journal article·2022-06-09Open access

Tea (Camellia sinensis): A Review of Nutritional Composition, Potential Applications, and Omics Research

Cheng Wang, Jingxue Han, Yuting Pu, Xiaojing Wang

Applied Sciences· Volume 12· Issue 12

Abstract

Tea (Camelliasinensis) is the world’s most widely consumed non-alcoholic beverage with essential economic and health benefits since it is an excellent source of polyphenols, catechins, amino acids, flavonoids, carotenoids, vitamins, and polysaccharides. The aim of this review is to summarize the main secondary metabolites in tea plants, and the content and distribution of these compounds in six different types of tea and different organs of tea plant were further investigated. The application of these secondary metabolites on food processing, cosmetics industry, and pharmaceutical industry was reviewed in this study. With the rapid advancements in biotechnology and sequencing technology, omics analyses, including genome, transcriptome, and metabolome, were widely used to detect the main secondary metabolites and their molecular regulatory mechanisms in tea plants. Numerous functional genes and regulatory factors have been discovered, studied, and applied to improve tea plants. Research advances, including secondary metabolites, applications, omics research, and functional gene mining, are comprehensively reviewed here. Further exploration and application trends are briefly described. This review provides a reference for basic and applied research on tea plants.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Tea Polyphenols and Effects · Phytochemicals and Antioxidant Activities · Food Quality and Safety Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Hubei Key Laboratory of Quality Control of Characteristic Fruits and Vegetables, College of Life Science and Technology, Hubei Engineering University, Xiaogan 432000, China

College of Tea Science, Guizhou University, Guiyang 550025, China

Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), Collaborative Innovation Center for Mountain Ecology & Agro-Bioengineering (CICMEAB), Institute of Agro-Bioengineering/College of Life Sciences, Guizhou University, Guiyang 550025, China

Funding

Science and Technology Project of Guizhou Province · Xiaogan Natural Science Project

References (100+)

