Crosslinking Collagen Constructs: Achieving Cellular Selectivity Through Modifications of Physical and Chemical Properties
Source abstract
Abstract
Collagen-based constructs have emerged in recent years as ideal candidates for tissue engineering implants. For many biomedical applications, collagen is crosslinked in order to improve the strength, stiffness and stability of the construct. However, the crosslinking process may also result in unintended changes to cell viability, adhesion or proliferation on the treated structures. This review provides a brief overview of some of both the most commonly used and novel crosslinkers used with collagen, and suggests a framework by which crosslinking methods can be compared and selected for a given tissue engineering application.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Collagen: Extraction and Characterization · biodegradable polymer synthesis and properties · Connective tissue disorders research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Cambridge Centre for Medical Materials, Department of Materials Science and Metallurgy, University of Cambridge, 27 Charles Babbage Road, Cambridge CB3 0FS, UK
Funding
Engineering and Physical Sciences Research Council · Bill and Melinda Gates Foundation
References (39)
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