Polycyclic Aromatic Hydrocarbon Occurrence and Formation in Processed Meat, Edible Oils, and Cereal-Derived Products: A Review
Source abstract
Abstract
The chemical group comprising polycyclic aromatic hydrocarbons (PAHs) has received prolonged evaluation and scrutiny in the past several decades. PAHs are ubiquitous carcinogenic pollutants and pose a significant threat to human health through their environmental prevalence and distribution. Regardless of their origin, natural or anthropogenic, PAHs generally stem from the incomplete combustion of organic materials. Dietary intake, one of the main routes of human exposure to PAHs, is modulated by pre-existing food contamination (air, water, soil) and their formation and accumulation during food processing. To this end, processing techniques and cooking options entailing thermal treatment carry additional weight in determining the PAH levels in the final product. With the background provided, this study aims to provide an improved understanding of PAH occurrence in meat, edible oils, and cereal products. The factors influencing PAH formation, including operational conditions and parameters, product composition, and storage settings, are described. The discussion also addresses reduction directions with respect to influencing factors informing the choice of the employed technique, fuel type, time–temperature settings, and ingredient variations. Considering the disparities caused by wide variations in PAH contamination, challenges associated with PAH control requirements are also outlined in the context of relevant preventive approaches during food processing.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Toxic Organic Pollutants Impact · Effects and risks of endocrine disrupting chemicals · Meat and Animal Product Quality
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
National Research & Development Institute for Food Bioresources—IBA Bucharest, 6 Dinu Vintilă Street, District 2, 021102 Bucharest, Romania
Faculty of Biotechnology, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 011464 Bucharest, Romania
Funding
Romanian Ministry of Research, Innovation and Digitalization
References (100+)
Show source-provided references
1. Polycyclic aromatic hydrocarbons’ formation and occurrence in processed food10.1016/j.foodchem.2015.12.074 ↗
2. Chapter Two—Polycyclic aromatic hydrocarbons in edible oils and fatty foods: Occurrence, formation, analysis, change and control10.1016/bs.afnr.2020.02.001 ↗
3. Worsfold, P., Poole, C., Townshend, A., and Miró, M. (2019). Encyclopedia of Analytical Science, Academic Press. [3rd ed.].
4. Overview of Polycyclic Aromatic Compounds (PAC)10.1080/10406638.2014.994071 ↗
5. Effect of frying and aluminium on the levels and migration of parent and oxygenated PAHs in a popular Chinese fried bread youtiao10.1016/j.foodchem.2016.04.036 ↗
6. Trends of research on polycyclic aromatic hydrocarbons in food: A 20-year perspective from 1997 to 201710.1016/j.tifs.2018.11.015 ↗
7. Reduction strategies for polycyclic aromatic hydrocarbons in processed foods10.1111/1541-4337.12905 ↗
8. Time to Say Goodbye to the 16 EPA PAHs? Toward an Up-to-Date Use of PACs for Environmental Purposes10.1080/10406638.2014.991042 ↗
9. Polycyclic Aromatic Hydrocarbons (PAHs) and their Derivatives (O-PAHs, N-PAHs, OH-PAHs): Determination in Suspended Particulate Matter (SPM)—A Review10.1007/s40710-021-00555-7 ↗
10. Environmental profile, distributions and potential sources of halogenated polycyclic aromatic hydrocarbons10.1016/j.jhazmat.2021.126164 ↗
11. Formation of Polycyclic Aromatic Hydrocarbons (PAHs) and Oxygenated PAHs in the Oxidation of Ethylene Using a Flow Reactor10.1080/00102202.2020.1771327 ↗
12. Challenges of halogenated polycyclic aromatic hydrocarbons in foods: Occurrence, risk, and formation10.1016/j.tifs.2022.11.015 ↗
13. Sampaio, G.R., Guizellini, G.M., da Silva, S.A., de Almeida, A.P., Pinaffi-Langley, A.C.C., Rogero, M.M., de Camargo, A.C., and Torres, E.A.F.S. (2021). Polycyclic aromatic hydrocarbons in foods: Biological effects, legislation, occurrence, analytical methods, and strategies to reduce their formation. Int. J. Mol. Sci., 22.10.3390/ijms22116010 ↗
