Toxicity of Different Chemical Components in Sun Cream Filters and Their Impact on Human Health: A Review
Source abstract
Abstract
Some chemical components in sun cream filters have endocrine-disrupting activity or can be carcinogenic, neurotoxic, bioaccumulative, allergens, or be toxic for human reproduction. It is important that sunscreens have safety requirements. The objective of this work is to compare sun cream filters used in conventional commercial sunscreens and those that are considered natural products, especially focused on endocrine-disrupting effects. In order to achieve the above objective, the compositions of different conventional and natural sun cream filters were evaluated and compared, taking into account the presence of the different sun cream filters whose effects were evaluated on the website specialized in safety and cosmetics, Environmental Working Group (EWG), and in the Register of chemical substances and mixtures in the EU Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) Regulation. The currently available evidence of each sun cream filter and their degree of safety has been summarized. Several organic sun cream filters present a potential risk to health and the environment; however, inorganic sun cream filters such as titanium dioxide and zinc oxide (ZnO and TiO2) show a very low risk in humans as they are not absorbed through intact or damaged tissues. The legislation does not oblige manufacturers to specify the concentration of each substance, which provides qualitative but not quantitative information for the consumer.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Skin Protection and Aging · Effects and risks of endocrine disrupting chemicals · Animal testing and alternatives
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Pharmacology, Phisiology, and Legal-Forensic Medicine, Faculty of Health and Sports Sciences, University of Zaragoza, 50009 Huesca, Spain
Department of Human Anatomy and Histology, Faculty of Medicine, University of Zaragoza, Domingo Miral s/n, 50009 Zaragoza, Spain
References (100+)
Show source-provided references
1. Anastas, P.T., and Warner, J.C. (1998). Green Chemistry: Theory and Practice, Oxford University Press.
2. Regulatory Assessment and Risk Management of Chemical Mixtures: Challenges and Ways Forward10.1080/10408444.2019.1579169 ↗
3. Review of the safety of octocrylene used as an ultraviolet filter in cosmetics. European Academy of Dermatology and Venereology10.1111/jdv.15945 ↗
4. Endocrine-Disrupting Chemicals and Public Health Protection: A Statement of Principles from The Endocrine Society10.1210/en.2012-1422 ↗
5. WHO (2013). State of the Science of Endocrine Disrupting Chemicals 2012, WHO Press.
6. The Adipose Tissue at the Crosstalk Between EDCs and Cancer Development10.3389/fendo.2021.691658 ↗
7. Identification of the Bisphenol A (BPA) and the Two Analogues BPS and BPF in Cryptorchidism10.3389/fendo.2021.694669 ↗
8. Endocrine Disrupting Chemicals and Reproductive Health in Boys and Men10.3389/fendo.2021.706532 ↗
9. Combined Exposure to Multiple Endocrine Disruptors and Uterine Leiomyomata and Endometriosis in US Women10.3389/fendo.2021.726876 ↗
10. A Structural Perspective on Nuclear Receptors as Targets of Environmental Compounds10.1038/aps.2014.133 ↗
11. Paraben Toxicology10.1097/DER.0000000000000428 ↗
12. Photostability of sunscreens10.1016/j.jphotochemrev.2011.12.001 ↗
13. Determination of parabens and benzophenone-type UV filters in human placenta: First description of the existence of benzyl paraben and benzophenone-410.1016/j.envint.2015.12.034 ↗
14. EDC IMPACT: Chemical UV filters can affect human sperm function in a progesterone-like manner10.1530/EC-17-0156 ↗
15. López-Hera, D. (2022, September 01). Medicina de Familia en la Red. Cremas Para el Sol Seguras: Como Elegir Fotoprotectores Solares No Tóxicos y Respetuosos Con El Medio Ambiente. Available online: https://www.drlopezheras.com/2014/07/cremas-para-el-sol-seguras-como-elegir.html.
