journal article·2022-03-17Open access

Hyaluronic Acid-Based Wound Dressing with Antimicrobial Properties for Wound Healing Application

Francesca Della Sala, Gennaro Longobardo, Antonio Fabozzi, Mario di Gennaro, Assunta Borzacchiello

Applied Sciences· Volume 12· Issue 6

Abstract

Wound healing is a naturally occurring process that can be aided by a wound dressing properly designed to assure an efficient healing process. An infection caused by several microorganisms could interfere with this process, delaying or even impairing wound healing. Hyaluronic acid (HA), a main constituent of the extracellular matrix (ECM) of a vertebrate’s connective tissue, represents a promising biomaterial for wound dressing thanks to its intrinsic biocompatibility, hydrophilicity and bacteriostatic properties. In this review, different and recent types of HA-based wound dressings endowed with intrinsic antimicrobial properties or co-adjuvated by antimicrobial natural or synthetic agents are highlighted.
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Research context

OpenAlex topics: Wound Healing and Treatments · Silk-based biomaterials and applications · Electrospun Nanofibers in Biomedical Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Polymers, Composites and Biomaterials, National Research Council (IPCB-CNR), Viale J.F. Kennedy 54, 80125 Naples, Italy

Department of Chemical, Materials and Production Engineering, University of Naples Federico II, Piazzale V. Tecchio 80, 80125 Naples, Italy

Altergon Italia s.r.l., Zona Industriale ASI, 83040 Morra De Sanctis, Italy

Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania “Luigi Vanvitelli”, Via Vivaldi 43, 81100 Caserta, Italy

References (44)