14. EFSA (2008). Findings of the EFSA Data Collection on Polycyclic Aromatic Hydrocarbons in Food.
15. Analysis of factors that influence the PAH profile and amount in meat products subjected to thermal processing10.1016/j.tifs.2021.06.043 ↗
16. Fate and behaviour of nitrogen-containing polycyclic aromatic hydrocarbons in soil10.1016/j.eti.2015.02.006 ↗
17. The Parallel Transformations of Polycyclic Aromatic Hydrocarbons in the Body and in the Atmosphere10.1289/EHP9984 ↗
18. Oxygenated and Nitrated Polycyclic Aromatic Hydrocarbons in Ambient Air—Levels, Phase Partitioning, Mass Size Distributions, and Inhalation Bioaccessibility10.1021/acs.est.9b06820 ↗
19. Oxygenated polycyclic aromatic hydrocarbons in the surface water environment: Occurrence, ecotoxicity, and sources10.1016/j.envint.2022.107232 ↗
20. Investigation into Photoinduced Auto-Oxidation of Polycyclic Aromatic Hydrocarbons Resulting in Brown Carbon Production10.1021/acs.est.8b05704 ↗
21. Simultaneous determination of polycyclic aromatic hydrocarbons and their chlorinated derivatives in grilled foods10.1016/j.ecoenv.2019.04.046 ↗
22. Formation and mitigation of PAHs in barbecued meat—A review10.1080/10408398.2020.1867056 ↗
23. The Occurrence of 16 EPA PAHs in Food—A Review10.1080/10406638.2014.918550 ↗
24. Monitoring and risk assessment of polycyclic aromatic hydrocarbons (PAHs) in processed foods and their raw materials10.1016/j.foodcont.2018.05.012 ↗
25. Analytical chemistry, formation, mitigation, and risk assessment of polycyclic aromatic hydrocarbons: From food processing to in vivo metabolic transformation10.1111/1541-4337.12705 ↗
26. Validation of QuEChERS for screening of 4 marker polycyclic aromatic hydrocarbons in fish and malt10.1016/j.foodcont.2018.12.010 ↗
27. Contamination of meat products during smoking by polycyclic aromatic hydrocarbons: Processes and prevention10.1016/j.foodcont.2015.07.016 ↗
28. Hokkanen, M. (2021). Polycyclic Aromatic Hydrocarbons in Foods and Their Mitigation, Food Mutagenicity and Children’s Dietary Exposure in Finland. [Ph.D. Disertation, University of Helsinki, Finnish Food Authority (Ruokavirasto) Laboratory and Research Division Chemistry Unit].
29. Extraction Techniques for Polycyclic Aromatic Hydrocarbons in Soils10.1155/2010/398381 ↗
30. Critical review of micro-extraction techniques used in the determination of polycyclic aromatic hydrocarbons in biological, environmental and food samples10.1080/19440049.2020.1733103 ↗
31. Pressurized liquid extraction of organic contaminants in environmental and food samples10.1016/j.trac.2019.06.038 ↗
32. Fast and easy multiresidue method employing acetonitrile extraction/partitioning and “dispersive solid-phase extraction” for the determination of pesticide residues in produce10.1093/jaoac/86.2.412 ↗
33. Review of the QuEChERS method for the analysis of organic pollutants: Persistent organic pollutants, polycyclic aromatic hydrocarbons, and pharmaceuticals10.1016/j.teac.2019.e00063 ↗
34. QuEChERS—Fundamentals, relevant improvements, applications and future trends10.1016/j.aca.2019.02.036 ↗
35. Evaluation of analyte protectants to improve gas chromatographic analysis of pesticides10.1016/S0021-9673(03)01208-1 ↗
36. (2018). Foods of Plant Origin. Multimethod for the Determination of Pesticide Residues Using GC- and LC-Based Analysis Following Acetonitrile Extraction/Partitioning and Clean-Up by Dispersive SPE. Modular QuEChERS-method (Standard No. BS EN 15662:2018).
37. Determination of Pesticide Residues in Foods by Acetonitrile Extraction and Partitioning with Magnesium Sulfate: Collaborative Study10.1093/jaoac/90.2.485 ↗
38. Current trends in QuEChERS method. A versatile procedure for food, environmental and biological analysis10.1016/j.trac.2019.04.018 ↗
39. Contamination of smoked meat and fish products from Polish market with polycyclic aromatic hydrocarbons10.1016/j.foodcont.2017.04.024 ↗
40. (2017). Animal and Vegetable Fats and Oils—Determination of Benzo[a]pyrene—Reverse-Phase High Performance Liquid Chromatography Method (Standard No. ISO 15302:2017).
41. (2016). Animal and Vegetable Fats and Oils—Determination of Polycyclic Aromatic Hydrocarbons (Standard No. ISO 15753:2016).
42. (2009). Animal and Vegetable Fats and Oils—Determination of Polycyclic Aromatic Hydrocarbons by On-Line Donor-Acceptor Complex Chromatography and HPLC with Fluorescence Detection (Standard No. ISO 22959:2009).
43. (2014). Food Analysis—Determination of Benzo[a]pyrene, benz[a]Anthracene, Chrysene and benzo[b]Fluoranthene in Foodstuffs by High Performance Liquid Chromatography with Fluorescence Detection (HPLC-FD) (Standard No. CEN/TS16621:2014).
