journal article·2024-11-21Open access

Sustainable Extraction of Bioactive Compounds and Nutrients from Agri-Food Wastes: Potential Reutilization of Berry, Honey, and Chicory Byproducts

Gregorio Peron, Irene Ferrarese, Nadia Carmo Dos Santos, Filippo Rizzo, Giorgio Gargari, Noemi Bertoli, Emanuela Gobbi, Alvise Perosa, Maurizio Selva, Stefano Dall’Acqua

Applied Sciences· Volume 14· Issue 23

Abstract

Several agri-food byproducts represent valuable sources of compounds to be reutilized for nutritional, nutraceutical, and cosmetic purposes. Examples especially comprise byproducts from the processing of fruits such as pomace, because of their richness in nutrients (e.g., fibers) and bioactive compounds (e.g., polyphenols) that can be destined for animal and human use. However, in agreement with the principles of circular economy that are being promoted during the most recent years, other understudied agri-food byproducts of both plant and animal origin are being evaluated to assess their possible reutilization and valorization. In this review, we aim at summarizing the most recent research dealing with the extraction of nutrients and bioactive compounds from agri-food byproducts using innovative and sustainable approaches. Specifically, the review is focused on byproducts generated in large amounts (tons/year) by the food industry of Northeast Italy, namely, honey, red fruits (grapes and berries), and chicory, which are especially of interest for their content in phenolic acids, flavonoids, anthocyanins, and dietary fiber. The potential applications of these byproducts and extracts in cosmetic, nutraceutical, and nutritional fields are also discussed, referring to the published literature, as well as their potential utilization as sources of novel bioactive compounds with pharmacological applications.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Bee Products Chemical Analysis · Phytochemicals and Antioxidant Activities · Essential Oils and Antimicrobial Activity

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Molecular and Translational Medicine (DMMT), University of Brescia, Viale Europa 11, 25123 Brescia, Italy

Department of Molecular Sciences and Nanosystems, Ca’ Foscari University of Venice, Via Torino 155, 30172 Venice, Italy

Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35100 Padova, Italy

Department of Food, Environmental and Nutritional Sciences, University of Milano, Via Mangiagalli 25, 20133 Milano, Italy

Funding

Fondazione Cariverona · Italian Ministry of Education, University and Research (MUR), PRIN 2022 PNRR

References (100+)

