journal article·2021-10-14Open access

Carbon Nanotubes-Based Hydrogels for Bacterial Eradiation and Wound-Healing Applications

Tejal V. Patil, Dinesh K. Patel, Sayan Deb Dutta, Keya Ganguly, Aayushi Randhawa, Ki-Taek Lim

Applied Sciences· Volume 11· Issue 20

Abstract

Biocompatible nanomaterials have attracted enormous interest for biomedical applications. Carbonaceous materials, including carbon nanotubes (CNTs), have been widely explored in wound healing and other applications because of their superior physicochemical and potential biomedical properties to the nanoscale level. CNTs-based hydrogels are widely used for wound-healing and antibacterial applications. CNTs-based materials exhibited improved antimicrobial, antibacterial, adhesive, antioxidants, and mechanical properties, which are beneficial for the wound-healing process. This review concisely discussed the preparation of CNTs-based hydrogels and their antibacterial and wound-healing applications. The conductive potential of CNTs and their derivatives is discussed. It has been observed that the conductivity of CNTs is profoundly affected by their structure, temperature, and functionalization. CNTs properties can be easily modified by surface functionalization. CNTs-based composite hydrogels demonstrated superior antibacterial potential to corresponding pure polymer hydrogels. The accelerated wound healing was observed with CNTs-based hydrogels.
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Research context

OpenAlex topics: Graphene and Nanomaterials Applications · Electrospun Nanofibers in Biomedical Applications · Nanoparticles: synthesis and applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Biosystems Engineering, Institute of Forest Science, Kangwon National University, Chuncheon 24341, Korea

Interdisciplinary Program in Smart Agriculture, Kangwon National University, Chuncheon 24341, Korea

Department of Microbiology & Biotechnology, Banglore University, Jnana Bharathi Campus, Banglore 560056, India

Funding

National Research Foundation of Korea

References (100+)

