Emerging Biomedical Applications of Carbon Dot and Polymer Composite Materials
Source abstract
Abstract
Carbon dot-based composite materials have been extensively developed for versatile biomedical applications, such as drug delivery, tissue engineering, bioimaging, biosensors, and photothermal cancer therapy, owing to their excellent mechanical properties, electrical and thermal conductivity, large surface-to-volume ratio, and biocompatibility. For instance, the hydrophobicity and delocalized π-electrons of carbon dots enable insoluble drug loading in carbon composite-based drug delivery carriers. In addition, carbon dot-based materials are suitable for optical and electrochemical biosensor applications owing to their intrinsic properties. Thus, this review briefly focuses on the following: (1) general aspects, (2) various sources, and (3) versatile biomedical applications of carbon dots and composite materials. More importantly, we present the emerging applications of carbon dot-based materials, such as in agricultural systems, COVID-19 theranostics, counterfeit, and security.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Carbon and Quantum Dots Applications · Nanocluster Synthesis and Applications · Advanced Nanomaterials in Catalysis
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Integrated Omics Institute, Wonkwang University, Iksan 54538, Jeonbuk, Korea
Department of Veterinary Medicine and Surgery, Sudan University of Science and Technology, Khartoum-North 11311, Khartoum, Sudan
Department of Pharmaceutical Sciences, North South University, Dhaka 1229, Bangladesh
Department of Carbon Convergence Engineering, Wonkwang University, Iksan 54538, Jeonbuk, Korea
Funding
Wonkwang University
References (100+)
Show source-provided references
1. Electrophoretic analysis and purification of fluorescent single-walled carbon nanotube fragments10.1021/ja040082h ↗
2. Carbon dots: Applications in bioimaging and theranostics10.1016/j.ijpharm.2019.04.055 ↗
3. Synthesis of highly fluorescent carbon dots from lemon and onion juices for determination of riboflavin in multivitamin/mineral supplements10.1016/j.jpha.2019.02.003 ↗
4. Chu, K.W., Lee, S.L., Chang, C.J., and Liu, L. (2019). Recent Progress of Carbon Dot Precursors and Photocatalysis Applications. Polymers, 11.10.3390/polym11040689 ↗
5. Synthesis of fluorescent nitrogen and phosphorous co-doped carbon quantum dots for sensing of iron, cell imaging and antioxidant activities10.1007/s10895-021-02696-2 ↗
6. Chiral carbon dots: Synthesis, optical properties, and emerging applications10.1038/s41377-022-00764-1 ↗
7. Carbon dots: Principles and their applications in food quality and safety detection10.1080/10408398.2018.1437712 ↗
8. Carbon dots for energy conversion applications10.1063/1.5094032 ↗
9. Carbon dots: A booming material for biomedical applications10.1039/C9QM00658C ↗
10. B, N co-doped carbon dots based fluorescent test paper and hydrogel for visual and efficient dual ion detection10.1016/j.inoche.2022.110047 ↗
11. Photoluminescent carbon nanomaterials for sensing of illicit drugs: Focus10.2116/analsci.21SAR06 ↗
12. Green synthesis of carbon dots toward anti-counterfeiting10.1021/acssuschemeng.9b06267 ↗
13. Advancement in science and technology of carbon dot-polymer hybrid composites: A review10.1088/2631-6331/ab0c80 ↗
14. Bioconjugation of quantum dots: Review & impact on future application10.1016/j.trac.2016.07.008 ↗
15. Zhou, Y., Sharma, S.K., Peng, Z., and Leblanc, R.M. (2017). Polymers in carbon dots: A review. Polymers, 9.10.3390/polym9020067 ↗
16. Nanoscale carbon-polymer dots for theranostics and biomedical exploration10.3390/jnt2030008 ↗
17. Evolution and Synthesis of Carbon Dots: From Carbon Dots to Carbonized Polymer Dots10.1002/advs.201901316 ↗
18. A convenient green method to synthesize luminescent carbon dots from edible carrot and its application in bioimaging and preparation of nanocatalyst10.1016/j.molliq.2019.01.070 ↗
