A Review on the Advancements in the Field of Metal Complexes with Schiff Bases as Antiproliferative Agents
Source abstract
Abstract
Metal complexes play an essential role in pharmaceutical sciences for their multiple and important activities. Schiff bases are versatile pharmacophores able to form chelating complexes with several metals in different oxidation states. Complexes with Schiff bases are widely described in the literature for their multiple actions and numerous advantages, such as low cost and easy synthesis. They show multiple biological activities, including antimicrobial, antioxidant, antimalarial, antinflammatory and antitumor. Schiff bases may also form complexes with lanthanides and actinides acting as catalysts (e.g., in various synthetic processes) and antitumor agents. This review intends to extend on our previous paper regarding Schiff bases as antitumorals, highlighting the importance, in the field of the anticancer agents, of these tools as ligands of metal complexes.
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Research context
OpenAlex topics: Metal complexes synthesis and properties · Synthesis and Characterization of Heterocyclic Compounds · Ferrocene Chemistry and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Pharmacy-Drug Sciences, University of Bari “Aldo Moro”, 70126 Bari, Italy
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, Italy
Department of Science, University of Basilicata, Viale Dell’Ateneo Lucano 10, 85100 Potenza, Italy
Proteomics and Mass Spectrometry Unit IRCCS Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genova, Italy
Department of Health Sciences, Magna Graecia University, 88100 Catanzaro, Italy
Spinoff TNcKILLERS, Viale Dell’Ateneo Lucano 10, 85100 Potenza, Italy
Department of Biology and Chemistry, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy
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