Show source-provided references
1. European Commission (2024, November 16). Food Waste. Available online: https://food.ec.europa.eu/food-safety/food-waste_en.
2. Global warming potential of food waste through the life cycle assessment: An analytical review10.1016/j.eiar.2021.106677 ↗
3. A systematic review of food losses and food waste generation in developed countries
4. United States Environmental Protection Agency (2024, October 31). United States 2030 Food Loss and Waste Reduction Goal, Available online: https://www.epa.gov/sustainable-management-food/united-states-2030-food-loss-and-waste-reduction-goal.
5. Eurostat (2024, October 31). Food Waste and Food Waste Prevention-Estimates-Statistics Explained, Available online: https://ec.europa.eu/eurostat/statistics-explained/index.php?title=Food_waste_and_food_waste_prevention_-_estimates.
6. Chatti, C.B., Hassen, T.B., and El Bilali, H. (2024). Closing the Loop: Exploring Food Waste Management in the Near East and North Africa (NENA) Region During the COVID-19 Pandemic. Sustainability, 16.10.3390/su16093772 ↗
7. Food and Agriculture Organization of the United Nations (FAO) (2024, November 05). Food Losses and Waste in Latin America and the Caribbean. Newsletter #3 February 2016. Available online: https://openknowledge.fao.org/server/api/core/bitstreams/5569e764-205c-4165-9251-1cbc78f7e0fb/content.
8. Bhat, R. (2022). Chapter 33—Food Waste and By-Product Valorization as an Integrated Approach with Zero Waste: Future Challenges, Academic Press.
9. Zannini, D., Dal Poggetto, G., Malinconico, M., Santagata, G., and Immirzi, B. (2021). Citrus Pomace Biomass as a Source of Pectin and Lignocellulose Fibers: From Waste to Upgraded Biocomposites for Mulching Applications. Polymers, 13.10.3390/polym13081280 ↗
10. Tomato pomace food waste from different variants as a high antioxidant potential resource10.1016/j.foodchem.2024.139509 ↗
11. Apple pomace, a bioresource of functional and nutritional components with potential of utilization in different food formulations: A review10.1016/j.focha.2023.100598 ↗
12. Fidelis, M., de Moura, C., Kabbas Junior, T., Pap, N., Mattila, P., Mäkinen, S., Putnik, P., Bursać Kovačević, D., Tian, Y., and Yang, B. (2019). Fruit Seeds as Sources of Bioactive Compounds: Sustainable Production of High Value-Added Ingredients from By-Products Within Circular Economy. Molecules, 24.10.3390/molecules24213854 ↗
13. Hadj Saadoun, J., Bertani, G., Levante, A., Vezzosi, F., Ricci, A., Bernini, V., and Lazzi, C. (2021). Fermentation of Agri-Food Waste: A Promising Route for the Production of Aroma Compounds. Foods, 10.10.3390/foods10040707 ↗
14. Philippini, R.R., Martiniano, S.E., Ingle, A.P., Franco Marcelino, P.R., Silva, G.M., Barbosa, F.G., dos Santos, J.C., and da Silva, S.S. (2020). Agroindustrial Byproducts for the Generation of Biobased Products: Alternatives for Sustainable Biorefineries. Front. Energy Res., 8.10.3389/fenrg.2020.00152 ↗
15. Torres-León, C., Ramírez-Guzman, N., Londoño-Hernandez, L., Martinez-Medina, G.A., Díaz-Herrera, R., Navarro-Macias, V., Alvarez-Pérez, O.B., Picazo, B., Villarreal-Vázquez, M., and Ascacio-Valdes, J. (2018). Food Waste and Byproducts: An Opportunity to Minimize Malnutrition and Hunger in Developing Countries. Front. Sustain. Food Syst., 2.10.3389/fsufs.2018.00052 ↗
16. Dilucia, F., Lacivita, V., Conte, A., and Del Nobile, M.A. (2020). Sustainable Use of Fruit and Vegetable By-Products to Enhance Food Packaging Performance. Foods, 9.10.3390/foods9070857 ↗
17. Teshome, E., Teka, T.A., Nandasiri, R., Rout, J.R., Harouna, D.V., Astatkie, T., and Urugo, M.M. (2023). Fruit By-Products and Their Industrial Applications for Nutritional Benefits and Health Promotion: A Comprehensive Review. Sustainability, 15.10.20944/preprints202302.0481.v1 ↗