19. Current and future perspectives of carbon and graphene quantum dots: From synthesis to strategy for building optoelectronic and energy devices10.1016/j.rser.2020.110391 ↗
20. Hydrothermal route to graphene quantum dots: Effects of precursor and temperature10.1016/j.diamond.2017.08.014 ↗
21. The analytical and biomedical applications of carbon dots and their future theranostic potential: A review
22. Small molecules derived carbon dots: Synthesis and applications in sensing, catalysis, imaging, and biomedicine10.1186/s12951-019-0525-8 ↗
23. Zulfajri, M., Sudewi, S., Ismulyati, S., Rasool, A., Adlim, M., and Huang, G.G. (2021). Carbon dot/polymer composites with various precursors and their sensing applications: A Review. Coatings, 11.10.3390/coatings11091100 ↗
24. Green chitosan–carbon dots nanocomposite hydrogel film with superior properties10.1016/j.carbpol.2014.08.021 ↗
25. Pyrophosphate ion-responsive alginate hydrogel as an effective fluorescent sensing platform for alkaline phosphatase detection10.1039/C9CC05223B ↗
26. Graphene quantum dots engineered nanofiltration membrane for ultrafast molecular separation10.1016/j.memsci.2018.11.044 ↗
27. Carbon quantum dots (CQDs) nanofiltration membranes towards efficient biogas slurry valorization10.1016/j.cej.2019.123993 ↗
28. Photoluminescence mechanism of carbon dots: Triggering high-color-purity red fluorescence emission through edge amino protonation10.1038/s41467-021-27071-4 ↗
29. Size controlled synthesis of carbon quantum dots using hydride reducing agents10.1039/C4TC00826J ↗
30. Carbon Dots: A new type of carbon-based nanomaterial with wide applications10.1021/acscentsci.0c01306 ↗
31. Amorphous carbon dots and their remarkable ability to detect 2,4,6-trinitrophenol10.1038/s41598-018-28021-9 ↗
32. Fluorescent nano-biomass dots: Ultrasonic-assisted extraction and their application as nanoprobe for Fe3+ detection10.1186/s11671-019-2950-x ↗
33. Zulfajri, M., Dayalan, S., Li, W.Y., Chang, C.J., Chang, Y.P., and Huang, G.G. (2019). Nitrogen-doped carbon dots from averrhoa carambola fruit extract as a fluorescent probe for methyl orange. Sensors, 19.10.3390/s19225008 ↗
34. Physicochemical characteristics that affect carbon dot safety: Lessons from a comprehensive study on a nanoparticle library10.1016/j.ijpharm.2019.118521 ↗
35. Photoluminescence tuning in carbon dots: Surface passivation or/and functionalization, heteroatom doping10.1039/C7TC05878K ↗
36. Engineering graphene quantum dots for enhanced ultraviolet and visible light p-si nanowire-based photodetector10.1021/acsami.7b07667 ↗
37. Fluorescent carbon dots: Fantastic electroluminescent materials for light-emitting diodes10.1002/advs.202001977 ↗
38. Solvent-controlled synthesis strategy of multicolor emission carbon dots and its applications in sensing and light-emitting devices10.1007/s12274-021-3495-8 ↗
39. Dose-dependent carbon-dot-induced ros promote uveal melanoma cell tumorigenicity via activation of mtor signaling and glutamine metabolism10.1002/advs.202002404 ↗
40. Herbal medicine derived carbon dots: Synthesis and applications in therapeutics, bioimaging and sensing10.1186/s12951-021-01072-3 ↗
41. Enzymatic degradation of graphene quantum dots by human peroxidases10.1002/smll.201905405 ↗
42. The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction10.2217/nnm.16.5 ↗
43. Carbon dot therapeutic platforms: Administration, distribution, metabolism, excretion, toxicity, and therapeutic potential10.1002/smll.202106342 ↗
44. Systematic safety evaluation on photoluminescent carbon dots10.1186/1556-276X-8-122 ↗
45. Investigating the bioavailability of graphene quantum dots in lung tissues via Fourier transform infrared spectroscopy10.1098/rsfs.2017.0054 ↗
