Adhesive Catechol-Conjugated Hyaluronic Acid for Biomedical Applications: A Mini Review
Source abstract
Abstract
Recently, catechol-containing polymers have been extensively developed as promising materials for surgical tissue adhesives, wound dressing, drug delivery depots, and tissue engineering scaffolds. Catechol conjugation to the polymer backbone provides adhesive properties to the tissue and does not significantly affect the intrinsic properties of the polymers. An example of a catecholic polymer is catechol-conjugated hyaluronic acid. In general, hyaluronic acid shows excellent biocompatibility and biodegradability; thus, it is used in various medical applications. However, hyaluronic acid alone has poor mechanical and tissue adhesion properties. Catechol modification considerably increases the mechanical and underwater adhesive properties of hyaluronic acid, while maintaining its biocompatibility and biodegradability and enabling its use in several biomedical applications. In this review, we briefly describe the synthesis and characteristics of catechol-modified hyaluronic acid, with a specific focus on catechol-involving reactions. Finally, we discuss the basic concepts and therapeutic effects of catechol-conjugated hyaluronic acid for biomedical applications.
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Research context
OpenAlex topics: Polymer Surface Interaction Studies · Electrospun Nanofibers in Biomedical Applications · Hydrogels: synthesis, properties, applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Carbon Composite Materials Research Center, Institute of Advanced Composite Materials, Korea Institute of Science and Technology (KIST), Wanju, Jeonbuk 55324, Korea
Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 03722, Korea
Department of Carbon Convergence Engineering, Wonkwang University, Iksan, Jeonbuk 54538, Korea
Funding
Wonkwang University
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