Application of Polymeric Nanocarriers for Enhancing the Bioavailability of Antibiotics at the Target Site and Overcoming Antimicrobial Resistance
Source abstract
Abstract
Antimicrobial resistance is one of the greatest threats to global health. Although the efforts in antibiotic drug discovery continue to play a pivotal role, this solution alone probably will not be enough to ensure the required level of infection control in the future. New strategies and innovative modes of action are desperately needed to preserve the effectiveness of antimicrobials. Accordingly, antibiotic delivery based on polymeric nanoparticles is one of the possible methods that has been recently explored to improve their pharmacokinetic profile. Through optimized access of antibiotics to their sites of action, nanocarriers can unlock the full potential of the antibiotic cargoes, extend the antimicrobial spectrum, and reduce the required dose of antibiotic while preserving efficacy. Additionally, the use of an antibiotic-loaded nanocarrier is also considered a steady solution as novel molecules can be continuously developed and incorporated into the delivery platform. This review describes the present state of polymeric nanocarriers in enhancing antibiotic treatment, including improved pharmacokinetic properties and restored antibiotic efficacy against drug-resistant bacteria. Additionally, the current challenges and the future direction of this field are discussed.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Advanced Drug Delivery Systems · Nanoplatforms for cancer theranostics · Antimicrobial agents and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Laboratory Polymers, Biopolymers & Surfaces, Normandie Université, UNIROUEN, INSA Rouen, CNRS, PBS, 76000 Rouen, France
Funding
Ministère de l’Enseignement Supérieur, de la Recherche et de l’Innovation
References (100+)
Show source-provided references
1. Towards the sustainable discovery and development of new antibiotics10.1038/s41570-021-00313-1 ↗
2. Mastering the Gram-negative bacterial barrier—Chemical approaches to increase bacterial bioavailability of antibiotics10.1016/j.addr.2021.02.014 ↗
3. Nanoparticle-based local antimicrobial drug delivery10.1016/j.addr.2017.09.015 ↗
4. Polymeric nano- and microparticulate drug delivery systems for treatment of biofilms10.1016/j.addr.2021.04.005 ↗
5. Nanocarriers for antibiotics: A promising solution to treat intracellular bacterial infections10.1016/j.ijantimicag.2014.02.009 ↗
6. Molecular mechanisms of antibiotic resistance10.1038/nrmicro3380 ↗
7. On the rapidity of antibiotic resistance evolution facilitated by a concentration gradient10.1073/pnas.1117716109 ↗
8. Nanomaterial-based therapeutics for antibiotic-resistant bacterial infections10.1038/s41579-020-0420-1 ↗
9. Nanotechnology approaches for global infectious diseases10.1038/s41565-021-00866-8 ↗
10. Delivery of antibiotics with polymeric particles10.1016/j.addr.2014.02.002 ↗
11. Antibiotic-Free Antibacterial Strategies Enabled by Nanomaterials: Progress and Perspectives10.1002/adma.201904106 ↗
12. The Biopharmaceutics Classification System: Subclasses for in vivo predictive dissolution (IPD) methodology and IVIVC10.1016/j.ejps.2014.01.009 ↗
13. Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice10.1021/jm301721e ↗
14. Nanosized Dendritic Polyguanidilyated Translocators for Enhanced Solubility, Permeability, and Delivery of Gatifloxacin10.1167/iovs.10-5388 ↗
15. Triclosan-based supramolecular hydrogels as nanoantibiotics for enhanced antibacterial activity10.1016/j.jconrel.2020.05.034 ↗
16. Antibacterial Activity of Ciprofloxacin-Loaded Poly(lactic-co-glycolic acid)-Nanoparticles Against Staphylococcus aureus10.1002/ppsc.202000253 ↗
17. Chloramphenicol encapsulated in poly-ε-caprolactone-pluronic composite: Nanoparticles for treatment of MRSA-infected burn wounds
