Nanomaterials in Bone Regeneration
Source abstract
Abstract
Nanomaterials are promising in the development of innovative therapeutic options that include tissue and organ replacement, as well as bone repair and regeneration. The expansion of new nanoscaled biomaterials is based on progress in the field of nanotechnologies, material sciences, and biomedicine. In recent decades, nanomaterial systems have bridged the line between the synthetic and natural worlds, leading to the emergence of a new science called nanomaterial design for biological applications. Nanomaterials replicating bone properties and providing unique functions help in bone tissue engineering. This review article is focused on nanomaterials utilized in or being explored for the purpose of bone repair and regeneration. After a brief overview of bone biology, including a description of bone cells, matrix, and development, nanostructured materials and different types of nanoparticles are discussed in detail.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Graphene and Nanomaterials Applications · Bone Metabolism and Diseases
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Medical Chemistry and Biochemistry, Faculty of Medicine in Pilsen, Charles University, Karlovarska 48, 301 66 Plzen, Czech Republic
Funding
Ministry of Education, Youth and Sports of the Czech Republic
References (100+)
Show source-provided references
1. Tanaka, M., Izumiya, M., Haniu, H., Ueda, K., Ma, C., Ueshiba, K., Ideta, H., Sobajima, A., Uchiyama, S., and Takahashi, J. (2022). Current Methods in the Study of Nanomaterials for Bone Regeneration. Nanomaterials, 12.10.3390/nano12071195 ↗
2. Rare Earth Smart Nanomaterials for Bone Tissue Engineering and Implantology: Advances, Challenges, and Prospects10.1002/btm2.10262 ↗
3. Application of Nanoparticles in Bone Tissue Engineering; A Review on the Molecular Mechanisms Driving Osteogenesis10.1039/D1BM00504A ↗
4. Nanostructured Biomaterials for Bone Regeneration10.3389/fbioe.2020.00922 ↗
5. Recent Advances in Nano Scaffolds for Bone Repair10.1038/boneres.2016.50 ↗
6. Evaluation of Polyphenols as Possible Therapeutics for Amyloidoses: Comparative Analysis of Kaempferol and Catechin10.1016/j.ijbiomac.2015.07.052 ↗
7. Kumar, P., Saini, M., Dehiya, B.S., Sindhu, A., Kumar, V., Kumar, R., Lamberti, L., Pruncu, C.I., and Thakur, R. (2020). Comprehensive Survey on Nanobiomaterials for Bone Tissue Engineering Applications. Nanomaterials, 10.10.3390/nano10102019 ↗
8. Nanotechnology in Bone Tissue Engineering10.1016/j.nano.2015.02.013 ↗
9. Salamanna, F., Gambardella, A., Contartese, D., Visani, A., and Fini, M. (2021). Nano-Based Biomaterials as Drug Delivery Systems Against Osteoporosis: A Systematic Review of Preclinical and Clinical Evidence. Nanomaterials, 11.10.3390/nano11020530 ↗
10. An Update into the Application of Nanotechnology in Bone Healing10.2174/1874325001610010808 ↗
11. Advances in Bone Repair with Nanobiomaterials: Mini-Review10.1007/s10616-011-9367-4 ↗
12. Silver Nanoparticles Promote Osteogenesis of Mesenchymal Stem Cells and Improve Bone Fracture Healing in Osteogenesis Mechanism Mouse Model10.1016/j.nano.2015.07.016 ↗
13. Chitosan Nanocarriers for MicroRNA Delivery and Detection: A Preliminary Review with Emphasis on Cancer10.1016/j.carbpol.2022.119489 ↗
14. Synergistic Sorption Performance of Karaya Gum Crosslink Poly(Acrylamide-Co-Acrylonitrile) @ Metal Nanoparticle for Organic Pollutants10.1016/j.ijbiomac.2022.05.019 ↗
