journal article·2024-02-08Open access

An Overview of Biopolymers for Drug Delivery Applications

Ocsana Opriș, Cristina Mormile, Ildiko Lung, Adina Stegarescu, Maria-Loredana Soran, Albert Soran

Applied Sciences· Volume 14· Issue 4

Abstract

Nowadays, drug delivery has an important role in medical therapy. The use of biopolymers in developing drug delivery systems (DDSs) is increasingly attracting attention due to their remarkable and numerous advantages, in contrast to conventional polymers. Biopolymers have many advantages (biodegradability, biocompatibility, renewability, affordability, and availability), which are extremely important for developing materials with applications in the biomedical field. Additionally, biopolymers are appropriate when they improve functioning and have a number of positive effects on human life. Therefore, this review presents the most used biopolymers for biomedical applications, especially in drug delivery. In addition, by combining different biopolymers DDSs with tailored functional properties (e.g., physical properties, biodegradability) can be developed. This review summarizes and provides data on the progress of research on biopolymers (chitosan, alginate, starch, cellulose, albumin, silk fibroin, collagen, and gelatin) used in DDSs, their preparation, and mechanism of action.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: biodegradable polymer synthesis and properties · Advanced Drug Delivery Systems · Electrospun Nanofibers in Biomedical Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

National Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donat, 400293 Cluj-Napoca, Romania

Faculty of Chemistry, University of Rome La Sapienza, P. le Aldo Moro 5, 00185 Rome, Italy

INFN—National Laboratories of Frascati, Via Enrico Fermi 54, 00044 Frascati, Italy

Department of Chemistry, Supramolecular Organic and Organometallic Chemistry Centre (SOOMCC), Faculty of Chemistry and Chemical Engineering, Babes-Bolyai University, 11 Arany Janos, 400028 Cluj-Napoca, Romania

References (100+)

