Non-Centrifugal Sugar (NCS) and Health: A Review on Functional Components and Health Benefits
Source abstract
Abstract
Non-centrifugal sugar (NCS) is the scientific term the Food and Agriculture Organization (FAO) uses to define a solid product, produced by sugarcane juice evaporation, which is unrefined or minimally refined. NCS is referred to in various names globally, the most significant ones are whole cane sugar, panela (Latin America), jaggery (India) and kokuto (Japan). NCS contains minerals, bioactive compounds, flavonoids and phenolic acids, which have therapeutic potentials from time immemorial. Even though the bioactive property is dependent on the composition, which relies mainly on the agronomic conditions and production process, NCS possesses antioxidant and anti-inflammatory properties. Hence, substituting the consumption of refined sugar with NCS might be helpful in the control of chronic diseases generally connected to oxidative stress and inflammation. Experimental facts from in vitro and in vivo models have proven that NCS plays an essential role in weight management, maintaining insulin sensitivity and preventing neurodegenerative diseases. NCS has also shown hypoglycemic and hypolipidemic effects. This review aims to synopsize the recent literature pertaining to the benefits of NCS in human health. The NCS can be considered a nutraceutical and functional food. However, detailed and regulated studies are important to enhance the beneficial effects in human and animal interventions.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Natural Products and Biological Research · Hibiscus Plant Research Studies · Sugarcane Cultivation and Processing
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Nutrition, Faculty of Medicine and Health Science, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia
Funding
Central Sugars Refinery Sdn Bhd
References (85)
Show source-provided references
1. Physicochemical, antioxidant, volatile component, and mass spectrometry-based electronic nose analyses differentiated unrefined non-centrifugal cane, palm, and coconut sugars10.1007/s11694-020-00749-x ↗
2. FAO (2021, October 09). Definition and Classification of Commodities. Sugar Crops and Sweeteners and Derived Products, Available online: http://www.fao.org/es/faodef/fdef03e.HTM.
3. WCO (World Customs Organization) (2021, October 09). HS Nomenclature 2012 Edition, Section 0417-2012E, Chapter 17, Sugar and Sugar Confectionery, Available online: https://www.wcoomd.org/en/faq/~/link.aspx?_id=3F9BB5F791484D45810FE0A5B9782E4C&_z=z.
4. Key aroma-active compounds in brown sugar and their influence on sweetness10.1016/j.foodchem.2020.128826 ↗
5. Changes in the physicochemical characteristics, including flavour components and Maillard reaction products, of non-centrifugal cane brown sugar during storage10.1016/j.foodchem.2013.10.089 ↗
6. Non-centrifugal cane sugar processing: A review on recent advances and the influence of process variables on qualities attributes of final products10.1016/j.jfoodeng.2019.03.009 ↗
7. Mohan, N., and Singh, P. (2020). Sugar and Sugar Derivatives: Changing Consumer Preferences, Springer.10.1007/978-981-15-6663-9 ↗
8. Compositional and Electronic Discrimination Analyses of Taste and Aroma Profiles of Non-Centrifugal Cane Brown Sugars10.1007/s12161-016-0746-5 ↗
9. Wax, policosanol, and long-chain aldehydes of different sugarcane (Saccharum officinarum L.) cultivars10.1002/ejlt.201100300 ↗
10. Determination of the putative cancer chemopreventive flavone tricin in plasma and tissues of mice by HPLC with UV-visible detection10.1002/bmc.473 ↗
11. On-line identification of sugarcane (Saccharum officinarum L.) methoxyflavones by liquid chromatography-UV detection using post-column derivatization and liquid chromatography-mass spectrometry10.1016/j.chroma.2005.01.083 ↗
12. Phenolic composition and antioxidant activity of culms and sugarcane (Saccharum officinarum L.) products
13. Health Effects of Non-Centrifugal Sugar (NCS): A Review10.1007/s12355-012-0145-1 ↗
14. Jaggery: A natural sweetener
15. Antiatherosclerotic function of Kokuto, Okinawan non-centrifugal cane sugar10.1021/jf802796m ↗
16. Cytoprotective and antioxidant activity studies of jaggery sugar10.1016/j.foodchem.2008.11.067 ↗
17. Physicochemical and antioxidant properties of non-refined sugarcane alternatives to white sugar10.1111/ijfs.12926 ↗
18. Cifuentes, J., Salazar, V.A., Cuellar, M., Castellanos, M.C., Rodríguez, J., Cruz, J.C., and Muñoz-Camargo, C. (2021). Antioxidant and neuroprotective properties of non-centrifugal cane sugar and other sugarcane derivatives in an in vitro induced parkinson’s model. Antioxidants, 10.10.3390/antiox10071040 ↗
19. Nutritional and functional components of non-centrifugal cane sugar: A compilation of the data from the analytical literature10.1016/j.jfca.2015.06.007 ↗
20. Comparative study of the physicochemical, nutritional, and antioxidant properties of some commercial refined and non-centrifugal sugars10.1016/j.foodres.2018.06.037 ↗
21. Effect of Liming Process on Physicochemical Properties and Phytochemical Components of Non-Centrifugal Sugar from Different Sugarcane Cultivars10.1007/s40003-019-00409-7 ↗
22. Chemical characteristics and colorimetric properties of non-centrifugal cane sugar (“panela”) obtained via different processing technologies10.1016/j.foodchem.2020.128183 ↗
23. Antioxidant activity, nutritional and physicochemical characteristics, and toxicity of minimally refined brown sugar and other sugars10.1002/fsn3.1803 ↗
24. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) (2014). Scientific Opinion on the substantiation of a health claim related to iron and contribution to normal formation of haemoglobin and red blood cells pursuant to Article 14 of Regulation
25. (EC) No 1924/2006. EFSA J., 12, 3515.
