Deep Eutectic Solvents for the Extraction of Bioactive Compounds from Natural Sources and Agricultural By-Products
Source abstract
Abstract
In this work, a review about the applicability of eutectic solvents, mainly deep eutectic solvents (DES) and natural deep eutectic solvents (NADES), for the extraction of bioactive compounds from natural products has been carried out. These alternative solvents have shown not only to have high extraction yields but also to be environmentally friendly, exhibiting very low or almost no toxicity, compared to conventional organic solvents. The last trends and main extraction methods that have been most widely used in studies using these emerging solvents have been reviewed, as well as the varied natural sources in which they have been used, including agro-food by-products. Besides the toxicity, biodegradability of these solvents is reviewed. Likewise, different reported bioactivity tests have been included, in which extracts obtained with these ecological solvents have been tested from antioxidant activity analysis to in vivo studies with rats, through in vitro cytotoxicity tests.
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Research context
OpenAlex topics: Ionic liquids properties and applications · Chemical and Physical Properties in Aqueous Solutions · Electrochemical Analysis and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Foodomics Laboratory, Institute of Food Science Research (CIAL, CSIC), C/Nicolás Cabrera 9, 28049 Madrid, Spain
Grupo de Ciencia, Tecnología e Innovación en Alimentos, Universidad San Ignacio de Loyola (USIL), Av. La Fontana 550, Lima 15024, Peru
Funding
Ministerio de Economía, Industria y Competitividad, Gobierno de España
References (50)
Show source-provided references
1. FAO (2017). Save Food for a Better Climate, FAO.
2. Which Is the Best Food Emerging Solvent: IL, DES or NADES?10.1016/j.tifs.2019.06.003 ↗
3. The Hype with Ionic Liquids as Solvents10.1016/j.cplett.2016.07.044 ↗
4. Extraction of Value-Added Components from Food Industry Based and Agro-Forest Biowastes by Deep Eutectic Solvents10.1016/j.jbiotec.2018.06.349 ↗
5. Are Natural Deep Eutectic Solvents the Missing Link in Understanding Cellular Metabolism and Physiology?10.1104/pp.111.178426 ↗
6. Application of Natural Deep Eutectic Solvents for Extraction and Determination of Phenolics in Cajanus Cajan Leaves by Ultra Performance Liquid Chromatography10.1016/j.seppur.2015.05.015 ↗
7. Novel Lactic Acid-Based Natural Deep Eutectic Solvents: Efficiency in the Ultrasound-Assisted Extraction of Antioxidant Polyphenols from Common Native Greek Medicinal Plants
8. Natural Deep Eutectic Solvents—Solvents for the 21st Century10.1021/sc500096j ↗
9. Green and Efficient Extraction of Rutin from Tartary Buckwheat Hull by Using Natural Deep Eutectic Solvents10.1016/j.foodchem.2016.11.013 ↗
10. Terpene-Based Natural Deep Eutectic Systems as Efficient Solvents to Recover Astaxanthin from Brown Crab Shell Residues10.1021/acssuschemeng.9b06283 ↗
11. Biocompatible Deep Eutectic Solvents Based on ChCl: Characterization and Application to the Extraction of Rutin from Sophora Japonica10.1021/acssuschemeng.5b00619 ↗
12. Toxicity of Natural Deep Eutectic Solvent Betaine:Glycerol in Rats10.1021/acs.jafc.8b01746 ↗
13. Supplementation of Glycerol or Fructose via Drinking Water to Grazing Lambs on Tissue Glycogen Level and Lipogenesis