Show source-provided references
1. Cui, X., Li, X., Xu, Z., Guan, X., Ma, J., Ding, D., and Zhang, W. (2021). Fabrication and characterization of chitosan/poly (lactic-co-glycolic acid) core-shell nanoparticles by coaxial electrospray technology for dual delivery of natamycin and clotrimazole. Front. Bioeng. Biotechnol., 9.10.3389/fbioe.2021.635485 ↗
2. 3D printing of mesoporous bioactive glass/silk fibroin composite scaffolds for bone tissue engineering10.1016/j.msec.2019.05.016 ↗
3. Varaprasad, K. (2022). Woodhead Publishing Series in Biomaterials, Polymeric Biomaterials for Healthcare Applications, Woodhead Publishing.
4. A review on poly lactic acid (PLA) as a biodegradable polymer10.1007/s00289-022-04160-y ↗
5. Biomedical biopolymers, their origin and evolution in biomedical sciences: A systematic review
6. Jummaat, F., Bashir Yahya, E., Khalil H.P.S., A., Adnan, A.S., Mohammed Alqadhi, A., Abdullah, C.K., Sofea, A.A., Olaiya, N.G., Abdat, M., and Hps, K. (2021). The role of biopolymer-based materials in obstetrics and gynecology applications: A review. Polymers, 13.10.3390/polym13040633 ↗
7. Reddy, M.S.B., Ponnamma, D., Choudhary, R., and Sadasivuni, K.K. (2021). A comparative review of natural and synthetic biopolymer composite scaffolds. Polymers, 13.10.3390/polym13071105 ↗
8. Olivia, M., Jingga, H., Toni, N., and Wibisono, G. (2018, January 24–26). Biopolymers to improve physical properties and leaching characteristics of mortar and concrete: A review. Proceedings of the IOP Conference Series: Materials Science and Engineering, Bangkok, Thailand.10.1088/1757-899X/345/1/012028 ↗
9. Natural-based plasticizers and biopolymer films: A review10.1016/j.eurpolymj.2010.12.011 ↗
10. Folic acid-conjugated pH and redox-sensitive ellipsoidal hybrid magnetic nanoparticles for dual-triggered drug release10.1021/acsabm.0c00488 ↗
11. Paclitaxel/gelatin coated magnetic mesoporous silica nanoparticles: Preparation and antitumor efficacy in vivo10.1016/j.micromeso.2014.11.013 ↗
12. Dumontel, B., Conejo-Rodríguez, V., Vallet-Regí, M., and Manzano, M. (2023). Natural biopolymers as smart coating materials of mesoporous silica nanoparticles for drug delivery. Pharmaceutics, 15.10.3390/pharmaceutics15020447 ↗
13. Synthetic biopolymers and their composites: Advantages and limitations—An overview10.1002/marc.202100130 ↗
14. Gnanasekaran, D. (2019). Green Polymers and Their Nanocomposites, Springer.10.1007/978-981-13-8063-1 ↗
15. Nanotech drug delivery system: The perfect physio-chemical deal for biological command10.18231/j.jpbs.2021.010 ↗
16. Chitosan: A natural antimicrobial agent—A review
17. Renewable cellulosic nanocomposites for food packaging to avoid fossil fuel plastic pollution: A review10.1007/s10311-020-01090-x ↗
18. Hamouda, T. (2021). Biopolymers and Biocomposites from Agro-Waste for Packaging Applications, Elsevier.
19. Recent developments on biodegradable polymers and their future trends
20. Chen, H., Wang, J., Cheng, Y., Wang, C., Liu, H., Bian, H., Pan, Y., Sun, J., and Han, W. (2019). Application of protein-based films and coatings for food packaging: A review. Polymers, 11.10.3390/polym11122039 ↗
21. Thakur, V.K., and Thakur, M.K. (2018). Functional Biopolymers, Springer.10.1007/978-3-319-66417-0 ↗
22. Varma, K., and Gopi, S. (2021). Biopolymers and Their Industrial Applications, Elsevier.
23. Temesgen, S., Rennert, M., Tesfaye, T., and Nase, M. (2021). Review on spinning of biopolymer fibers from starch. Polymers, 13.10.3390/polym13071121 ↗
24. Gustafsson, J., Landberg, M., Bátori, V., Akesson, D., Taherzadeh, M.J., and Zamani, A. (2019). Development of bio-based films and 3D objects from apple pomace. Polymers, 11.10.3390/polym11020289 ↗
25. Smart biopolymers and their biomedical applications10.1016/j.promfg.2017.08.030 ↗
26. Torres, F.G., Troncoso, O.P., Pisani, A., Gatto, F., and Bardi, G. (2019). Natural polysaccharide nanomaterials: An overview of their immunological properties. Int. J. Mol. Sci., 20.10.3390/ijms20205092 ↗
27. Effective drug delivery system of biopolymers based on nanomaterials and hydrogels—A review10.4172/2169-0138.1000129 ↗
28. Natural polymers—A comprehensive review
29. Biopolymer based nanomaterials in drug delivery systems: A review10.1016/j.mtchem.2018.05.002 ↗
30. Physicochemical characterization of chitin and chitosan from crab shells10.1016/j.carbpol.2008.06.006 ↗
31. Hydroxyapatite grafted chitosan/laponite RD hydrogel: Evaluation of the encapsulation capacity, pH-responsivity, and controlled release behavior10.1016/j.ijbiomac.2021.08.220 ↗
32. Preparation and evaluation of chitosan biocompatible electronic skin10.1016/j.compind.2018.03.040 ↗