Show source-provided references
1. Reduction in wound healing times, cost of consumables and number of visits treated through the implementation of an electronic wound care system in rural Australia10.1111/iwj.12414 ↗
2. Recent advances in inorganic nanomaterials for wound-healing applications10.1039/C9BM00423H ↗
3. Feily, A., Moeineddin, F., and Mehraban, S. (2016). Physical Modalities in the Management of Wound (s). Wound Healing-New Insights into Ancient Challenges, IntechOpen.10.5772/64340 ↗
4. Stem cell therapies for wound healing10.1080/14712598.2019.1596257 ↗
5. Use of oxygen therapies in wound healing10.12968/jowc.2017.26.Sup5.S1 ↗
6. Nitric oxide therapy for diabetic wound healing10.1002/adhm.201801210 ↗
7. Engineered nanomaterials for infection control and healing acute and chronic wounds10.1021/acsami.6b00291 ↗
8. Regenerative skin wound healing in mammals: State-of-the-art on growth factor and stem cell based treatments10.1159/000374049 ↗
9. Traditional therapies for skin wound healing10.1089/wound.2013.0506 ↗
10. Role of 13-(di)phenylalkyl berberine derivatives in the modulation of the activity of human topoisomerase IB10.1016/j.ijbiomac.2015.02.051 ↗
11. Nanotechnology-driven therapeutic interventions in wound healing: Potential uses and applications10.1021/acscentsci.6b00371 ↗
12. Conductive materials for healing wounds: Their incorporation in electroactive wound dressings, characterization, and perspectives10.1002/adhm.202001384 ↗
13. Vashist, A., Kaushik, A., Vashist, A., Sagar, V., Ghosal, A., Gupta, Y.K., Ahmad, S., and Nair, M. (2018). Advances in carbon nanotubes-hydrogel hybrids in nanomedicine for therapeutics. Adv. Healthc. Mater., 7.10.1002/adhm.201701213 ↗
14. Review on nanoparticles and nanostructured materials: History, sources, toxicity and regulations10.3762/bjnano.9.98 ↗
15. Biomimetic carbon nanotubes for neurological disease therapeutics as inherent medication10.1016/j.apsb.2019.11.003 ↗
16. Carbon nanotubes: Biomaterial applications10.1039/b804822n ↗
17. Carbon nanotubes in biomedical applications: Factors, mechanisms, and remedies of toxicity10.1021/acs.jmedchem.5b01770 ↗
18. Synthesis, characterization and optical limiting property of covalently oligothiophene-functionalized graphene material10.1016/j.carbon.2009.07.027 ↗
19. Carbon nanotubes for biomedical applications10.1109/TNB.2005.850478 ↗
20. Prajapati, S.K., Malaiya, A., Kesharwani, P., Soni, D., and Jain, A. (2020). Biomedical applications and toxicities of carbon nanotubes. Drug Chem. Toxicol., 1–16.10.1080/01480545.2019.1709492 ↗
21. Adorinni, S., Rozhin, P., and Marchesan, S. (2021). Smart hydrogels meet carbon nanomaterials for new frontiers in medicine. Biomedicines, 9.10.3390/biomedicines9050570 ↗
22. Multifunctional hydrogels for wound healing: Special focus on biomacromolecular based hydrogels10.1016/j.ijbiomac.2020.12.202 ↗
23. Cyclophosphamide@ CNT: In silico exploration of nano drug delivery system
24. Sohrabi, N., Alihosseini, A., Pirouzfar, V., and Pedram, M.Z. (2020). Analysis of dynamics targeting CNT-based drug delivery through lung cancer cells: Design, simulation, and computational approach. Membranes, 10.10.3390/membranes10100283 ↗
25. Surface modification of CNT reinforced UHMWPE composite for sustained drug delivery10.1016/j.jddst.2019.05.044 ↗
26. DFT computational study on the phosphate functionalized SWCNTs as efficient drug delivery systems for anti-osteoporosis zolendronate and risedronate drugs10.1016/j.physe.2017.04.011 ↗
27. The effect of surface modification of poly-lactide-co-glycolide/carbon nanotube nanofibrous scaffolds by laminin protein on nerve tissue engineering10.1002/jbm.a.37013 ↗
28. Exhaled gas detection by a novel Rh-doped CNT biosensor for prediagnosis of lung cancer: A DFT study10.1080/00268976.2018.1467057 ↗
29. The fabrication of antibacterial hydrogels for wound healing10.1016/j.eurpolymj.2021.110268 ↗
30. Injectable antibacterial conductive nanocomposite cryogels with rapid shape recovery for noncompressible hemorrhage and wound healing10.1038/s41467-018-04998-9 ↗
31. Bioinspired multilayer membranes as potential adhesive patches for skin wound healing10.1039/C8BM00319J ↗
32. Cell infiltrative hydrogel fibrous scaffolds for accelerated wound healing10.1016/j.actbio.2016.11.017 ↗
33. Tavakoli, J., Mirzaei, S., and Tang, Y. (2018). Cost-effective double-layer hydrogel composites for wound dressing applications. Polymers, 10.10.3390/polym10030305 ↗
34. Carbon nanotube-based substrates promote cardiogenesis in brown adipose-derived stem cells via β1-integrin-dependent TGF-β1 signaling pathway10.2147/IJN.S114357 ↗
