PFAS: A Review of the State of the Art, from Legislation to Analytical Approaches and Toxicological Aspects for Assessing Contamination in Food and Environment and Related Risks
Source abstract
Abstract
More than 7000 synthetic compounds known as per- and poly-fluoroalkyl substances (PFAS) are applied to food packaging and other materials to provide fat, fire, and/or water resistance properties. These compounds have exceptional environmental stability and persistence due to the strong C-F chemical bond, earning them the moniker “forever chemicals”. Emission of PFAS from industrial waste leads to water, air, and soil contamination. Due to this ubiquitous nature, combined with the fact that PFAS in humans are known to have carcinogenic and reprotoxic effects and to cause vaccine resistance and depression of the immunity system, PFAS may constitute a major threat to human health. For this reason, the attention of the scientific community and of control bodies is increasing and as a consequence legislation and the scientific literature on PFAS are constantly evolving. This review aims to provide a comprehensive overview of the state of the art about current legislation addressing PFAS; targeted and screening method for identification, detection and quantification of PFAS; toxicity of PFAS; and contamination of environmental and food matrices and from food contact matrices. A comprehensive review of the latest scientific research and recent developments in the legislation of PFAS will provide insights into the current understanding of PFAS and its health implications. Moreover, it will serve as a valuable reference for further studies related to PFAS and could help in informing future policy decisions.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Per- and polyfluoroalkyl substances research · Effects and risks of endocrine disrupting chemicals · Toxic Organic Pollutants Impact
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
National Institute of Metrological Research (INRIM), Strada delle Cacce 91, 10135 Torino, Italy
Politecnico di Torino, Corso Castelfilardo 39, 10129 Torino, Italy
Funding
EURAMET EMPIR programme · Participating States · European Union’s Horizon 2020 research and innovation programme
References (100+)
Show source-provided references
1. (2023, May 12). Available online: https://echa.europa.eu/it/hot-topics/perfluoroalkyl-chemicals-pfas.
2. (2023, May 12). Available online: https://www.niehs.nih.gov/health/topics/agents/pfc/index.cfm.
3. Perfluoroalkyl and polyfluoroalkyl substances in the environment: Terminology, classification, and origins10.1002/ieam.258 ↗
4. Per- and polyfluoroalkyl substance (PFAS) exposure assessment in a community exposed to contaminated drinking water, New Hampshire, 201510.1016/j.ijheh.2018.02.007 ↗
5. The occurrence of perfluoroalkyl substances (PFAS) in drinking water in the Czech Republic: A pilot study10.1007/s11356-022-20156-7 ↗
6. Perfluoroalkyl contaminants in eggs from backyard chickens reared in Italy10.1016/j.foodchem.2021.130178 ↗
7. (2023, May 12). Available online: https://trends.google.com/trends/explore?date=all&q=PFAS.
8. (2023, May 12). Available online: https://www.webofscience.com/wos/woscc/basic-search.
9. Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research10.1002/etc.4890 ↗
10. Maternal exposure to perfluorinated chemicals and reduced fecundity: The MIREC study10.1093/humrep/deu350 ↗
11. Maternal levels of perfluorinated chemicals and subfecundity10.1093/humrep/den490 ↗
12. Perfluorinated compounds and subfecundity in pregnant women10.1097/EDE.0b013e31823b5031 ↗
13. Association between perfluorinated compounds and time to pregnancy in a prospective cohort of Danish couples attempting to conceive10.1093/humrep/der450 ↗
14. Persistent environmental pollutants and couple fecundity: The LIFE study10.1289/ehp.1205301 ↗
15. Estimated exposures to perfluorinated compounds in infancy predict attenuated vaccine antibody concentrations at age 5-years10.1080/1547691X.2017.1360968 ↗
16. Transdermal absorption of 13C4-perfluorooctanoic acid (13C4-PFOA) from a sunscreen in a male volunteer—What could be the contribution of cosmetics to the internal exposure of perfluoroalkyl substances (PFAS)?10.1016/j.envint.2022.107549 ↗
17. Changes in perfluoroalkyl substances (PFAS) concentrations in human milk over the course of lactation: A study in Ronneby mother-child cohort10.1016/j.envres.2022.115096 ↗
18. (2023, May 12). Available online: https://www.epa.gov/sdwa/and-polyfluoroalkyl-substances-pfas#:~:text=EPA%20is%20developing%20a%20proposed,by%20the%20end%20of%202023.
19. (2023, May 12). Available online: https://www.fda.gov/food/environmental-contaminants-food/and-polyfluoroalkyl-substances-pfas.
20. Risk to human health related to the presence of perfluoroalkyl substances in food
21. Jahnke, A., and Marchand, P. (2022). Guidance Document on Analytical Parameters for the Determination of Per- and Polyfluoroalkyl Substances (PFAS) in Food and Feed, EURL POPs.
