Nanotechnology Development for Formulating Essential Oils in Wound Dressing Materials to Promote the Wound-Healing Process: A Review
Source abstract
Abstract
Wound healing refers to the replacement of damaged tissue through strongly coordinated cellular events. The patient’s condition and different types of wounds complicate the already intricate healing process. Conventional wound dressing materials seem to be insufficient to facilitate and support this mechanism. Nanotechnology could provide the physicochemical properties and specific biological responses needed to promote the healing process. For nanoparticulate dressing design, growing interest has focused on natural biopolymers due to their biocompatibility and good adaptability to technological needs. Polysaccharides are the most common natural biopolymers used for wound-healing materials. In particular, alginate and chitosan polymers exhibit intrinsic antibacterial and anti-inflammatory effects, useful for guaranteeing efficient treatment. Recent studies highlight that several natural plant-derived molecules can influence healing stages. In particular, essential oils show excellent antibacterial, antifungal, antioxidant, and anti-inflammatory properties that can be amplified by combining them with nanotechnological strategies. This review summarizes recent studies concerning essential oils as active secondary compounds in polysaccharide-based wound dressings.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Wound Healing and Treatments · Nanocomposite Films for Food Packaging · Antimicrobial agents and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Elleva Pharma S.R.L. Via Pietro Castellino, 111, 80131 Naples, Italy
Department of Chemical, Materials and Industrial Production Engineering, University of Naples Federico II, 80138 Napoli, Italy
Center for Advanced Biomaterials for Healthcare, Istituto Italiano di Tecnologia (IIT@CRIB), 80125 Naples, Italy
Fluid Dynamics of Complex Biosystems, School of Life Sciences Weihenstephan, Technical University of Munich, 85354 Freising, Germany
Institute for Polymers, Composites and Biomaterials (IPCB-CNR), Via Campi Flegrei 34, 80078 Pozzuoli, Italy
Research Institute on Terrestrial Ecosystems (IRET)—CNR, Via Pietro Castellino 111, 80131 Naples, Italy
Funding
Allianz Industrie Forschung · Italian Ministry of University and Research · POR Campania FESR 2014_2020 · H2020- MSCA-RISE-Marie Sklodowska-Curie Actions (MSCA) Research and Innovation Staff Exchange (RISE)
References (100+)
Show source-provided references
1. Current wound healing procedures and potential care10.1016/j.msec.2014.12.068 ↗
2. Progress and opportunities for tissue-engineered skin10.1038/nature05664 ↗
3. Tissue Engineered Skin and Wound Healing: Current Strategies and Future Directions10.2174/1381612823666170526094606 ↗
4. Wound healing: Abnormalities and future therapeutic targets10.1016/j.cacc.2005.03.005 ↗
5. Recent advances on the development of wound dressings for diabetic foot ulcer treatment—A review10.1016/j.actbio.2013.03.033 ↗
6. Skin Acute Wound Healing: A Comprehensive Review
7. Complements and the Wound Healing Cascade: An Updated Review
8. Natural wound healing and bioactive natural products
9. The Wound Healing Process: An Overview of the Cellular and Molecular Mechanisms10.1177/147323000903700531 ↗
10. Stephens, P., and Thomas, D.W. (2013). The cellular proliferative phase of the wound repair process. J. Wound Care, 11.10.12968/jowc.2002.11.7.26421 ↗
11. Wound repair and regeneration10.1038/nature07039 ↗
12. Cutaneous wound healing: Recruiting developmental pathways for regeneration10.1007/s00018-012-1152-9 ↗
13. Biomaterials and Nanotherapeutics for Enhancing Skin Wound Healing10.3389/fbioe.2016.00082 ↗
14. Moeini, A., Pedram, P., Makvandi, P., Malinconico, M., and d’Ayala, G.G. (2020). Wound healing and Antimicrobial effect of active Secondary Metabolites in Chitosan-based Wound dressings: A review. Carbohydr. Polym., 115839.10.1016/j.carbpol.2020.115839 ↗
