Collagen Nanoparticles in Drug Delivery Systems and Tissue Engineering
Source abstract
Abstract
The versatile natural polymer, collagen, has gained vast attention in biomedicine. Due to its biocompatibility, biodegradability, weak antigenicity, biomimetics and well-known safety profile, it is widely used as a drug, protein and gene carrier, and as a scaffold matrix in tissue engineering. Nanoparticles develop favorable chemical and physical properties such as increased drug half-life, improved hydrophobic drug solubility and controlled and targeted drug release. Their reduced toxicity, controllable characteristics of scaffolds and stimuli-responsive behavior make them suitable in regenerative medicine and tissue engineering. Collagen associates and absorbs nanoparticles leading to significant impacts on their biological functioning in any biofluid. This review will discuss collagen nanoparticle preparation methods and their applications and developments in drug delivery systems and tissue engineering.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Collagen: Extraction and Characterization · Bone Tissue Engineering Materials · Silk-based biomaterials and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemical Engineering, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal 576104, India
Engineering Research Center in Biomaterials, Sichuan University, Chengdu 610064, China
Center of Nanofibers and Nanotechnology, National University of Singapore, Singapore 117581, Singapore
References (100+)
Show source-provided references
1. Current development of biodegradable polymeric materials for biomedical applications10.2147/DDDT.S165440 ↗
2. Patino, M.G., Neiders, M.E., Andreana, S., Noble, B., and Cohen, R.E. (2021, June 01). Collagen as an Implantable Material in Medicine and Dentistry. Volume XXVIII. Available online: http://meridian.allenpress.com/joi/article-pdf/28/5/220/2033011/1548-1336.10.1563/1548-1336(2002)028<0220:CAAIMI>2.3.CO;2 ↗
3. Use of collagen as a biomaterial: An update10.4103/0972-124X.118333 ↗
4. Polymers for drug delivery systems10.1146/annurev-chembioeng-073009-100847 ↗
5. Molecular structure, mechanical behavior and failure mechanism of the C-terminal cross-link domain in type I collagen10.1016/j.jmbbm.2010.07.003 ↗
6. Synthesis, characterization and bioevaluation of irinotecan-collagen hybrid materials for biomedical applications as drug delivery systems in tumoral treatments10.2478/s11532-013-0341-1 ↗
7. Biomedical applications of collagen10.1016/S0378-5173(01)00691-3 ↗
8. Kinetics of collagen microneedle drug delivery system10.1016/j.jddst.2019.03.007 ↗
9. (2021, April 22). Collagen in Gene Delivery Applications|Sigma-Aldrich [Internet]. Available online: https://www.sigmaaldrich.com/technical-documents/articles/material-matters/collagen-in-gene-delivery-applications.html.
10. A review on collagen based drug delivery systems
11. Injectable hydrogels delivering therapeutic agents for disease treatment and tissue engineering10.1186/s40824-018-0138-6 ↗
12. The role of collagen in cancer: From bench to bedside10.1186/s12967-019-2058-1 ↗
13. Medical Applications of Collagen and Collagen-Based Materials10.2174/0929867325666171205170339 ↗
14. The application of collagen sheet in open wound healing
15. Gouveia, R.M., and Connon, C.J. (2016). Collagen scaffolds for corneal regeneration. Biomaterials and Regenerative Medicine in Ophthalmology, Elsevier Inc.. [2nd ed.].10.1016/B978-0-08-100147-9.00007-9 ↗
16. Advancing biomaterials of human origin for tissue engineering10.1016/j.progpolymsci.2015.02.004 ↗
17. Collagen-Based Biomaterials for Tissue Engineering Applications10.3390/ma3031863 ↗