14. Natural Deep Eutectic Solvents Couple with Integrative Extraction Technique as an Effective Approach for Mulberry Anthocyanin Extraction10.1016/j.foodchem.2019.05.196 ↗
15. Anti-Diabetic Effect of Isoflavone Rich Kudzu Root Extract in Experimentally Induced Diabetic Rats10.1016/j.jff.2020.103922 ↗
16. Deep Eutectic Solvents as Green Media for Extraction of Flavonoid Glycosides and Aglycones from Platycladi Cacumen10.1016/j.jpba.2016.11.049 ↗
17. Efficient Extraction of Bioactive Flavonoids from Ginkgo Biloba Leaves Using Deep Eutectic Solvent/Water Mixture as Green Media10.15255/CABEQ.2017.1146 ↗
18. Deep Eutectic Solvent Combined with Ultrasound-Assisted Extraction as High Efficient Extractive Media for Extraction and Quality Evaluation of Herba Epimedii10.1016/j.jpba.2020.113228 ↗
19. Torres-Vega, J., Gomez-Alonso, S., Perez-Navarro, J., and Pastene-navarrete, E. (2020). Green Extraction of Alkaloids and Polyphenols from Peumus Boldus Leaves with Natural Deep Eutectic. Plants, 9.10.3390/plants9020242 ↗
20. Enhanced Extraction of Bioactive Natural Products Using Tailor-Made Deep Eutectic Solvents: Application to Flavonoid Extraction from Flos Sophorae10.1039/C4GC01556H ↗
21. Effective Extraction of Flavonoids from Lycium Barbarum L. Fruits by Deep Eutectic Solvents-Based Ultrasound-Assisted Extraction10.1016/j.talanta.2019.05.012 ↗
22. Natural Deep Eutectic Solvents as a New Extraction Media for Phenolic Metabolites in Carthamus Tinctorius L.10.1021/ac400432p ↗
23. Application of Natural Deep Eutectic Solvents to the Extraction of Anthocyanins from Catharanthus Roseus with High Extractability and Stability Replacing Conventional Organic Solvents10.1016/j.chroma.2016.01.037 ↗
24. Deep Eutectic Solvents Applied in the Extraction and Stabilization of Rosemary (Rosmarinus officinalis L.) Phenolic Compounds10.1016/j.indcrop.2019.112049 ↗
25. Chemat, F., Vian, M.A., Ravi, H.K., Khadhraoui, B., Hilali, S., Perino, S., and Tixier, A.S.F. (2019). Review of Alternative Solvents for Green Extraction of Food and Natural Products: Panorama, Principles, Applications and Prospects. Molecules, 24.10.3390/molecules24163007 ↗
26. Extraction of Phenolic Compounds from Olive Pomace by Using Natural Deep Eutectic Solvents and Innovative Extraction Techniques10.1016/j.ifset.2018.07.001 ↗
27. ChCl Derivative-Based Deep Eutectic Liquids as Novel Green Alternative Solvents for Extraction of Phenolic Compounds from Olive Leaf10.1016/j.arabjc.2018.01.003 ↗
28. Osorio, L.L.D.R., Flórez-López, E., and Grande-Tovar, C.D. (2021). The Potential of Selected Agri-Food Loss and Waste to Contribute to a Circular Economy: Applications in the Food, Cosmetic and Pharmaceutical Industries. Molecules, 26.10.3390/molecules26020515 ↗
29. Putnik, P., Bursać Kovačević, D., Režek Jambrak, A., Barba, F.J., Cravotto, G., Binello, A., Lorenzo, J.M., and Shpigelman, A. (2017). Innovative “Green” and Novel Strategies for the Extraction of Bioactive Added Value Compounds from Citruswastes—A Review. Molecules, 22.10.3390/molecules22050680 ↗
30. Green Approaches for the Extraction of Antioxidants from Eucalyptus Leaves10.1016/j.indcrop.2019.111473 ↗
31. Sustainable Extraction of Proteins and Bioactive Substances from Pomegranate Peel (Punica granatum L.) Using Pressurized Liquids and Deep Eutectic Solvents10.1016/j.ifset.2020.102314 ↗
