journal article·2020-10-14Open access

Bone Healing Evaluation Following Different Osteotomic Techniques in Animal Models: A Suitable Method for Clinical Insights

Alexandre Anesi, Mattia Di Bartolomeo, Arrigo Pellacani, Marzia Ferretti, Francesco Cavani, Roberta Salvatori, Riccardo Nocini, Carla Palumbo, Luigi Chiarini

Applied Sciences· Volume 10· Issue 20

Abstract

Osteotomy is a common step in oncological, reconstructive, and trauma surgery. Drilling and elevated temperature during osteotomy produce thermal osteonecrosis. Heat and associated mechanical damage during osteotomy can impair bone healing, with consequent failure of fracture fixation or dental implants. Several ex vivo studies on animal bone were recently focused on heating production during osteotomy with conventional drill and piezoelectric devices, particularly in endosseous dental implant sites. The current literature on bone drilling and osteotomic surface analysis is here reviewed and the dynamics of bone healing after osteotomy with traditional and piezoelectric devices are discussed. Moreover, the methodologies involved in the experimental osteotomy and clinical studies are compared, focusing on ex vivo and in vivo findings.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Dental Implant Techniques and Outcomes · Bone Tissue Engineering Materials · Oral and Maxillofacial Pathology

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Medical and Surgical Sciences for Children & Adults, Cranio-Maxillo-Facial Surgery, University of Modena and Reggio Emilia, Largo del Pozzo 71, 41124 Modena, Italy

Unit of Dentistry and Maxillo-Facial Surgery, Surgery, Dentistry, Maternity and Infant Department, University of Verona, P.le L.A. Scuro 10, 37134 Verona, Italy

Section of Human Morphology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Largo del Pozzo 71, 41125 Modena, Italy

Section of Ear Nose and Throat (ENT), Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, 37124 Verona, Italy

References (100+)