33. Synthesis and performance evaluation of PES/ chitosan membranes coated with polyamide for acid mine drainage treatment10.1038/s41598-019-53512-8 ↗
34. Stability of chitosan—A challenge for pharmaceutical and biomedical applications10.3390/md13041819 ↗
35. The promise of chitosan microspheres in drug delivery systems10.1517/17425247.4.3.263 ↗
36. Chitosan as an environment friendly biomaterial—A review on recent modifications and applications10.1016/j.ijbiomac.2019.10.113 ↗
37. Chitosan biomaterials application in dentistry10.1016/j.ijbiomac.2020.06.211 ↗
38. Recent advancement of biopolymers and their potential biomedical applications10.1007/s10924-021-02199-y ↗
39. pH-responsive chitosan based hydrogels affect the release of dapsone: Design, set-up, and physicochemical characterization10.1016/j.ijbiomac.2019.04.178 ↗
40. Biodegradable thermoresponsive polymers: Applications in drug delivery and tissue engineering10.1016/j.polymer.2020.123063 ↗
41. Morin-Crini, N., Lichtfouse, E., Torri, G., and Crini, G. (2019). Sustainable Agriculture Reviews, Springer.10.1007/978-3-030-16538-3 ↗
42. A review on chitosan-cellulose blends and nanocellulose reinforced chitosan biocomposites: Properties and their applications10.1016/j.carbpol.2016.05.028 ↗
43. Kaur, M., Sharma, A., Puri, V., Aggarwal, G., Maman, P., Huanbutta, K., Nagpal, M., and Sangnim, T. (2023). Chitosan-based polymer blends for drug delivery systems. Polymers, 15.10.3390/polym15092028 ↗
44. Preparation and properties of chitosan/dialdehyde sodium alginate/dopamine magnetic drug-delivery hydrogels10.1016/j.colsurfa.2023.132739 ↗
45. Folate-modified carboxymethyl chitosan-based drug delivery system for breast cancer specific combination therapy via regulating mitochondrial calcium concentration10.1016/j.carbpol.2023.121434 ↗
46. Effect of molecular weight of chitosan on the physicochemical, morphological, and biological properties of polyplex nanoparticles intended for gene delivery
47. Low molecular weight chitosan nanoparticulate system at low N:P ratio for nontoxic polynucleotide delivery
48. Chitosan-DNA nanoparticles as gene carriers: Synthesis, characterization and transfection efficiency10.1016/S0168-3659(00)00361-8 ↗
49. Garshasbi, H., Salehi, S., Naghib, S.M., Ghorbanzadeh, S., and Zhang, W. (2023). Stimuli-responsive injectable chitosan-based hydrogels for controlled drug delivery systems. Front. Bioeng. Biotechnol., 10.10.3389/fbioe.2022.1126774 ↗
50. Preparation methods of alginate nanoparticles10.1016/j.cis.2014.03.009 ↗
51. Alginate nanoparticles for drug delivery and targeting10.2174/1381612825666190425163424 ↗
52. Martau, G.A., Mihai, M., and Vodnar, D.C. (2019). The use of chitosan, alginate, and pectin in the biomedical and food sector-biocompatibility, bioadhesiveness, and biodegradability. Polymers, 11.10.3390/polym11111837 ↗
53. Smith, A.M., and Miri, T. (2010). Practical Food Rheology: An Interpretive Approach, John Wiley & Sons.
54. Biopolymer-based nanoparticles and microparticles: Fabrication, characterization, and application10.1016/j.cocis.2014.07.002 ↗
55. Dual cross-linked chitosan/alginate hydrogels prepared by Nb-Tz ‘click’ reaction for pH responsive drug delivery10.1016/j.carbpol.2022.119389 ↗
56. Fabrication of self-healing pectin/chitosan hybrid hydrogel via Diels-Alder reactions for drug delivery with high swelling property, pH-responsiveness, and cytocompatibility10.1016/j.carbpol.2021.118244 ↗
57. Effect of heat-moisture treatment under mildly acidic condition on fragmentation of waxy maize starch granules into nanoparticles10.1016/j.foodhyd.2016.08.018 ↗
58. Fast and scalable preparation of starch nanoparticles by stirred media milling10.1016/j.apt.2016.04.021 ↗
59. Development of native and modified banana starch nanoparticles as vehicles for curcumin10.1016/j.ijbiomac.2018.01.063 ↗
60. Study of the shear and extensional rheology of casein, waxy maize starch and their mixtures10.1016/j.foodhyd.2007.02.001 ↗
61. Formulation and in-vitro evaluation of novel starch-based tableted microspheres for controlled release of ampicillin10.1016/j.carbpol.2007.05.013 ↗
62. Intranasal administration of melatonin starch microspheres
63. Starch chemical modifications applied to drug delivery systems: From fundamentals to FDA-approved raw materials10.1016/j.ijbiomac.2021.06.077 ↗
64. Research advances in chemical modifications of starch for hydrophobicity and its applications: A review10.1016/j.carbpol.2020.116292 ↗
65. Ab’lah, N., Yusuf, C.Y.L., Rojsitthisak, P., and Wong, T.W. (2023). Reinvention of starch for oral drug delivery system design. Int. J. Biol. Macromol., 241.10.1016/j.ijbiomac.2023.124506 ↗