22. (2023, May 25). Available online: https://eur-lex.europa.eu/legal-content/EN/TXT/PDF/?uri=CELEX:32020L2184&from=EN.
23. (2023, May 25). Available online: https://www.epa.gov/sdwa/and-polyfluoroalkyl-substances-pfas.
24. National Health and Medical Research Council (Australia), and Natural Resource Management Ministerial Council (Australia) (2022). Australian Drinking Water Guidelines Version 3.8.
25. (2023, May 25). Available online: https://www.canada.ca/en/health-canada/services/environmental-workplace-health/reports-publications/water-quality/water-talk-per-polyfluoroalkyl-substances-drinking-water.html.
26. Contamination of per- and polyfluoroalkyl substances in the water source from a typical agricultural area in North China10.3389/fenvs.2022.1071134 ↗
27. (2023, May 25). Available online: https://eur-lex.europa.eu/eli/reg/2022/2388/oj.
28. (2023, May 12). Available online: https://eur-lex.europa.eu/legal-content/EN/ALL/?uri=celex:32004R0850.
29. (2023, May 12). Available online: https://eur-lex.europa.eu/legal-content/en/TXT/?uri=CELEX%3A32019R1021.
30. Opinion of the Scientific Panel on Contaminants in the Food chain on Perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA) and their salts
31. Risk to human health related to the presence of perfluorooctane sulfonic acid and perfluorooctanoic acid in food
32. (2023, May 12). Available online: https://echa.europa.eu/it/registry-of-restriction-intentions/-/dislist/details/0b0236e1827f87da.
33. (2023, May 12). Available online: https://echa.europa.eu/documents/10162/fdaed5b0-b6e4-9a21-b45d-ca607c05f845.
34. (2023, May 12). Available online: https://echa.europa.eu/-/proposal-to-ban-forever-chemicals-in-firefighting-foams-throughout-the-eu.
35. (2023, May 12). Available online: https://echa.europa.eu/documents/10162/4524f49c-ae14-b01b-71d2-ac3fa916c4e9.
36. (2023, May 12). Available online: https://echa.europa.eu/-/echa-adds-nine-hazardous-chemicals-to-candidate-list.
37. (2023, May 12). Available online: https://echa.europa.eu/-/echa-receives-pfass-restriction-proposal-from-five-national-authorities.
38. (2023, May 12). Available online: https://www.ncsl.org/environment-and-natural-resources/per-and-polyfluoroalkyl-substances.
39. (2023, May 12). Available online: https://www.epa.gov/pfas/pfas-strategic-roadmap-epas-commitments-action-2021-2024.
40. (2023, May 12). Available online: https://www.stantec.com/en/ideas/topic/covid-19/pfas-in-canadian-provinces-where-are-the-regulations#:~:text=federal%20government%20doing%3F-,On%20a%20federal%20level%2C%20Canada%20took%20steps%20to%20deal%20with,environment%20or%20its%20biological%20diversity.
41. Brazilian overview of per- and polyfluoroalkyl substances listed as persistent organic pollutants in the stockholm convention10.1016/j.chemosphere.2021.132674 ↗
42. Ministry of the Environment (2015). National Implementation Plan Brazil: Convention Stockholm/Ministry of the Environment.
43. (2023, May 12). Available online: https://enviliance.com/regions/others/asia-pfoa.
44. (2023, May 12). Available online: https://www.tcsb.gov.tw/fp-288-5776-06543-2.html.
45. Risks posed by per- and polyfluoroalkyl substances (PFAS) on the African continent, emphasizing aquatic ecosystems10.1002/ieam.4404 ↗
46. Environmental levels and human body burdens of per- and poly-fluoroalkyl substances in Africa: A critical review10.1016/j.scitotenv.2020.139913 ↗
47. Newman, M. (2015). Fundamentals of Ecotoxicology: The Science of Pollution, CRC Press. [4th ed.].
48. Claassen, M., Dabrowski, J.M., Nepfumbada, T., van der Laan, M., Shadung, J., and Thwala, M. (2020). Incorporating Environmental Fate Models into Risk Assessment for Pesticide Registration in South Africa, Water Research Commission.
49. (2023, May 12). Available online: https://federation.gov.au/about/agreements/intergovernmental-agreement-national-framework-responding-pfas-contamination.