26. The role of selenium in insulin resistance10.1590/s2175-97902018000100139 ↗
27. Ngo, D.-H., and Vo, T.S. (2019). An Updated Review on Pharmaceutical Properties of Gamma-Aminobutyric Acid. Molecules, 24.10.3390/molecules24152678 ↗
28. Finding of Cyclodextrans and Attempts of their Industrialization for Cariostatic Oligosaccharides10.5458/jag.54.103 ↗
29. Psicose contents in various food products and its origin
30. Physico-chemical properties, wax composition, aroma profiles, and antioxidant activity of granulated non-centrifugal sugars from sugarcane cultivars of Thailand10.1007/s13197-016-2415-5 ↗
31. Chemistry and biochemistry of dietary polyphenols10.3390/nu2121231 ↗
32. Phenolic Profile of Cane Sugar Derivatives Exhibiting Antioxidant and Antibacterial Properties10.1007/s12355-020-00817-y ↗
33. Exploration of sugarcane products as a major source of antioxidant phenolic extracts in commercial foods and beverages
34. Polyphenol Profiles and Antioxidant Activities of Non-centrifugal Sugars Derived from Different Varieties of Membrane-Clarified Sugarcane Juice
35. Nutritional and antioxidant properties of non-centrifugal cane sugar derived from membrane clarified juice10.1016/j.lwt.2020.109717 ↗
36. Anti-stress and antioxidant effects of non- centrifuged cane sugar, Kokuto, in restraint-stressed mice10.5650/jos.ess18198 ↗
37. Circular Sustainability of Sugarcane: Natural, Nutritious, and Functional Unrefined Sweeteners That Meet New Consumer Demands10.1007/s12355-021-00994-4 ↗
38. Positive aspects of cane sugar and sugar cane derived products in food and nutrition10.1021/acs.jafc.7b05734 ↗
39. Total antioxidant content of alternatives to refined sugar10.1016/j.jada.2008.10.014 ↗
40. Azlan, A., Ebadi, S., Yusof, B.N.M., Othman, N.M.H., Kannar, D., Sultana, S., and Mahmood, Z. (Nutrition, 2021). Determination of Satiety, Glycaemic Profiles, Total Antioxidant Capacity and Postprandial Glycemic Responses of Minimally Refined Sugar and Others in Malaysian Healthy Adults, Nutrition, in press.10.1016/j.nut.2021.111551 ↗
41. Application of near infrared spectroscopy in the sugar industry10.1255/jnirs.175 ↗
42. Application of near-infrared spectroscopy in the sugar industry for the detection of betaine10.1016/j.aca.2003.09.032 ↗
43. Near-infrared spectroscopic analysis of total phenolic content and antioxidant activity of berry fruits
44. (2021, December 21). Closed Loop Sugar Processing. Available online: https://shop.exchange.se.com/en-US/apps/60696/closed-loop-sugar-processing.