66. Acetylated starch nanocrystals: Preparation and antitumor drug delivery study10.1016/j.ijbiomac.2016.04.037 ↗
67. Yasar, H., Ho, D.K., De Rossi, C., Herrmann, J., Gordon, S., Loretz, B., and Lehr, C.M. (2018). Starch-chitosan polyplexes: A versatile carrier system for anti-infectives and gene delivery. Polymers, 10.10.3390/polym10030252 ↗
68. Development of ibuprofen microspheres using acetylated plantain starches as polymer for sustained release10.1007/s40005-017-0345-5 ↗
69. Targeted hydroxyethyl starch prodrug for inhibiting the growth and metastasis of prostate cancer10.1016/j.biomaterials.2016.11.030 ↗
70. Starch modified alginate nanoparticles for drug delivery application10.1016/j.ijbiomac.2020.12.227 ↗
71. Atanase, L.I. (2021). Micellar drug delivery systems based on natural biopolymers. Polymers, 13.10.3390/polym13030477 ↗
72. Cellulose: A fascinating biopolymer for hydrogel synthesis10.1039/D1TB02848K ↗
73. Recent advancements in 3D bioprinting technology of carboxymethyl cellulose-based hydrogels: Utilization in tissue engineering10.1016/j.cis.2021.102415 ↗
74. Yang, J., Medronho, B., Lindman, B., and Norgren, M. (2020). Simple one pot preparation of chemical hydrogels from cellulose dissolved in cold LiOH/Urea. Polymers, 12.10.3390/polym12020373 ↗
75. Preparation of cellulose-based hydrogel: A review10.1016/j.jmrt.2020.12.012 ↗
76. Chitosan-ethyl cellulose microspheres of domperidone for nasal delivery: Preparation, in-vitro characterization, in-vivo study for pharmacokinetic evaluation and bioavailability enhancement10.1016/j.jddst.2021.102471 ↗
77. Barium ion cross-linked alginate-carboxymethyl cellulose composites for controlled release of anticancer drug methotrexate10.1016/j.jddst.2019.101324 ↗
78. Synthesis of thermoresponsive composite hydrogel from Pluronic F127 reinforced by oil palm empty fruit bunches-extracted cellulose for silver sulfadiazine drug delivery10.1016/j.scp.2022.100939 ↗
79. Hyaluronan as tunable drug delivery system10.1016/j.addr.2019.08.006 ↗
80. Hyaluronic acid-based nano-composite hydrogels for ocular drug delivery applications10.1002/jbm.a.34976 ↗
81. Hyaluronic acid-based biopharmaceutical delivery and tumor-targeted drug delivery system10.1016/j.jconrel.2018.04.015 ↗
82. Bera, H., Hossain, C.M., and Saha, S. (2021). Biopolymer-Based Nanomaterials in Drug Delivery and Biomedical Applications, Academic Press.10.1016/B978-0-12-820874-8.00002-6 ↗
83. Petrovici, A.R., Pinteala, M., and Simionescu, N. (2023). Dextran formulations as effective delivery systems of therapeutic agents. Molecules, 28.10.3390/molecules28031086 ↗
84. Dextran based polymeric micelles as carriers for delivery of hydrophobic drugs10.2174/1567201813666160513132456 ↗
85. Polymeric micelles in cancer therapy: State of the art10.1016/j.jconrel.2021.02.016 ↗
86. Cyclodextrins and derivatives in drug delivery: New developments, relevant clinical trials, and advanced products10.1016/j.carbpol.2023.121500 ↗
87. Synthesis and physico-chemical characterization of a β-cyclodextrin conjugate for sustained release of Acyclovir10.1016/j.carbpol.2015.05.071 ↗
88. β-Cyclodextrin-dextran polymers for the solubilization of poorly soluble drugs10.1016/j.ijpharm.2014.04.029 ↗
89. Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles10.1016/j.jconrel.2008.05.010 ↗
90. Albumin-based drug delivery: Harnessing nature to cure disease10.1186/s40591-016-0048-8 ↗
91. Graphene quantum dots conjugated albumin nanoparticles for targeted drug delivery and imaging of pancreatic cancer10.1039/C4TB00015C ↗
92. Advances in research on preparation, characterization, interaction with proteins, digestion and delivery systems of starch-based nanoparticles10.1016/j.ijbiomac.2020.02.156 ↗
93. New and novel approaches for enhancing the oral absorption and bioavailability of protein and peptides therapeutics10.4155/tde-2020-0068 ↗
94. Formation of complexes between tannic acid with bovine serum albumin, egg ovalbumin and bovine beta-lactoglobulin10.1016/j.foodres.2017.10.007 ↗
95. Hyaluronic acid and albumin based nanoparticles for drug delivery10.1016/j.jconrel.2021.01.033 ↗
96. Spinning and applications of bioinspired fiber systems10.1021/acsnano.8b09651 ↗
97. Silk fibroin-based biomaterials for biomedical10.3390/polym11121933 ↗
98. Silk-based biomaterials for sustained drug delivery10.1016/j.jconrel.2014.05.059 ↗
99. Tomeh, M.A., Hadianamrei, R., and Zhao, X. (2019). Silk fibroin as a functional biomaterial for drug and gene delivery. Pharmaceutics, 11.10.3390/pharmaceutics11100494 ↗
100. Silk-based biopolymers promise extensive biomedical applications in tissue engineering, drug delivery, and BioMEMS10.1007/s10924-023-02906-x ↗