Continuous-Wave THz Imaging for Biomedical Samples
Source abstract
Abstract
In the past few decades, the applications of terahertz (THz) spectroscopy and imaging technology have seen significant developments in the fields of biology, medical diagnosis, food safety, and nondestructive testing. Label-free diagnosis of malignant tumours has been obtained and also achieved significant development in THz biomedical imaging. This review mainly presents the research status and prospects of several common continuous-wave (CW) THz medical imaging systems and applications of THz medical imaging in biological tissues. Here, we first introduce the properties of THz waves and how these properties play a role in biomedical imaging. Then, we analyse both the advantages and disadvantages of the CW THz imaging methods and the progress of these methods in THz biomedical imaging in recent ten years. Finally, we summarise the obstacles in the way of the application of THz bio-imaging application technology in clinical detection, which need to be investigated and overcome in the future.
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Research context
OpenAlex topics: Terahertz technology and applications · Superconducting and THz Device Technology · Spectroscopy and Laser Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Faculty of Science, College of Physics and Optoelectronics, Beijing University of Technology, Beijing 100124, China
Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Department of Electronic Engineering, Tsinghua University, Haidian District, Beijing 100084, China
Beijing Engineering Research Center of Precision Measurement Technology and Instruments, Beijing 100124, China
Academy of Medical Science, Peking Union Medical College, Beijing 100730, China
Funding
National Natural Science Foundation of China · Science Foundation of Education Commission of Beijing · Beijing Nova Program · WBE Liver Fibrosis Foundation
References (97)
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1. Erik, B., Heinz-Wilhelm, H., and Maurice, F. (2012). Terahertz Techniques, Springer. [1st ed.].
2. Lee, Y. (2009). Principles of Terahertz Science and Technology, Springer.10.1007/978-0-387-09540-0_5 ↗
3. Terahertz spectroscopy of human skin tissue models with different melanin content10.1364/BOE.10.002942 ↗
4. Terahertz technology and its applications10.1016/j.dit.2013.03.009 ↗
5. The growth of biomedical terahertz research
6. Terahertz spectroscopy: Signatures and fingerprints10.1038/nphoton.2008.174 ↗
7. Study of water concentration measurement in thin tissues with terahertz-wave parametric source10.1364/OE.18.015504 ↗
8. A High-Power Broadband Terahertz Source Enabled by Three Dimensional Light Confinement in a Plasmonic Nanocavity10.1038/s41598-017-04553-4 ↗
9. Terahertz molecular resonance of cancer DNA10.1038/srep37103 ↗
10. Terahertz Time-Domain Spectroscopy of Human Blood10.1109/TTHZ.2013.2267414 ↗
11. Pilot study of freshly excised breast tissue response in the 300–600 GHz range10.1364/BOE.9.002930 ↗
12. Imaging with terahertz waves10.1364/OL.20.001716 ↗
13. Far Infrared Properties of Electro-Optic Crystals Measured by THz Time-Domain Spectroscopy10.1023/A:1022636421426 ↗
14. A decade-spanninghigh-resolution asynchronous optical sampling terahertz time-domain and frequency comb spectrometer10.1063/1.4932567 ↗
15. Terahertz optically pumped Si:Sb laser10.1063/1.1515377 ↗
16. He, W., Zhang, L., Bowes, D., Yin, H., Ronald, K., Phelps, A.D.R., and Cross, A.W. (2015). Generation of broadband terahertz radiation using a backward wave oscillator and pseudospark-sourced electron beam. Appl. Phys. Lett., 133501.10.1063/1.4932099 ↗
17. High-power terahertz quantum cascade lasers with 0.23 W in continuous wave mode10.1063/1.4959195 ↗
18. Schottky diode-based terahertz frequency multipliers and mixers10.1016/j.crhy.2010.05.002 ↗
19. (2020, October 25). Golay Detectors. Available online: http://www.tydexoptics.com/pdf/Golay_Detectors.pdf.
20. Real-time imaging using a 2.8 THz quantum cascade laser and uncooled infrared micrometer camera10.1364/OL.33.000440 ↗
21. (2020, October 25). Ophir THz Laser Measurement Products. Available online: https://www.ophiropt.com/laser-measurement/sites/default/files/Pyrocam_1.pdf.
