MDA-Unet: A Multi-Scale Dilated Attention U-Net for Medical Image Segmentation
Source abstract
Abstract
The advanced development of deep learning methods has recently made significant improvements in medical image segmentation. Encoder–decoder networks, such as U-Net, have addressed some of the challenges in medical image segmentation with an outstanding performance, which has promoted them to be the most dominating deep learning architecture in this domain. Despite their outstanding performance, we argue that they still lack some aspects. First, there is incompatibility in U-Net’s skip connection between the encoder and decoder features due to the semantic gap between low-processed encoder features and highly processed decoder features, which adversely affects the final prediction. Second, it lacks capturing multi-scale context information and ignores the contribution of all semantic information through the segmentation process. Therefore, we propose a model named MDA-Unet, a novel multi-scale deep learning segmentation model. MDA-Unet improves upon U-Net and enhances its performance in segmenting medical images with variability in the shape and size of the region of interest. The model is integrated with a multi-scale spatial attention module, where spatial attention maps are derived from a hybrid hierarchical dilated convolution module that captures multi-scale context information. To ease the training process and reduce the gradient vanishing problem, residual blocks are deployed instead of the basic U-net blocks. Through a channel attention mechanism, the high-level decoder features are used to guide the low-level encoder features to promote the selection of meaningful context information, thus ensuring effective fusion. We evaluated our model on 2 different datasets: a lung dataset of 2628 axial CT images and an echocardiographic dataset of 2000 images, each with its own challenges. Our model has achieved a significant gain in performance with a slight increase in the number of trainable parameters in comparison with the basic U-Net model, providing a dice score of 98.3% on the lung dataset and 96.7% on the echocardiographic dataset, where the basic U-Net has achieved 94.2% on the lung dataset and 93.9% on the echocardiographic dataset.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Advanced Neural Network Applications · Radiomics and Machine Learning in Medical Imaging · Medical Image Segmentation Techniques
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
College of Computer Science, Arab Academy for Science and Technology (AAST) University, Smart Village, Cairo B12 577, Egypt
School of Computer Science, College of Science, University of Lincoln, Brayford Pool, Lincoln LN6 7TS, UK
School of Natural and Computing Sciences, Aberdeen University, Old Aberdeen Campus, Aberdeen AB24 3UE, UK
References (47)
Show source-provided references
1. A comparative evaluation of interactive segmentation algorithms10.1016/j.patcog.2009.03.008 ↗
2. Naik, S., Doyle, S., Agner, S., Madabhushi, A., Feldman, M., and Tomaszewski, J. (2008, January 14–17). Automated gland and nuclei segmentation for grading of prostate and breast cancer histopathology. Proceedings of the 2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, Paris, France.10.1109/ISBI.2008.4540988 ↗
3. Benign and malignant breast tumors classification based on region growing and CNN segmentation10.1016/j.eswa.2014.09.020 ↗
4. Zhou, Z., Siddiquee, M.M.R., Tajbakhsh, N., and Liang, J. (2018). Unet++: A nested u-net architecture for medical image segmentation. Deep Learning in Medical Image Analysis and Multimodal Learning for Clinical Decision Support, Springer.10.1007/978-3-030-00889-5_1 ↗
5. Unet++: Redesigning skip connections to exploit multiscale features in image segmentation10.1109/TMI.2019.2959609 ↗
6. Huang, H., Lin, L., Tong, R., Hu, H., Zhang, Q., Iwamoto, Y., Han, X., Chen, Y.W., and Wu, J. (2020, January 4–8). Unet 3+: A full-scale connected unet for medical image segmentation. Proceedings of the ICASSP 2020-2020 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP), Barcelona, Spain.10.1109/ICASSP40776.2020.9053405 ↗
7. Alom, M.Z., Hasan, M., Yakopcic, C., Taha, T.M., and Asari, V.K. (2018). Recurrent Residual Convolutional Neural Network based on U-Net (R2U-Net) for Medical Image Segmentation. arXiv.10.1109/NAECON.2018.8556686 ↗
8. Guo, C., Szemenyei, M., Pei, Y., Yi, Y., and Zhou, W. (2019, January 28–30). SD-UNet: A structured dropout U-Net for retinal vessel segmentation. Proceedings of the 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering (BIBE), Athens, Greece.10.1109/BIBE.2019.00085 ↗
9. ResDUnet: A Deep Learning based Left Ventricle Segmentation Method for Echocardiography10.1109/ACCESS.2021.3122256 ↗
10. Learning cascade attention for fine-grained image classification10.1016/j.neunet.2019.10.009 ↗
11. Hu, J., Shen, L., and Sun, G. (2018, January 18–23). Squeeze-and-Excitation Networks. Proceedings of the 2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition, Salt Lake City, UT, USA.10.1109/CVPR.2018.00745 ↗
12. Ferrari, V., Hebert, M., Sminchisescu, C., and Weiss, Y. (2018). CBAM: Convolutional Block Attention Module. Computer Vision—ECCV 2018, Springer International Publishing.10.1007/978-3-030-01252-6 ↗