15. Barani, M., Hosseinikhah, S.M., Rahdar, A., Farhoudi, L., Arshad, R., Cucchiarini, M., and Pandey, S. (2021). Nanotechnology in Bladder Cancer: Diagnosis and Treatment. Cancers, 13.10.3390/cancers13092214 ↗
16. Nanoparticles in Tissue Engineering: Applications, Challenges and Prospects10.2147/IJN.S153758 ↗
17. Silver, Copper, Magnesium and Zinc Contained Electroactive Mesoporous Bioactive S53P4 Glass–Ceramics Nanoparticle for Bone Regeneration: Bioactivity, Biocompatibility and Antibacterial Activity10.1007/s10904-022-02295-z ↗
18. Synthesis and Characterization of Cu2Zn1.75Mo3O12 Ceramic Nanoparticles with Excellent Antibacterial Property10.1016/j.molliq.2022.119035 ↗
19. Radioactive Organic Semiconducting Polymer Nanoparticles for Multimodal Cancer Theranostics10.1016/j.jcis.2022.03.107 ↗
20. Fabrication of In Situ Grown Hydroxyapatite Nanoparticles Modified Porous Polyetheretherketone Matrix Composites to Promote Osteointegration and Enhance Bone Repair10.3389/fbioe.2022.831288 ↗
21. Preparation of Osteoinductive—Antimicrobial Nanocomposite Scaffolds Based on Poly (D,L-Lactide-Co-Glycolide) Modified with Copper–Doped Bioactive Glass Nanoparticles
22. Green Electrospinning for Biomaterials and Biofabrication10.1088/1758-5090/ac0964 ↗
23. Cell-Inspired All-Aqueous Microfluidics: From Intracellular Liquid–Liquid Phase Separation toward Advanced Biomaterials10.1002/advs.201903359 ↗
24. Modulation of Self-Assembly Process of Fibroin: An Insight for Regulating the Conformation of Silk Biomaterials10.1021/acs.biomac.5b01258 ↗
25. Pulsed Laser Deposition of Thin Coatings: Applications on Biomaterials
26. Exploration of Plasma-Enhanced Chemical Vapor Deposition as a Method for Thin-Film Fabrication with Biological Applications10.1021/am302989x ↗
27. Protein-Protein Nanoimprinting of Silk Fibroin Films10.1002/adma.201204678 ↗
28. The Generation of Biomolecular Patterns in Highly Porous Collagen-GAG Scaffolds Using Direct Photolithography10.1016/j.biomaterials.2011.02.018 ↗
29. Nanomanufacturing of Biopolymers Using Electron and Ion Beams10.1088/1361-6439/ab673d ↗
30. Nanofibers and Their Applications in Tissue Engineering10.2147/nano.2006.1.1.15 ↗
31. Protein-Based Smart Microtubes and Nanotubes as Ultrasmall Biomaterials10.1246/cl.200433 ↗
32. Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells
33. Normal Bone Anatomy and Physiology10.2215/CJN.04151206 ↗
34. The Bone Remodelling Cycle10.1177/0004563218759371 ↗
35. Bone Biology10.1016/S0950-351X(97)80473-9 ↗
36. Bone Tissue and Histological and Molecular Events during Development of the Long Bones10.1016/j.aanat.2021.151704 ↗
37. Concerning the Origin and Nature of Osteoblasts
38. Regulation of Gene Expression in Osteoblasts10.1002/biof.72 ↗
39. Osteoblast Differentiation at a Glance10.12659/MSMBR.901142 ↗
40. Modulation of Osteoclast Differentiation
41. Biology of the Osteoclast10.1007/978-3-642-77991-6_3 ↗
42. Carbonic Anhydrase and Osteoclasts: Localization by Labeled Inhibitor Autoradiography10.1126/science.183.4123.432 ↗
43. Abundant Calcitonin Receptors in Isolated Rat Osteoclasts. Biochemical and Autoradiographic Characterization10.1172/JCI112584 ↗
44. Mechanotransduction in Bone: Do Bone Cells Act as Sensors of Fluid Flow?10.1096/fasebj.8.11.8070637 ↗
45. A Model for the Excitation of Osteocytes by Mechanical Loading-Induced Bone Fluid Shear Stresses10.1016/0021-9290(94)90010-8 ↗
46. Affective Disorders, Bone Metabolism, and Osteoporosis10.1007/s12018-009-9025-y ↗