18. Recent developments of collagen-based materials for medical applications and drug delivery systems10.1163/156856295X00526 ↗
19. Dual and multi-stimuli responsive polymeric nanoparticles for programmed site-specific drug delivery10.1016/j.biomaterials.2013.01.084 ↗
20. Polymeric nanostructured materials for biomedical applications10.1016/j.progpolymsci.2016.05.005 ↗
21. Use of Nanoparticles in Tissue Engineering and Regenerative Medicine10.3389/fbioe.2019.00113 ↗
22. Naturally and synthetic smart composite biomaterials for tissue regeneration10.1016/j.addr.2012.03.009 ↗
23. Therapeutic nanoparticles for drug delivery in cancer10.1158/1078-0432.CCR-07-1441 ↗
24. Nanoparticle-based drug delivery systems for cancer therapy10.1016/j.smaim.2020.04.001 ↗
25. Nanoparticle-Based Dressing: The Future of Wound Treatment?10.1016/j.tibtech.2017.05.005 ↗
26. Controlled self assembly of collagen nanoparticle10.1007/s11051-011-0327-x ↗
27. Collagen-nanoparticle Interactions: Type I Collagen Stabilization Using Functionalized Nanoparticles10.1080/1539445X.2015.1009550 ↗
28. Naskar, A., and Kim, K.-s. (2020). Recent Advances in Nanomaterial-Based Wound-Healing Therapeutics. Pharmaceutics, 12.10.3390/pharmaceutics12060499 ↗
29. The biocompatibility and antibacterial properties of collagen-stabilized, photochemically prepared silver nanoparticles10.1016/j.biomaterials.2012.03.033 ↗
30. Hong, S., Choi, D.W., Kim, H.N., Park, C.G., Lee, W., and Park, H.H. (2020). Protein-Based Nanoparticles as Drug Delivery Systems. Pharmaceutics, 12.10.3390/pharmaceutics12070604 ↗
31. Lo, S., and Fauzi, M.B. (2021). Current Update of Collagen Nanomaterials—Fabrication, Characterisation and Its Applications: A Review. Pharmaceutics, 13.10.3390/pharmaceutics13030316 ↗
32. Preparation and characterisation of nanoparticles containing ketoprofen and acrylic polymers prepared by emulsion solvent evaporation method10.1080/17458080.2010.515247 ↗
33. Mendoza-Muñoz, N., Alcalá-Alcalá, S., and Quintanar-Guerrero, D. (2016). Preparation of Polymer Nanoparticles by the Emulsification-Solvent Evaporation Method: From Vanderhoff’s Pioneer Approach to Recent Adaptations. Polymer Nanoparticles for Nanomedicines, 1st ed, Springer.10.1007/978-3-319-41421-8_4 ↗
34. Recent developments in nanoparticle-based drug delivery and targeting systems with emphasis on protein-based nanoparticles10.1517/17425247.5.5.499 ↗
35. New Pickering emulsions stabilized with chitosan/collagen peptides nanoparticles: Synthesis, characterization and tracking of the nanoparticles after skin application10.1016/j.colsurfa.2021.126327 ↗
36. Liquid–Liquid Phase Separation as the Second Step of Complex Coacervation10.1021/acs.jpcb.0c07349 ↗
37. Kariduraganavar, M.Y., Heggannavar, G.B., Amado, S., and Mitchell, G.R. (2018). Protein Nanocarriers for Targeted Drug Delivery for Cancer Therapy. Nanocarriers for Drug Delivery, Elsevier.10.1016/B978-0-12-814033-8.00006-0 ↗
38. Collagen-Based Non-Viral Gene Carriers10.1016/S1525-0016(16)41014-2 ↗
39. Conjugated polymer nanoparticles: Preparation, properties, functionalization and biological applications10.1039/c3cs60036j ↗
40. Conjugated polymer nanoparticles10.1039/b9nr00374f ↗
41. Nanoparticles of Conjugated Polymers Prepared from Phase-Separated Films of Phospholipids and Polymers for Biomedical Applications10.1002/adma.201400906 ↗
42. DeFrates, K., Markiewicz, T., Gallo, P., Rack, A., Weyhmiller, A., Jarmusik, B., and Hu, X. (2018). Protein Polymer-Based Nanoparticles: Fabrication and Medical Applications. Int. J. Mol. Sci., 19.10.3390/ijms19061717 ↗
