journal article·2022-07-15Open access

Residual-Attention UNet++: A Nested Residual-Attention U-Net for Medical Image Segmentation

Zan Li, Hong Zhang, Zhengzhen Li, Zuyue Ren

Applied Sciences· Volume 12· Issue 14

Abstract

Image segmentation is a basic technology in the field of image processing and computer vision. Medical image segmentation is an important application field of image segmentation and plays an increasingly important role in clinical diagnosis and treatment. Deep learning has made great progress in medical image segmentation. In this paper, we proposed Residual-Attention UNet++, which is an extension of the UNet++ model with a residual unit and attention mechanism. Firstly, the residual unit improves the degradation problem. Secondly, the attention mechanism can increase the weight of the target area and suppress the background area irrelevant to the segmentation task. Three medical image datasets such as skin cancer, cell nuclei, and coronary artery in angiography were used to validate the proposed model. The results showed that the Residual-Attention UNet++ achieved superior evaluation scores with an Intersection over Union (IoU) of 82.32%, and a dice coefficient of 88.59% with the skin cancer dataset, a dice coefficient of 85.91%, and an IoU of 87.74% with the cell nuclei dataset and a dice coefficient of 72.48%, and an IoU of 66.57% with the angiography dataset.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Advanced Neural Network Applications · Radiomics and Machine Learning in Medical Imaging · AI in cancer detection

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Computer Science and Technology, Minzu University of China, Beijing 100081, China

References (37)