18. Characterization and application of roxithromycin loaded cyclodextrin based nanoparticles for treatment of multidrug resistant bacteria10.1016/j.msec.2015.11.076 ↗
19. pH-activated nanoparticles for controlled topical delivery of farnesol to disrupt oral biofilm virulence10.1021/nn507170s ↗
20. Cross-Linked Polymer-Stabilized Nanocomposites for the Treatment of Bacterial Biofilms10.1021/acsnano.6b07537 ↗
21. Antibacterial effects of curcumin encapsulated in nanoparticles on clinical isolates of Pseudomonas aeruginosa through downregulation of efflux pumps10.1007/s11033-019-04700-2 ↗
22. The value of antimicrobial peptides in the age of resistance10.1016/S1473-3099(20)30327-3 ↗
23. Formulation technologies and advances for oral delivery of novel nitroimidazoles and antimicrobial peptides10.1016/j.jconrel.2020.05.002 ↗
24. Improved oral therapeutic potential of nanoencapsulated cryptdin formulation against Salmonella infection10.1016/j.ejps.2015.02.014 ↗
25. Antibiotic Cross-linked Micelles with Reduced Toxicity for Multidrug-Resistant Bacterial Sepsis Treatment10.1021/acsami.0c21459 ↗
26. Jani, S., Ramirez, M.S., and Tolmasky, M.E. (2021). Silencing Antibiotic Resistance with Antisense Oligonucleotides. Biomedicines, 9.10.20944/preprints202103.0050.v1 ↗
27. Solid lipid nanoparticles for the delivery of anti-microbial oligonucleotides10.1016/j.ejpb.2018.11.017 ↗
28. Using CRISPR-Cas systems as antimicrobials10.1016/j.mib.2017.08.005 ↗
29. RNAi for silencing drug resistance in microbes toward development of nanoantibiotics10.1016/j.jconrel.2014.06.054 ↗
30. Perche, F., le Gall, T., Montier, T., Pichon, C., and Malinge, J.-M. (2019). Cardiolipin-Based Lipopolyplex Platform for the Delivery of Diverse Nucleic Acids into Gram-Negative Bacteria. Pharmaceuticals, 12.10.3390/ph12020081 ↗
31. In vivo studies of polyacrylate nanoparticle emulsions for topical and systemic applications10.1016/j.nano.2008.07.004 ↗
32. Imipenem/cilastatin encapsulated polymeric nanoparticles for destroying carbapenem-resistant bacterial isolates10.1186/s12951-017-0262-9 ↗
33. Antibody-Conjugated Nanocarriers for Targeted Antibiotic Delivery: Application in the Treatment of Bacterial Biofilms10.1021/acs.biomac.1c00082 ↗
34. Recent advances in materials for extended-release antibiotic delivery system10.1038/ja.2011.58 ↗
35. Treatment of osteomyelitis with teicoplanin-encapsulated biodegradable thermosensitive hydrogel nanoparticles10.1016/j.biomaterials.2010.03.027 ↗
36. Controlling Particle Size and Release Kinetics in the Sustained Delivery of Oral Antibiotics Using pH-Independent Mucoadhesive Polymers10.1021/acs.molpharmaceut.0c00408 ↗
37. Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release10.1021/acs.chemrev.5b00346 ↗
38. A Bioadhesive Nanoparticle-Hydrogel Hybrid System for Localized Antimicrobial Drug Delivery10.1021/acsami.6b04858 ↗
39. Evaluation of ciprofloxacin-loaded Eudragit® RS100 or RL100/PLGA nanoparticles10.1016/j.ijpharm.2006.01.041 ↗
40. Degradable polyphosphoester-based silver-loaded nanoparticles as therapeutics for bacterial lung infections10.1039/C4NR07103D ↗
41. Lectin-functionalized poly (lactide-co-glycolide) nanoparticles as oral/aerosolized antitubercular drug carriers for treatment of tuberculosis10.1093/jac/dkh411 ↗
42. Nanotherapeutic provides dose sparing and improved antimicrobial activity against Brucella melitensis infections10.1016/j.jconrel.2018.12.024 ↗
43. Preparation, physical-chemical and biological characterization of chitosan nanoparticles loaded with lysozyme10.1016/j.ijbiomac.2014.03.016 ↗
44. Cellular pharmacodynamics and pharmacokinetics of antibiotics: Current views and perspectives
45. Pharmacokinetics and pharmacodynamics of antibacterial agents10.1016/j.idc.2009.06.008 ↗
46. pH-Responsive Lipid-Dendrimer Hybrid Nanoparticles: An Approach To Target and Eliminate Intracellular Pathogens10.1021/acs.molpharmaceut.9b00713 ↗
