journal article·2024-03-30Open access

State-of-All-the-Art and Prospective Hydrogel-Based Transdermal Drug Delivery Systems

Meera Alex, Nour M. Alsawaftah, Ghaleb A. Husseini

Applied Sciences· Volume 14· Issue 7

Abstract

Over the past few decades, notable advancements have been made in the field of transdermal drug delivery systems (TDDSs), presenting a promising alternative to conventional oral drug administration. This comprehensive review aims to enhance understanding of this method by examining various transdermal techniques, the skin’s role as a barrier to TDDS, factors affecting skin diffusion, and current challenges in TDDSs. The primary focus of this analysis centers on TDDSs utilizing hydrogels. A thorough exploration of hydrogel fundamentals, encompassing structure, properties, and synthesis, is provided to underscore the importance of hydrogels as carriers in transdermal drug delivery. The concluding section delves into strategies for hydrogel-based drug delivery, addressing challenges and exploring future directions.
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Research context

OpenAlex topics: Advancements in Transdermal Drug Delivery · Advanced Drug Delivery Systems · Hydrogels: synthesis, properties, applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Biosciences and Bioengineering PhD Program, American University of Sharjah, 26666 Sharjah, United Arab Emirates

Materials Science and Engineering PhD Program, American University of Sharjah, 26666 Sharjah, United Arab Emirates

Department of Chemical and Biological Engineering, American University of Sharjah, 26666 Sharjah, United Arab Emirates

Funding

American University of Sharjah Faculty Research Grants · Sheikh Hamdan Award for Medical Sciences · Friends of Cancer Patients (FoCP) · Professional Development Fund of GAH at the American University of Sharjah

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