Show source-provided references
1. Surgical physiology of wound healing: A review
2. Wound repair and regeneration10.1159/000339613 ↗
3. Factors affecting wound healing10.1177/0022034509359125 ↗
4. Antibiofilm and antimicrobial efficacy of DispersinB®-KSL-W peptide-based wound gel against chronic wound infection associated bacteria10.1007/s00284-014-0519-6 ↗
5. Development of a novel, highly quantitative in vivo model for the study of biofilm-impaired cutaneous wound healing10.1111/j.1524-475X.2011.00690.x ↗
6. Wound dressings: Current advances and future directions10.1002/app.47738 ↗
7. Bacteriostatic properties of biomatrices against common orthopaedic pathogens10.1016/j.bbrc.2004.06.165 ↗
8. Recent progress of in situ formed gels for biomedical applications10.1016/j.progpolymsci.2012.08.002 ↗
9. Della Sala, F., di Gennaro, M., Lista, G., Messina, F., Ambrosio, L., and Borzacchiello, A. (2021). Effect of Hyaluronic Acid on the Differentiation of Mesenchymal Stem Cells into Mature Type II Pneumocytes. Polymers, 13.10.3390/polym13172928 ↗
10. Hyaluronan-coated nanoparticles for active tumor targeting: Influence of polysaccharide molecular weight on cell uptake10.1016/j.colsurfb.2021.112240 ↗
11. On the bacteriostatic activity of hyaluronic acid composite films10.1016/j.carbpol.2021.117803 ↗
12. Fallacara, A., Vertuani, S., Panozzo, G., Pecorelli, A., Valacchi, G., and Manfredini, S. (2017). Novel artificial tears containing cross-linked hyaluronic acid: An in vitro re-epithelialization study. Molecules, 22.10.3390/molecules22122104 ↗
13. Biosynthesis and characterization of antibacterial thermosensitive hydrogels based on corn silk extract, hyaluronic acid and nanosilver for potential wound healing10.1016/j.carbpol.2019.115023 ↗
14. Makvandi, P., Caccavale, C., Della Sala, F., Zeppetelli, S., Veneziano, R., and Borzacchiello, A. (2020). Natural Formulations Provide Antioxidant Complement to Hyaluronic Acid-Based Topical Applications Used in Wound Healing. Polymers, 12.10.3390/polym12081847 ↗
15. Electrospinning in water and in situ crosslinking of hyaluronic acid/cyclodextrin nanofibers: Towards wound dressing with controlled drug release10.1016/j.carbpol.2018.11.085 ↗
16. Potential of novel electrospun core-shell structured polyurethane/starch (hyaluronic acid) nanofibers for skin tissue engineering: In vitro and in vivo evaluation10.1016/j.ijbiomac.2019.11.233 ↗
17. A non-woven fabric wound dressing containing layer–by–layer deposited hyaluronic acid and chitosan10.1016/j.ijbiomac.2018.03.149 ↗
18. A clinical evaluation of the comparable efficacy of hyaluronic acid-based foam and ceramide-containing emulsion cream in the treatment of mild-to-moderate atopic dermatitis10.1111/j.1473-2165.2011.00568.x ↗
19. Hyaluronan based materials with catanionic sugar-derived surfactants as drug delivery systems10.1016/j.colsurfb.2018.01.037 ↗
20. Dermal wound healing processes with curcumin incorporated collagen films10.1016/S0142-9612(03)00625-2 ↗
21. Hyaluronic acid and its composites as a local antimicrobial/antiadhesive barrier10.7150/jbji.17705 ↗
22. Bacteriostatic effects of hyaluronic acid10.1902/jop.1999.70.4.370 ↗
23. Bacteriostatic effects of hyaluronan-based bioresorbable membrane10.4236/ss.2011.29094 ↗
24. Synthesis and characterization of hyaluronic acid hydrogels crosslinked using a solvent-free process for potential biomedical applications10.1016/j.carbpol.2017.12.015 ↗
25. The ability of bacteria to use Na-hyaluronate as a nutrient10.1111/j.1600-0420.1996.tb00736.x ↗
26. Octadecyl chains immobilized onto hyaluronic acid coatings by thiol–ene Click Chemistry increase the surface antimicrobial properties and prevent platelet adhesion and activation to polyurethane10.1021/acsami.6b16415 ↗
27. Polyethyleneimine modified poly (Hyaluronic acid) particles with controllable antimicrobial and anticancer effects10.1016/j.carbpol.2016.12.024 ↗
28. Addition of antimicrobial properties to hyaluronic acid by grafting of antimicrobial peptide10.1016/j.eurpolymj.2013.11.012 ↗
29. Wound healing of different molecular weight of hyaluronan; in-vivo study10.1016/j.ijbiomac.2016.05.021 ↗
30. Hyaluronic acid and metallic silver treatment of chronic wounds: Healing rate and bacterial load control10.12968/jowc.2019.28.7.482 ↗
31. Antimicrobial activity of new materials based on the blends of collagen/chitosan/hyaluronic acid with gentamicin sulfate addition10.1016/j.msec.2018.01.005 ↗
32. Biofunctions of antimicrobial peptide-conjugated alginate/hyaluronic acid/collagen wound dressings promote wound healing of a mixed-bacteria-infected wound10.1016/j.ijbiomac.2019.08.087 ↗
33. Formulation and bacterial phototoxicity of curcumin loaded alginate foams for wound treatment applications: Studies on curcumin and curcuminoides XLII10.1002/jps.22263 ↗
34. Wound healing activity of curcumin conjugated to hyaluronic acid: In vitro and in vivo evaluation10.1080/21691401.2017.1358731 ↗
35. Curcuma longa L. constituents inhibit sortase A and Staphylococcus aureus cell adhesion to fibronectin10.1021/jf051765z ↗
36. Curcumin inhibits FtsZ assembly: An attractive mechanism for its antibacterial activity10.1042/BJ20070891 ↗
37. Preparation and evaluation of curcumin grafted hyaluronic acid modified pullulan polymers as a functional wound dressing material10.1016/j.carbpol.2020.116195 ↗
38. Mussel-inspired dual-cross-linking hyaluronic acid/ε-polylysine hydrogel with self-healing and antibacterial properties for wound healing10.1021/acsami.0c00782 ↗
39. Preparation of antimicrobial hyaluronic acid/quaternized chitosan hydrogels for the promotion of seawater-immersion wound healing10.3389/fbioe.2019.00360 ↗
40. Role of Hyaluronic Acids and Potential as Regenerative Biomaterials in Wound Healing10.1021/acsabm.0c01364 ↗
41. Hyaluronic acid: A boon in periodontal therapy10.4103/1947-2714.112473 ↗
42. Group A streptococcus cell-associated pathogenic proteins as revealed by growth in hyaluronic acid-enriched media10.1002/pmic.200600578 ↗
43. Estudio del crecimiento bacteriano in vitro en sustancias viscoelasticas
44. Hyaluronic acid/corn silk extract based injectable nanocomposite: A biomimetic antibacterial scaffold for bone tissue regeneration10.1016/j.msec.2019.110195 ↗