journal article·2020-04-25Open access

Applications of Sesquiterpene Lactones: A Review of Some Potential Success Cases

Laila Moujir, Oliver Callies, Pedro M. C. Sousa, Farukh Sharopov, Ana M. L. Seca

Applied Sciences· Volume 10· Issue 9

Abstract

Sesquiterpene lactones, a vast range of terpenoids isolated from Asteraceae species, exhibit a broad spectrum of biological effects and several of them are already commercially available, such as artemisinin. Here the most recent and impactful results of in vivo, preclinical and clinical studies involving a selection of ten sesquiterpene lactones (alantolactone, arglabin, costunolide, cynaropicrin, helenalin, inuviscolide, lactucin, parthenolide, thapsigargin and tomentosin) are presented and discussed, along with some of their derivatives. In the authors’ opinion, these compounds have been neglected compared to others, although they could be of great use in developing important new pharmaceutical products. The selected sesquiterpenes show promising anticancer and anti-inflammatory effects, acting on various targets. Moreover, they exhibit antifungal, anxiolytic, analgesic, and antitrypanosomal activities. Several studies discussed here clearly show the potential that some of them have in combination therapy, as sensitizing agents to facilitate and enhance the action of drugs in clinical use. The derivatives show greater pharmacological value since they have better pharmacokinetics, stability, potency, and/or selectivity. All these natural terpenoids and their derivatives exhibit properties that invite further research by the scientific community.
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Research context

OpenAlex topics: Sesquiterpenes and Asteraceae Studies · Plant Toxicity and Pharmacological Properties · Herbal Medicine Research Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Biochemistry, Microbiology, Genetics and Cell Biology, Facultad de Farmacia, Universidad de La Laguna, 38206 San Cristóbal de La Laguna, Spain

AbbVie Deutschland GmbH & Co. KG, Knollstrasse, 67061 Ludwigshafen, Germany

Faculty of Sciences and Technology, University of Azores, 9500-321 Ponta Delgada, Portugal

Research Institution “Chinese-Tajik Innovation Center for Natural Products”, Academy of Sciences of the Republic of Tajikistan, Ayni 299/2, Dushanbe 734063, Tajikistan

cE3c—Centre for Ecology, Evolution and Environmental Changes/Azorean Biodiversity Group & Faculty of Sciences and Technology, University of Azores, Rua Mãe de Deus, 9500-321 Ponta Delgada, Portugal

LAQV-REQUIMTE, University of Aveiro, 3810-193 Aveiro, Portugal

Funding

Fundação para a Ciência e a Tecnologia · Ministerio de Economía, Industria y Competitividad, Gobierno de España

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