Domiciliary Use of Chlorhexidine vs. Postbiotic Gels in Patients with Peri-Implant Mucositis: A Split-Mouth Randomized Clinical Trial
Source abstract
Abstract
Peri-implant mucositis is a pathological condition characterized by an inflammatory process in the peri-implant soft tissues. Progression to peri-implantitis takes place in case of peri-implant bone resorption. Recently, an aid for non-surgical treatment by mechanical debridement (SRP) has been identified in probiotics. As there are no recent studies regarding their use for peri-implant mucositis, the aim of this study was to test a new postbiotic gel for this clinical condition. A split-mouth randomized clinical trial was performed. Twenty patients undergoing SRP were randomly assigned to two treatments based on the following oral gels: chlorhexidine-based Curasept Periodontal Gel (Group 1) and postbiotic-based Biorepair Parodontgel Intensive (Group 2). At baseline (T0) and after three (T1) and six (T2) months, the following peri-implant mucositis indexes were recorded: Probing Pocket Depth (PPD), Plaque Index (PI), Gingival Bleeding Index (GBI), Bleeding Score (BS), Marginal Mucosal Condition (MMC). A significant decrease is reported for both postbiotic and chlorhexidine for all peri-implant mucositis indices studied. Quite the opposite, no significant variation was present in intergroup comparisons. Greater improvements for BS, GBI and MMC inflammatory indices of the postbiotic gel compared to chlorhexidine suggest the importance of further studies to investigate the relevance of the product alone.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Dental Implant Techniques and Outcomes · Oral microbiology and periodontitis research · Scientific and Engineering Research Topics
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Unit of Dental Hygiene, Section of Dentistry, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy
Unit of Orthodontics and Pediatric Dentistry, Section of Dentistry, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy
Section of Dentistry, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy
References (52)
Show source-provided references
1. A systematic review of the 5-year survival and complication rates of implant-supported single crowns10.1111/j.1600-0501.2007.01453.x ↗
2. Primary prevention of peri-implantitis: Managing peri-implant mucositis10.1111/jcpe.12369 ↗
3. Peri-implantitis10.1111/jcpe.12954 ↗
4. Dental Implant Complications10.1053/j.sult.2015.09.007 ↗
5. Peri-implant diseases: Consensus Report of the Sixth European Workshop on Periodontology10.1111/j.1600-051X.2008.01283.x ↗
6. Peri-implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions10.1111/jcpe.12957 ↗
7. Soft tissue reaction to de novo plaque formation on implants and teeth10.1034/j.1600-0501.1992.030101.x ↗
8. Reversibility of experimental peri-implant mucositis compared with experimental gingivitis in humans10.1111/j.1600-0501.2011.02220.x ↗
9. Experimental peri-implant mucositis at different implant surfaces10.1111/jcpe.12240 ↗
10. Ten-year results of a three arms prospective cohort study on implants in periodontally compromised patients. Part 2: Clinical results10.1111/j.1600-0501.2011.02309.x ↗
11. A prospective 15-year follow-up study of mandibular fixed prostheses supported by osseointegrated implants10.1034/j.1600-0501.1996.070405.x ↗
12. Prevalence and risk variables for peri-implant disease in Brazilian subjects10.1111/j.1600-051X.2006.01001.x ↗
13. Peri-implant disease in subjects with and without preventive maintenance: A 5-year follow-up10.1111/j.1600-051X.2011.01819.x ↗
14. The effect of keratinized mucosa width on peri-implant health: A systematic review10.11607/jomi.3244 ↗
15. IL-1RN gene polymorphism is associated with peri-implantitis10.1111/j.1600-0501.2006.01249.x ↗
16. Cement-associated peri-implantitis: A retrospective clinical observational study of fixed implant-supported restorations using a methacrylate cement10.1111/clr.12173 ↗
17. Factors related to peri-implantitis-A retrospective study10.1111/clr.12208 ↗
18. Periimplant diseases: Where are we now?—Consensus of the Seventh European Workshop on Periodontology10.1111/j.1600-051X.2010.01674.x ↗
19. Impact of implant overloading on the peri-implant bone in inflamed and non-inflamed peri-implant mucosa10.1111/j.1600-0501.2007.01374.x ↗
20. Metal elements in tissue with dental peri-implantitis: A pilot study10.1111/clr.12718 ↗