16. Photoprotection: Facts and controversies
17. Does the use of protective creams with UV filters inhibit the synthesis of vitamin D?—For and against
18. What’s new in photoprotection: A review of new concepts and controversies10.1016/j.det.2018.11.003 ↗
19. Photoprotection: A review of the current and future technologies10.1111/j.1529-8019.2009.01289.x ↗
20. UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer10.1016/S1011-1344(01)00199-3 ↗
21. Ultraviolet radiation and risk of cutaneous melanoma and squamous cell carcinoma in males and females in the Norwegian Offshore Petroleum Workers cohort10.1002/ajim.23240 ↗
22. El sol y los filtros solares
23. Metal Oxide Sunscreens Protect Skin by Absorption, Not by Reflection or Scattering10.1111/phpp.12214 ↗
24. The absorption properties of “physical” sunscreens10.1001/archderm.135.2.209-a ↗
25. Fotoprotección. Factores de protección y filtros solares
26. Food and Drug Administration (US) (2022, April 15). CFR—Code of Federal Regulations Title 21; 2017, FDA Approved UV Filters for Sunscreens, Available online: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr.
27. (2022, May 18). FDA Advances New Proposed Regulation to Make Sure That Sunscreens are Safe and Effective. Federal Register 84FR6204, 2019-03019, Available online: https://www.fda.gov/news-events/press-announcements/fda-advances-new-proposed-regulation-make-sure-sunscreens-are-safe-and-effective.
28. Sunscreens cause coral bleaching by promoting viral infections10.1289/ehp.10966 ↗
29. Investigating the exposure and impact of chemical UV filters on coral reef ecosystems: Review and research gap prioritization10.1002/ieam.4411 ↗
30. (2022, June 13). National Institute of Health 2020. Endocrine Disruptors, Available online: https://www.niehs.nih.gov/health/topics/agents/endocrine/index.cfm.
31. Environmental Protection Agency (US) (2022, June 13). Nanomaterial Case Studies: Nanoscale Titanium Dioxide in Water Treatment and in Topical Sunscreen (Final). EPA/600/R-09/057F, Available online: https://cfpub.epa.gov/ncea/risk/recordisplay.cfm?deid=230972.
32. Environmental Protection Agency (US) (2022, July 14). Endocrine Disruptor Screening Program, Available online: https://www.epa.gov/endocrine-disruption.
33. OECD (2018). Revised Guidance Document 150 on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption, OECD Publishing.
34. DeLeo, V. (2012). Sunscreen. Bolognia J. Dermatology, Elsevier.
35. Effects of solar radiation and an update on photoprotection
36. Sunscreens—Which and what for?10.1159/000087606 ↗
37. Additive estrogenic effects of mixtures of frequently used UV filters on pS2-gene transcription in MCF-7 cells10.1016/j.taap.2005.02.006 ↗
38. In vitro and in vivo estrogenicity of UV screens10.1289/ehp.01109239 ↗
39. Estrogenic activity and reproductive effects of the UV-filter oxybenzone (2-hydroxy-4-methoxyphenyl-methanone) in fish10.1016/j.aquatox.2008.08.018 ↗
40. Sunscreens: Are they beneficial for health? An overview of endocrine disrupting properties of UV-Filters10.1111/j.1365-2605.2012.01280.x ↗
41. The effect of dermal benzophenone-2 administration on immune system activity, hypothalamic-pituitary-thyroid axis activity and hematological parameters in male Wistar rats10.1016/j.tox.2018.04.002 ↗
42. The effects of benzophenone-3 on apoptosis and the expression of sex hormone receptors in the frontal cortex and hippocampus of rats10.1016/j.toxlet.2018.08.006 ↗
43. Estrogenic activity of UV filters determined by an in vitro reporter gene assay and an in vivo transgenic zebrafish assay10.1007/s00204-002-0348-4 ↗
44. Akhiyat, S., and Olasz-Harken, E.B. (2019). Update on human safety and the environmental impact of physical and chemical sunscreen filters: What do we know about the effects of these commonly used and important molecules?. Pract. Dermatol., 48–51. Available online: https://practicaldermatology.com/articles/201.