18. Yadav, S., Malik, K., Moore, J.M., Kamboj, B.R., Malik, S., Malik, V.K., Arya, S., Singh, K., Mahanta, S., and Bishnoi, D.K. (2024). Valorisation of Agri-Food Waste for Bioactive Compounds: Recent Trends and Future Sustainable Challenges. Molecules, 29.10.3390/molecules29092055 ↗
19. A review of sustainable and intensified techniques for extraction of food and natural products10.1039/C9GC03878G ↗
20. Pre-treatment and extraction techniques for recovery of added value compounds from wastes throughout the agri-food chain10.1039/C6GC01389A ↗
21. Maicas, S., and Mateo, J.J. (2020). Sustainability of Wine Production. Sustainability, 12.10.3390/su12020559 ↗
22. Ioannidou, S.M., Filippi, K., Kookos, I.K., Koutinas, A., and Ladakis, D. (2022). Techno-economic evaluation and life cycle assessment of a biorefinery using winery waste streams for the production of succinic acid and value-added co-products. Bioresour. Technol., 348.10.1016/j.biortech.2021.126295 ↗
23. Ente Nazionale per la Meccanizzazione Agricola (ENAMA) (2024, November 05). Biomasse ed Energia & Disponibilità delle Biomasse. Available online: https://www.progettobiomasse.it/it/pdf/studio/p1c2.pdf.
24. Barcaccia, G., Ghedina, A., and Lucchin, M. (2016). Current Advances in Genomics and Breeding of Leaf Chicory (Cichorium intybus L.). Agriculture, 6.10.3390/agriculture6040050 ↗
25. Antiradical and antimicrobial properties of fermented red chicory (Cichorium intybus L.) by-products10.1007/s13213-016-1225-3 ↗
26. Techniques and modeling of polyphenol extraction from food: A review10.1007/s10311-021-01217-8 ↗
27. Techniques for extraction and isolation of natural products: A comprehensive review10.1186/s13020-018-0177-x ↗
28. Plaskova, A., and Mlcek, J. (2023). New insights of the application of water or ethanol-water plant extract rich in active compounds in food. Front. Nutr., 10.10.3389/fnut.2023.1118761 ↗
29. A review of modern and conventional extraction techniques and their applications for extracting phytochemicals from plants
30. The effect of long-term frozen storage on the nutraceutical compounds, antioxidant properties and color indices of different kinds of berries
31. Isolation and Identification of Strawberry Phenolics with Antioxidant and Human Cancer Cell Antiproliferative Properties10.1021/jf071989c ↗
32. Salas-Arias, K., Irías-Mata, A., Sánchez-Kopper, A., Hernández-Moncada, R., Salas-Morgan, B., Villalta-Romero, F., and Calvo-Castro, L.A. (2023). Strawberry Fragaria x ananassa cv. Festival: A Polyphenol-Based Phytochemical Characterization in Fruit and Leaf Extracts. Molecules, 28.10.3390/molecules28041865 ↗
33. The Origin of the Soxhlet Extractor10.1021/ed084p1913 ↗
34. Saini, R.K., Prasad, P., Shang, X., and Keum, Y.-S. (2021). Advances in Lipid Extraction Methods—A Review. Int. J. Mol. Sci., 22.10.3390/ijms222413643 ↗
35. Bioactive compounds from blueberry and blackcurrant powder alter the physicochemical and hypoglycaemic properties of oat bran paste10.1016/j.lwt.2021.111167 ↗
36. Phytochemical Study and Antibacterial and Antibiotic Modulation Activity of Punica granatum (Pomegranate) Leaves10.1155/2020/8271203 ↗
37. A comparative study on composition and antioxidant activities of supercritical carbon dioxide, hexane and ethanol extracts from blackberry (Rubus fruticosus) growing in Poland10.1002/jsfa.8216 ↗
38. Eco-friendly technology for preparation, characterization and promotion of honey bee propolis extract loaded cellulose acetate nanofibers in medical domains10.1007/s10570-018-1921-1 ↗
39. Ultrasound assisted extraction of food and natural products. Mechanisms, techniques, combinations, protocols and applications. A review10.1016/j.ultsonch.2016.06.035 ↗
