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Abstract The simultaneous achievement of mechanical/thermal sensitivity and extreme environmental tolerance is an enormous challenge for hydrogel‐based sensors. Herein, the authors (DOI: 10.1002/inf2.12409) develop a novel skin‐inspired hydrogel–elastomer hybrid with a sandwich structure and strong interfacial bonding that combines high transmittance, temperature resistance, waterproofness, fatigue resistance and biocompatibility, which can be used for mechanical–thermal multimode sensing applications. image