journal article·2014-09-19Open access

Towards Laser Driven Hadron Cancer Radiotherapy: A Review of Progress

Ken Ledingham, Paul Bolton, Naoya Shikazono, C.-M. Ma

Applied Sciences· Volume 4· Issue 3

Abstract

It has been known for about sixty years that proton and heavy ion therapy is a very powerful radiation procedure for treating tumors. It has an innate ability to irradiate tumors with greater doses and spatial selectivity compared with electron and photon therapy and, hence, is a tissue sparing procedure. For more than twenty years, powerful lasers have generated high energy beams of protons and heavy ions and it has, therefore, frequently been speculated that lasers could be used as an alternative to radiofrequency (RF) accelerators to produce the particle beams necessary for cancer therapy. The present paper reviews the progress made towards laser driven hadron cancer therapy and what has still to be accomplished to realize its inherent enormous potential.
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Research context

OpenAlex topics: Laser-Plasma Interactions and Diagnostics · High-pressure geophysics and materials · Radiation Therapy and Dosimetry

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

SUPA, Department of Physics, University of Strathclyde, Glasgow G40NG, Scotland, UK

Department of Physics, Faculty of Science, University of Selcuk, Konya 42031, Turkey

Faculty of Physics, Ludwig Maximilians University, Am Coulombwall 1, 85748 Garching, Germany

Kansai Photon Science Institute, Japan Atomic Energy Agency, 8-1-7 Umemidai, Kizugawa, Kyoto 619-0215, Japan

Radiation Oncology Department, Fox Chase Cancer Center, 333 Cottman Ave., Philadelphia, PA 19111, USA

References (100+)