15. Borrowing From Nature: Biopolymers and Biocomposites as Smart Wound Care Materials10.3389/fbioe.2018.00137 ↗
16. Sikka, M.P., and Midha, V.K. (2019). The Role of Biopolymers and Biodegradable Polymeric Dressings in Managing Chronic Wounds, Woodhead Publishing. [2nd ed.].10.1016/B978-0-08-102192-7.00016-3 ↗
17. Wound Dressings and Comparative Effectiveness Data10.1089/wound.2012.0401 ↗
18. Naskar, A., and Kim, K.S. (2020). Recent advances in nanomaterial-based wound-healing therapeutics. Pharmaceutics, 12.10.3390/pharmaceutics12060499 ↗
19. Biopolymers: Applications in wound healing and skin tissue engineering10.1007/s11033-018-4296-3 ↗
20. A study on the ability of quaternary ammonium groups attached to a polyurethane foam wound dressing to inhibit bacterial attachment and biofilm formation10.1111/wrr.12244 ↗
21. Park, J.-H., Choi, S.-H., Park, S.-J., Lee, Y.J., Park, J.H., Song, P.H., Cho, C.-M., Ku, S.-K., and Song, C.-H. (2017). Promoting Wound Healing Using Low Molecular Weight Fucoidan in a Full-Thickness Dermal Excision Rat Model. Mar. Drugs, 15.10.3390/md15040112 ↗
22. Review article-role of Chitosan in Wound Healing—A Review of the Recent Advances
23. Exogenous hyaluronic acid and wound healing: An updated vision
24. Alginate hydrogels coated with chitosan for wound dressing10.3390/md13052890 ↗
25. Evaluation of dense collagen matrices as medicated wound dressing for the treatment of cutaneous chronic wounds10.1039/C4BM00370E ↗
26. Improving anti-hemolytic, antibacterial and wound healing properties of alginate fibrous wound dressings by exchanging counter-cation for infected full-thickness skin wounds10.1016/j.msec.2019.110321 ↗
27. Silk fibroin/chitosan/alginate multilayer membranes as a system for controlled drug release in wound healing10.1016/j.ijbiomac.2020.02.140 ↗
28. Drug-free and non-crosslinked chitosan scaffolds with efficient antibacterial activity against both Gram-negative and Gram-positive bacteria10.1016/j.carbpol.2020.116386 ↗
29. β-Cyclodextrin-Functionalized Chitosan/Alginate Compact Polyelectrolyte Complexes (CoPECs) as Functional Biomaterials with Anti-Inflammatory Properties10.1021/acsami.8b09733 ↗
30. Competitive Biological Activities of Chitosan and Its Derivatives: Antimicrobial, Antioxidant, Anticancer, and Anti-Inflammatory Activities
31. A review on nanoparticle based treatment for wound healing10.1016/j.jddst.2018.01.009 ↗
32. A review of injectable and implantable biomaterials for treatment and repair of soft tissues in wound healing10.1155/2017/6341710 ↗
33. Encapsulation of inuloxin A, a plant germacrane sesquiterpene with potential herbicidal activity, in β-cyclodextrins10.1039/C8OB03156H ↗
34. Absolute configurations of chiral molecules with multiple stereogenic centers without prior knowledge of the relative configurations: A case study of inuloxin C10.1002/chir.23013 ↗
35. Phytochemical Study on Antioxidant and Antiproliferative Activities of Moroccan Caralluma europaea Extract and Its Bioactive Compound Classes10.1155/2020/8409718 ↗
36. Medicinal plants and their natural components as future drugs for the treatment of burn wounds: An integrative review10.1007/s00403-014-1474-6 ↗
37. Atta-ur, R. (2013). Chapter 15—Natural Antioxidants in Cosmetics. Studies in Natural Products Chemistry, Elsevier.
38. Studies on essential oils: Part 10; Antibacterial activity of volatile oils of some spices10.1002/ptr.951 ↗
39. In vitro tests and ethnopharmacological investigations: Wound healing as an example10.1016/j.jep.2005.07.001 ↗
40. Effects of molecular weight and deacetylation degree of chitin/chitosan on wound healing10.1016/j.carbpol.2006.07.007 ↗
41. Marine Polysaccharides: A Source of Bioactive Molecules for Cell Therapy and Tissue Engineering10.3390/md9091664 ↗
42. Amaghnouje, A., Mechchate, H., Es-Safi, I., Alotaibi, A.A., Noman, O.M., Nasr, F.A., Al-Zharani, M., Cerruti, P., Calarco, A., and el Fatemi, H. (2020). Anxiolytic, antidepressant-like proprieties and impact on the memory of the hydro-ethanolic extract of origanum majorana L. On mice. Appl. Sci., 10.10.3390/app10238420 ↗