47. AB2-type amphiphilic block copolymer containing a pH-cleavable hydrazone linkage for targeted antibiotic delivery10.1016/j.ijpharm.2019.118948 ↗
48. Polymyxin B-Polysaccharide Polyion Nanocomplex with Improved Biocompatibility and Unaffected Antibacterial Activity for Acute Lung Infection Management10.1002/adhm.201901542 ↗
49. Development of pH-responsive chitosan/heparin nanoparticles for stomach-specific anti-Helicobacter pylori therapy10.1016/j.biomaterials.2009.02.036 ↗
50. Dynamic intracellular delivery of antibiotics via pH-responsive polymersomes10.1039/C4PY01249F ↗
51. Dual pH-Responsive Macrophage-Targeted Isoniazid Glycoparticles for Intracellular Tuberculosis Therapy10.1021/acs.biomac.1c00554 ↗
52. Development of novel pH-sensitive thiolated chitosan/PMLA nanoparticles for amoxicillin delivery to treat Helicobacter pylori10.1016/j.msec.2017.08.038 ↗
53. Nanoparticles Incorporated in pH-Sensitive Hydrogels as Amoxicillin Delivery for Eradication of Helicobacter pylori10.1021/bm900985h ↗
54. Antibacterial Micelles with Vancomycin-Mediated Targeting and pH/Lipase-Triggered Release of Antibiotics10.1021/acsami.8b16092 ↗
55. Bioresponsive Nanoparticles Targeted to Infectious Microenvironments for Sepsis Management10.1002/adma.201803618 ↗
56. Triclosan loaded polyurethane micelles with pH and lipase sensitive properties for antibacterial applications and treatment of biofilms10.1016/j.msec.2018.08.063 ↗
57. Bacteria-Responsive Multifunctional Nanogel for Targeted Antibiotic Delivery10.1002/adma.201202847 ↗
58. Lipase-Sensitive Polymeric Triple-Layered Nanogel for “On-Demand” Drug Delivery10.1021/ja211279u ↗
59. Mir, M., Ahmed, N., Permana, A.D., Rodgers, A.M., Donnelly, R.F., and Rehman, A.U. (2019). Enhancement in Site-Specific Delivery of Carvacrol against Methicillin Resistant Staphylococcus aureus Induced Skin Infections Using Enzyme Responsive Nanoparticles: A Proof of Concept Study. Pharmaceutics, 11.10.3390/pharmaceutics11110606 ↗
60. An “On-Site Transformation” Strategy for Treatment of Bacterial Infection10.1002/adma.201703461 ↗
61. Enzyme-Responsive Polymeric Vesicles for Bacterial-Strain-Selective Delivery of Antimicrobial Agents10.1002/anie.201509401 ↗
62. A charge-adaptive nanosystem for prolonged and enhanced in vivo antibiotic delivery10.1039/C6CC01269H ↗
63. Size and Charge Adaptive Clustered Nanoparticles Targeting the Biofilm Microenvironment for Chronic Lung Infection Management10.1021/acsnano.0c00269 ↗
64. Enzyme Responsive Hyaluronic Acid Nanocapsules Containing Polyhexanide and Their Exposure to Bacteria to Prevent Infection10.1021/bm302003m ↗
65. Layer-by-Layer (LBL) Self-Assembled Biohybrid Nanomaterials for Efficient Antibacterial Applications10.1021/acsami.5b04216 ↗
66. Bacterial Hyaluronidase Self-Triggered Prodrug Release for Chemo-Photothermal Synergistic Treatment of Bacterial Infection10.1002/smll.201601729 ↗
67. Enzymatic degradation of poly(l-lactide) nanoparticles followed by the release of octenidine and their bactericidal effects10.1016/j.nano.2013.07.002 ↗
68. Enzyme-responsive polyion complex (PIC) nanoparticles for the targeted delivery of antimicrobial polymers10.1039/C6PY00146G ↗
69. NanoKeepers: Stimuli responsive nanocapsules for programmed specific targeting and drug delivery10.1039/C4CC04248D ↗
70. Endogenous stimulus-powered antibiotic release from nanoreactors for a combination therapy of bacterial infections10.1038/s41467-019-12233-2 ↗
71. A pH/H2O2 dual triggered nanoplatform for enhanced photodynamic antibacterial efficiency10.1039/D1TB00441G ↗
72. Targeted delivery of antibiotics to the infected pulmonary tissues using ROS-responsive nanoparticles10.1186/s12951-019-0537-4 ↗