44. (2015). Food Analysis—Determination of benzo[a]pyrene, benz[a]anthracene, chrysene and benzo[b]fluoranthene in foodstuffs by gas chromatography mass spectrometry (GC-MS) (Standard No. EN 16619:2015).
45. (2019). Animal and Vegetable Fats and Oils—Determination of Polycyclic Aromatic Hydrocarbons (PAH)—Method Using Gas Chromatography/Mass Spectrometry (GC/MS) (Standard No. PD ISO/TR 24054:2019).
46. Application of QuEChERS-EMR-Lipid-DLLME method for the determination of polycyclic aromatic hydrocarbons in smoked food of animal origin10.1016/j.jfca.2020.103420 ↗
47. Formation and growth mechanisms of polycyclic aromatic hydrocarbons: A mini-review10.1016/j.chemosphere.2021.132793 ↗
48. Formation Mechanism of Polycyclic Aromatic Hydrocarbons beyond the Second Aromatic Ring10.1021/jp402481y ↗
49. Polycyclic aromatic hydrocarbon formation chemistry in a plasma jet revealed by IR-UV action spectroscopy10.1038/s41467-019-14092-3 ↗
50. Detailed kinetic modeling of soot formation in shock-tube pyrolysis of acetylene10.1016/S0082-0784(85)80578-6 ↗
51. Detailed modeling of soot particle nucleation and growth10.1016/S0082-0784(06)80426-1 ↗
52. Reaction mechanism of soot formation in flames10.1039/b110045a ↗
53. A reaction mechanism for gasoline surrogate fuels for large polycyclic aromatic hydrocarbons10.1016/j.combustflame.2011.08.011 ↗
54. Composition profiles and reaction mechanisms in a near-sooting premixed benzene/oxygen/argon flame10.1016/S0082-0784(81)80115-4 ↗
55. Temperature- and pressure-dependent rate coefficients for the HACA pathways from benzene to naphthalene10.1016/j.proci.2016.07.013 ↗
56. Theoretical Studies of Diels−Alder Reactions of Acetylenic Compounds10.1021/jo970811u ↗
57. Formation mechanism for polycyclic aromatic hydrocarbons in methane flames10.1063/1.480648 ↗
58. Hydrogen Abstraction Acetylene Addition and Diels−Alder Mechanisms of PAH Formation: A Detailed Study Using First Principles Calculations10.1021/ct0500491 ↗
59. Formation Mechanisms of Naphthalene and Indene: From the Interstellar Medium to Combustion Flames10.1021/acs.jpca.6b09735 ↗
60. Experimental and kinetic modeling investigation on laminar premixed benzene flames with various equivalence ratios10.1016/j.proci.2014.05.085 ↗
61. The carriers of the unidentified infrared emission features: Clues from polycyclic aromatic hydrocarbons with aliphatic sidegroups10.1016/j.newar.2017.01.001 ↗
62. Reaction pathways for the formation of five-membered rings onto polyaromatic hydrocarbon framework10.1016/j.fuel.2020.119023 ↗
63. Role of Methyl Radicals in the Growth of PAHs10.1016/j.jasms.2009.12.019 ↗
64. Growth of polycyclic aromatic hydrocarbons (PAHs) by methyl radicals: Pyrene formation from phenanthrene10.1016/j.combustflame.2017.07.011 ↗
65. Formation of benzene in the interstellar medium10.1073/pnas.1012468108 ↗
66. Photoinduced Mechanism of Formation and Growth of Polycyclic Aromatic Hydrocarbons in Low-Temperature Environments via Successive Ethynyl Radical Additions10.1021/ja804198a ↗
67. Theoretical investigation of benzo(a)pyrene formation10.1016/j.cplett.2021.138564 ↗
68. A novel route for PAH growth in HACA based mechanisms10.1016/j.combustflame.2012.08.007 ↗
69. A review on polycyclic aromatic hydrocarbons: Source, environmental impact, effect on human health and remediation10.1016/j.ejpe.2015.03.011 ↗
70. Role of Phenyl Radicals in the Growth of Polycyclic Aromatic Hydrocarbons10.1021/jp7098398 ↗
71. New polycyclic aromatic hydrocarbon (PAH) surface processes to improve the model prediction of the composition of combustion-generated PAHs and soot10.1016/j.carbon.2009.09.030 ↗
72. Comparative study on the growth mechanisms of PAHs10.1016/j.combustflame.2010.09.012 ↗
73. Synthesis of Polycyclic Aromatic Hydrocarbons by Phenyl Addition–Dehydrocyclization: The Third Way10.1002/anie.201909876 ↗
74. PAH Growth Initiated by Propargyl Addition: Mechanism Development and Computational Kinetics10.1021/jp410704b ↗