Show source-provided references
1. Variation in Catechin Composition of Popularly Cultivated Tea Clones in East Africa (Kenya)10.4236/ajps.2013.43081 ↗
2. Identification of Teas Cultivated in Eastern, Southeastern and Southern Asia Based on Nucleotide Sequence Comparison of Ribulose 1,5-bisphosphate Carboxylase Large-subunit of Chloroplast DNA and 18S Ribosomal RNA of Nuclear DNA10.3136/fstr.21.381 ↗
3. Scaling relations of moment magnitude, local magnitude, and duration magnitude for earthquakes originated in northeast India10.1007/s11589-016-0154-3 ↗
4. A Study on Aflatoxin Content in Black Tea Available in Domestic Market in India10.29055/jccs/615 ↗
5. My tea party
6. Mondal, T.K. (2003). Micropropagation of tea (Camellia sinensis L.). Micropropagation of Woody Trees and Fruits, Springer.10.1007/978-94-010-0125-0_23 ↗
7. Antioxidant and antifungal activities of Camellia sinensis (L.) Kuntze leaves obtained by different forms of production10.1590/1519-6984.18814 ↗
8. Effects of bioactive components of Pu-erh tea on gut microbiomes and health: A review10.1016/j.foodchem.2021.129439 ↗
9. History of pu’er tea and comparative study for the effect of its various extracts on lipid-lowering diet
10. Associations of coffee genetic risk scores with consumption of coffee, tea and other beverages in the UK Biobank10.1111/add.13975 ↗
11. Tea polyphenols (TP): A promising natural additive for the manufacture of multifunctional active food packaging films
12. Dubey, K.K., Janve, M., Ray, A., and Singhal, R.S. (2020). Ready-to-Drink Tea. Trends in Non-Alcoholic Beverages, Academic Press.10.1016/B978-0-12-816938-4.00004-5 ↗
13. Effect of black tea on antioxidant, textural, and sensory properties of Chinese steamed bread10.1016/j.foodchem.2015.08.110 ↗
14. Comparative study on textural and rheological properties between dry white salted noodle and yellow alkaline noodle as influenced by different tea extracts10.1111/jfpp.14981 ↗
15. Formulation of a Dry Green Tea-Apple Product: Study on Antioxidant and Color Stability10.1111/j.1750-3841.2009.01489.x ↗
16. Green tea catechins reduced the glycaemic potential of bread: An in vitro digestibility study10.1016/j.foodchem.2015.02.054 ↗
17. Antioxidative effect of dietary tea catechins on lipid oxidation of long-term frozen stored chicken meat10.1016/S0309-1740(00)00112-1 ↗
18. Use of Antioxidants in Chicken Nuggets Manufactured with and Without the Use of Salt and/or Sodium Tripolyphosphate: Effects on Product Quality and Shelf-life Stability10.3923/ijps.2004.345.353 ↗
19. Addition of tea catechins and vitamin C on sensory evaluation, colour and lipid stability during chilled storage in cooked or raw beef and chicken patties10.1016/j.meatsci.2004.11.010 ↗
20. Koch, W., Zagórska, J., Marzec, Z., and Kukula-Koch, W. (2019). Applications of Tea (Camellia sinensis) and Its Active Constituents in Cosmetics. Molecules, 24.10.3390/molecules24234277 ↗
21. Green tea polyphenol (–)-epigallocatechin-3-gallate treatment to mouse skin prevents UVB-induced infiltration of leukocytes, depletion of antigen-presenting cells, and oxidative stress10.1189/jlb.69.5.719 ↗
22. Physiological effects of formulation containing tannase-converted green tea extract on skin care: Physical stability, collagenase, elastase, and tyrosinase activities10.1016/j.imr.2013.12.003 ↗
23. l-Theanine attenuates neointimal hyperplasia via suppression of vascular smooth muscle cell phenotypic modulation10.1016/j.jnutbio.2020.108398 ↗
24. γ-Radiation induced L-glutamic acid grafted highly porous, pH-responsive chitosan hydrogel beads: A smart and biocompatible vehicle for controlled anti-cancer drug delivery10.1016/j.ijbiomac.2021.03.134 ↗
25. The Effects of Glycine on Subjective Daytime Performance in Partially Sleep-Restricted Healthy Volunteers
26. Ultrahigh molecular weight polyethylene with improved crosslink density, oxidation stability, and microbial inhibition by chemical crosslinking and tea polyphenols for total joint replacements10.1002/app.51261 ↗
27. Preventive role of green tea catechins from obesity and related disorders especially hypercholesterolemia and hyperglycemia10.1186/s12967-015-0436-x ↗
28. Recent advances in tea polysaccharides: Extraction, purification, physicochemical characterization and bioactivities10.1016/j.carbpol.2016.08.022 ↗
29. Kitagawa, N., Morikawa, T., Motai, C., Ninomiya, K., Okugawa, S., Nishida, A., Yoshikawa, M., and Muraoka, O. (2016). The Antiproliferative Effect of Chakasaponins I and II, Floratheasaponin A, and Epigallocatechin 3-O-Gallate Isolated from Camellia sinensis on Human Digestive Tract Carcinoma Cell Lines. Int. J. Mol. Sci., 17.10.3390/ijms17121979 ↗
30. Content of Vitamin C and Ruthin in Krasnodar Tea
31. A review on selenium-enriched green tea: Fortification methods, biological activities and application prospect