40. A comprehensive review of ultrasonic assisted extraction (UAE) for bioactive components: Principles, advantages, equipment, and combined technologies10.1016/j.ultsonch.2023.106646 ↗
41. Ultrasound assisted extraction (UAE) of bioactive compounds from fruit and vegetable processing by-products: A review10.1016/j.ultsonch.2020.105325 ↗
42. Sonication enhances polyphenolic compounds, sugars, carotenoids and mineral elements of apple juice10.1016/j.ultsonch.2013.06.002 ↗
43. Selection of Conditions of Ultrasound-Assisted, Three-Step Extraction of Ellagitannins from Selected Berry Fruit of the Rosaceae Family Using the Response Surface Methodology10.1007/s12161-020-01762-y ↗
44. The effect of ultrasound irradiation on the physicochemical properties and α-glucosidase inhibitory effect of blackberry fruit polysaccharide10.1016/j.foodhyd.2019.06.002 ↗
45. Composition of essential oil of leaves and fruits of green strawberry (Fragaria viridis Weston) growing wild in Northern Kazakhstan
46. Evaluation of four isolation techniques for honey aroma compounds10.1002/jsfa.1934 ↗
47. Piazza, S., Martinelli, G., Magnavacca, A., Fumagalli, M., Pozzoli, C., Terno, M., Canilli, L., Angarano, M., Maranta, N., and Dell’Agli, M. (2022). Unveiling the Ability of Witch Hazel (Hamamelis virginiana L.) Bark Extract to Impair Keratinocyte Inflammatory Cascade Typical of Atopic Eczema. Int. J. Mol. Sci., 23.10.3390/ijms23169279 ↗
48. By-products from herbs essential oil production as ingredient in marinade for turkey thighs10.1016/j.lwt.2007.01.014 ↗
49. Rostagno, M.A., and Prado, J.M. (2013). Microwave-assisted Extraction. Natural Product Extraction: Principles and Applications, The Royal Society of Chemistry.10.1039/9781849737579 ↗
50. Extraction characteristics and optimal parameters of anthocyanin from blueberry powder under microwave-assisted extraction conditions10.1016/j.seppur.2012.11.011 ↗
51. Optimization of the microwave-assisted extraction and antioxidant activities of anthocyanins from blackberry using a response surface methodology10.1039/C4RA16396F ↗
52. Pereira, A.G., Cruz, L., Cassani, L., Chamorro, F., Lourenço-Lopes, C., Freitas, V., Otero, P., Fraga-Corral, M., Prieto, M.A., and Simal-Gandara, J. (2023). Comparative Study of Microwave-Assisted Extraction and Ultrasound-Assisted Extraction Techniques (MAE vs. UAE) for the Optimized Production of Enriched Extracts in Phenolic Compounds of Camellia japonica var Eugenia de Montijo. Eng. Proc., 37.10.3390/ECP2023-14615 ↗
53. Microwave-assisted extraction of hempseed oil: Studying and comparing of fatty acid composition, antioxidant activity, physiochemical and thermal properties with Soxhlet extraction10.1007/s13197-019-03890-8 ↗
54. Recent advances in the extraction of bioactive compounds from plant matrices and their use as potential antioxidants for vegetable oils enrichment10.1016/j.jfca.2024.105995 ↗
55. Barp, L., Višnjevec, A.M., and Moret, S. (2023). Pressurized Liquid Extraction: A Powerful Tool to Implement Extraction and Purification of Food Contaminants. Foods, 12.10.3390/foods12102017 ↗
56. Pressurized liquid extraction for the determination of bioactive compounds in plants with emphasis on phenolics10.1016/j.trac.2024.117620 ↗
57. Tena, N., and Asuero, A.G. (2022). Up-To-Date Analysis of the Extraction Methods for Anthocyanins: Principles of the Techniques, Optimization, Technical Progress, and Industrial Application. Antioxidants, 11.10.3390/antiox11020286 ↗
58. García, P., Fredes, C., Cea, I., Lozano-Sánchez, J., Leyva-Jiménez, F.J., Robert, P., Vergara, C., and Jimenez, P. (2021). Recovery of Bioactive Compounds from Pomegranate (Punica granatum L.) Peel Using Pressurized Liquid Extraction. Foods, 10.10.3390/foods10020203 ↗