35. Carbon nanotubes promote cell migration in hydrogels10.1038/s41598-020-59463-9 ↗
36. Effect of polyethylene glycol on the antibacterial properties of polyurethane/carbon nanotube electrospun nanofibers10.1039/C6RA00363J ↗
37. Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis10.1186/s12951-020-00755-7 ↗
38. Helical microtubules of graphitic carbon10.1038/354056a0 ↗
39. Low temperature growth of carbon nanotubes—A review10.1016/j.carbon.2019.11.061 ↗
40. Carbon nanotubes: Synthesis, properties and engineering applications10.1007/s42823-019-00068-2 ↗
41. Ultralight anisotropic foams from layered aligned carbon nanotube sheets10.1039/C5NR03899E ↗
42. Design of lithium cobalt oxide electrodes with high thermal conductivity and electrochemical performance using carbon nanotubes and diamond particles10.1016/j.carbon.2017.12.061 ↗
43. Thermal conduction phenomena in carbon nanotubes and related nanostructured materials10.1103/RevModPhys.85.1295 ↗
44. Thermal conductivity of carbon nanotubes and their polymer nanocomposites: A review10.1016/j.progpolymsci.2010.11.004 ↗
45. A molecular dynamics simulation of heat conduction of a finite length single-walled carbon nanotube10.1080/10893950390150467 ↗
46. Thermal conductivity of carbon nanotube networks: A review10.1007/s10853-019-03368-0 ↗
47. Unusually high thermal conductivity of carbon nanotubes10.1103/PhysRevLett.84.4613 ↗
48. Temperature dependence of the thermal conductivity of single-wall carbon nanotubes10.1088/0957-4484/12/1/305 ↗
49. Titania/carbon nanotube composite (TiO2/CNT) and its application for removal of organic pollutants10.1007/s10098-013-0581-y ↗
50. Simon, J., Flahaut, E., and Golzio, M. (2019). Overview of carbon nanotubes for biomedical applications. Materials, 12.10.3390/ma12040624 ↗
51. A review on carbon nanotube: An overview of synthesis, properties, functionalization, characterization, and the application10.1016/j.mseb.2021.115095 ↗
52. Carbon nanotube synthesis in a flame using laser ablation for in situ catalyst generation10.1007/s00339-003-2196-3 ↗
53. Synthesis of carbon nanotubes by catalytic chemical vapour deposition: A review on carbon sources, catalysts and substrates10.1016/j.mssp.2015.08.013 ↗
54. Arc discharge synthesis of carbon nanotubes: Comprehensive review10.1016/j.diamond.2014.10.001 ↗
55. Carbon nanotube—A review on synthesis, properties and plethora of applications in the field of biomedical science10.1016/j.sintl.2020.100003 ↗
56. Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing10.1016/j.biomaterials.2018.08.044 ↗
57. Zn2+-loaded TOBC nanofiber-reinforced biomimetic calcium alginate hydrogel for antibacterial wound dressing10.1016/j.ijbiomac.2019.12.046 ↗
58. Adhesive hemostatic conducting injectable composite hydrogels with sustained drug release and photothermal antibacterial activity to promote full-thickness skin regeneration during wound healing10.1002/smll.201900046 ↗
59. The chemistry and engineering of polymeric hydrogel adhesives for wound closure: A tutorial10.1039/C4CS00332B ↗
60. Nanocomposite hydrogels for biomedical applications10.1002/bit.25160 ↗
61. Highly efficient self-healable and dual responsive hydrogel-based deformable triboelectric nanogenerators for wearable electronics10.1039/C9TA02711D ↗
62. A highly transparent and ultra-stretchable conductor with stable conductivity during large deformation10.1038/s41467-019-11364-w ↗
63. Injectable hypoxia-induced conductive hydrogel to promote diabetic wound healing10.1021/acsami.0c13197 ↗
64. Mechanical strong stretchable conductive multi-stimuli-responsive nanocomposite double network hydrogel as biosensor and actuator10.1080/09205063.2020.1775760 ↗
65. Multifunctional conductive hydrogels and their applications as smart wearable devices10.1039/D0TB02929G ↗
66. Antistaphylococcal and neutrophil chemotactic injectable κ-carrageenan hydrogel for infectious wound healing10.1021/acsabm.8b00625 ↗
67. Biofilm-inspired adhesive and antibacterial hydrogel with tough tissue integration performance for sealing hemostasis and wound healing
68. Engineering a sprayable and elastic hydrogel adhesive with antimicrobial properties for wound healing10.1016/j.biomaterials.2017.05.011 ↗
69. Property improvement of antibacterial wound dressing from basil seed (O. basilicum L.) mucilage- ZnO nanocomposite by borax cross-linking10.1016/j.carbpol.2019.115360 ↗
70. Advanced technology for functionalization of carbon nanotubes10.1016/j.pnsc.2008.08.011 ↗