47. The Bone Extracellular Matrix in Bone Formation and Regeneration10.3389/fphar.2020.00757 ↗
48. Stock, M., and Schett, G. (2021). Vitamin K-Dependent Proteins in Skeletal Development and Disease. Int. J. Mol. Sci., 22.10.3390/ijms22179328 ↗
49. Undercarboxylated Osteocalcin Inhibits the Early Differentiation of Osteoclast Mediated by Gprc6a10.7717/peerj.10898 ↗
50. New Insights into the Biology of Osteocalcin10.1016/j.bone.2015.05.046 ↗
51. Low Serum Osteocalcin Levels Are Associated with Diabetes Mellitus in Glucocorticoid Treated Patients10.1007/s00198-021-06167-z ↗
52. Relationship Between Chronic Kidney Disease, Glucose Homeostasis, and Plasma Osteocalcin Carboxylation and Fragmentation10.1053/j.jrn.2020.05.013 ↗
53. Broadening the Role of Osteocalcin in the Hypothalamic-Pituitary-Gonadal Axis10.1530/JOE-20-0203 ↗
54. Role of Osteopontin in Bone Remodeling and Orthodontic Tooth Movement: A Review10.1186/s40510-018-0216-2 ↗
55. Bone Matrix Proteins: Their Function, Regulation, and Relationship to Osteoporosis10.1007/s00198-002-1342-7 ↗
56. Churchill, G.D., Dutour Sikirić, M., Čolović, B., and Füredi Milhofer, H. (2020). Bone Mineralisation. Contemporary Topics about Phosphorus in Biology and Materials, IntechOpen.10.5772/intechopen.80727 ↗
57. Bone Development10.1016/j.bone.2015.04.035 ↗
58. The Embryonic Development of Bone
59. Wnt/β-Catenin Signaling in Mesenchymal Progenitors Controls Osteoblast and Chondrocyte Differentiation during Vertebrate Skeletogenesis10.1016/j.devcel.2005.03.016 ↗
60. Developmental Regulation of the Growth Plate10.1038/nature01657 ↗
61. Bone Development10.1146/annurev.cellbio.16.1.191 ↗
62. Hypoxia in Cartilage: HIF-1α Is Essential for Chondrocyte Growth Arrest and Survival10.1101/gad.934301 ↗
63. Reaching a Genetic and Molecular Understanding of Skeletal Development10.1016/S1534-5807(02)00157-0 ↗
64. Role of Insulin-like Growth Factors in Embryonic and Postnatal Growth10.1016/S0092-8674(05)80085-6 ↗
65. The Transcription Factors L-Sox5 and Sox6 Are Essential for Cartilage Formation10.1016/S1534-5807(01)00003-X ↗
66. Matrix Remodeling during Endochondral Ossification10.1016/j.tcb.2003.12.003 ↗
67. What Do BMPs Do in Mammals? Clues from the Mouse Short-Ear Mutation10.1016/0168-9525(94)90014-0 ↗
68. Nanostructured Titanium-Based Materials for Medical Implants: Modeling and Development10.1016/j.mser.2014.04.002 ↗
69. Bulk Nanostructured Materials10.1007/s11661-017-4298-0 ↗
70. Effect of Mechanical Surface Pretreatment on Metal Ion Release10.1016/S0142-9612(99)00200-8 ↗
71. Accelerated Stem Cell Attachment to Ultrafine Grained Titanium10.1016/j.actbio.2010.09.033 ↗
72. An in Vivo Evaluation of Ultra-Fine Grained Titanium Implants
73. Comparison of Fibroblast and Osteoblast Response to Cultivation on Titanium Implants with Different Grain Sizes10.1155/2015/920893 ↗
74. Combined Effect of Grain Refinement and Surface Modification of Pure Titanium on the Attachment of Mesenchymal Stem Cells and Osteoblast-like SaOS-2 Cells10.1016/j.msec.2016.10.035 ↗
75. Babuska, V., Palan, J., Kolaja Dobra, J., Kulda, V., Duchek, M., Cerny, J., and Hrusak, D. (2018). Proliferation of Osteoblasts on Laser-Modified Nanostructured Titanium Surfaces. Materials, 11.10.3390/ma11101827 ↗
76. Xu, L., Zhang, K., Wu, C., Lei, X., Ding, J., Shi, X., and Liu, C. (2017). Micro-Arc Oxidation Enhances the Blood Compatibility of Ultrafine-Grained Pure Titanium. Materials, 10.10.3390/ma10121446 ↗
