Korea
Marine Bio Research Center, Chosun University, 230-1, Myeongsasimni 61beon-gil, Sinji-myeon, Wando-gun, Jeollanam-do, Gwangju 59146, Republic of Korea
Seung-Chul Lee Dermatology Clinic, 57 Jebong-ro, Dong-gu, Gwangju 61486, Republic of Korea
Funding
Technology Development Program · Ministry of SMEs and Startups (Republic of Korea)
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