Show source-provided references
1. A Control Engineer’s Guide to Sliding Mode Control10.1109/87.761053 ↗
2. GrabCut: Interactive foreground extraction using iterated graph cut10.1145/1015706.1015720 ↗
3. Region Extraction by Averaging and Thresholding10.1109/TSMC.1975.5408419 ↗
4. Senthilkumaran, N., and Rajesh, R. (2009, January 27–28). Edge Detection Techniques for Image Segmentation—A Survey of Soft Computing Approaches. Proceedings of the 2009 International Conference on Advances in Recent Technologies in Communication and Computing, Kottayam, India.10.1109/ARTCom.2009.219 ↗
5. Structured Learning and Prediction in Computer Vision10.1561/0600000033 ↗
6. Adaptive fuzzy-K-means clustering algorithm for image segmentation10.1109/TCE.2010.5681154 ↗
7. A thresholding selection method from gray level histogram
8. Alom, M.Z., Hasan, M., Yakopcic, C., Taha, T.M., and Asari, V.K. (2018). Recurrent Residual Convolutional Neural Network based on U-Net (R2U-Net) for Medical Image Segmentation. arXiv.10.1109/NAECON.2018.8556686 ↗
9. Xi, H., Chen, J., Chen, L., Liang, H., and Wang, Q. (2020, January 24–25). Pyramid Residual Convolutional Neural Network based on an end-to-end model. Proceedings of the 2020 13th International Conference on Intelligent Computation Technology and Automation (ICICTA), Xi’an, China.10.1109/ICICTA51737.2020.00040 ↗
10. Long, J., Shelhamer, E., and Darrell, T. (2015, January 7–12). Fully Convolutional Networks for Semantic Segmentation. Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, Boston, MA, USA.10.1109/CVPR.2015.7298965 ↗
11. Song, W., Zhong, B., and Sun, X. (2019). Building Corner Detection in Aerial Images with Fully Convolutional Networks. Sensors, 19.10.3390/s19081915 ↗
12. Chen, L.C., Papandreou, G., Kokkinos, I., Murphy, K., and Yuille, A.L. (2014). Semantic Image Segmentation with Deep Convolutional Nets and Fully Connected CRFs. Comput. Sci., 357–361.
13. Efficient Inference in Fully Connected CRFs with Gaussian Edge Potentials
14. DeepLab: Semantic Image Segmentation with Deep Convolutional Nets, Atrous Convolution, and Fully Connected CRFs10.1109/TPAMI.2017.2699184 ↗
15. Liu, X., Song, L., Liu, S., and Zhang, Y. (2021). A Review of Deep-Learning-Based Medical Image Segmentation Methods. Sustainability, 13.10.3390/su13031224 ↗
16. Chen, L.C., Papandreou, G., Schroff, F., and Adam, H. (2017). Rethinking Atrous Convolution for Semantic Image Segmentation. arXiv.
17. Chen, L.C., Zhu, Y., Papandreou, G., Schroff, F., and Adam, H. (2018, January 8–14). Encoder-Decoder with Atrous Separable Convolution for Semantic Image Segmentation. Proceedings of the European Conference on Computer Vision (ECCV), Munich, Germany.10.1007/978-3-030-01234-2_49 ↗
18. SegNet: A Deep Convolutional Encoder-Decoder Architecture for Image Segmentation10.1109/TPAMI.2016.2644615 ↗
19. Ronneberger, O., Fischer, P., and Brox, T. (2015, January 5–9). U-Net: Convolutional Networks for Biomedical Image Segmentation. Proceedings of the International Conference on Medical Image Computing and Computer-Assisted Intervention, Munich, Germany.10.1007/978-3-319-24574-4_28 ↗
20. Özgün, Ç., Abdulkadir, A., Lienkamp, S.S., Brox, T., and Ronneberger, O. (2016, January 17–21). 3D U-Net: Learning Dense Volumetric Segmentation from Sparse Annotation. Proceedings of the International Conference on Medical Image Computing and Computer-Assisted Intervention, Athens, Greece.
21. Milletari, F., Navab, N., and Ahmadi, S.A. (2016, January 25–28). V-Net: Fully Convolutional Neural Networks for Volumetric Medical Image Segmentation. Proceedings of the 2016 Fourth International Conference on 3D Vision (3DV), Stanford, CA, USA.10.1109/3DV.2016.79 ↗
22. He, K., Zhang, X., Ren, S., and Sun, J. (2015, January 7–13). Delving Deep into Rectifiers: Surpassing Human-Level Performance on ImageNet Classification. Proceedings of the IEEE International Conference on Computer Vision, Santiago, Chile.10.1109/ICCV.2015.123 ↗
23. H-DenseUNet: Hybrid Densely Connected UNet for Liver and Tumor Segmentation From CT Volumes10.1109/TMI.2018.2845918 ↗
24. Oktay, O., Schlemper, J., Folgoc, L.L., Lee, M., Heinrich, M., Misawa, K., Mori, K., Mcdonagh, S., Hammerla, N.Y., and Kainz, B. (2018). Attention U-Net: Learning Where to Look for the Pancreas. arXiv.
25. Medical image segmentation model based on triple gate MultiLayer perceptron
26. Zhou, Z., Siddiquee, M., Tajbakhsh, N., and Liang, J. (2018). UNet++: A Nested U-Net Architecture for Medical Image Segmentation. Deep Learning in Medical Image Analysis and Multimodal Learning for Clinical Decision Support, Springer.10.1007/978-3-030-00889-5_1 ↗
27. He, K., Zhang, X., Ren, S., and Sun, J. (2016, January 27–30). Deep Residual Learning for Image Recognition. Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, Las Vegas, NV, USA.10.1109/CVPR.2016.90 ↗
28. Dropout: A Simple Way to Prevent Neural Networks from Overfitting
29. Zagoruyko, S., and Komodakis, N. (2016). Wide Residual Networks. arXiv.10.5244/C.30.87 ↗
30. Wang, X., Girshick, R., Gupta, A., and He, K. (2018, January 18–23). Non-local Neural Networks. Proceedings of the IEEE Conference on Computer vision and Pattern Recognition, Salt Lake City, UT, USA.10.1109/CVPR.2018.00813 ↗
31. ANU-Net: Attention-based Nested U-Net to exploit full resolution features for medical image segmentation10.1016/j.cag.2020.05.003 ↗
32. Lee, C.Y., Xie, S., Gallagher, P., Zhang, Z., and Tu, Z. (2015, January 9–12). Deeply-Supervised Nets. Proceedings of the Artificial Intelligence and Statistics, San Diego, CA, USA.
33. UNet++: Redesigning Skip Connections to Exploit Multiscale Features in Image Segmentation10.1109/TMI.2019.2959609 ↗
34. (2021, July 11). ISIC 2017 Challenge. Available online: https://challenge2017.isic-archive.com.
35. (2021, June 14). Data Science Bowl 2018. Available online: https://www.kaggle.com/c/data-science-bowl-2018.
36. Cervantes-Sanchez, F., Cruz-Aceves, I., Hernandez-Aguirre, A., Hernandez-Gonzalez, M.A., and Solorio-Meza, S.E. (2019). Automatic Segmentation of Coronary Arteries in X-ray Angiograms using Multiscale Analysis and Artificial Neural Networks. Appl. Sci., 9.10.3390/app9245507 ↗
37. Measures of the Amount of Ecologic Association Between Species10.2307/1932409 ↗