Show source-provided references
1. Pattern of Cortical Fracture following Corticotomy for Distraction Osteogenesis10.5704/MOJ.1511.005 ↗
2. The history, evolution and basic science of osteotomy techniques10.1007/s11751-017-0296-4 ↗
3. Basic Ilizarov Techniques
4. Percutaneous gigli saw osteotomy10.1007/s00064-010-9007-8 ↗
5. Deformity correction using supramalleolar gigli saw osteotomy and Taylor spatial frame: How to perform this osteotomy safely?10.1097/BPB.0b013e328345d877 ↗
6. Ilizarov External Fixation: Percutaneous Gigli Saw Versus Multiple Drill-hole Osteotomy Techniques for Distraction Osteogenesis
7. A comparison of two osteotomy techniques for tibial lengthening10.1007/s00402-004-0646-9 ↗
8. Structural and ultrastructural analyses of bone regeneration in rabbit cranial osteotomy: Piezosurgery versus traditional osteotomes10.1016/j.jcms.2017.10.004 ↗
9. Critical Evaluation of Piezoelectric Osteotomy in Orthognathic Surgery: Operative Technique, Blood Loss, Time Requirement, Nerve and Vessel Integrity10.1016/j.joms.2007.06.633 ↗
10. Vertical ramus osteotomy with Er:YAG laser: A feasibility study10.1016/j.ijom.2007.05.019 ↗
11. Ultrasonic osteotomy in oral surgery and implantology10.1016/j.tripleo.2009.04.018 ↗
12. Mid-infrared erbium: YAG laser ablation of bone: The effect of laser osteotomy on bone healing10.1002/lsm.1900090409 ↗
13. Effect of Er:YAG laser holes on osteoinduction in demineralized rat calvarial allografts10.1002/jor.1100140118 ↗
15. Parametric effect of vibrational drilling on osteonecrosis and comparative histopathology study with conventional drilling of cortical bone10.1177/0954411918794983 ↗
16. A comparison of the thermal properties of 2- and 3-fluted drills and the effects on bone cell viability and screw pull-out strength in an ovine model10.1016/j.clinbiomech.2010.02.007 ↗
17. Biological Bone Drilling in Oral Implantology
18. Bone healing in 2016
19. Radiation effects on bone healing and reconstruction: Interpretation of the literature10.1016/j.tripleo.2009.10.001 ↗
20. The Effects of Early Postoperative Radiation on Vascularized Bone Grafts10.1097/00000637-199106000-00002 ↗
21. Effects of irradiation on bone remodelling around mandibular implants: An experimental study in dogs10.1016/j.ijom.2006.03.016 ↗
22. Brogniez, V., Nyssen-Behets, C., Reychler, H., and Benoit, L. (1998). Implant osseointegration in the irradiated mandible microradiographic and histologic assessment. Clin. Oral Implant. Res., 234–242.10.1034/j.1600-0501.2002.130302.x ↗
23. Peri-implant tissue reaction in bone irradiated the fifth day after implantation in rabbits: Histologic and histomorphometric measurements
24. The biology of fracture healing10.1016/j.injury.2011.03.031 ↗
25. Association of survival with shorter time to radiation therapy after surgery for US patients with head and neck cancer10.1001/jamaoto.2017.3406 ↗
26. Drilling in bone: Modeling heat generation and temperature distribution10.1115/1.1535190 ↗
27. An overview of thermal necrosis: Present and future10.1080/03007995.2019.1603671 ↗
28. Heat-shock-induced cellular responses to temperature elevations occurring during orthopaedic cutting10.1098/rsif.2012.0520 ↗
29. The Effect of Irrigation on Osteotomy Depth and Bur Diameter
30. Temperatures measured in human cortical bone when drilling10.2106/00004623-197254020-00008 ↗
31. Thermological study of drilling bone tissue with a high-speed drill10.1097/00006123-200005000-00029 ↗
32. Drilling of bone: A comprehensive review10.1016/j.jcot.2013.01.002 ↗
33. Thermal osteonecrosis and bone drilling parameters revisited10.1007/s00402-007-0427-3 ↗
34. Histological analysis of bone10.1007/978-1-59745-242-7_21 ↗
35. Press, C.U. (1972). Biology of Bone, Cambridge University Press. [1st ed.].
36. Intracortical remodeling in adult rat long bones after fatigue loading10.1016/S8756-3282(98)00104-5 ↗
37. A novel cutting tool design to avoid surface damage in bone machining10.1016/j.ijmachtools.2017.01.003 ↗
38. Bone remodelling in humans is load-driven but not lazy10.1038/ncomms5855 ↗
39. Analysis and estimation of cutting-temperature distribution during end milling in relation to orthopedic surgery10.1016/j.medengphy.2008.05.001 ↗