Show source-provided references
1. Radiological use of fast protons10.1148/47.5.487 ↗
2. Proton Therapy. Available online:http://en.wikipedia.org./wiki/Proton.
3. Accelerators for hadron therapy: From lawrence cyclotrons to linacs10.1016/j.nima.2010.03.130 ↗
4. The case for particle therapy
5. Within the next decade conventional cyclotrons for proton therapy will become obsolete and replaced by far less expensive machines using compact laser systems for the acceleration of the protons10.1118/1.2150220 ↗
6. Radiation therapy with charged particles10.1016/j.semradonc.2006.04.008 ↗
7. Heavy ion tumour therapy10.1016/S0168-583X(99)00669-2 ↗
8. Tumortherapy with Ion Beams10.1016/S0168-9002(00)00802-0 ↗
9. Tumour therapy with high energy carbon ion beams10.1016/j.nuclphysa.2006.12.097 ↗
10. Ion beam radiobiology and cancer: Time to update ourselves
11. Charged particle therapy-optimisation, challenges and future directions10.1038/nrclinonc.2013.79 ↗
12. Charged particles in radiotherapy: A 5-year update of a systematic review10.1016/j.radonc.2012.01.003 ↗
13. Laser acceleration of ions for radiation therapy10.1142/S1793626809000296 ↗
14. Applications of nuclear phenomena generated by ultra-intense lasers10.1126/science.1080552 ↗
15. Laser-driven particle and photon beams and some applications10.1088/1367-2630/12/4/045005 ↗
16. Daido, H., Nishiuchi, M., and Pirozhkov, A.S. (2012). Review of laser driven ion sources and their applications. Rep. Prog. Phys., 75.10.1088/0034-4885/75/5/056401 ↗
17. Ion acceleration by superintense laser-plasma interaction10.1103/RevModPhys.85.751 ↗
18. Oncological hadrontherapy with laser ion accelerators10.1016/S0375-9601(02)00521-2 ↗
19. Accelerating protons to therapeutic energies with ultraintense, ultraclean and ultrashort laser pulses10.1118/1.2900112 ↗
20. Desktop accelerators going up10.1038/nphys206 ↗
21. Laser driven proton oncology—A unique new cancer therapy10.1259/bjr/29504942 ↗
22. Laser accelerated radiotherapy: Is it on its way to the clinic?10.1093/jnci/djp071 ↗
23. Radiobiological effectiveness of laser accelerated electrons in comparison to electron beams from a conventional linear accelerator10.1269/jrr.11080 ↗
24. Ultra-short Electron Beams based spatio-temporal radiation biology and radiotherapy10.1016/j.mrrev.2010.01.006 ↗
25. Measurement of relative biological effectiveness of protons in human cancer cells using a laser driven quasi-monoenergetic proton beamline10.1063/1.3551623 ↗
26. Dose-Controlled irradiation of cancer cells with-laser-accelerated proton pulses10.1007/s00340-012-5275-3 ↗
27. Preparation of laser-accelerated proton beams for radiobiological applications10.1016/j.nima.2010.12.065 ↗
28. What will it take for laser driven proton accelerators to be applied to tumour therapy?10.1103/PhysRevSTAB.10.094801 ↗
29. Laser driven generation of fast particles10.2478/s11772-006-0048-3 ↗
30. Electron, photon and ion beams from the relativistic interaction of petawatt laser pulses with solid targets10.1063/1.874030 ↗
31. Energetic proton generation in ultra-intense laser-solid interactions10.1063/1.1333697 ↗
32. Laser generation of proton beams for the production of short-lived positron emitting radioisotopes10.1016/S0168-583X(01)00771-6 ↗
33. Scaling of proton acceleration driven by petawatt-laser-plasma interactions10.1038/nphys476 ↗
34. The scaling of proton energies in ultra-short pulse laser plasma acceleration10.1088/1367-2630/12/4/045015 ↗
35. Enhanced proton beams from ultra thin targets driven by high contrast laser pulses10.1063/1.2220011 ↗
36. GeV laser ion acceleration from ultra thin targets: The laser break-out afterburner10.1017/S0263034606060459 ↗
37. Relativistic buneman instability in the laser breakout afterburner10.1063/1.2768933 ↗
38. Break-out afterburner ion acceleration in the longer pulse length regime10.1063/1.3596555 ↗
39. Laser driven ion acceleration from relativistically transparent nanotargets10.1088/1367-2630/15/8/085015 ↗
40. Enhanced laser driven ion acceleration in the relativistic transparency regime10.1103/PhysRevLett.103.045002 ↗
41. Woods, K., Boucher, S., and O’Shea, F.H. (2013, January 14–19). Beam conditioning system for laser driven hadron therapy. Proceedings of the IPAC2013, Shaghai, China 08 Applications of Accelerators U01 Medical Applications THPWA050, Shanghai, China.
42. Efficient carbon ion beam generation from laser driven volume acceleration10.1088/1367-2630/15/2/023007 ↗
43. Highly efficient relativistic ion generation in the laser-piston regime10.1103/PhysRevLett.92.175003 ↗
44. Laser ion acceleration scaling laws in multiparametric particle-in-cell simulations10.1103/PhysRevLett.96.105001 ↗
45. Radiation pressure acceleration of thin foils with circularly polarised laser pulses10.1088/1367-2630/10/1/013021 ↗
46. Dominance of radiation pressure in ion acceleration with linearly polarised pulses at intensities of 1021 W·cm−210.1103/PhysRevLett.108.115002 ↗
47. Collisionless shocks in laser-produced plasma generate monoenergetic high-energy proton beams10.1038/nphys2130 ↗
48. Monoenergetic proton beams accelerated by a radiation pressure driven shock10.1103/PhysRevLett.106.014801 ↗
49. Direct high power laser acceleration of ions for medical applications10.1103/PhysRevLett.100.155004 ↗
50. Proposed double layer target for the generation of high quality laser accelerated ion beams10.1103/PhysRevLett.89.175003 ↗
51. Laser plasma acceleration of quasi-monoenergetic protons from microstructured targets10.1038/nature04492 ↗
52. Spectral shaping of laser generated proton beams10.1088/1367-2630/10/3/033034 ↗