22. Terahertz transmission vs. reflection imaging and model-based characterization for excised breast carcinomas10.1364/BOE.7.003756 ↗
23. Confocal THz Laser Microscope
24. Lisauskas, A., Boppel, S., Krozer, V., and Roskos, H.G. (2011, January 28–31). Silicon CMOS-based THz detection. Proceedings of the 10th IEEE Conference on Sensors, Limerick, Ireland.10.1109/ICSENS.2011.6127065 ↗
25. Terahertz confocal microscopy with a quantum cascade laser source
26. Single-channel prototype terahertz endoscopic system10.1117/1.JBO.19.8.080501 ↗
27. A CMOS Fully Integrated 860-GHz Terahertz Sensor10.1109/TTHZ.2017.2692040 ↗
28. Detection of incoherent terahertz light using antenna-coupled high-electron-mobility field-effect transistors10.1063/1.4982604 ↗
29. Terahertz-Wave Imaging System Based on Backward Wave Oscillator10.1109/TTHZ.2012.2210282 ↗
30. A cryogen-free HTS Josephson junction detector for terahertz imaging10.1088/0953-2048/28/8/084001 ↗
31. Terahertz Imaging Based on Morphological Reconstruction10.1109/JSTQE.2017.2649461 ↗
32. Label-free bacterial colony detection and viability assessment by continuous-wave terahertz transmission imaging10.1002/jbio.201700386 ↗
33. Panula, P.A.J. (2003). Handbook of Biological Confocal Microscopy, Springer. [2nd ed.].10.1016/S0891-0618(03)00007-3 ↗
34. Investigation of optically pumped continuous terahertz laser in biological imaging10.3724/SP.J.1249.2014.02160 ↗
35. Enhanced Continuous-Wave Terahertz Imaging with a Horn Antenna for Food Inspection10.1007/s10762-012-9902-1 ↗
36. High-speed terahertz imaging toward food quality inspection10.1364/AO.53.001406 ↗
37. Sung, S., Garritano, J., Bajwa, N., Deng, S., and Taylor, Z.D. (2015, January 10–12). Preliminary results of non-contact THz imaging of cornea. Proceedings of the Conference on Terahertz, RF, Millimeter, and Submillimeter-Wave Technology and Applications VIII, San Francisco, CA, USA.10.1117/12.2086866 ↗
38. Reflective scanning imaging based on a fast terahertz photodetector10.1016/j.optcom.2018.06.030 ↗
39. A hybrid method based region of interest segmentation for continuous wave terahertz imaging10.1088/1361-6463/ab58b6 ↗
40. Imaging of ex vivo nonmelanoma skin cancers in the optical and terahertz spectral regions optical and terahertz skin cancers imaging10.1002/jbio.201200111 ↗
41. Detection of colon cancer by continuous-wave terahertz polarization imaging technique10.1117/1.JBO.18.9.090504 ↗
42. Continuous-wave circular polarization terahertz imaging10.1117/1.JBO.21.7.070502 ↗
43. Huang, Y., Singh, R., Xie, L., and Ying, Y. (2020). Attenuated Total Reflection for Terahertz Modulation, Sensing, Spectroscopy and Imaging Applications: A Review. Appl. Sci., 10.10.3390/app10144688 ↗
44. Optimization for vertically scanning terahertz attenuated total reflection imaging10.1364/OE.26.020744 ↗
45. High-sensitivity attenuated total internal reflection continuous-wave terahertz imaging10.1088/1361-6463/aa7d9a ↗
46. Born, M., Wolf, E., Bhatia, A.B., Clemmow, P.C., Gabor, D., Stokes, A.R., Taylor, A.M., Wayman, P.A., and Wilcock, W.L. (1999). Interference and Diffraction with Partially Coherent Light, Cambridge University Press.
47. Review of Near-Field Terahertz Measurement Methods and Their Applications10.1007/s10762-011-9809-2 ↗
48. The Diagnosis of Human Liver Cancer by using THz Fiber-Scanning Near-Field Imaging10.1088/0256-307X/30/3/030702 ↗
49. All-terahertz fiber-scanning near-field microscopy10.1364/OL.34.001084 ↗
50. Near-field sub-THz transmission-type image system for vessel imaging in-vivo10.1364/OE.23.025058 ↗
51. Propagation of ultrawideband short pulses of terahertz radiation through submillimeter-diameter circular waveguides10.1364/OL.24.001431 ↗
52. Rao, N. (2004). Elements of Engineering Electromagnetics, Pearson Prentice Hall. [6th ed.].
53. Solid immersion terahertz imaging with sub-wavelength resolution10.1063/1.4984952 ↗
54. Reflection-mode continuous-wave 0.15λ-resolution terahertz solid immersion microscopy of soft biological tissues10.1063/1.5045480 ↗
55. Continuous-wave THz vector imaging system utilizing two-tone signal generation and self-mixing detection10.1364/OE.25.020718 ↗
56. High-contrast coherent terahertz imaging of porcine tissue via swept-frequency feedback interferometry10.1364/BOE.5.003981 ↗