77. Nazarov, D., Zemtsova, E., Solokhin, A., Valiev, R., and Smirnov, V. (2017). Modification of the Surface Topography and Composition of Ultrafine and Coarse Grained Titanium by Chemical Etching. Nanomaterials, 7.10.3390/nano7010015 ↗
78. The Role of Titanium Surface Nanostructuring on Preosteoblast Morphology, Adhesion, and Migration10.1002/adhm.201601244 ↗
79. Osseointegration of Ultrafine-Grained Titanium with a Hydrophilic Nano-Patterned Surface: An in Vivo Examination in Miniature Pigs10.1039/C8BM00671G ↗
80. In-Vivo Study of Ultrafine-Grained CP-Ti Dental Implants Surface Modified by SLActive with Excellent Wettability10.1016/j.ijadhadh.2020.102684 ↗
81. Surface Modifications and Their Effects on Titanium Dental Implants10.1155/2015/791725 ↗
82. Corrosion and Surface Modification on Biocompatible Metals: A Review10.1016/j.msec.2017.04.102 ↗
83. Biocompatibility of Osteoblasts in Titanium Morphology Created by Dc Voltage
84. One-Dimensional Titanium Dioxide Nanomaterials: Nanotubes10.1021/cr500061m ↗
85. Baker, E.A., Fleischer, M.M., Vara, A.D., Salisbury, M.R., Baker, K.C., Fortin, P.T., and Friedrich, C.R. (2021). Local and Systemic In Vivo Responses to Osseointegrative Titanium Nanotube Surfaces. Nanomaterials, 11.10.3390/nano11030583 ↗
86. Camargo, S.E.A., Xia, X., Fares, C., Ren, F., Hsu, S.-M., Budei, D., Aravindraja, C., Kesavalu, L., and Esquivel-Upshaw, J.F. (2021). Nanostructured Surfaces to Promote Osteoblast Proliferation and Minimize Bacterial Adhesion on Titanium. Materials, 14.10.3390/ma14164357 ↗
87. Femtosecond Laser Surface Texturing of Titanium as a Method to Reduce the Adhesion of Staphylococcus Aureus and Biofilm Formation10.1016/j.apsusc.2015.10.102 ↗
88. Herman, P.R., Meunier, M., and Osellame, R. (2019). Application of Laser Surface Nanotexturing for the Reduction of Peri-Implantitis on Biomedical Grade 5 Ti-6Al-4V Dental Abutments. Proceedings of the Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XIX, SPIE.
89. Schnell, G., Staehlke, S., Duenow, U., Nebe, J.B., and Seitz, H. (2019). Femtosecond Laser Nano/Micro Textured Ti6Al4V Surfaces—Effect on Wetting and MG-63 Cell Adhesion. Materials, 12.10.3390/ma12132210 ↗
90. Nikolova, M.P., and Chavali, M.S. (2020). Metal Oxide Nanoparticles as Biomedical Materials. Biomimetics, 5.10.3390/biomimetics5020027 ↗
91. Nanotechnology Based Approaches in Cancer Therapeutics10.1088/2043-6262/5/4/043001 ↗
92. Overview on Green Synthesis of Metallic Nanoparticles10.1007/s11696-021-01693-w ↗
93. A Review on Green Synthesis, Characterization and Anticancer Application of Metallic Nanoparticles10.1007/s12010-021-03598-6 ↗
94. Biomedical Applications of Functionalized Gold Nanoparticles: A Review10.1007/s10876-020-01955-9 ↗
95. Biofabrication of Gold Nanoparticles with Bone Remodeling Potential: An in Vitro and in Vivo Assessment10.1007/s11051-020-04883-x ↗
96. Gold Nanoparticles Promote the Bone Regeneration of Periodontal Ligament Stem Cell Sheets Through Activation of Autophagy10.2147/IJN.S282246 ↗
97. Size-Dependent Effects of Gold Nanoparticles on Osteogenic Differentiation of Human Periodontal Ligament Progenitor Cells10.7150/thno.17252 ↗
98. Gold Nanoparticles Promote Osteogenic Differentiation in Human Adipose-Derived Mesenchymal Stem Cells through the Wnt/β-Catenin Signaling Pathway
99. Gold Nanoparticles Promote Osteogenic Differentiation of Mesenchymal Stem Cells through P38 MAPK Pathway10.1021/nn101373r ↗
100. Oligonucleotide-Modified Gold Nanoparticles for Intracellular Gene Regulation10.1126/science.1125559 ↗