45. Oxidative stress and metabolic syndrome10.1016/j.lfs.2009.02.026 ↗
46. Total phenolic, chromium contents and antioxidant activity of raw and processed sugars
47. Antidiabetes and antihypertension potential of commonly consumed carbohydrate sweeteners using in vitro models10.1089/jmf.2007.689 ↗
48. Adverse health effects due to arsenic exposure: Modification by dietary supplementation of jaggery in mice10.1016/j.taap.2009.10.014 ↗
49. Phenolic content, antioxidant and antibacterial activity of selected natural sweeteners available on the Polish market10.1080/03601234.2013.824236 ↗
50. Inflammatory responses and inflammation-associated diseases in organs10.18632/oncotarget.23208 ↗
51. Sánchez-Tapia, M., Martínez-Medina, J., Tovar, A.R., and Torres, N. (2019). Natural and artificial sweeteners and high fat diet modify differential taste receptors, insulin, and TLR4-mediated inflammatory pathways in adipose tissues of rats. Nutrients, 11.10.3390/nu11040880 ↗
52. Rogero, M.M., and Calder, P.C. (2018). Obesity, inflammation, toll-like receptor 4 and fatty acids. Nutrients, 10.10.3390/nu10040432 ↗
53. The development of metabolic endotoxemia is dependent on the type of sweetener and the presence of saturated fat in the diet10.1080/19490976.2020.1801301 ↗
54. Metabolic syndrome—A new world-wide definition. A consensus statement from the international diabetes federation10.1111/j.1464-5491.2006.01858.x ↗
55. Effects of high white and brown sugar consumption on serum level of brain-derived neurotrophic factor, insulin resistance, and body weight in albino rats
56. Burgeiro, A., Cerqueira, M.G., Varela-Rodríguez, B.M., Nunes, S., Neto, P., Pereira, F.C., Reis, F., and Carvalho, E. (2017). Glucose and Lipid Dysmetabolism in a Rat Model of Prediabetes Induced by a High-Sucrose Diet. Nutrients, 9.10.20944/preprints201704.0185.v1 ↗
57. RSSDI-ESI clinical practice recommendations for the management of type 2 diabetes mellitus 202010.4103/ijem.IJEM_225_20 ↗
58. Ramli, N.Z., Chin, K.Y., Zarkasi, K.A., and Ahmad, F. (2018). A review on the protective effects of honey against metabolic syndrome. Nutrients, 10.10.3390/nu10081009 ↗
59. Comparison of the enhancement of plasma glucose levels in type 2 diabetes Otsuka Long-Evans Tokushima Fatty rats by oral administration of sucrose or maple syrup10.5650/jos.62.737 ↗
60. Natural Alternative Sweeteners and Diabetes Management10.1007/s11892-019-1273-8 ↗
61. Effects on non-sugar fraction in black sugar on lipid and carbohydrate metabolism; Part I10.1055/s-2007-969774 ↗
62. Rozanska, O., Uruska, A., and Zozulinska-Ziolkiewicz, D. (2020). Brain-derived neurotrophic factor and diabetes. Int. J. Mol. Sci., 21.10.3390/ijms21030841 ↗
63. GLUT2 accumulation in enterocyte apical and intracellular membranes: A study in morbidly obese human subjects and ob/ob and high fat-fed mice10.2337/db10-1740 ↗
64. GLUT4 content decreases along with insulin resistance and high levels of inflammatory markers in rats with metabolic syndrome10.1186/1475-2840-11-100 ↗
65. Comparative Effects of Cane Sugar, Honey & Jaggery on Plasma Glucose Level & Body Weight of Alloxan Induced Diabetic Rats10.47489/PSZMC-807-35-3-44-49 ↗
66. In vitro α -amylase and α-glucosidase inhibitory potential of Trigonella foenum-graecum leaves extract10.4103/0974-8520.115446 ↗
67. Role of Chromium in Human Health and in Diabetes10.2337/diacare.27.11.2741 ↗
68. Chromium in metabolic and cardiovascular disease10.1055/s-2007-985847 ↗
69. Selenium: An insulin-mimetic10.1007/PL00000669 ↗
70. Saibandith, B., Spencer, J.P.E., Rowland, I.R., and Commane, D.M. (2017). Olive Polyphenols and the Metabolic Syndrome. Molecules, 22.10.3390/molecules22071082 ↗
71. Effect of Kokuto, a non-centrifugal cane sugar, on the development of experimental atherosclerosis in Japanese quail and apolipoprotein E deficient mice10.3136/fstr.13.61 ↗
72. Oxidative Stress in Autoimmune and Neurodegenerative Diseases
73. Rotenone-induced PC12 cell toxicity is caused by oxidative stress resulting from altered dopamine metabolism10.1016/j.tiv.2008.04.019 ↗
74. Oxidative Stress in Neurodegenerative Diseases: From a Mitochondrial Point of View10.1155/2019/2105607 ↗
75. Determinación de acrilamida en el procesamiento de la panela por cromatografía líquida (Acrylamide Determintion in the Sugar Cane Juice Process by the Liquid Chromatography Technique)
76. Dietary Acrylamide and Human Cancer: A Systematic Review of Literature10.1080/01635581.2014.916323 ↗
77. NTP (National Toxicology Program) (2012). Technical Report on the Toxicology and Carcinogenesis Studies of Acrylamide in F344/N Rats and B6C3F1 Mice (Feed and Drinking Water Studies). Natl. Toxicol. Program, 79, 1–234.
78. Review of epidemiologic studies of dietary acrylamide intake and the risk of cancer10.1097/CEJ.0b013e3283529b64 ↗
79. Human exposure and internal dose assessments of acrylamide in food10.1016/j.fct.2004.11.004 ↗
80. INAA and AAS of different products from sugar cane industry in Pakistan: Toxic trace elements for nutritional safety10.1007/s10967-008-7332-2 ↗
81. Polycyclic aromatic hydrocarbons (PAHs) in raw cane sugar (rapadura) in Brazil10.1016/j.jfca.2010.08.012 ↗
82. Contamination of commercial cane sugars by some organic acids and some inorganic anions10.1016/j.foodchem.2012.07.036 ↗
83. Sugars and sweeteners: Science, innovations, and consumer guidance for Asia
84. Physical and chemical properties of granulated cane sugar “panelas”10.1590/S0101-20612010005000012 ↗
85. Physical-chemical and microbiological evaluation of commercial brown sugar10.53393/rial.2009.v68.32726 ↗