45. Skin absorption and human exposure estimation of three widely discussed UV filters in sunscreens–In vitro study mimicking real-life consumer habits10.1016/j.fct.2015.06.025 ↗
46. Exposure to phenols, parabens and UV filters: Associations with loss-of-function mutations in the filaggrin gene in men from the general population10.1016/j.envint.2017.05.013 ↗
47. Developmental toxicity of UV filters and environmental exposure: A review10.1111/j.1365-2605.2007.00856.x ↗
48. Occurrences, toxicities, and ecological risks of benzophenone-3, a common component of organic sunscreen products: A mini-review10.1016/j.envint.2014.05.015 ↗
49. Olson, E. (New York Times, 2006). The rub on sunscreen, New York Times.
50. Dermatological and environmental toxicological impact of the sunscreen ingredient oxybenzone/benzophenone-310.1111/jocd.12449 ↗
51. The relationship between prenatal exposure to BP-3 and Hirschsprung’s disease10.1016/j.chemosphere.2015.09.019 ↗
52. Can oxybenzone cause Hirschsprung’s disease?10.1016/j.reprotox.2019.02.014 ↗
53. Effects of exposure to six chemical ultraviolet filters commonly used in personal care products on motility of MCF-7 and MDA-MB-231 human breast cancer cells in vitro10.1002/jat.3525 ↗
54. Bisphenol A, benzophenone-type ultraviolet filters, and phthalates in relation to uterine leiomyoma10.1016/j.envres.2014.06.028 ↗
55. Benzophenone-3 increases metastasis potential in lung cancer cells via epithelial to mesenchymal transition10.1007/s10565-016-9368-3 ↗
56. Wang, W.Q., Duan, H.X., Pei, Z.T., Xu, R.R., Qin, Z.T., Zhu, G.C., and Sun, L.W. (2018). Evaluation by the Ames assay of the mutagenicity of UV filters using benzophenone and benzophenone-1. Int. J. Environ. Res. Public Health, 15.10.3390/ijerph15091907 ↗
57. Rigel, D.S., Weiss, R.A., and Lim, H.W. (2004). Photoprotection. Photoaging, Marcel Dekker.10.3109/9780203913482 ↗
58. Contact and photocontact sensitivity to sunscreens. Review of a 15-year experience and of the literature10.1111/j.1600-0536.1997.tb02439.x ↗
59. Adverse reactions to sunscreen agents: Epidemiology, responsible irritants and allergens, clinical characteristics, and management10.1097/DER.0000000000000079 ↗
60. El futuro se hace presente en fotoprotección solar10.1016/j.piel.2011.03.002 ↗
61. Fotoprotectores tópicos
62. (2021, September 26). EWG’s Low Danger: 1–2. Available online: https://www.ewg.org/sunscreen/report/executive-summary/#.WxcjvVMvxmB.
63. (2021, September 26). Cosmetics Regulation (EC) No. 1223/2009. Available online: https://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2009:342:0059:0209:es:PDF.
64. Ultraviolet filter contact and photocontact allergy: Consumer exposure and risk assessment for octocrylene from personal care products and sunscreens10.1111/bjd.13372 ↗
65. Determination of urinary metabolites of the emerging UV filter octocrylene by online-SPE-LC-MS/MS10.1021/acs.analchem.7b03996 ↗
66. (2021, January 26). Available online: https://ec.europa.eu/growth/content/call-data-ingredients-potential-endocrine-disrupting-properties-used-cosmetic-products_en.
67. Drug substances presented as sulfonic acid salts: Overview of utility, safety and regulation10.1211/jpp.61.03.0001 ↗
68. Sunscreens: UV filters to protect us: Part 2-Increasing awareness of UV filters and their potential toxicities to us and our environment10.1016/j.ijwd.2020.08.008 ↗
69. Sunscreen allergy: A review of epidemiology, clinical characteristics, and responsible allergens10.2310/6620.2006.05017 ↗
70. Zinc oxide nanoparticles in modern sunscreens: An analysis of potential exposure and hazard10.3109/17435390903502028 ↗
71. Trade-offs in ecosystem impacts from nanomaterial versus organic chemical ultraviolet filters in sunscreens10.1016/j.watres.2018.03.062 ↗
72. Titanium dioxide and zinc oxide nanoparticles in sunscreens: Focus on their safety and effectiveness10.2147/NSA.S19419 ↗
73. Human safety review of “nano” titanium dioxide and zinc oxide10.1039/b9pp00180h ↗
74. Study on penetration of titanium dioxide (TiO2) nanoparticles into intact and damaged skin in vitro10.2131/jts.35.107 ↗
75. Characterization of the mineral content of a physical sunscreen emulsion and its distribution onto human stratum corneum10.1111/j.1467-2494.1997.tb00175.x ↗
76. Imaging of zinc oxide nanoparticle penetration in human skin in vitro and in vivo10.1117/1.3041492 ↗
77. Scientific Committee on Consumer Safety (SCCS) (2021, February 24). Opinion on Zinc Oxide (Nano Form). Available online: http://ec.europa.eu/health/scientific_committ.