43. Oliveira, A.M., Guimarães, K.L., Cerize, N.N., Tunussi, A.S., and Poço, J.G. (2013). Nano Spray Drying as an Innovative Technology for Encapsulating Hydrophilic Active Pharmaceutical Ingredients (API). J. Nanomed. Nanotechnol., 4.10.4172/2157-7439.1000186 ↗
44. Evaluation of nano spray drying as a method for drying and formulation of therapeutic peptides and proteins10.3389/fphar.2015.00140 ↗
45. Anticancer Drug-Loaded Gliadin Nanoparticles Induce Apoptosis in Breast Cancer Cells10.1021/la300691n ↗
46. Fabrication of elastin-like polypeptide nanoparticles for drug delivery by electrospraying10.1021/bm801033f ↗
47. Particle shape: A new design parameter for micro- and nanoscale drug delivery carriers10.1016/j.jconrel.2007.03.022 ↗
48. Electrospraying, a Reproducible Method for Production of Polymeric Microspheres for Biomedical Applications10.3390/polym3010131 ↗
49. Fabrication of Solid Collagen Nanoparticles Using Electrospray Deposition10.1248/cpb.c13-01004 ↗
50. Batrakova, E.V., Bronich, T.K., Vetro, J.A., and Kabanov, A.V. (2006). Polymer micelles as drug carriers. Nanoparticulates as Drug Carriers, Imperial College Press.10.1142/9781860949074_0005 ↗
51. A denatured collagen microfiber scaffold seeded with human fibroblasts and keratinocytes for skin grafting10.1016/j.biomaterials.2011.03.023 ↗
52. Self-assembly of collagen-based biomaterials: Preparation, characterizations and biomedical applications10.1039/C7TB02999C ↗
53. Desolvation process and surface characterisation of protein nanoparticles10.1016/S0378-5173(99)00370-1 ↗
54. Cost Effective Ball Milling Machine for Producing Nanopowder
55. Ball milling as a mechanochemical technology for fabrication of novel biochar nanomaterials10.1016/j.biortech.2020.123613 ↗
56. Chang, H., and Leung, H. (2010). Nano Scale Collagen Particles and Membranes. (8,951,598), U.S. Patent.
57. Morgan, P.W. (2011). Interfacial Polymerization. Encycl. Polym. Sci. Technol.10.1002/0471440264.pst168 ↗
58. Recent progress in interfacial polymerization10.1039/C6QM00325G ↗
59. Efficient fabrication of polymer nanoparticles via sonogashira cross-linking of linear polymers in dilute solution10.1002/pola.27942 ↗
60. Biocompatible Single-Chain Polymer Nanoparticles for Drug Delivery—A Dual Approach10.1021/acsami.8b07450 ↗
61. Scalable Synthesis of Single-Chain Nanoparticles under Mild Conditions10.1021/acs.macromol.7b00497 ↗
62. Multi-orthogonal folding of single polymer chains into soft nanoparticles10.1039/C4SM00459K ↗
63. Protein Nanoparticles as Drug Delivery Carriers for Cancer Therapy10.1155/2014/180549 ↗
64. Biopolymer-based nanoparticles for drug/gene delivery and tissue engineering10.3390/ijms14011629 ↗
65. Nanoparticles for brain-specific drug and genetic material delivery, imaging and diagnosis10.2217/nnm.16.15 ↗
66. Efficiency of nanoparticles as a carrier system for antiviral agents in human immunodeficiency virus-infected human monocytes/macrophages in vitro10.1128/AAC.40.6.1467 ↗
67. Collagen Nanoparticle-Mediated Brain Silymarin Delivery: An Approach for Treating Cerebral Ischemia and Reperfusion-Induced Brain Injury10.3389/fnins.2020.538404 ↗
68. Collagen for brain repair: Therapeutic perspectives10.4103/1673-5374.230273 ↗
69. Transport of drugs across the blood-brain barrier by nanoparticles10.1016/j.jconrel.2011.08.017 ↗
70. Brain targeting of nerve growth factor using poly(butyl cyanoacrylate) nanoparticles10.1080/10611860903112842 ↗
71. Rapid microwave-assisted synthesis of gold loaded hydroxyapatite collagen nano-bio materials for drug delivery and tissue engineering application10.1016/j.ceramint.2018.10.016 ↗
72. Evaluation of the antibacterial activity of silver nanoparticles, doxycycline, collagen and their amalgamation—An in vitro study10.1016/j.matpr.2021.01.396 ↗