13. Park, J., Woo, S., Lee, J.Y., and Kweon, I.S. (2018). BAM: Bottleneck Attention Module. arXiv.
14. Attention gated networks: Learning to leverage salient regions in medical images10.1016/j.media.2019.01.012 ↗
15. Li, H., Xiong, P., An, J., and Wang, L. (2018). Pyramid attention network for semantic segmentation. arXiv.
16. Oktay, O., Schlemper, J., Folgoc, L.L., Lee, M., Heinrich, M., Misawa, K., Mori, K., McDonagh, S., Hammerla, N.Y., and Kainz, B. (2018). Attention u-net: Learning where to look for the pancreas. arXiv.
17. Guo, C., Szemenyei, M., Yi, Y., Wang, W., Chen, B., and Fan, C. (2021, January 10–15). Sa-unet: Spatial attention u-net for retinal vessel segmentation. Proceedings of the 2020 25th International Conference on Pattern Recognition (ICPR), Milan, Italy.10.1109/ICPR48806.2021.9413346 ↗
18. Channel-attention U-Net: Channel attention mechanism for semantic segmentation of esophagus and esophageal cancer10.1109/ACCESS.2020.3007719 ↗
19. Fu, J., Liu, J., Tian, H., Li, Y., Bao, Y., Fang, Z., and Lu, H. (2019, January 15–20). Dual attention network for scene segmentation. Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition, Long Beach, CA, USA.10.1109/CVPR.2019.00326 ↗
20. SCAU-Net: Spatial-Channel Attention U-Net for Gland Segmentation10.3389/fbioe.2020.00670 ↗
21. DA-Capnet: Dual Attention Deep Learning Based on U-Net for Nailfold Capillary Segmentation10.1109/ACCESS.2020.2965651 ↗
22. Dense dilated network with probability regularized walk for vessel detection10.1109/TMI.2019.2950051 ↗
23. Ran, S., Ding, J., Liu, B., Ge, X., and Ma, G. (2021). Multi-U-Net: Residual Module under Multisensory Field and Attention Mechanism Based Optimized U-Net for VHR Image Semantic Segmentation. Sensors, 21.10.3390/s21051794 ↗
24. Deeplab: Semantic image segmentation with deep convolutional nets, atrous convolution, and fully connected crfs10.1109/TPAMI.2017.2699184 ↗
25. Zhao, H., Shi, J., Qi, X., Wang, X., and Jia, J. (2017, January 21–26). Pyramid scene parsing network. Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, Honolulu, HI, USA.10.1109/CVPR.2017.660 ↗
26. Long, J., Shelhamer, E., and Darrell, T. (2015, January 7–12). Fully convolutional networks for semantic segmentation. Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, Boston, MA, USA.10.1109/CVPR.2015.7298965 ↗
27. He, K., Zhang, X., Ren, S., and Sun, J. (July, January 26). Deep residual learning for image recognition. Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, Las Vegas, NV, USA.