57. Photomechanical meta-molecule array for real-time terahertz imaging10.1038/micronano.2017.71 ↗
58. Terahertz wave generation using a soliton microcomb10.1364/OE.27.035257 ↗
59. Goodman, J.W. (2005). Introduction to Fourier Optics, Roberts and Company. [3rd ed.].
60. Continuous-wave terahertz in-line digital holography10.1364/OL.37.003228 ↗
61. Continuous-wave terahertz digital holography by use of a pyroelectric array camera10.1364/OL.36.001993 ↗
62. Terahertz in-line digital holography of dragonfly hindwing: Amplitude and phase reconstruction at enhanced resolution by extrapolation10.1364/OE.22.017236 ↗
63. Synthetic aperture in terahertz in-line digital holography for resolution enhancement10.1364/AO.55.000A43 ↗
64. Sparsity-based continuous wave terahertz lens-free on-chip holography with sub-wavelength resolution10.1364/OE.27.000702 ↗
65. Terahertz synthetic aperture in-line holography with intensity correction and sparsity autofocusing reconstruction10.1364/PRJ.7.001391 ↗
66. Visualization of internal structure and internal stress in visibly opaque objects using full-field phase-shifting terahertz digital holography10.1364/OE.27.033854 ↗
67. Real-time terahertz digital holography with a quantum cascade laser10.1038/srep13566 ↗
68. Continuous-wave off-axis and in-line terahertz digital holography with phase unwrapping and phase autofocusing10.1016/j.optcom.2018.06.011 ↗
69. Continuous-wave terahertz self-referencing digital holography based on Fresnel’s mirrors10.1364/OL.385943 ↗
70. Probe position correction based on overlapped object wavefront cross-correlation for continuous-wave terahertz ptychography10.1364/OE.27.000938 ↗
71. Application of a robotic THz imaging system for sub-surface analysis of ancient human remains10.1038/s41598-019-40211-7 ↗
72. Computed tomography image using sub-terahertz waves generated from a high-Tc superconducting intrinsic Josephson junction oscillator10.1063/1.4866898 ↗
73. Cancer statistics10.3322/caac.21551 ↗
74. Terahertz spectroscopy of liver cirrhosis: Investigating the origin of contrast10.1088/0031-9155/55/24/013 ↗
75. Terahertz biophotonics as a tool for studies of dielectric and spectral properties of biological tissues and liquids10.1016/j.pquantelec.2018.10.001 ↗
76. The progress and perspectives of terahertz technology for diagnosis of neoplasms: A review10.1088/2040-8986/ab4dc3 ↗
77. Study of freshly excised brain tissues using terahertz imaging10.1364/BOE.5.002837 ↗
78. Evaluation and Validation of Total RNA Extraction Methods for MicroRNA Expression Analyses in Formalin-Fixed, Paraffin-Embedded Tissues10.2353/jmoldx.2008.070153 ↗
79. Terahertz imaging of excised oral cancer at frozen temperature10.1364/BOE.4.001413 ↗
80. Measurement depth enhancement in terahertz imaging of biological tissues10.1364/OE.21.021299 ↗
81. Current Concepts in the Surgical Management of Non-melanoma Skin Cancers10.1016/j.clon.2019.08.009 ↗
82. Dual Frequency Continuous Wave Terahertz Transmission Imaging of Nonmelanoma Skin Cancers10.1002/lsm.21078 ↗
83. Performance of THz fiber-scanning near-field microscopy to diagnose breast tumors10.1364/OE.19.019523 ↗
84. Development and Testing of a Single Frequency Terahertz Imaging System for Breast Cancer Detection10.1109/TTHZ.2013.2241429 ↗
85. Numerical analysis and experimental study of terahertz solid immersion microscopy10.1117/1.OE.59.6.061605 ↗
86. Exciting New Advances in Neuro-Oncology: The Avenue to a Cure for Malignant Glioma10.3322/caac.20069 ↗
87. Study of in vivo brain glioma in a mouse model using continuous-wave terahertz reflection imaging10.1364/BOE.10.003953 ↗
88. Terahertz-wave water concentration and distribution measurement in thin biotissue based on a novel sample preparation10.1088/0031-9155/56/14/018 ↗
89. Neoadjuvant chemotherapy in locally advanced colon cancer. A phase II trial10.3109/0284186X.2015.1037007 ↗
90. Terahertz absorption and reflection imaging of carcinoma-affected colon tissues embedded in paraffin10.1016/j.molstruc.2015.11.048 ↗
91. Doradla, P., Alavi, K., Joseph, C.S., and Giles, R.H. (2016, January 15–18). Development of terahertz endoscopic system for cancer detection. Proceedings of the Conference on Terahertz, RF, Millimeter, and Submillimeter-Wave Technology and Applications IX, San Francisco, CA, USA.10.1117/12.2209404 ↗
92. Primary Liver Cancer: An NCDB Analysis of Overall Survival and Margins After Hepatectomy10.1245/s10434-019-07843-5 ↗
93. Terahertz in-line digital holography of human hepatocellular carcinoma tissue10.1038/srep08445 ↗
94. Primary Liver Cancers: Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma10.1016/j.suc.2020.02.013 ↗
95. Automatic evaluation of traumatic brain injury based on terahertz imaging with machine learning10.1364/OE.26.006371 ↗
96. Three-dimensional terahertz computed tomography of human bones10.1364/AO.51.006738 ↗
97. Application of continuous-wave terahertz computed tomography for the analysis of chicken bone structure