59. Evaluation of Red Chicory Extract as a Natural Antioxidant by Pure Lipid Oxidation and Yeast Oxidative Stress Response as Model Systems10.1021/jf2003317 ↗
60. Pressurized liquid extraction of bioactive compounds from blackberry (Rubus fruticosus L.) residues: A comparison with conventional methods10.1016/j.foodres.2014.12.042 ↗
61. Guo, P., Chen, H., Ma, J., Zhang, Y., Chen, H., Wei, T., Gao, D., and Li, J. (2023). Enzyme-assisted extraction, characterization, and in vitro antioxidant activity of polysaccharides from Potentilla anserina L.. Front. Nutr., 10.10.3389/fnut.2023.1216572 ↗
62. Microwave-enzyme-assisted extraction of pectin from feijoa (Acca sellowiana) fruit: Extraction optimization, physicochemical and functional properties10.1016/j.lwt.2024.116445 ↗
63. Optimization of enzyme-assisted extraction of anthocyanins from eggplant (Solanum melongena L.) peel10.1016/j.fochx.2023.100643 ↗
64. Enzyme-assisted extraction of anthocyanins and other phenolic compounds from blackcurrant (Ribes nigrum L.) press cake: From processing to bioactivities10.1016/j.foodchem.2022.133240 ↗
65. Ricarte, G.N., Coelho, M.A.Z., Marrucho, I.M., and Ribeiro, B.D. (2020). Enzyme-assisted extraction of carotenoids and phenolic compounds from sunflower wastes using green solvents. 3 Biotech, 10.10.1007/s13205-020-02393-0 ↗
66. Optimization of enzyme-assisted lipid extraction from Nannochloropsis microalgae10.1016/j.jtice.2016.08.016 ↗
67. Use of an enzyme-assisted method to improve protein extraction from olive leaves10.1016/j.foodchem.2014.07.116 ↗
68. Enzyme-assisted extractions of polyphenols—A comprehensive review10.1016/j.tifs.2019.03.029 ↗
69. Biorefining of blackcurrant pomace into high value functional ingredients using supercritical CO2, pressurized liquid and enzyme assisted extractions10.1016/j.supflu.2017.01.003 ↗
70. Enzyme-Assisted Extraction of Bioactive Compounds from Raspberry (Rubus idaeus L.) Pomace10.1111/1750-3841.14625 ↗
71. On the use of pulsed electric field technology as a pretreatment to reduce the content of potentially toxic elements in dried Saccharina latissima10.1016/j.lwt.2022.114033 ↗
72. Ranjha, M.M.A.N., Kanwal, R., Shafique, B., Arshad, R.N., Irfan, S., Kieliszek, M., Kowalczewski, P.Ł., Irfan, M., Khalid, M.Z., and Roobab, U. (2021). A Critical Review on Pulsed Electric Field: A Novel Technology for the Extraction of Phytoconstituents. Molecules, 26.10.3390/molecules26164893 ↗
73. Pulsed electric field assisted extraction of natural food pigments and colorings from plant matrices10.1016/j.fochx.2022.100398 ↗
74. Comparison of aqueous extraction efficiency and biological activities of polyphenols from pomegranate peels assisted by infrared, ultrasound, pulsed electric fields and high-voltage electrical discharges10.1016/j.ifset.2019.102212 ↗
75. Optimization of Pulsed Electric Field Treatment for the Extraction of Bioactive Compounds from Blackcurrant10.1007/s11947-019-02283-1 ↗
76. V Changes in Quality Characteristics of Strawberry Juice After Equivalent High Pressure, Ultrasound, and Pulsed Electric Fields Processes10.1007/s12393-020-09250-z ↗
77. Negative pressure cavitation extraction: A novel method for extraction of food bioactive compounds from plant materials10.1016/j.tifs.2016.04.005 ↗
78. Panda, D., and Manickam, S. (2019). Cavitation Technology—The Future of Greener Extraction Method: A Review on the Extraction of Natural Products and Process Intensification Mechanism and Perspectives. Appl. Sci., 9.10.3390/app9040766 ↗
79. Ultrasound-negative pressure cavitation extraction of phenolic compounds from blueberry leaves and evaluation of its DPPH radical scavenging activity10.1016/j.fbp.2018.01.003 ↗