40. Modeling and experimentation of bone drilling forces10.1016/j.jbiomech.2011.12.012 ↗
41. Basic concepts regarding fracture healing and the current options and future directions in managing bone fractures10.1111/iwj.12231 ↗
42. Bone remodeling during fracture repair: The cellular picture10.1016/j.semcdb.2008.07.004 ↗
43. Lieberman, J.R., Daluiski, A., and Einhorn, T.A. (2002). The role of growth factors in the repair of bone biology and clinical applications. J. Bone Jt. Surg. Am., 1032–1044.10.2106/00004623-200206000-00022 ↗
44. Static and dynamic osteogenesis: Two different types of bone formation10.1007/s00429-002-0265-6 ↗
45. Osteocyte dendrogenesis in static and dynamic bone formation: An ultrastructural study10.1002/ar.a.20032 ↗
46. Static and dynamic osteogenesis in the processes of bone repair
47. Static osteogenesis and dynamic osteogenesis: Their relevance in dental bone implants and biomaterial osseointegration
48. Biology of bone endothelial cells10.1016/0169-6009(90)90084-S ↗
49. Promotion of calvarial cell osteogenesis by endothelial cells10.1002/jbmr.5650050710 ↗
50. Endothelin-1 is a potent regulator of human bone cell metabolism in vitro10.1007/s002239900245 ↗
51. Vasoactive peptide-regulated gene expression during osteoblastic differentiation10.1097/00005344-200036051-00084 ↗
52. Does static precede dynamic osteogenesis in endochondral ossification as occurs in intramembranous ossification?10.1002/ar.a.20386 ↗
53. Bone and Bone Healing10.1016/S0195-5616(99)50101-0 ↗
54. Barré-Sinoussi, F., and Montagutelli, X. (2015). Animal models are essential to biological research: Issues and perspectives. Future Sci. OA, 1.10.4155/fso.15.63 ↗
55. The effect of piezoelectric surgery implant osteotomy on radiological and molecular parameters of peri-implant crestal bone loss: A randomized, controlled, split-mouth trial10.1111/clr.12620 ↗
56. A comparison of piezosurgery and conventional surgery by heat shock protein 70 expression10.1016/j.ijom.2012.10.027 ↗
57. Interspecies differences in bone composition, density, and quality: Potential implications for in vivo bone research10.1210/endo.139.2.5751 ↗
58. McGovern, J.A., Griffin, M., and Hutmacher, D.W. (2018). Animal models for bone tissue engineering and modelling disease. Dis. Model. Mech., 11.10.1242/dmm.033084 ↗
59. Animal models for implant biomaterial research in bone: A review10.22203/eCM.v013a01 ↗
60. A Review of Major Animal Models Relevant to Contemporary Orthopaedic Repair of the Appendicular Skeleton in Humans
61. The challenge of establishing preclinical models for segmental bone defect research10.1016/j.biomaterials.2008.12.050 ↗
62. Animal modeling in bone research—Should we follow the White Rabbit?10.1002/ame2.12083 ↗
63. Animal Models for Evaluation of Bone Implants and Devices10.1177/0300985815593124 ↗
64. Bellucci, D., Cannillo, V., Anesi, A., Salvatori, R., Chiarini, L., Manfredini, T., and Zaffe, D. (2018). Bone Regeneration by Novel Bioactive Glasses Containing Strontium and/or Magnesium: A Preliminary In-Vivo Study. Materials, 11.10.3390/ma11112223 ↗
65. A comparative in vivo evaluation of bioactive glasses and bioactive glass-based composites for bone tissue repair10.1016/j.msec.2017.05.062 ↗
66. Russell, W.M.S., and Burch, R.L. (1959). The Principles of Human Experimental Technique, Methuen, UFAW. Available online: http://117.239.25.194:7000/jspui/bitstream/123456789/1342/1/PRILIMINERY%20%20AND%20%20CONTENTS.pdf.
67. European Commission (2015). Annex to the Communication from the Commission on the European Citizen’s Initiative, ‘Stop Vivisection’. European Commission, European Commission. Available online: https://ec.europa.eu/environment/chemicals/lab_animals/pdf/vivisection/en.pdf.
68. A novel standardized bone model for thermal evaluation of bone osteotomies with various irrigation methods10.1111/clr.12090 ↗
69. Measurement of thermal conductivity of bovine cortical bone10.1016/S1350-4533(01)00003-0 ↗
70. Repubblica Italiana (2020, April 10). Italian Laws for Protection of Animals Used for Scientific Purposes–DECRETO LEGISLATIVO 4 marzo 2014, n. 26–Repubblica Italiana. Available online: http://extwprlegs1.fao.org/docs/pdf/ita153404.pdf.