50. Developmental Toxicity of Perfluorooctanesulfonate (PFOS) and Its Chlorinated Polyfluoroalkyl Ether Sulfonate Alternative F-53B in the Domestic Chicken10.1021/acs.est.8b04749 ↗
51. The Subacute Toxicity of Perfluorooctane Sulfonate and/or Perfluorooctanoic Acid and Legacy Aqueous Film-Forming Foams to Japanese Quail (Coturnix japonica) Chicks10.1002/etc.4684 ↗
52. Lethal and sublethal toxicity of perfluorooctanoic acid (PFOA) in chronic tests with Hyalella azteca (amphipod) and early-life stage tests with Pimephales promelas (Fathead minnow)10.1016/j.ecoenv.2020.111250 ↗
53. Evaluating the sub-lethal toxicity of PFOS and PFOA using rotifer Brachionus calyciflorus10.1016/j.envpol.2013.04.031 ↗
54. Developmental toxicity and alteration of gene expression in zebrafish embryos exposed to PFOS10.1016/j.taap.2008.01.043 ↗
55. Comparing the Ecotoxicological Effects of Perfluorooctanoic Acid (PFOA) and Perfluorohexanoic Acid (PFHxA) on Freshwater Microbial Community10.3389/fenvs.2022.888171 ↗
56. Bioaccumulation and trophic transfer of perfluorinated alkyl substances (PFAS) in marine biota from the Belgian North Sea: Distribution and human health risk implications10.1016/j.envpol.2022.119907 ↗
57. United Nations Industrial Development Organization (UNIDO) (2009). Preparing for HCFC Phase-Out: Fundamentals of Uses, Alternatives, Implications and Funding for Article 5 Countries, UNIDO.
58. Comprehensive Exposure Studies of Per- and Polyfluoroalkyl Substances in the General Population: Target, Nontarget Screening, and Toxicity Prediction10.1021/acs.est.2c03345 ↗
59. Dietary predictors of prenatal per- and poly-fluoroalkyl substances exposure10.1038/s41370-021-00386-6 ↗
60. Occurrence of per- and polyfluoroalkyl substances (PFASs) in raw milk and feed from nine Chinese provinces and human exposure risk assessment10.1016/j.chemosphere.2022.134521 ↗
61. Integration of Toxicogenomics and Physiologically Based Pharmacokinetic Modeling in Human Health Risk Assessment of Perfluorooctane Sulfonate10.1021/acs.est.1c06479 ↗
62. Investigating the cytotoxicity of per- and polyfluoroalkyl substances in HepG2 cells: A structure-activity relationship approach10.1016/j.tox.2022.153312 ↗
63. Comparative cytotoxicity of seven per- and polyfluoroalkyl substances (PFAS) in six human cell lines10.1016/j.tox.2022.153281 ↗
64. Perfluoroalkyl substance mixtures and cardio-metabolic outcomes in highly exposed male workers in the Veneto Region: A mixture-based approach10.1016/j.envres.2022.113225 ↗
65. Association between serum per- and polyfluoroalkyl substances and thrombograms in young and middle-aged Taiwanese populations10.1016/j.ecoenv.2022.113457 ↗
66. (2023, May 25). Available online: https://www.canada.ca/en/health-canada/services/environmental-workplace-health/reports-publications/environmental-contaminants/human-biomonitoring-resources/per-polyfluoroalkyl-substances-canadians.html.
67. Per- and polyfluoroalkyl substances in source and treated drinking waters of the United States10.1016/j.scitotenv.2018.10.245 ↗
68. Occurrence of quantifiable and semi-quantifiable poly- and perfluoroalkyl substances in united states wastewater treatment plants10.1016/j.watres.2023.119724 ↗
69. Perfluoroalkyl substances in water, sediment, and fish from a subtropical river of China: Environmental behaviors and potential risk10.1016/j.chemosphere.2021.132513 ↗
70. Evaluation of the current contamination status of PFASs and OPFRs in South Korean tap water associated with its origin10.1016/j.scitotenv.2018.04.068 ↗
71. Emerging and legacy per-and polyfluoroalkyl substances in the rivers of a typical industrialized province of China: Spatiotemporal variations, mass discharges and ecological risks
72. Perfluoroalkyl Substances (PFASs) in the Canadian Freshwater Environment10.1007/s00244-022-00922-x ↗
73. Screening for 32 per- and polyfluoroalkyl substances (PFAS) including GenX in sludges from 43 WWTPs located in the Czech Republic—Evaluation of potential accumulation in vegetables after application of biosolids10.1016/j.chemosphere.2020.128018 ↗
74. Fluorine Mass Balance Analysis of Effluent and Sludge from Nordic Countries10.1021/acsestwater.1c00168 ↗
75. Per- and polyfluoroalkyl substances (PFAS) in sludge from wastewater treatment plants in Sweden—First findings of novel fluorinated copolymers in Europe including temporal analysis10.1016/j.scitotenv.2022.157406 ↗
76. Occurrence and fate of poly- and perfluoroalkyl substances (PFAS) in urban waters of New Zealand10.1016/j.jhazmat.2022.128257 ↗
77. Mussabek, D., Söderman, A., Imura, T., Persson, K.M., Nakagawa, K., Ahrens, L., and Berndtsson, R. (2023). PFAS in the Drinking Water Source: Analysis of the Contamination Levels, Origin and Emission Rates. Water, 15.10.3390/w15010137 ↗
78. Perfluoroalkyl and Polyfluoroalkyl Substances in Groundwater Used as a Source of Drinking Water in the Eastern United States10.1021/acs.est.1c04795 ↗
79. (2023, May 12). Available online: https://www3.epa.gov/carbon-footprint-calculator/tool/definitions/crude-oil.html#:~:text=Crude%20oil%20means%20a%20mixture,passing%20through%20surface%20separating%20facilities.