21. Anti-infective therapy of peri-implantitis with adjunctive local drug delivery or photodynamic therapy: 12-month outcomes of a randomized controlled clinical trial10.1111/clr.12155 ↗
22. Microbial colonization of the periodontal pocket and its significance for periodontal therapy10.1111/prd.12147 ↗
23. Antibiotics in the treatment of periodontal diseases: Microbiological basis and clinical applications
24. Butera, A., Gallo, S., Pascadopoli, M., Luraghi, G., and Scribante, A. (2021). Ozonized Water Administration in Peri-Implant Mucositis Sites: A Randomized Clinical Trial. Appl. Sci., 11.10.3390/app11177812 ↗
25. The Effect of Photodynamic Therapy in the Treatment of Chronic Periodontitis: A Review of Literature10.15171/jlms.2017.s2 ↗
26. Effects of Bifidobacterium probiotic on the treatment of chronic periodontitis: A randomized clinical trial10.1111/jcpe.12995 ↗
27. Antibiotics and the Human Gut Microbiome: Dysbioses and Accumulation of Resistances10.3389/fmicb.2015.01543 ↗
28. Clinical and Biochemical Evaluation of Lozenges Containing Lactobacillus reuteri as an Adjunct to Non-Surgical Periodontal Therapy in Chronic Periodontitis10.1902/jop.2015.140612 ↗
29. Żółkiewicz, J., Marzec, A., Ruszczyński, M., and Feleszko, W. (2020). Postbiotics-A Step beyond Pre-and Probiotics. Nutrients, 12.10.3390/nu12082189 ↗
30. Laugisch, O., Auschill, T.M., Heumann, C., Sculean, A., and Arweiler, N.B. (2022). Clinical Evaluation of a New Electronic Periodontal Probe: A Randomized Controlled Clinical Trial. Diagnostics, 12.10.3390/diagnostics12010042 ↗
31. The plaque control record10.1902/jop.1972.43.1.38 ↗
32. Problems and proposals for recording gingivitis and plaque
33. The microbiota associated with successful or failing osseointegrated titanium implants10.1111/j.1399-302X.1987.tb00298.x ↗
34. The longitudinal effectiveness of osseointegrated dental implants. The Toronto Study: Peri-implant mucosal response
35. Adjunctive glycine powder air-polishing for the treatment of peri-implant mucositis: An observational clinical trial10.1111/idh.12114 ↗
36. An Algorithm for a Letter-Based Representation of All-Pairwise Comparisons10.1198/1061860043515 ↗
37. A systematic review of the incidence of biological and technical complications in implant dentistry reported in prospective longitudinal studies of the least 5 years10.1034/j.1600-051X.29.s3.12.x ↗
38. A Proposal of New Classification for Dental Implant Complications10.5005/jp-journals-10024-2375 ↗
39. Prevalence of subjects with progressive bone loss at implants10.1111/j.1600-0501.2005.01137.x ↗
40. Systematic review of implant outcomes in treated periodontitis subjects10.1111/j.1600-051X.2008.01207.x ↗
41. Comparative biology of chronic and aggressive periodontitis vs. peri-implantitis10.1111/j.1600-0757.2010.00348.x ↗
42. Consensus statements and recommended clinical procedures regarding implant survival and complications
43. Systematic review and meta-analysis of double- blind, placebo-controlled, randomized clinical trials using probiotics in chronic periodontitis10.1111/jicd.12338 ↗
44. Effect of the probiotic Lactobacilli reuteri (Prodentis) in the management of periodontal disease: A preliminary randomized clinical trial10.3402/jom.v2i0.5344 ↗
45. Probiotics and mucositis10.1097/MCO.0000000000000487 ↗
46. Efficacy of Probiotics as Adjunctive Therapy to Nonsurgical Treatment of Peri-Implant Mucositis: A Systematic Review and Meta-Analysis10.3389/fphar.2020.541752 ↗
47. Chlorhexidine (CHX) in dentistry: State of the art
48. Comparing the effect of 0.06%-, 0.12% and 0.2% Chlorhexidine on plaque, bleeding and side effects in an experimental gingivitis model: A parallel group, double masked randomized clinical trial10.1186/s12903-017-0400-7 ↗
49. Lactobacilli postbiotics reduce biofilm formation and alter transcription of virulence genes of Aggregatibacter actinomycetemcomitans10.1111/omi.12330 ↗
50. Effect of probiotic Lactobacillus rhamnosus by-products on gingival epithelial cells challenged with Prphyromonas gingivalis10.1016/j.archoralbio.2021.105174 ↗
51. Butera, A., Gallo, S., Pascadopoli, M., Taccardi, D., and Scribante, A. (2022). Home Oral Care of Periodontal Patients Using Antimicrobial Gel with Postbiotics, Lactoferrin, and Aloe Barbadensis Leaf Juice Powder vs. Conventional Chlorhexidine Gel: A Split-Mouth Randomized Clinical Trial. Antibiotics, 11.10.3390/antibiotics11010118 ↗
52. Oral intake of Lactobacillus plantarum L-14 extract alleviates TLR2- and AMPK-mediated obesity- associated disorders in hight-fat-diet-induced obese C57BL/6J mice10.1111/cpr.13039 ↗