71. Designable synthesis of nanocomposite hydrogels with excellent mechanical properties based on chemical cross-linked interactions10.1039/c0cc02839h ↗
72. Mechanical reinforcement of polyethylene using polyethylene-grafted multiwalled carbon nanotubes10.1002/adfm.200600599 ↗
73. Enhanced mechanical properties in cellulose nanocrystal–poly(oligoethylene glycol methacrylate) injectable nanocomposite hydrogels through control of physical and chemical cross-linking10.1021/acs.biomac.5b01598 ↗
74. Controllable hydrogel-thermal synthesis of Mn2O3/CNT aerogels: Shape evolution, growth mechanism and electrochemical properties10.1016/j.matdes.2019.108022 ↗
75. Novel electrically-conductive electro-responsive hydrogels for smart actuators with a carbon-nanotube-enriched three-dimensional conductive network and a physical-phase-type three-dimensional interpenetrating network10.1039/C9TC04428K ↗
76. Specific functionalization and polymer grafting on multi-walled carbon nanotubes to fabricate advanced nylon 12 composites10.1039/c3ta14528j ↗
77. Tough and responsive oppositely charged nanocomposite hydrogels for use as bilayer actuators assembled through interfacial electrostatic attraction10.1039/C6TB00583G ↗
78. Bacterial skin and soft tissue infections in adults: A review of their epidemiology, pathogenesis, diagnosis, treatment and site of care10.1155/2008/846453 ↗
79. Skin and soft-tissue infections: A critical review and the role of telavancin in their treatment10.1093/cid/civ528 ↗
80. Immune surveillance mechanisms of the skin against the stealth infection strategy of Pseudomonas aeruginosa—Review10.1016/j.cimid.2013.03.003 ↗
81. Improved biclique cryptanalysis of the lightweight block cipher piccolo10.1155/2017/7589306 ↗
82. Chronic wound infection: Facts and controversies10.1016/j.clindermatol.2010.03.009 ↗
83. Vig, K., Chaudhari, A., Tripathi, S., Dixit, S., Sahu, R., Pillai, S., Dennis, V.A., and Singh, S.R. (2017). Advances in skin regeneration using tissue engineering. Int. J. Mol. Sci., 18.10.3390/ijms18040789 ↗
84. Unalan, I., Endlein, S.J., Slavik, B., Buettner, A., Goldmann, W.H., Detsch, R., and Boccaccini, A.R. (2019). Evaluation of electrospun poly(ε-caprolactone)/gelatin nanofiber mats containing clove essential oil for antibacterial wound dressing. Pharmaceutics, 11.10.3390/pharmaceutics11110570 ↗
85. Single-walled carbon nanotubes exhibit strong antimicrobial activity10.1021/la701067r ↗
86. Antimicrobial activity of carbon-based nanoparticles
87. Prasad, R., Siddhardha, B., and Dyavaiah, M. (2020). Antibacterial activity by functionalized carbon nanotubes. Nanostructures for Antimicrobial and Antibiofilm Applications, Springer International Publishing.10.1007/978-3-030-40337-9 ↗
88. Carbon-based nanomaterials for removal of chemical and biological contaminants from water: A review of mechanisms and applications10.1016/j.carbon.2015.04.043 ↗
89. Antimicrobial activity of single-walled carbon nanotubes suspended in different surfactants10.1155/2012/928924 ↗
90. Single-walled carbon nanotubes-ciprofloxacin nanoantibiotic: Strategy to improve ciprofloxacin antibacterial activity10.2147/IJN.S140625 ↗
91. Heterojunction formation between copper(II) oxide nanoparticles and single-walled carbon nanotubes to enhance antibacterial performance10.1016/j.ijpharm.2020.119937 ↗
92. Masoumeh, A.M., Nejad, H.R., Pardis, S., and Ali, K.N.R. (2021). Improving antibacterial activity of methicillin by conjugation to functionalized single-wall carbon nanotubes against S. aureus. Res. Sq.10.21203/rs.3.rs-842189/v1 ↗
93. Lead sensors development and antimicrobial activities based on graphene oxide/carbon nanotube/poly(O-toluidine) nanocomposite10.1016/j.ijbiomac.2016.04.064 ↗
94. Bacteria capture and inactivation with functionalized multi-walled carbon nanotubes (MWCNTs)10.1166/jnn.2020.17332 ↗
95. A polycationic antimicrobial and biocompatible hydrogel with microbe membrane suctioning ability10.1038/nmat2915 ↗
96. A single-walled-carbon-nanotube filter for removal of viral and bacterial pathogens10.1002/smll.200700863 ↗
97. Antibiotic-induced bacterial cell death exhibits physiological and biochemical hallmarks of apoptosis10.1016/j.molcel.2012.04.027 ↗
98. Antimicrobial activity of single-walled carbon nanotubes: Length effect10.1021/la103110g ↗
99. A critical review of the biological mechanisms underlying the in vivo and in vitro toxicity of carbon nanotubes: The contribution of physico-chemical characteristics10.3109/17435390903569639 ↗
100. Carbon nanotube incorporation in PMMA to prevent microbial adhesion10.1038/s41598-019-41381-0 ↗