71. An interspecies comparison of bone fracture properties
72. Effects of a new piezoelectric device on periosteal microcirculation after subperiosteal preparation10.1016/j.mvr.2014.06.003 ↗
73. Bellucci, D., Salvatori, R., Giannatiempo, J., Anesi, A., Bortolini, S., and Cannillo, V. (2019). A New Bioactive Glass/Collagen Hybrid Composite for Applications in Dentistry. Materials, 12.10.3390/ma12132079 ↗
74. Anesi, A., Generali, L., Sandoni, L., Pozzi, S., and Grande, A. (2019). From Osteoclast Differentiation to Osteonecrosis of the Jaw: Molecular and Clinical Insights. Int. J. Mol. Sci., 20.10.3390/ijms20194925 ↗
75. Malavasi, G., Salvatori, R., Zambon, A., Lusvardi, G., Rigamonti, L., Chiarini, L., and Anesi, A. (2019). Cytocompatibility of Potential Bioactive Cerium-Doped Glasses based on 45S5. Materials, 12.10.3390/ma12040594 ↗
76. Bone defect animal models for testing efficacy of bone substitute biomaterials
77. Osteocyte-osteoclast morphological relationships and the putative role of osteocytes in bone remodeling
78. Histopathologic reaction of bone to surgical cutting10.1016/0030-4220(64)90515-8 ↗
79. Early reaction in bone following the use of burs rotating at conventional and ultra speeds; a comparison study10.1016/0030-4220(65)90353-1 ↗
80. The healing of surgical defects in alveolar bone produced with ultrasonic instrumentation, chisel, and rotary bur10.1016/0030-4220(75)90192-9 ↗
81. Heat caused by drilling cortical bone: Temperature measured in vivo in patients and animals10.3109/17453678408992410 ↗
82. Increase of temperature during osteotomy. In vitro and in vivo investigations10.1016/S0901-5027(05)80185-7 ↗
83. Effect of drill speed on bone temperature10.1016/S0901-5027(06)80040-8 ↗
84. Cryosurgery in long bones; an experimental study of necrosis and revitalization in rabbits10.1007/s004020050017 ↗
85. The effects of drilling force on cortical temperatures and their duration: An in vitro study10.1016/S1350-4533(01)00016-9 ↗
86. Osseous response following resective therapy with piezosurgery
87. Cytokines and growth factors involved in the osseointegration of oral titanium implants positioned using piezoelectric bone surgery versus a drill technique: A pilot study in minipigs10.1902/jop.2007.060285 ↗
88. Micromorphometrical analysis of conventional osteotomy techniques and ultrasonic osteotomy at the rabbit skull10.1111/j.1600-0501.2007.01516.x ↗
89. Evaluation of immediate bone-cell viability and of drill wear after implant osteotomies: Immunohistochemistry and scanning electron microscopy analysis10.1016/j.joms.2007.12.037 ↗
90. Heat production during different ultrasonic and conventional osteotomy preparations for dental implants10.1111/j.1600-0501.2010.02126.x ↗
91. Temperature changes during cortical bone drilling with a newly designed step drill and an internally cooled drill10.1007/s00264-012-1491-z ↗
92. Experimental and histological investigations of the bone using two different oscillating osteotomy techniques compared with conventional rotary osteotomy10.1016/j.aanat.2011.10.005 ↗
93. Micromorphometrical analyses of five different ultrasonic osteotomy devices at the rabbit skull10.1111/j.1600-0501.2011.02185.x ↗
94. Intraosseous temperature changes during the use of piezosurgical inserts in vitro10.1016/j.ijom.2012.06.007 ↗
95. Characterisation of bone following ultrasonic cutting10.1007/s00784-012-0754-9 ↗
96. Dynamics of bone healing after osteotomy with piezosurgery or conventional drilling–histomorphometrical, immunohistochemical, and molecular analysis10.1186/1479-5876-11-221 ↗
97. Healing of osteotomy sites applying either piezosurgery or two conventional saw blades: A pilot study in rabbits10.1007/s00264-013-1908-3 ↗
98. Effect of irrigation and stainless steel drills on dental implant bed heat generation10.1007/s10856-015-5412-8 ↗
99. Identification of possible factors influencing temperatures elevation during implant site preparation with piezoelectric technique
100. The effect of load on heat production, thermal effects and expenditure of time during implant site preparation–An experimental ex vivo comparison between piezosurgery and conventional drilling10.1111/clr.12077 ↗