32. A Comparative Study of Caffeinated Beverages; Tea and Energy Drink Consumption on Attention Span of Healthy Male and Female Subjects10.29052/IJEHSR.v4.i2.2016.22-26 ↗
33. Stepwise Identification of Six Tea (Camellia sinensis (L.)) Categories Based on Catechins, Caffeine, and Theanine Contents Combined with Fisher Discriminant Analysis10.1007/s12161-016-0518-2 ↗
34. Comparative effect of black, green, oolong, and white tea intake on weight gain and bile acid metabolism10.1016/j.nut.2019.02.006 ↗
35. Flavonoids, phenolic acids, alkaloids and theanine in different types of authentic Chinese white tea samples10.1016/j.jfca.2016.12.011 ↗
36. Investigation of free amino acids, bioactive and neuroactive compounds in different types of tea and effect of black tea processing10.1016/j.lwt.2019.108655 ↗
37. Fermentation process enhanced production and bioactivities of oolong tea polysaccharides10.1016/j.foodres.2011.11.027 ↗
38. Determination of flavonol glycosides in green tea, oolong tea and black tea by UHPLC compared to HPLC10.1016/j.foodchem.2015.03.024 ↗
39. Discriminating geographical origins of green tea based on amino acid, polyphenol, and caffeine content through high-performance liquid chromatography: Taking Lu’an guapian tea as an example10.1002/fsn3.1062 ↗
40. Bioactive compounds and antioxidant activity of black and green tea available in Bangladesh10.26656/fr.2017.5(3).491 ↗
41. Dynamic change in amino acids, catechins, alkaloids, and gallic acid in six types of tea processed from the same batch of fresh tea (Camellia sinensis L.) leaves10.1016/j.jfca.2019.01.005 ↗
42. Effect of whole green tea products including catechins, polysaccharides, and flavonols on the metabolism of added sugars10.1016/j.fbio.2021.100936 ↗
43. Assessment of the content and stability of tea polyphenols, free amino acids and vitamin C in four kinds of tea beverages
44. Erratum: Corrigendum: Safety and anti-hyperglycemic efficacy of various tea types in mice10.1038/srep35699 ↗
45. Determination of amino acids in white, green, black, oolong, pu-erh teas and tea products10.1016/j.jfca.2013.03.005 ↗
46. Black tea polyphenols and polysaccharides improve body composition, increase fecal fatty acid, and regulate fat metabolism in high-fat diet-induced obese rats10.1039/C6FO00401F ↗
47. Characterization of the antioxidant functions of flavonoids and proanthocyanidins in Mauritian black teas10.1016/j.foodres.2004.10.005 ↗
48. Jiang, X., Liu, Y., Li, W., Zhao, L., Meng, F., Wang, Y., Tan, H., Yang, H., Wei, C., and Wan, X. (2013). Tissue-Specific, Development-Dependent Phenolic Compounds Accumulation Profile and Gene Expression Pattern in Tea Plant (Camellia sinensis). PLoS ONE, 8.10.1371/journal.pone.0062315 ↗
49. Integration of non-targeted metabolomics and E-tongue evaluation reveals the chemical variation and taste characteristics of five typical dark teas10.1016/j.lwt.2021.111875 ↗
50. Dark tea extracts: Chemical constituents and modulatory effect on gastrointestinal function10.1016/j.biopha.2020.110514 ↗
51. Analysis of Tea Polyphenols
52. Composition of Polyphenols in Fresh Tea Leaves and Associations of Their Oxygen-Radical-Absorbing Capacity with Antiproliferative Actions in Fibroblast Cells10.1021/jf950652k ↗
53. Total Polyphenol Content and Antioxidant Capacity of Commercially Available Tea (Camellia sinensis) in Argentina10.1021/jf8022782 ↗
54. Identification of d-amino acids in tea leaves10.1016/j.foodchem.2020.126428 ↗
55. Developmental changes in carbon and nitrogen metabolism affect tea quality in different leaf position10.1016/j.plaphy.2016.06.027 ↗
56. Characterization of white tea metabolome: Comparison against green and black tea by a nontargeted metabolomics approach10.1016/j.foodres.2017.03.028 ↗
57. Identification and characterization of cationic amino acid transporters (CATs) in tea plant (Camellia sinensis)10.1007/s10725-017-0321-0 ↗
58. Amino acid composition of soybean seeds as affected by climatic variables10.1590/S0100-204X2011001200001 ↗
59. Effect of light quality on the accumulation of photosynthetic pigments, proteins and mycosporine-like amino acids in the red alga Porphyra leucosticta (Bangiales, Rhodophyta)10.1016/j.jphotobiol.2005.03.002 ↗
60. Quality evaluation of green tea leaf cultured under artificial light condition using gas chromatography/mass spectrometry10.1016/j.jbiosc.2016.07.017 ↗
61. Dynamic changes in amino acids, catechins, caffeine and gallic acid in green tea during withering10.1016/j.jfca.2017.12.008 ↗
62. Antimicrobial activity of tea catechin against canine oral bacteria and the functional mechanisms10.1292/jvms.16-0198 ↗
63. Comparative study of polyphenols and caffeine in different coffee varieties affected by the degree of roasting10.1016/j.foodchem.2011.05.059 ↗