43. Amaghnouje, A., Mechchate, H., Es-safi, I., Boukhira, S., Aliqahtani, A.S., Noman, O.M., Nasr, F.A., Conte, R., Calarco, A., and Bousta, D. (2020). Subacute Assessment of the Toxicity and Antidepressant-Like Effects of Origanum Majorana L. Polyphenols in Swiss Albino Mice. Molecules, 25.10.3390/molecules25235653 ↗
44. Development of a rapid and sensitive HPLC method for the identification and quantification of cavoxin and cavoxone in Phoma cava culture filtrates
45. Marturano, V., Bizzarro, V., Ambrogi, V., Cutignano, A., Tommonaro, G., Abbamondi, G.R., Giamberini, M., Tylkowski, B., Carfagna, C., and Cerruti, P. (2019). Light-responsive nanocapsule-coated polymer films for antimicrobial active packaging. Polymers, 11.10.3390/polym11010068 ↗
46. Visible-Light Responsive Nanocapsules for Wavelength-Selective Release of Natural Active Agents10.1021/acsanm.9b00882 ↗
47. α-costic acid, a plant sesquiterpenoid from Dittrichia viscosa, as modifier of Poly (lactic acid) properties: A novel exploitation of the autochthone biomass metabolite for a wholly biodegradable system10.1016/j.indcrop.2020.112134 ↗
48. Thermoplastic starch and bioactive chitosan sub-microparticle biocomposites: Antifungal and chemico-physical properties of the films10.1016/j.carbpol.2019.115627 ↗
49. The incorporation and release of ungeremine, an antifungal Amaryllidaceae alkaloid, in poly(lactic acid)/poly(ethylene glycol) nanofibers10.1002/app.49098 ↗
50. Effect of pH and TPP concentration on chemico-physical properties, release kinetics and antifungal activity of Chitosan-TPP-Ungeremine microbeads10.1016/j.carbpol.2018.05.005 ↗
51. Antimould microbial and plant metabolites with potential use in intelligent food packaging
52. Kumar, L., Brice, J., Toberer, L., Klein-Seetharaman, J., Knauss, D., and Sarkar, S.K. (2019). Antimicrobial biopolymer formation from sodium alginate and algae extract using aminoglycosides. PLoS ONE, 14.10.1371/journal.pone.0214411 ↗
53. Antibacterial biohybrid nanofibers for wound dressings10.1016/j.actbio.2020.02.022 ↗
54. Overview of Silk Fibroin Use in Wound Dressings10.1016/j.tibtech.2018.04.004 ↗
55. Advanced Therapeutic Dressings for Effective Wound Healing—A Review10.1002/jps.24610 ↗
56. Harrison, I.P., and Spada, F. (2018). Hydrogels for Atopic Dermatitis and Wound Management: A Superior Drug Delivery Vehicle. Pharmaceutics, 10.10.3390/pharmaceutics10020071 ↗
57. An injectable self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic skin wound repair10.1038/s41427-018-0103-9 ↗
58. A Novel Superhydrophilic and Underwater Superoleophobic Hydrogel-Coated Mesh for Oil/Water Separation10.1002/adma.201102616 ↗
59. Antibiotic loaded carboxymethylcellulose/MCM-41 nanocomposite hydrogel films as potential wound dressing10.1016/j.ijbiomac.2015.12.076 ↗
60. Carboxyl-modified poly(vinyl alcohol)-crosslinked chitosan hydrogel films for potential wound dressing10.1016/j.carbpol.2015.02.034 ↗
61. A Performance Comparison of Graft Copolymer Hydrogels Based on Functionalized-Tragacanth Gum/Polyacrylic Acid and Polyacrylamide as Antibacterial and Antifungal Drug Release Vehicles
62. Radiation synthesis of PVP/alginate hydrogel containing nanosilver as wound dressing10.1007/s10856-012-4730-3 ↗
63. A review on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings10.1016/j.jare.2017.01.005 ↗
64. Polymeric and inorganic nanoscopical antimicrobial fillers in dentistry10.1016/j.actbio.2019.09.025 ↗
65. Update on wound dressings: Indications and best use10.1053/j.ctep.2004.08.006 ↗
66. Biomaterials based on chitin and chitosan in wound dressing applications10.1016/j.biotechadv.2011.01.005 ↗
67. Bacterial cellulose and bacterial cellulose–chitosan membranes for wound dressing applications10.1016/j.carbpol.2013.01.076 ↗
68. Sezer, A.D., and Cevher, E. (2011). Biopolymers as Wound Healing Materials: Challenges and New Strategies. Biomaterials Applications for Nanomedicine, IntechOpen.