32. Effect of Deep Eutectic Solvent’s Characteristics on Extraction and Bioactivity of Polyphenols from Sapodilla Pulp10.1007/s11696-020-01330-y ↗
33. Effect of ChCl-Oxalic Acid Based Deep Eutectic Solvent on the Ultrasonic Assisted Extraction of Polyphenols from Aegle Marmelos10.1016/j.molliq.2019.110956 ↗
34. Ready-to-Use Green Polyphenolic Extracts from Food by-Products10.1016/j.foodchem.2019.01.061 ↗
35. de los Á.; Espino, M.; Gomez, F.J.V.; Silva, M.F. Novel Approaches Mediated by Tailor-Made Green Solvents for the Extraction of Phenolic Compounds from Agro-Food Industrial by-Products10.1016/j.foodchem.2017.06.150 ↗
36. Green Extraction of Polyphenols from Grapefruit Peels Using High Voltage Electrical Discharges, Deep Eutectic Solvents and Aqueous Glycerol10.1016/j.foodchem.2019.05.111 ↗
37. Extraction and Preliminary Purification of Polysaccharides from Camellia Oleifera Abel. Seed Cake Using a Thermoseparating Aqueous Two-Phase System Based on EOPO Copolymer and Deep Eutectic Solvents10.1016/j.foodchem.2020.126164 ↗
38. Natural Deep Eutectic Solvents and Ultrasound-Assisted Extraction: Green Approaches for Extraction of Wine Lees Anthocyanins10.1016/j.fbp.2016.12.005 ↗
39. Lin, Z., Jiao, G., Zhang, J., Celli, G.B., and Brooks, M.S.L. (2020). Optimization of Protein Extraction from Bamboo Shoots and Processing Wastes Using Deep Eutectic Solvents in a Biorefinery Approach. Biomass Convers. Biorefinery, in press.10.1007/s13399-020-00614-3 ↗
40. Phenolic Compounds from Virgin Olive Oil Obtained by Natural Deep Eutectic Solvent (NADES): Effect of the Extraction and Recovery Conditions10.1007/s13197-020-04567-3 ↗
41. Extraction for Profiling Free and Bound Phenolic Compounds in Tea Seed Oil by Deep Eutectic Solvents10.1111/1750-3841.15019 ↗
42. Deep Deterpenation of Citrus Essential Oils Intensified by in Situ Formation of a Deep Eutectic Solvent in Associative Extraction10.1021/acs.iecr.0c00442 ↗
43. Extraction of Phenolic Compounds from Virgin Olive Oil by Deep Eutectic Solvents (DESs)10.1016/j.foodchem.2015.10.131 ↗
44. Deterpenation of Citrus Essential Oils Using Glycerol-Based Deep Eutectic Solvents10.1021/acs.jced.7b00944 ↗
45. A Highly Efficient Microextraction Technique Based on Deep Eutectic Solvent Formed by ChCl and P-Cresol for Simultaneous Determination of Lignans in Sesame Oils10.1016/j.foodchem.2018.12.088 ↗
46. Performance of Choline-Based Deep Eutectic Solvents in the Extraction of Tocols from Crude Palm Oil10.1007/s11746-015-2720-6 ↗
47. Green, Fast and Simple Dispersive Liquid-Liquid Microextraction Method by Using Hydrophobic Deep Eutectic Solvent for Analysis of Folic Acid in Fortified Flour Samples before Liquid Chromatography Determination10.1016/j.foodchem.2020.126486 ↗
48. High Selective Purification of IgY from Quail Egg: Process Design and Quantification of Deep Eutectic Solvent Based Ultrasound Assisted Liquid Phase Microextraction Coupled with Preparative Chromatography10.1016/j.ijbiomac.2019.12.242 ↗
49. Green and Simple Extraction of Free Seleno-Amino Acids from Powdered and Lyophilized Milk Samples with Natural Deep Eutectic Solvents10.1016/j.foodchem.2020.126965 ↗
50. Enhanced Extraction of Hydroxyapatite from Bighead Carp (Aristichthys Nobilis) Scales Using Deep Eutectic Solvent10.1111/1750-3841.14971 ↗