78. Cerium oxide for sunscreen cosmetics10.1016/S0022-4596(02)00139-1 ↗
79. Stability of sunscreens containing CePO4: Proposal for a new inorganic UV filter10.3390/molecules19079907 ↗
80. Natural components in sunscreens: Topical formulations with sun protection factor (SPF)10.1016/j.biopha.2020.111161 ↗
81. Non-sunscreen photoprotection: Antioxidants add value to a sunscreen10.1038/jidsymp.2009.14 ↗
82. Estrés oxidativo, carcinogénesis cutánea por radiación solar y quimioproteccion con polifenoles10.1016/j.piel.2011.11.015 ↗
83. Preparation of organic acid lignin submicrometer particle as a natural broad-spectrum photo-protection agent10.1016/j.ijbiomac.2019.03.177 ↗
84. Development, characterization, and evaluation of sunscreen cream contain-ing solid lipid nanoparticles of silymarin10.1111/jocd.12470 ↗
85. Álvarez-Gómez, F., Korbee, N., Casas-Arrojo, V., Abdala-Díaz, R.T., and Figueroa, F.L. (2019). UV photoprotection, cytotoxicity and immunology capacity of red algae extracts. Molecules, 24.10.3390/molecules24020341 ↗
86. Evidence regarding the UV sunscreen role of a mycosporine-like compound in the cyanobacterium Gloeocapsa sp.10.1128/aem.59.1.170-176.1993 ↗
87. Development of topical drug delivery system with Sphaeranthus indicus flower extract and its investigation on skin as a cosmeceutical product10.1111/jocd.13108 ↗
88. Sun protective potential and physical stability of herbal sunscreen de-veloped from afghan medicinal plants10.4274/tjps.galenos.2019.15428 ↗
89. Baldisserotto, A., Buso, P., Radice, M., Dissette, V., Lampronti, I., Gambari, R., Manfredini, S., and Vertuani, S. (2018). Moringa oleifera leaf extracts as multifunctional ingredients for “natural and organic” sunscreens and photoprotective preparations. Molecules, 23.10.3390/molecules23030664 ↗
90. Formulation and characterization of a Heli annuus-alkyl polyglucoside emulsion cream for topical applications10.1111/jocd.12756 ↗
91. Gaweł-Bęben, K., Kukula-Koch, W., Hoian, U., Czop, M., Strzępek-Gomółka, M., and Antosiewicz, B. (2020). Characterization of Cistus × incanus L. and Cistus ladanifer L. ex-tracts as potential multifunctional antioxidant ingredients for skin protecting cosmetics. Antioxidants, 9.10.3390/antiox9030202 ↗
92. Systemic availability of lipophilic organic UV filters through dermal sunscreen exposure10.1016/j.envint.2019.105068 ↗
93. Personal care products and endocrine disruption: A critical review of the literature10.3109/10408444.2010.515563 ↗
94. Chemical UV filters mimic the effect of progesterone on Ca2+ signaling in human sperm cells10.1210/en.2016-1473 ↗
95. Evidence of reproductive disruption associated with neuroendocrine changes induced by UV-B filters, phtalates and nonylphenol during sexual maturation in rats of both gender10.1016/j.tox.2013.05.014 ↗
96. Effects of pre- and postnatal exposure to the UV-filter Octyl Methoxycinnamate (OMC) on the reproductive, auditory and neurological development of rat offspring10.1016/j.taap.2010.10.031 ↗
97. Effects of in vivo exposure to UV filters (4-MBC, OMC, BP-3, 4-HB, OC, OD-PABA) on endocrine signaling genes in the insect Chironomus riparius
98. Joint Effects of Multiple UV Filters on Zebrafish Embryo Development10.1021/acs.est.8b02418 ↗
99. Effects of 4-methylbenzylidene camphor (4-MBC) on neuronal and muscular development in zebrafish (Danio rerio) embryos10.1007/s11356-016-6180-9 ↗
100. Hormonal activity, cytotoxicity and developmental toxicity of UV filters10.1016/j.ecoenv.2016.04.037 ↗