75. Modeling of two- and three-ring aromatics formation in the pyrolysis of toluene10.1016/j.proci.2012.06.032 ↗
76. Gas-phase synthesis of benzene via the propargyl radical self-reaction10.1126/sciadv.abf0360 ↗
77. The growth mechanism of polycyclic aromatic hydrocarbons from the reactions of anthracene and phenanthrene with cyclopentadienyl and indenyl10.1016/j.chemosphere.2017.09.004 ↗
78. Pressure dependent kinetic analysis of pathways to naphthalene from cyclopentadienyl recombination10.1016/j.combustflame.2017.09.008 ↗
79. On the chemical kinetics of cyclopentadiene oxidation10.1016/j.combustflame.2010.12.001 ↗
80. Computed Rate Coefficients and Product Yields for c-C5H5 + CH3 → Products10.1021/jp900679t ↗
81. The mechanism and rate constants for oxidation of indenyl radical C9H7 with molecular oxygen O2: A theoretical study10.1039/C9CP01122F ↗
82. Scission of the Five-Membered Ring in 1-H-Inden-1-one C9H6O and Indenyl C9H7 in the Reactions with H and O Atoms10.1021/acs.jpca.9b04578 ↗
83. On the role of resonantly stabilized radicals in polycyclic aromatic hydrocarbon (PAH) formation: Pyrene and fluoranthene formation from benzyl–indenyl addition10.1039/C7CP02539D ↗
84. Human dietary exposure to polycyclic aromatic hydrocarbons: A review of the scientific literature10.1016/j.fct.2015.10.002 ↗
85. Polycyclic aromatic hydrocarbons (PAHs) and their bioaccessibility in meat: A tool for assessing human cancer risk10.7314/APJCP.2016.17.1.15 ↗
86. Scientific Committee on Food (SCF) (2002). Opinion of the Scientific Committee on Food on the Risks to Human Health of Polycyclic Aromatic Hydrocarbons in Food.
87. European Commission (2006). Commission Regulation
88. (EC) No 1881/2006 of 19 December 2006 Setting Maximum Levels for Certain Contaminants in Foodstuffs, OJ L364/5.
89. European Commission (2011). Commission Regulation (EU) No 835/2011 of 19 August 2011 amending Regulation (EC) No 1881/2006 as regards maximum levels for polycyclic aromatic hydrocarbons in foodstuffs. Off. J. Eur. Union, 215, 4–8.
90. EFSA European Food Safety Authority (2008). Polycyclic Aromatic Hydrocarbons in Food—Scientific Opinion of the Panel on Contaminants in the Food Chain. EFSA J., 724, 1–114.10.2903/j.efsa.2008.724 ↗
91. A Critical Review about the Health Risk Assessment of PAHs and Their Metabolites in Foods10.1080/10408398.2012.697497 ↗
92. Levels of polycyclic aromatic hydrocarbons in edible and fried vegetable oil: A health risk assessment study10.1007/s11356-021-14755-z ↗
93. Effects of Phenolic Acid Marinades on the Formation of Polycyclic Aromatic Hydrocarbons in Charcoal-Grilled Chicken Wings10.4315/0362-028X.JFP-18-420 ↗
94. Effect of charcoal type on the formation of polycyclic aromatic hydrocarbons in grilled meats10.1016/j.foodchem.2020.128453 ↗
95. Combination of Precolumn Nitro-reduction and Ultraperformance Liquid Chromatography with Fluorescence Detection for the Sensitive Quantification of 1-Nitronaphthalene, 2-Nitrofluorene, and 1-Nitropyrene in Meat Products10.1021/acs.jafc.5b00523 ↗
96. Effects of oil types and pH on carcinogenic polycyclic aromatic hydrocarbons (PAHs) in grilled chicken10.1016/j.foodcont.2017.03.029 ↗
97. Solid-Phase Extraction Combined with Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry for the Determination of 5 Trace Nitro-Polycyclic Aromatic Hydrocarbons in Barbecued Foods10.1093/jaoacint/qsaa062 ↗
98. The effect of common spices and meat type on the formation of heterocyclic amines and polycyclic aromatic hydrocarbons in deep-fried meatballs10.1016/j.foodcont.2018.05.018 ↗
99. The effects of cooking on wire and stone barbecue at different cooking levels on the formation of heterocyclic aromatic amines and polycyclic aromatic hydrocarbons in beef steak10.1016/j.foodchem.2016.02.041 ↗
100. Effects of grilling procedures on levels of polycyclic aromatic hydrocarbons in grilled meats10.1016/j.foodchem.2015.12.017 ↗