80. Non-target discovery of emerging PFAS homologues in Dagang Oilfield: Multimedia distribution and profiles in crude oil10.1016/j.jhazmat.2022.129300 ↗
81. Target and suspect screening of 4777 per- and polyfluoroalkyl substances (PFAS) in river water, wastewater, groundwater and biota samples in the Danube River Basin10.1016/j.jhazmat.2022.129276 ↗
82. Target determination and suspect screening of legacy and emerging per- and poly-fluoro poly-ethers in wild boar liver, in Italy10.1016/j.chemosphere.2022.137214 ↗
83. Presence of organic halogenated compounds, organophosphorus insecticides and polycyclic aromatic hydrocarbons in meat of different game animal species from an Italian subalpine area10.1080/19440049.2019.1627003 ↗
84. Comprehensive target analysis and TOP assay of per- and polyfluoroalkyl substances (PFAS) in wild boar livers indicate contamination hot-spots in the environment10.1016/j.scitotenv.2023.162028 ↗
85. Serum levels of perfluoroalkyl substances (PFAS) in adolescents and young adults exposed to contaminated drinking water in the Veneto region, Italy: A cross-sectional study based on a health surveillance program10.1289/EHP5337 ↗
86. Serum concentration trends and apparent half-lives of per- and polyfluoroalkyl substances (PFAS) in Australian firefighters10.1016/j.ijheh.2022.114040 ↗
87. Measurement of novel, drinking water-associated pfas in blood from adults and children in Wilmington, North Carolina10.1289/EHP6837 ↗
88. Per and polyfluoroalkyl substances (PFAS) blood levels after contamination of a community water supply and comparison with 2013–2014 NHANES10.1038/s41370-018-0096-z ↗
89. Analysis of per- and poly-fluoroalkyl substances (PFAS) in processed foods from FDA’s Total Diet Study10.1007/s00216-021-03610-2 ↗
90. Perfluoroalkyl substances (PFAS) in river and ground/drinking water of the Ganges River basin: Emissions and implications for human exposure10.1016/j.envpol.2015.10.050 ↗
91. Reade, A., Quinn, T., and Schreiber, J.S. (2019). PFAS in Drinking Water 2019: Scientific and Policy Assessment for Addressing Per- and Polyfluoroalkyl Substances (PFAS) in Drinking Water, Natural Resources Defense Council.
92. Major perfluoroalkyl acid (PFAA) concentrations and influence of food consumption among the general population of Daegu, Korea10.1016/j.scitotenv.2012.08.007 ↗
93. Per- and polyfluoroalkyl substances (PFASs) in Chinese drinking water: Risk assessment and geographical distribution10.1186/s12302-020-00425-3 ↗
94. Human exposure to perfluorinated compounds in Catalonia, Spain: Contribution of drinking water and fish and shellfish10.1021/jf300355c ↗
95. Occurrence of perfluoroalkyl substances (PFAS) in garden produce at homes with a history of PFAS-contaminated drinking water10.1016/j.chemosphere.2017.12.179 ↗
96. PFAS in drinking water and serum of the people of a southeast Alaska community: A pilot study10.1016/j.envpol.2022.119246 ↗
97. Invited Perspective: Current Breast Milk PFAS Levels in the United States and Canada Indicate Need for Additional Monitoring and Actions to Reduce Maternal Exposures
98. Occurrences of legacy and emerging per- and polyfluoroalkyl substances in human milk in China: Results of the third National Human Milk Survey (2017–2020)10.1016/j.jhazmat.2022.130163 ↗
99. PFAS levels in fish species in the Po River (Italy): New generation PFAS, fish ecological traits and parasitism in the foreground10.1016/j.scitotenv.2023.162828 ↗
100. Locally caught freshwater fish across the United States are likely a significant source of exposure to PFOS and other perfluorinated compounds10.1016/j.envres.2022.115165 ↗