73. Erythrocyte membrane-coated nanogel for combinatorial antivirulence and responsive antimicrobial delivery against Staphylococcus aureus infection10.1016/j.jconrel.2017.01.016 ↗
74. Polyprodrug Antimicrobials: Remarkable Membrane Damage and Concurrent Drug Release to Combat Antibiotic Resistance of Methicillin-Resistant Staphylococcus aureus10.1002/smll.201802008 ↗
75. Hyaluronic acid-based levofloxacin nanomicelles for nitric oxide-triggered drug delivery to treat bacterial infections10.1016/j.carbpol.2019.115479 ↗
76. Light-controlled active release of photocaged ciprofloxacin for lipopolysaccharide-targeted drug delivery using dendrimer conjugates10.1039/C6CC05179K ↗
77. Near-infrared light-controllable on-demand antibiotics release using thermo-sensitive hydrogel-based drug reservoir for combating bacterial infection10.1016/j.biomaterials.2018.09.045 ↗
78. A rapid drug release system with a NIR light-activated molecular switch for dual-modality photothermal/antibiotic treatments of subcutaneous abscesses10.1016/j.jconrel.2014.12.011 ↗
79. Spatiotemporal drug delivery using laser-generated-focused ultrasound system10.1016/j.jconrel.2015.08.033 ↗
80. Mechanochemical bond scission for the activation of drugs10.1038/s41557-020-00624-8 ↗
81. Hua, X., Tan, S., Bandara, H.M.H.N., Fu, Y., Liu, S., and Smyth, H.D.C. (2014). Externally Controlled Triggered-Release of Drug from PLGA Micro and Nanoparticles. PLoS ONE, 9.10.1371/journal.pone.0114271 ↗
82. Magnetically stimulated ciprofloxacin release from polymeric microspheres entrapping iron oxide nanoparticles10.2147/IJN.S82830 ↗
83. Magnetic stimulus responsive vancomycin drug delivery system based on chitosan microbeads embedded with magnetic nanoparticles10.1002/jbm.b.34015 ↗
84. Visible-Light Controlled Release of a Fluoroquinolone Antibiotic for Antimicrobial Photopharmacology10.1021/acsomega.7b01906 ↗
85. Photodynamic therapy: A new antimicrobial approach to infectious disease?10.1039/b311900a ↗
86. Ultrasound-triggered drug delivery for cancer treatment using drug delivery systems: From theoretical considerations to practical applications10.1016/j.jconrel.2016.09.026 ↗
87. A Review of the Combination Therapy of Low Frequency Ultrasound with Antibiotics10.1155/2017/2317846 ↗
88. The enhanced permeability retention effect: A new paradigm for drug targeting in infection10.1093/jac/dks379 ↗
89. Strategies in the design of nanoparticles for therapeutic applications10.1038/nrd2591 ↗
90. Tumor targeting via EPR: Strategies to enhance patient responses10.1016/j.addr.2018.07.007 ↗
91. The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect10.1016/j.addr.2010.04.009 ↗
92. Liposomes with Prolonged Blood Circulation and Selective Localization in Klebsiella pneumoniae-Infected Lung Tissue10.1093/infdis/168.1.164 ↗
93. Amoxicillin-loaded polyethylcyanoacrylate nanoparticles: Influence of PEG coating on the particle size, drug release rate and phagocytic uptake10.1016/S0142-9612(01)00030-8 ↗
94. Principles of nanoparticle design for overcoming biological barriers to drug delivery10.1038/nbt.3330 ↗
95. Surface Charge-Switching Polymeric Nanoparticles for Bacterial Cell Wall-Targeted Delivery of Antibiotics10.1021/nn3008383 ↗
96. Vancomycin-Modified Nanoparticles for Efficient Targeting and Preconcentration of Gram-Positive and Gram-Negative Bacteria10.1021/nn700183g ↗
97. A lipopolysaccharide binding heteromultivalent dendrimer nanoplatform for Gram negative cell targeting10.1039/C4TB01690D ↗
98. Self-enhanced targeted delivery of a cell wall- and membrane-active antibiotics, daptomycin, against staphylococcal pneumonia10.1016/j.apsb.2016.05.010 ↗
99. Bacteria-Targeting Nanoparticles with Microenvironment-Responsive Antibiotic Release to Eliminate Intracellular Staphylococcus aureus and Associated Infection10.1021/acsami.7b15678 ↗
100. Glycosylated Nanoparticles as Efficient Antimicrobial Delivery Agents10.1021/acs.biomac.6b00711 ↗