journal article·2019-06-13Open access

Region-Based Automated Localization of Colonoscopy and Wireless Capsule Endoscopy Polyps

Sudhir Sornapudi, Frank Meng, Steven Yi

Applied Sciences· Volume 9· Issue 12

Abstract

The early detection of polyps could help prevent colorectal cancer. The automated detection of polyps on the colon walls could reduce the number of false negatives that occur due to manual examination errors or polyps being hidden behind folds, and could also help doctors locate polyps from screening tests such as colonoscopy and wireless capsule endoscopy. Losing polyps may result in lesions evolving badly. In this paper, we propose a modified region-based convolutional neural network (R-CNN) by generating masks around polyps detected from still frames. The locations of the polyps in the image are marked, which assists the doctors examining the polyps. The features from the polyp images are extracted using pre-trained Resnet-50 and Resnet-101 models through feature extraction and fine-tuning techniques. Various publicly available polyp datasets are analyzed with various pertained weights. It is interesting to notice that fine-tuning with balloon data (polyp-like natural images) improved the polyp detection rate. The optimum CNN models on colonoscopy datasets including CVC-ColonDB, CVC-PolypHD, and ETIS-Larib produced values (F1 score, F2 score) of (90.73, 91.27), (80.65, 79.11), and (76.43, 78.70) respectively. The best model on the wireless capsule endoscopy dataset gave a performance of (96.67, 96.10). The experimental results indicate the better localization of polyps compared to recent traditional and deep learning methods.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Colorectal Cancer Screening and Detection · Gastrointestinal Bleeding Diagnosis and Treatment · Gastric Cancer Management and Outcomes

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Currently at Missouri University of Science and Technology, Rolla, MO 65401, USA

Xyken LLC, McLean, VA 22102, USA

Funding

National Institute on Aging

References (44)