46. Polymer carbon dots-a highlight reviewing their unique structure, bright emission and probable photoluminescence mechanism10.1002/pola.28416 ↗
47. Solution-processed two-dimensional materials for next-generation photovoltaics10.1039/D1CS00106J ↗
48. Tuning optical properties of nitrogen-doped carbon dots through fluorescence resonance energy transfer using Rhodamine B for the ratiometric sensing of mercury ions10.1039/D1AY00068C ↗
49. Material and optical properties of fluorescent carbon quantum dots fabricated from lemon juice via hydrothermal reaction10.1186/s11671-018-2581-7 ↗
50. The polymeric characteristics and photoluminescence mechanism in polymer carbon dots: A review10.1016/j.mtchem.2017.09.001 ↗
51. Highly photoluminescent carbon dots for multicolor patterning, sensors, and bioimaging10.1002/anie.201300519 ↗
52. Xu, J., Cui, K., Gong, T., Zhang, J., Zhai, Z., Hou, L., Zaman, F.U., and Yuan, C. (2022). Ultrasonic-assisted synthesis of n-doped, multicolor carbon dots toward fluorescent inks, fluorescence sensors, and logic gate operations. Nanomaterials, 12.10.3390/nano12030312 ↗
53. The photoluminescence mechanism in carbon dots (graphene quantum dots, carbon nanodots, and polymer dots): Current state and future perspective10.1007/s12274-014-0644-3 ↗
54. Fluorescent self-healing carbon dot/polymer gels
55. Quantum-sized carbon dots for bright and colorful photoluminescence10.1021/ja062677d ↗
56. Exploring the blue luminescence origin of nitrogen-doped carbon dots by controlling the water amount in synthesis10.1039/C5RA11796H ↗
57. One-step synthesis of surface passivated carbon nanodots by microwave assisted pyrolysis for enhanced multicolor photoluminescence and bioimaging10.1039/c1jm12744f ↗
58. Hexagonal Boron Nitrides (White Graphene): A promising method for cancer drug delivery10.2147/IJN.S205095 ↗
59. Chemical modifications and bioconjugate reactions of nanomaterials for sensing, imaging, drug delivery and therapy10.1039/C3CS60273G ↗
60. Fluorescent carbon dots as carriers for intracellular doxorubicin delivery and track10.1016/j.jddst.2018.12.015 ↗
61. Zhu, J., Liu, W., Zhang, B., Zhou, D., Fan, X., Wang, X., and Liu, X. (2022). Carbon dots embedded hybrid microgel with phenylboronic acid as monomer for fluorescent glucose sensing and glucose-triggered insulin release at physiological pH. Nanomaterials, 12.10.3390/nano12173065 ↗
62. Multi-functionalized carbon dots as theranostic nanoagent for gene delivery in lung cancer therapy10.1038/srep21170 ↗
63. Light-responsive nanomedicine for biophotonic imaging and targeted therapy10.1016/j.addr.2018.10.002 ↗
64. Recent progress of carbon dots in targeted bioimaging and cancer therapy10.7150/thno.70721 ↗
65. Synthesis and applications of red-emissive carbon dots10.1002/tcr.201800172 ↗
66. Hydrothermal treatment of grass: A low-cost, green route to nitrogen-doped, carbon-rich, photoluminescent polymer nanodots as an effective fluorescent sensing platform for label-free detection of Cu(II) ions10.1002/adma.201200164 ↗
67. Near-Infrared photoluminescent polymer-carbon nanodots with two-photon fluorescence10.1002/adma.201603443 ↗
68. Photoluminescent carbon dots as biocompatible nanoprobes for targeting cancer cells in vitro10.1021/jp911539r ↗
69. Carbonized polymer dots: A brand new perspective to recognize luminescent carbon-based nanomaterials10.1021/acs.jpclett.9b01384 ↗
70. Amphibious fluorescent carbon dots: One-step green synthesis and application for light-emitting polymer nanocomposites10.1039/c3cc43295e ↗
71. A facile and versatile approach to biocompatible “fluorescent polymers” from polymerizable carbon nanodots10.1039/c2cc35966a ↗
72. Hyperbranched polymer functionalized carbon dots with multistimuli-responsive property10.1021/mz400474v ↗
73. Nano-carrier for gene delivery and bioimaging based on carbon dots with PEI-passivation enhanced fluorescence10.1016/j.biomaterials.2012.01.052 ↗