69. Bianchera, A., Catanzano, O., Boateng, J., and Elviri, L. (2020). The Place of Biomaterials in Wound Healing. Ther. Dress. Wound Heal. Appl., 337–366.10.1002/9781119433316.ch15 ↗
70. Marturano, V., and Ambrogi, V. (2020). Marine biopolymers: Alginate and chitosan. Sustainability of Polymeric Materials, De Gruyter.10.1515/9783110590586 ↗
71. Naturally derived materials-based cell and drug delivery systems in skin regeneration10.1016/j.jconrel.2009.10.018 ↗
72. Nanofibrillar cellulose wound dressing in skin graft donor site treatment10.1016/j.jconrel.2016.07.053 ↗
73. Recent advancements in biopolymer and metal nanoparticle-based materials in diabetic wound healing management10.1016/j.ijbiomac.2018.10.120 ↗
74. Tayeb, A.H., Amini, E., Ghasemi, S., and Tajvidi, M. (2018). Cellulose nanomaterials-binding properties and applications: A review. Molecules, 23.10.3390/molecules23102684 ↗
75. Yadav, T.C., Srivastava, A.K., Raghuwanshi, N., Kumar, N., Prasad, R., and Pruthi, V. (2019). Wound Healing Potential of Natural Polymer: Chitosan “A Wonder Molecule”. Integr. Green Chem. Sustain. Eng., 527–579.10.1002/9781119509868.ch16 ↗
76. Biopolymers—Application in Nanoscience and Nanotechnology
77. First-Line Interactive Wound Dressing Update: A Comprehensive Review of the Evidence10.3389/fphar.2020.00155 ↗
78. Nanotechnology-Driven Therapeutic Interventions in Wound Healing: Potential Uses and Applications10.1021/acscentsci.6b00371 ↗
79. Can regenerative medicine and nanotechnology combine to heal wounds? the search for the ideal wound dressing10.2217/nnm-2017-0173 ↗
80. Nanoparticle-Based Dressing: The Future of Wound Treatment?10.1016/j.tibtech.2017.05.005 ↗
81. Development of nanotechnology for advancement and application in wound healing: A review10.1049/iet-nbt.2018.5312 ↗
82. Du, J., and Wong, K.K.Y. (2019). Nanomaterials for Wound Healing: Scope and Advances, Elsevier Inc.10.1016/B978-0-12-815341-3.00009-2 ↗
83. Nanoemulsion: Concepts, development and applications in drug delivery10.1016/j.jconrel.2017.03.008 ↗
84. Metal nanoparticles in dermatology and cosmetology: Interactions with human skin cells10.1016/j.cbi.2017.06.018 ↗
85. Nanocolloids in Natural Water: Isolation, Characterization, and Toxicity10.1021/acs.est.7b05364 ↗
86. Recent advancements in nanotechnological strategies in selection, design and delivery of biomolecules for skin regeneration10.1016/j.msec.2016.05.074 ↗
87. Polymers for drug delivery systems10.1146/annurev-chembioeng-073009-100847 ↗
88. Preparation of novel berberine nano-colloids for improving wound healing of diabetic rats by acting Sirt1/NF-κB pathway10.1016/j.colsurfb.2019.110647 ↗
89. Wound healing essentials: Let there be oxygen10.1111/j.1524-475X.2008.00436.x ↗
90. Ashter, S.A. (2014). Thermoforming of Single and Multilayer Laminates: Plastic Films Technologies, Testing, and Applications, Thermoforming of Single and Multilayer Laminates: Plastic Films Technologies, Testing and Applications, William Andrew Publishing.
91. Aspects of Nanomaterials in Wound Healing10.2174/1567201815666180918110134 ↗
92. The Wound Dressings and Their Applications in Wound Healing and Management
93. Essential oils loaded in nanosystems: A developing strategy for a successful therapeutic approach10.1155/2014/651593 ↗
94. Echeverría, J., and de Albuquerque, R.D.D.G. (2019). Nanoemulsions of Essential Oils: New Tool for Control of Vector-Borne Diseases and In Vitro Effects on Some Parasitic Agents. Medicines, 6.10.3390/medicines6020042 ↗
95. Nanoemulsion: A promising tool for solubility and dissolution enhancement of celecoxib10.3109/10837450902967954 ↗
96. Azmi, N.A., Elgharbawy, A.A.M., Motlagh, S.R., Samsudin, N., and Salleh, H.M. (2019). Nanoemulsions: Factory for food, pharmaceutical and cosmetics. Processes, 7.10.3390/pr7090617 ↗
97. Nanoemulsions: Formation, properties and applications10.1039/C5SM02958A ↗
98. Grumezescu, A.M. (2018). Chapter 3—Nanotechnology Applications in Drug Controlled Release. Drug Targeting and Stimuli Sensitive Drug Delivery Systems, William Andrew Publishing.
99. Nano-emulsions10.1016/j.cocis.2005.06.004 ↗
100. Sayed, S. (2019). Essential Oil Nanoformulations as a Novel Method for Insect Pest Control in Horticulture. Horticultural Crops, IntechOpen.