Show source-provided references
1. American Cancer Society (2019, March 07). Cancer Facts & Figures 2019. Available online: https://www.cancer.org/research/cancer-facts-statistics/colorectal-cancer-facts-figures.html.
2. Accuracy of CT Colonography for Detection of Large Adenomas and Cancers10.1056/NEJMoa0800996 ↗
3. Outcomes of Colorectal Cancer in the United States: No Change in Survival (1986–1997)
4. Computer-aided tumor detection in endoscopic video using color wavelet features10.1109/TITB.2003.813794 ↗
5. Iakovidis, D.K., Maroulis, D.E., Karkanis, S.A., and Brokos, A. (2005, January 23–24). A Comparative Study of Texture Features for the Discrimination of Gastric Polyps in Endoscopic Video. Proceedings of the 18th IEEE Symposium on Computer-Based Medical Systems (CBMS’05), Dublin, Ireland.
6. Color and Position versus Texture Features for Endoscopic Polyp Detection
7. Automatic Detection of Colorectal Polyps in Static Images10.4015/S1016237211002761 ↗
8. Rajaraman, S., Antani, S.K., Poostchi, M., Silamut, K., Hossain, M.A., Maude, R.J., Jaeger, S., and Thoma, G.R. (2018). Pre-trained convolutional neural networks as feature extractors toward improved malaria parasite detection in thin blood smear images. PeerJ, 6.10.7717/peerj.4568 ↗
9. Deep Learning Nuclei Detection in Digitized Histology Images by Superpixels10.4103/jpi.jpi_74_17 ↗
10. Park, S.Y., and Sargent, D. (2016). Colonoscopic polyp detection using convolutional neural networks. Proc. SPIE 9785, Medical Imaging 2016: Computer-Aided Diagnosis, International Society for Optics and Photonics.
11. Ribeiro, E., Uhl, A., and Häfner, M. (2016, January 20–23). Colonic Polyp Classification with Convolutional Neural Networks. Proceedings of the IEEE 29th International Symposium on Computer-Based Medical Systems (CBMS), Dublin, Ireland.10.1109/CBMS.2016.39 ↗
12. Automated polyp detection in colonoscopy videos using shape and context information10.1109/TMI.2015.2487997 ↗
13. Convolutional Neural Networks for Medical Image Analysis: Full Training or Fine Tuning?10.1109/TMI.2016.2535302 ↗
14. Automatic Colon Polyp Detection using Region based Deep CNN and Post Learning Approaches10.1109/ACCESS.2018.2856402 ↗
15. Faster R-CNN: Towards Real-time Object Detection with Region Proposal Networks
16. Mo, X., Tao, K., Wang, Q., and Wang, G. (2018, January 20–24). An Efficient Approach for Polyps Detection in Endoscopic Videos Based on Faster R-CNN. Proceedings of the 24th International Conference on Pattern Recognition (ICPR), Bejing, China.10.1109/ICPR.2018.8545174 ↗
17. Development and validation of a deep-learning algorithm for the detection of polyps during colonoscopy10.1038/s41551-018-0301-3 ↗
18. Mori, Y., and Kudo, S. (2018). Detecting colorectal polyps via machine learning. Nat. Biomed. Eng., 713–714.10.1038/s41551-018-0308-9 ↗
19. Deep Learning Localizes and Identifies Polyps in Real Time With 96% Accuracy in Screening Colonoscopy10.1053/j.gastro.2018.06.037 ↗
20. Zheng, Y., Zhang, R., Yu, R., Jiang, Y., Mak, T.W.C., Wong, S.H., Lau, J.Y.W., and Poon, C.C.Y. (2018, January 17–21). Localisation of Colorectal Polyps by Convolutional Neural Network Features Learnt from White Light and Narrow Band Endoscopic Images of Multiple Databases. Proceedings of the 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Honolulu, HI, USA.10.1109/EMBC.2018.8513337 ↗
21. Comparative Validation of Polyp Detection Methods in Video Colonoscopy: Results from the MICCAI 2015 Endoscopic Vision Challenge10.1109/TMI.2017.2664042 ↗
22. Toward embedded detection of polyps in WCE images for early diagnosis of colorectal cancer10.1007/s11548-013-0926-3 ↗
23. Figueiredo, I., Kumar, S., and Figueiredo, P. (2013, January 14–16). An Intelligent System for Polyp Detection in Wireless Capsule Endoscopy Images. Proceedings of the IV ECCOMAS Thematic Conference on Computational Vision and Medical Image Processing, Madeira Island, Funchal, Portugal.
24. Automated Polyp Detection in Colon Capsule Endoscopy10.1109/TMI.2014.2314959 ↗
25. Zhou, M., Bao, G., Geng, Y., Alkandari, B., and Li, X. (2014, January 14–16). Polyp Detection and Radius Measurement in Small Intestine Using Video Capsule Endoscopy. Proceedings of the 7th International Conference on Biomedical Engineering and Informatics, Dalian, China.10.1109/BMEI.2014.7002777 ↗
26. Automatic polyp detection for wireless capsule endoscopy images10.1016/j.eswa.2012.03.029 ↗
27. Deep learning for polyp recognition in wireless capsule endoscopy images10.1002/mp.12147 ↗
28. Yu, J., Chen, J., Xiang, Z.Q., and Zou, Y. (2015, January 6–9). A Hybrid Convolutional Neural Networks with Extreme Learning Machine for WCE Image Classification. Proceedings of the IEEE International Conference on Robotics and Biomimetics (ROBIO), Zhuhai, China.10.1109/ROBIO.2015.7419037 ↗
29. Zhu, R., Zhang, R., and Xue, D. (2015, January 14–16). Lesion Detection of Endoscopy Images Based on Convolutional Neural Network Features. Proceedings of the 8th International Congress on Image and Signal. Processing (CISP), Shenyang, China.10.1109/CISP.2015.7407907 ↗
30. Prasath, V.B.S. (2016). Polyp Detection and Segmentation from Video Capsule Endoscopy: A Review. J. Imaging, 3.10.3390/jimaging3010001 ↗
31. Artificial intelligence in gastrointestinal endoscopy: The future is almost here10.4253/wjge.v10.i10.239 ↗
32. Deng, J., Dong, W., Socher, R., Li, L., Li, K., and Li., F.F. (2009, January 20–25). ImageNet: A Large-Scale Hierarchical Image Database. Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition (CVPR’09), Miami Beach, FL, USA.10.1109/CVPR.2009.5206848 ↗
33. Fleet, D., Pajdla, T., Schiele, B., and Tuytelaars, T. (2014). Microsoft COCO: Common Objects in Context. Computer Vision ECCV 2014, Springer International Publishing.
34. Endoscopic Vision Challenge (2018, June 21). Sub-challenge: Gastrointestinal Image ANAlysis (GIANA). Available online: https://giana.grand-challenge.org.
35. WM-DOVA maps for accurate polyp highlighting in colonoscopy: Validation vs. saliency maps from physicians10.1016/j.compmedimag.2015.02.007 ↗
36. A Benchmark for Endoluminal Scene Segmentation of Colonoscopy Images
37. Towards automatic polyp detection with a polyp appearance model10.1016/j.patcog.2012.03.002 ↗
38. Medical Image Data and Datasets in the Era of Machine Learning—Whitepaper from the 2016 C-MIMI Meeting Dataset Session10.1007/s10278-017-9976-3 ↗
39. He, K., Zhang, X., Ren, S., and Sun, J. (2016). Deep residual learning for image recognition. Proc. IEEE, 770–778.10.1109/CVPR.2016.90 ↗
40. Lin, T.Y., Dollar, P., Girshick, R., He, K., Hariharan, B., and Belongie, S. (2017, January 21–26). Feature Pyramid Networks for Object Detection. Proceedings of the 30th IEEE Conference Computer Vision Pattern Recognition, CVPR, Honolulu, HI, USA.10.1109/CVPR.2017.106 ↗
41. He, K., Gkioxari, G., Dollár, P., and Girshick, R. (2017, January 22–29). Mask R-CNN. Proceedings of the IEEE International Conference on Computer Vision (ICCV), Venice, Italy.10.1109/ICCV.2017.322 ↗
42. Polyp Detection via Imbalanced Learning and Discriminative Feature Learning10.1109/TMI.2015.2434398 ↗
43. Chen, H., Qi, X., Cheng, J., and Heng, P. (2016, January 12–17). Deep Contextual Networks for Neuronal Structure Segmentation. Proceedings of the 30th Conference on Artificial Intelligence (AAAI 2016), Phoenix, AZ, USA.10.1609/aaai.v30i1.10141 ↗
44. ImageNet Classification with Deep Convolutional Neural Networks