53. Quasi-monoenergetic ion acceleration from a homogeneous composite target by an intense laser pulse10.1063/1.2404928 ↗
54. Production of proton beams with narrow band energy spectra from laser irradiated ultrathin foils10.1103/PhysRevE.75.015401 ↗
55. Ultrafast laser-driven microlens to focus and energy select mega-electron volt protons10.1126/science.1124412 ↗
56. Controlled transport and focusing of laser accelerated protons with miniature magnetic devices10.1103/PhysRevLett.101.055004 ↗
57. In situ characterisation of permanent magnetic quadrupoles for focussing proton beams10.1016/j.nima.2012.02.014 ↗
58. Laser accelerated protons captured and transported by a pulse power solenoid10.1103/PhysRevSTAB.14.121301 ↗
59. Enhanced proton acceleration by an ultrashort laser interaction with structured dynamic plasma targets10.1103/PhysRevLett.110.215004 ↗
60. Botton, M. Private communication.
61. Efficient and stable proton acceleration by irradiating a two layer target with a linearly polarised laser pulse10.1063/1.4773198 ↗
62. Isochoric heating of solid-density matter with an ultrafast proton beam10.1103/PhysRevLett.91.125004 ↗
63. Laser generated proton beam focusing and high temperature isochoric heating of solid matter10.1063/1.2774001 ↗
64. Autofocused, enhanced proton acceleration from a nanometer-scale bulged foil10.1063/1.3503610 ↗
65. On the small divergence of laser driven ion beams from nanometer thick foils10.1063/1.4816031 ↗
66. Focussing of short-pulse high intensity laser accelerated proton beams10.1038/nphys2153 ↗
67. Prospect for campact medical laser accelerators
68. Feasibility of using laser ion accelerators in proton therapy10.1134/1.1478534 ↗
69. Practicability of proton therapy using compact laser systems10.1118/1.1747751 ↗
70. Laser accelerated proton beams for radiation therapy
71. Particle selection for laser accelerated proton therapy feasibility study10.1118/1.1586268 ↗
72. Particle selection and beam collimation for laser accelerated proton beam therapy10.1118/1.1861772 ↗
73. Measured and simulated transport of 1.9 MeV laser-accelerated proton bunches through an integrated test beam line at 1 Hz10.1103/PhysRevSTAB.13.071304 ↗
74. Shielding design for a laser accelerator proton therapy system10.1088/0031-9155/52/13/017 ↗
75. Development of a laser driven proton accelerator for cancer therapy10.1134/S1054660X06040165 ↗
76. Bolton, P.R., Bulanov, S.V., and Daido, H. (2009). New Developments in Proton Therapy Systems, Laser Driven Relativistic Plasmas Applied to Science, Industry and Medicine 2nd International Symposium, American Institute of Physics.
77. Collection and focussing of laser accelerator ion beams for therapy applications10.1103/PhysRevSTAB.14.031304 ↗
78. Chromatic energy filter and characterisation of laser accelerated proton beams for particle therapy10.1016/j.nima.2012.04.022 ↗
79. Advanced treatment planning methods for efficient radiation therapy with laser accelerated proton and ion beams10.1118/1.3491406 ↗
80. Laser driven beam lines for delivering intensity modulated radiation therapy with particle beams10.1002/jbio.201200078 ↗
81. Review of electron beam therapy physics10.1088/0031-9155/51/13/R25 ↗
82. A laser-plasma accelerator producing monoenergetic electron beams10.1038/nature02963 ↗
83. Bolton, P.R., Bulanov, S.V., and Daido, H. (2009). Laser Driven Relativistic Plasmas Applied to Science, Industry and Medicine 2nd International Symposium, American Institute of Physics.
84. Radiotherapy with laser-plasma accelerators: Monte Carlo simulation of dose deposited by an experimental quasimonoenergetic electron beam10.1118/1.2140115 ↗
85. Exploring ultrashort high energy electron induced damage in human carcinoma cells10.1038/cddis.2010.46 ↗
86. Treatment planning for laser accelerated very high energy electrons10.1088/0031-9155/54/11/003 ↗
87. Comparison of mesured with calculated dose distribution from 120 MeV electron beam from a laser plasma accelerator10.1118/1.4719962 ↗
88. Are epigenetic mechanisms involved in radiation-induced bystander effects?10.3389/fgene.2012.00074 ↗
89. Bystander signalling: Exploring clinical relevance through new approaches and new models10.1016/j.clon.2013.06.005 ↗
90. Hall, E.J., and Giaccia, A.J. (2006). Radiobiology for the Radiologist, Lippincott Williams and Wilkins.
91. Initial events in the cellular effects of ionizing radiations: Clustered damage in DNA10.1080/09553009414550021 ↗
92. The complexity of DNA damage: Relevance to biological consequences10.1080/09553009414551401 ↗
93. Mozumder, A., and Hatano, Y. (2004). Charged Particle and Photon Interactions with Matter: Chemical, Physicochemical, and Biological Consequences with Applications, CRC Press.10.1201/9780203913284 ↗
94. Berlin, Y.A., and Siebbeles, D.A. (2008). Radiation Chemistry: From Basics to Applications in Material and Life Sciences, EDP Sciences.
95. Estimation of life times and diffusion distances of radicals involved in X-ray-induced DNA strand breaks of killing of mammalian cells10.2307/3574267 ↗
96. Effects of single-pulse (<or =1 ps) X-rays from laser-produced plasmas on mammalian cells10.1269/jrr.45.509 ↗
97. Is the increased relative biological effectiveness of high LET particles due to spatial or temporal effects? Characterization and OER in V79-4 cells10.1088/0031-9155/47/19/308 ↗
98. Survival of mammalian cells exposed to ultrahigh dose rates from a laser-produced plasma X-ray source10.1148/radiology.213.3.r99dc13860 ↗
99. Interaction of ion tracks in spatial and temporal proximity10.1007/s00411-009-0234-z ↗
100. Biological effectiveness on live cells of laser driven proton exceeding 109 Gy/s10.1063/1.3699063 ↗