64. Studies of quality development and major chemical composition of green tea processed from tea with different shoot maturity10.1016/j.lwt.2021.111055 ↗
65. Determination of Caffeine Content in Tea and Maté Tea by using Different Methods10.17221/612-CJFS ↗
66. Prediction of amino acids, caffeine, theaflavins and water extract in black tea using FT-NIR spectroscopy coupled chemometrics algorithms10.1039/C8AY00731D ↗
67. Tea aroma formation from six model manufacturing processes10.1016/j.foodchem.2019.01.174 ↗
68. Pre- and post-harvest exposure to stress influence quality-related metabolites in fresh tea leaves (Camellia sinensis)10.1016/j.scienta.2021.109984 ↗
69. Chen, C., Zhu, H., Kang, J., Warusawitharana, H.K., Chen, S., Wang, K., Yu, F., Wu, Y., He, P., and Tu, Y. (2022). Comparative Transcriptome and Phytochemical Analysis Provides Insight into Triterpene Saponin Biosynthesis in Seeds and Flowers of the Tea Plant (Camellia sinensis). Metabolites, 12.10.3390/metabo12030204 ↗
70. Wu, X., Jia, L., Wu, J., Liu, Y., Kang, H., Liu, X., Li, P., He, P., Tu, Y., and Li, B. (2019). Simultaneous determination and quantification of triterpene saponins from Camellia sinensis seeds using UPLC-PDA-QTOF-MS/MS. Molecules, 24.10.3390/molecules24203794 ↗
71. Composition and bioactivity of tea flower polysaccharides obtained by different methods10.1016/j.carbpol.2009.08.030 ↗
72. Prevention of Chronic Diseases by Tea: Possible Mechanisms and Human Relevance10.1146/annurev-nutr-071811-150717 ↗
73. A review of latest research findings on the health promotion properties of tea10.1016/S0955-2863(01)00155-3 ↗
74. Tea polyphenols for health promotion10.1016/j.lfs.2007.06.011 ↗
75. Antioxidant Activity of Tea Polyphenols In Vivo: Evidence from Animal Studies10.1093/jn/133.10.3275S ↗
76. Recent advances on tea polyphenols10.2741/e363 ↗
77. Tea polyphenols: Prevention of cancer and optimizing health10.1093/ajcn/71.6.1698S ↗
78. Khan, N., and Mukhtar, H. (2018). Tea Polyphenols in Promotion of Human Health. Nutrients, 11.10.3390/nu11010039 ↗
79. Antioxidative and anti-carcinogenic activities of tea polyphenols10.1007/s00204-008-0372-0 ↗
80. l-Theanine reduces psychological and physiological stress responses10.1016/j.biopsycho.2006.06.006 ↗
81. L-theanine—A unique amino acid of green tea and its relaxation effect in humans10.1016/S0924-2244(99)00044-8 ↗
82. An overview of biological production of L-theanine10.1016/j.biotechadv.2015.04.004 ↗
83. Reduction Effect of Theanine on Blood Pressure and Brain 5-Hydroxyindoles in Spontaneously Hypertensive Rats10.1271/bbb.59.615 ↗
84. Anti-obesity effects of three major components of green tea, catechins, caffeine and theanine, in mice
85. Effect of coffee on endothelial function in healthy subjects: The role of caffeine10.1042/CS20040358 ↗
86. Caffeine withdrawal: A parametric analysis of caffeine dosing conditions
87. Effect of caffeine on skeletal muscle function before and after fatigue
88. The influences of age and caffeine on psychomotor and cognitive function10.1007/s002130051047 ↗
89. The impact of caffeine on mood, cognitive function, performance and hydration: A review of benefits and risks10.1111/j.1467-3010.2007.00665.x ↗
90. Thermal Effects on the Stability and Antioxidant Activity of an Acid Polysaccharide Conjugate Derived from Green Tea10.1021/jf9007696 ↗
91. Extraction, characterization and antioxidant activities of Se-enriched tea polysaccharides10.1016/j.ijbiomac.2015.02.052 ↗
92. Structure–function relationships of immunostimulatory polysaccharides: A review10.1016/j.carbpol.2015.05.079 ↗
93. Inhibitory Effects and Molecular Mechanisms of Selenium-Containing Tea Polysaccharides on Human Breast Cancer MCF-7 Cells10.1021/jf3036929 ↗
94. Effect of tea polysaccharides on immune functions and antioxdative activity in broilers
95. Structure characterization of an arabinogalactan from green tea and its anti-diabetic effect10.1016/j.carbpol.2015.01.070 ↗
96. Antioxidant mechanism of tea polyphenols and its impact on health benefits10.1016/j.aninu.2020.01.001 ↗
97. Protective effects of catechin and quercetin on antioxidant status, lipid peroxidation and testis-histoarchitecture induced by chlorpyrifos in male rats10.1016/j.etap.2011.12.008 ↗
98. Oral administration of green tea polyphenols (TP) improves ileal injury and intestinal flora disorder in mice with Salmonella typhimurium infection via resisting inflammation, enhancing antioxidant action and preserving tight junction10.1016/j.jff.2019.103654 ↗
99. EGCG protects against UVB-induced apoptosis via oxidative stress and the JNK1/c-Jun pathway in ARPE19 cells
100. Activation of antioxidant-response element (ARE), mitogen-activated protein kinases (MAPKs) and caspases by major green tea polyphenol components during cell survival and death10.1007/BF02975249 ↗