journal article·2020-10-13Open access

Mechanisms of Fluoride Toxicity: From Enzymes to Underlying Integrative Networks

Anna Strunecka, Otakar Strunecky

Applied Sciences· Volume 10· Issue 20

Abstract

Fluoride has been employed in laboratory investigations since the early 20th century. These studies opened the understanding of fluoride interventions to fundamental biological processes. Millions of people living in endemic fluorosis areas suffer from various pathological disturbances. The practice of community water fluoridation used prophylactically against dental caries increased concern of adverse fluoride effects. We assessed the publications on fluoride toxicity until June 2020. We present evidence that fluoride is an enzymatic poison, inducing oxidative stress, hormonal disruptions, and neurotoxicity. Fluoride in synergy with aluminum acts as a false signal in G protein cascades of hormonal and neuronal regulations in much lower concentrations than fluoride acting alone. Our review shows the impact of fluoride on human health. We suggest focusing the research on fluoride toxicity to the underlying integrative networks. Ignorance of the pluripotent toxic effects of fluoride might contribute to unexpected epidemics in the future.
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Research context

OpenAlex topics: Fluoride Effects and Removal · Dental Health and Care Utilization · Bone and Dental Protein Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

The Institute of Technology and Business, Okružní 517/10, 370 01 České Budějovice, Czech Republic

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