80. Integrated and sustainable separation of chlorogenic acid from blueberry leaves by deep eutectic solvents coupled with aqueous two-phase system10.1016/j.fbp.2017.07.010 ↗
81. Comuzzo, P., and Calligaris, S. (2019). Potential Applications of High Pressure Homogenization in Winemaking: A Review. Beverages, 5.10.3390/beverages5030056 ↗
82. High pressure homogenization and retention of bioactive compounds in fruits and vegetables products10.1016/j.foohum.2023.11.003 ↗
83. Microbial, nutritional, and organoleptic quality of pomegranate juice following high-pressure homogenization and low-temperature pasteurization10.1111/1750-3841.15032 ↗
84. The effect of pressure level and cycling in high-pressure homogenization on physicochemical, structural and functional properties of filtered and non-filtered strawberry nectar10.1016/j.ifset.2019.102203 ↗
85. Kruszewski, B., Zawada, K., and Karpiński, P. (2021). Impact of High-Pressure Homogenization Parameters on Physicochemical Characteristics, Bioactive Compounds Content, and Antioxidant Capacity of Blackcurrant Juice. Molecules, 26.10.3390/molecules26061802 ↗
86. Pech-Almeida, J.L., Téllez-Pérez, C., Alonzo-Macías, M., Teresa-Martínez, G.D., Allaf, K., Allaf, T., and Cardador-Martínez, A. (2021). An Overview on Food Applications of the Instant Controlled Pressure-Drop Technology, an Innovative High Pressure-Short Time Process. Molecules, 26.10.3390/molecules26216519 ↗
87. Impact of instant controlled pressure drop on phenolic compounds extraction from pomegranate peel10.1016/j.ifset.2016.08.017 ↗
88. Comparison of two methods of solvent extraction of phenolic compounds from pomegranate (Punica granatum L.) peels
89. Industrial applications of supercritical fluid extraction: A review
90. Carpentieri, S., Soltanipour, F., Ferrari, G., Pataro, G., and Donsì, F. (2021). Emerging Green Techniques for the Extraction of Antioxidants from Agri-Food By-Products as Promising Ingredients for the Food Industry. Antioxidants, 10.10.3390/antiox10091417 ↗
91. Mini-Review: Green sustainable processes using supercritical fluid carbon dioxide10.1016/S1001-0742(08)62330-X ↗
92. Supercritical Carbon Dioxide and Its Potential as a Life-Sustaining Solvent in a Planetary Environment10.3390/life4030331 ↗
93. Uwineza, P.A., and Waśkiewicz, A. (2020). Recent Advances in Supercritical Fluid Extraction of Natural Bioactive Compounds from Natural Plant Materials. Molecules, 25.10.3390/molecules25173847 ↗
94. Role of supercritical carbon dioxide (scCO2) in fabrication of inorganic-based materials: A green and unique route10.1080/14686996.2021.1955603 ↗
95. de From waste to sustainable industry: How can agro-industrial wastes help in the development of new products?10.1016/j.resconrec.2021.105466 ↗
96. Extractability, selectivity, and comprehensiveness in supercritical fluid extraction of seaweed using ternary mixtures of carbon dioxide, ethanol, and water10.1016/j.chroma.2023.464267 ↗
97. Supercritical CO2 as a green solvent for the circular economy: Extraction of fatty acids from fruit pomace10.1016/j.jcou.2020.101259 ↗
98. Sanchez-Salvador, J.L., Marques, M.P., Brito, M.S.C.A., Negro, C., Monte, M.C., Manrique, Y.A., Santos, R.J., and Blanco, A. (2022). Valorization of Vegetable Waste from Leek, Lettuce, and Artichoke to Produce Highly Concentrated Lignocellulose Micro- and Nanofibril Suspensions. Nanomaterials, 12.10.3390/nano12244499 ↗
99. Pinotti, L., Manoni, M., Fumagalli, F., Rovere, N., Luciano, A., Ottoboni, M., Ferrari, L., Cheli, F., and Djuragic, O. (2020). Reduce, Reuse, Recycle for Food Waste: A Second Life for Fresh-Cut Leafy Salad Crops in Animal Diets. Animals, 10.10.3390/ani10061082 ↗
100. Lettuce and Chicory Byproducts as a Source of Antioxidant Phenolic Extracts10.1021/jf040055a ↗