A Hybrid DenseNet-LSTM Model for Epileptic Seizure Prediction
Source abstract
Abstract
The number of people diagnosed with epilepsy as a common brain disease accounts for about 1% of the world’s total population. Seizure prediction is an important study that can improve the lives of patients with epilepsy, and, in recent years, it has attracted more and more attention. In this paper, we propose a novel hybrid deep learning model that combines a Dense Convolutional Network (DenseNet) and Long Short-Term Memory (LSTM) for epileptic seizure prediction using EEG data. The proposed method first converts the EEG data into the time-frequency domain through Discrete Wavelet Transform (DWT) for use in the input of the model. Then, we train the previously transformed image through a hybrid model combining Densenet and LSTM. To evaluate the performance of the proposed method, experiments are conducted for each preictal length of 5, 10, and 15 min using the CHB-MIT scalp EEG dataset. As a result, we obtained a prediction accuracy of 93.28%, a sensitivity of 92.92%, a specificity of 93.65%, a false positive rate of 0.063 per hour, and an F1-score of 0.923 when the preictal length was 5 min. Finally, as the proposed method is compared to previous studies, it is confirmed that the seizure prediction performance was improved significantly.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: EEG and Brain-Computer Interfaces · Epilepsy research and treatment · Advanced Memory and Neural Computing
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Computer Science, Hanyang University, Seoul 40763, Korea
Funding
Institute for Information communications Technology Promotion (IITP) grant funded by the Korea government (MSIP)
References (28)
Show source-provided references
1. ILAE official report: A practical clinical definition of epilepsy10.1111/epi.12550 ↗
2. World Health Organization (2006). Neurological Disorders: Public Health Challenges, World Health Organization.
3. Chiang, C.Y., Chang, N.F., Chen, T.C., Chen, H.H., and Chen, L.G. (September, January 30). Seizure prediction based on classification of EEG synchronization patterns with on-line retraining and post-processing scheme. Proceedings of the 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Boston, MA, USA.
4. Imagenet classification with deep convolutional neural networks10.1145/3065386 ↗
5. Huang, G., Liu, Z., Van Der Maaten, L., and Weinberger, K.Q. (2017, January 21–26). Densely connected convolutional networks. Proceedings of the 2017 IEEE Conference on Computer Vision and Pattern Recognition (CVPR), Honolulu, HI, USA.10.1109/CVPR.2017.243 ↗
6. Long short-term memory10.1162/neco.1997.9.8.1735 ↗
7. Comparison of three nonlinear seizure prediction methods by means of the seizure prediction characteristic10.1016/j.physd.2004.02.013 ↗
8. Spatio-temporal patient–individual assessment of synchronization changes for epileptic seizure prediction10.1016/j.clinph.2006.07.312 ↗
9. Seizure prediction using spike rate of intracranial EEG10.1109/TNSRE.2013.2282153 ↗
10. Epileptic seizure prediction using phase synchronization based on bivariate empirical mode decomposition10.1016/j.clinph.2013.09.047 ↗
11. Eftekhar, A., Juffali, W., El-Imad, J., Constandinou, T.G., and Toumazou, C. (2014). Ngram-derived pattern recognition for the detection and prediction of epileptic seizures. PLoS ONE, 9.10.1371/journal.pone.0096235 ↗
12. Elgohary, S., Eldawlatly, S., and Khalil, M.I. (2016, January 5–7). Epileptic seizure prediction using zero-crossings analysis of EEG wavelet detail coefficients. Proceedings of the 2016 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB), Chiang Mai, Thailand.10.1109/CIBCB.2016.7758115 ↗
13. Tsiouris, K.M., Pezoulas, V.C., Koutsouris, D.D., Zervakis, M., and Fotiadis, D.I. (2017, January 22–24). Discrimination of preictal and interictal brain states from long-term EEG data. Proceedings of the 2017 IEEE 30th International Symposium on Computer-Based Medical Systems (CBMS), Thessaloniki, Greece.10.1109/CBMS.2017.33 ↗
14. Prediction of epileptic seizures from EEG using analysis of ictal rules on Poincaré plane10.1016/j.cmpb.2017.04.001 ↗
15. Wavelet based deep learning approach for epilepsy detection10.1007/s13755-019-0069-1 ↗
16. Boonyakitanont, P., Lek-uthai, A., Chomtho, K., and Songsiri, J. (2019). A Comparison of Deep Neural Networks for Seizure Detection in EEG Signals. bioRxiv, 702654.10.1101/702654 ↗
17. Karim, A.M., Karal, Ö., and Çelebi, F. (2018, January 17–21). A new automatic epilepsy serious detection method by using deep learning based on discrete wavelet transform. Proceedings of the 3rd International Conference on Engineering Technology and Applied Sciences (ICETAS), Skopje, North Macedonia.
18. Scalp EEG epileptogenic zone recognition and localization based on long-term recurrent convolutional network10.1016/j.neucom.2018.10.108 ↗
19. Seizure prediction with spectral power of EEG using cost-sensitive support vector machines10.1111/j.1528-1167.2011.03138.x ↗
20. Low-complexity seizure prediction from iEEG/sEEG using spectral power and ratios of spectral power10.1109/TBCAS.2015.2477264 ↗
21. EEG-based prediction of epileptic seizures using phase synchronization elicited from noise-assisted multivariate empirical mode decomposition10.1109/TNSRE.2016.2618937 ↗
22. Convolutional neural networks for seizure prediction using intracranial and scalp electroencephalogram10.1016/j.neunet.2018.04.018 ↗
23. Focal onset seizure prediction using convolutional networks10.1109/TBME.2017.2785401 ↗
24. Seizure prediction in scalp EEG using 3D convolutional neural networks with an image-based approach10.1109/TNSRE.2019.2943707 ↗
25. Shoeb, A.H. (2009). Application of Machine Learning to Epileptic Seizure Onset Detection and Treatment. [Ph.D. Thesis, Massachusetts Institute of Technology].
26. Choi, G., Park, C., Kim, J., Cho, K., Kim, T.J., Bae, H., Min, K., Jung, K.Y., and Chong, J. (2019, January 11–13). A Novel Multi-scale 3D CNN with Deep Neural Network for Epileptic Seizure Detection. Proceedings of the 2019 IEEE International Conference on Consumer Electronics (ICCE), Las Vegas, NV, USA.10.1109/ICCE.2019.8661969 ↗
27. Continuous and discrete wavelet transforms10.1137/1031129 ↗
28. He, K., Zhang, X., Ren, S., and Sun, J. (2016, January 8–16). Identity mappings in deep residual networks. Proceedings of the European Conference on Computer Vision, Amsterdam, The Netherlands.10.1007/978-3-319-46493-0_38 ↗