28. Yang, M., Yu, K., Zhang, C., Li, Z., and Yang, K. (2018, January 18–23). Denseaspp for semantic segmentation in street scenes. Proceedings of the IEEE conference on computer vision and pattern recognition, Salt Lake City, UT, USA.10.1109/CVPR.2018.00388 ↗
29. Deep residual learning for image steganalysis10.1007/s11042-017-4440-4 ↗
30. Stacked fully convolutional networks with multi-channel learning: Application to medical image segmentation10.1007/s00371-017-1379-4 ↗
31. Tumor attention networks: Better feature selection, better tumor segmentation10.1016/j.neunet.2021.03.006 ↗
32. Wang, P., Chen, P., Yuan, Y., Liu, D., Huang, Z., Hou, X., and Cottrell, G. (2018, January 12–15). Understanding convolution for semantic segmentation. Proceedings of the 2018 IEEE winter conference on applications of computer vision (WACV), Lake Tahoe, NV, USA.10.1109/WACV.2018.00163 ↗
33. Amer, A., Ye, X., and Janan, F. (2021, January 11–17). Residual Dilated U-Net for the Segmentation of COVID-19 Infection From CT Images. Proceedings of the IEEE/CVF International Conference on Computer Vision, Montreal, BC, Canada.10.1109/ICCVW54120.2021.00056 ↗
34. Amer, A., Ye, X., Zolgharni, M., and Janan, F. (2020, January 20–24). ResDUnet: Residual dilated UNet for left ventricle segmentation from echocardiographic images. Proceedings of the 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Montreal, QC, Canada.10.1109/EMBC44109.2020.9175436 ↗
35. Yu, F., Koltun, V., and Funkhouser, T. (2017, January 21–26). Dilated residual networks. Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, Honolulu, HI, USA.10.1109/CVPR.2017.75 ↗
36. Chen, L.C., Papandreou, G., Schroff, F., and Adam, H. (2017). Rethinking atrous convolution for semantic image segmentation. arXiv.
37. Yu, F., and Koltun, V. (2015). Multi-scale context aggregation by dilated convolutions. arXiv.
38. Mehta, S., Mercan, E., Bartlett, J., Weaver, D., Elmore, J., and Shapiro, L. (2018, January 12–15). Learning to segment breast biopsy whole slide images. Proceedings of the 2018 IEEE Winter Conference on Applications of Computer Vision (WACV), Lake Tahoe, NV, USA.10.1109/WACV.2018.00078 ↗
39. Mehta, S., Rastegari, M., Caspi, A., Shapiro, L., and Hajishirzi, H. (2018, January 8–14). Espnet: Efficient spatial pyramid of dilated convolutions for semantic segmentation. Proceedings of the European Conference on Computer Vision (ECCV), Munich, Germany.10.1007/978-3-030-01249-6_34 ↗
40. Tong, X., Wei, J., Sun, B., Su, S., Zuo, Z., and Wu, P. (2021). ASCU-Net: Attention Gate, Spatial and Channel Attention U-Net for Skin Lesion Segmentation. Diagnostics, 11.10.3390/diagnostics11030501 ↗
41. Deep learning for segmentation using an open large-scale dataset in 2D echocardiography10.1109/TMI.2019.2900516 ↗
42. (2021, October 26). COVID-19—Medical Segmentation. Available online: http://medicalsegmentation.com/covid19/.
43. Dropout: A simple way to prevent neural networks from overfitting
44. Measures of the amount of ecologic association between species10.2307/1932409 ↗
45. The distribution of the flora in the alpine zone10.1111/j.1469-8137.1912.tb05611.x ↗
46. Pastor-Pellicer, J., Zamora-Martínez, F., España-Boquera, S., and Castro-Bleda, M.J. (2013, January 12–14). F-measure as the error function to train neural networks. Proceedings of the International Work-Conference on Artificial Neural Networks, Tenerife, Spain.10.1007/978-3-642-38679-4_37 ↗
47. Ronneberger, O., Fischer, P., and Brox, T. (2015, January 5–9). U-net: Convolutional networks for biomedical image segmentation. Proceedings of the International Conference on Medical Image Computing and Computer-Assisted Intervention, Munich, Germany.10.1007/978-3-319-24574-4_28 ↗