73. A collagen-based multicellular tumor spheroid model for evaluation of the efficiency of nanoparticle drug delivery10.3109/21691401.2014.968820 ↗
74. Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain10.1016/S0168-3659(99)00007-3 ↗
75. Collagen microparticles: Carriers for glucocorticosteroids10.1016/S0939-6411(97)00119-7 ↗
76. Application of Cryopreserved Fibroblast Culture with Au Nanoparticles to Treat Burns10.1186/s11671-016-1242-y ↗
77. Role of nanoparticle size in self-assemble processes of collagen for tissue engineering application10.1016/j.ijbiomac.2017.02.102 ↗
78. Nanoparticles in tissue engineering: Applications, challenges and prospects10.2147/IJN.S153758 ↗
79. Composite Scaffolds Based on Silver Nanoparticles for Biomedical Applications10.1155/2015/587989 ↗
80. Fluorescent nanonetworks: A novel bioalley for collagen scaffolds and Tissue Engineering10.1038/srep05968 ↗
81. Surface modification of ultra thin poly (ε-caprolactone) films using acrylic acid and collagen10.1016/j.biomaterials.2003.08.038 ↗
82. Cyclic Mechanical Preconditioning Improves Engineered Muscle Contraction10.1089/tea.2007.0104 ↗
83. Nano-collagen artificial bone for alveolar ridge preservation in the Kazakh from Xinjiang Tacheng Region
84. Allogeneic adipose-derived stem cells combined with nano collagen-based bone for repair of ulna bone defects
85. Hypoxia-mimicking bioactive glass/collagen glycosaminoglycan composite scaffolds to enhance angiogenesis and bone repair10.1016/j.biomaterials.2015.02.006 ↗
86. Influence of freezing rate on pore structure in freeze-dried collagen-GAG scaffolds10.1016/S0142-9612(03)00630-6 ↗
87. Effect of the nano/microscale structure of biomaterial scaffolds on bone regeneration10.1038/s41368-020-0073-y ↗
88. Functionalization of a Collagen-Hydroxyapatite Scaffold with Osteostatin to Facilitate Enhanced Bone Regeneration10.1002/adhm.201500439 ↗
89. The tissue-engineered vascular graft-Past, present, and future10.1089/ten.teb.2015.0100 ↗
90. Collagen/nano-sized β-tricalcium phosphate conduits combined with collagen filaments and nerve growth factor promote facial nerve regeneration in miniature swine: An in vivo study10.1016/j.oooo.2018.12.006 ↗
91. Cell attachment effects of collagen nanoparticles on crosslinked electrospun nanofibers10.1177/0391398820947737 ↗
92. Natural collagenic skeleton of marine sponges in pharmaceutics: Innovative biomaterial for topical drug delivery10.1016/j.msec.2016.09.041 ↗
93. Marine-Derived Collagen as Biomaterials for Human Health10.3389/fnut.2021.702108 ↗
94. Sadasivuni, K.K., Ponnamma, D., Rajan, M., Ahamed, M.B., and Al-Maadeed, M.A.S.A. (2019). Correction to: Polymer Nanocomposites in Biomedical Engineering. Polymer Nanocomposites in Biomedical Engineering, Springer.10.1007/978-3-030-04741-2 ↗
95. Effects of sintering temperature on the compressive mechanical properties of collagen/hydroxyapatite composite scaffolds for bone tissue engineering10.1016/j.matlet.2016.03.028 ↗
96. Collagen-Based Drug Delivery Systems for Tissue Engineering
97. Biomedical Biopolymers, their Origin and Evolution in Biomedical Sciences: A Systematic Review
98. Kaul, G., and Amiji, M. (2004). Protein Nanoparticles for Gene Delivery. Polymeric Gene Delivery, CRC Press.10.1201/9780203500477.ch27 ↗
99. Nanotechnology-Driven Therapeutic Interventions in Wound Healing: Potential Uses and Applications10.1021/acscentsci.6b00371 ↗
100. Senturk, B., Uzunalli, G., Mammadov, R., Guler, M.O., and Tekinay, A.B. (2016). Wound Healing Applications of Nanomaterials, Wiley.10.1002/9781118987483.ch5 ↗