74. Transfection and intracellular trafficking properties of carbon dot-gold nanoparticle molecular assembly conjugated with PEI-pDNA10.1016/j.biomaterials.2013.05.072 ↗
75. Carbon dots incorporated polymeric hydrogels as multifunctional platform for imaging and induction of apoptosis in lung cancer cells10.1016/j.colsurfb.2016.01.043 ↗
76. Carbon dots assisted formation of DNA hydrogel for sustained release of drug10.1016/j.carbon.2016.12.020 ↗
77. Low chemically cross-linked PAM/C-dot hydrogel with robustness and superstretchability in both as-prepared and swelling equilibrium states10.1021/acs.macromol.5b02352 ↗
78. Nanocomposite carbon dots/PAM fluorescent hydrogels and their mechanical properties10.1007/s10965-017-1389-y ↗
79. Immobilization of carbon dots in molecularly imprinted microgels for optical sensing of glucose at physiological pH10.1021/acsami.5b04744 ↗
80. Biocompatible PEG-chitosan@ carbon dots hybrid nanogels for two-photon fluorescence imaging, near-infrared light/pH dual-responsive drug carrier, and synergistic therapy10.1002/adfm.201501524 ↗
81. Polyamidoamine dendrimers-capped carbon dots/Au nanocrystal nanocomposites and its application for electrochemical immunosensor10.1016/j.bios.2013.05.048 ↗
82. Carbon dots and chitosan composite film based biosensor for the sensitive and selective determination of dopamine10.1039/c3an00510k ↗
83. Label-free fluorimetric detection of histone using quaternized carbon dot–DNA nanobiohybrid10.1039/c3cc44492a ↗
84. High performance luminescent thermosetting waterborne hyperbranched polyurethane/carbon quantum dot nanocomposite with in vitro cytocompatibility10.1016/j.compscitech.2015.08.010 ↗
85. Supramolecular assembly of biobased graphene oxide quantum dots controls the morphology of and induces mineralization on poly (ε-caprolactone) films10.1021/acs.biomac.5b01339 ↗
86. Cellulose-derived nanographene oxide reinforced macroporous scaffolds of high internal phase emulsion-templated cross-Linked poly (ε-caprolactone)10.1021/acs.biomac.9b01330 ↗
87. A mini review on carbon quantum dots: Preparation, properties, and electrocatalytic application10.3389/fchem.2019.00671 ↗
88. Wu, D., Samanta, A., Srivastava, R.K., and Hakkarainen, M. (2018). Nano-graphene oxide functionalized bioactive poly (lactic acid) and poly (ε-caprolactone) nanofibrous scaffolds. Materials, 11.10.3390/ma11040566 ↗
89. pH/redox-triggered photothermal treatment for cancer therapy based on a dual-responsive cationic polymer dot10.1002/cmdc.201800538 ↗
90. Two-photon excitation triggers combined chemo-photothermal therapy via doped carbon nanohybrid dots for effective breast cancer treatment10.1016/j.cej.2017.07.165 ↗
91. Dual-emission carbonized polymer dots for ratiometric ph sensing, ph-dependent generation of singlet oxygen, and imaging-guided dynamics monitoring of photodynamic therapy10.1021/acsabm.1c00892 ↗
92. Incorporation of green emission polymer dots into pyropheophorbide-α enhance the PDT effect and biocompatibility10.1016/j.pdpdt.2021.102562 ↗
93. Green synthesis of Spirulina-based carbon dots for stimulating agricultural plant growth
94. Fluorescent carbon-dots enhance light harvesting and photosynthesis by overexpressing PsbP and PsiK genes10.1186/s12951-021-01005-0 ↗
95. Carbon dots promote the growth and photosynthesis of mung bean sprouts10.1016/j.carbon.2018.04.051 ↗
96. Effect of carbon dots with chitosan coating on microorganisms and storage quality of modified-atmosphere-packaged fresh-cut cucumber10.1002/jsfa.9879 ↗
97. Application of carbon dots-chitosan coating in preservation of mango
98. carbon dots for efficient small interfering RNA delivery and gene silencing in plants10.1104/pp.20.00733 ↗
99. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China10.1016/S0140-6736(20)30183-5 ↗
100. COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice10.1038/s41586-020-2943-z ↗