Copper Nanoparticles: Synthesis and Characterization, Physiology, Toxicity and Antimicrobial Applications
Source abstract
Abstract
Metallic nanoparticles are a new class of materials with applications in medicine, pharmaceutical and agriculture. Using biological, chemical and physical approaches, nanoparticles with amazing properties are obtained. Copper is one of the most-found elements and plays an important part in the normal functioning of organisms. Coper nanoparticles have superior antibacterial properties when comparing them to present day antibiotics. Moreover, apart from their antibacterial role, antifungal, antiviral and anticancer properties have been described. Although the mechanism of actions is not completely understood, copper nanoparticles can become a viable alternative in fighting multi-resistant bacteria strains. We hereby review the already existing data on copper nanoparticle synthesis, effects and mechanisms of action as well as toxicity.
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Research context
OpenAlex topics: Nanoparticles: synthesis and applications · Gold and Silver Nanoparticles Synthesis and Applications · Advanced Nanomaterials in Catalysis
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
3rd Surgery Clinic, University of Medicine and Pharmacy, 400162 Cluj-Napoca, Romania
Physiology Discipline, University of Medicine and Pharmacy, 400162 Cluj-Napoca, Romania
Nanomedicine Department, Regional Institute of Gastroenterology and Hepatology, 400162 Cluj-Napoca, Romania
References (90)
Show source-provided references
1. Nanomaterials an introduction to synthesis, properties and application
2. Nanoparticulate functional materials10.1002/anie.200903053 ↗
3. Bruna, T., Maldonado-Bravo, F., Jara, P., and Caro, N. (2021). Silver nanoparticles and their antibacterial applications. Int. J. Mol. Sci., 22.10.3390/ijms22137202 ↗
4. One step synthesis and characterization of gold nanoparticles and their antibacterial activities against E. coli (ATCC 25922 strain)
5. Biogenic platinum nanoparticles using black cumin seed and their potential usage as antimicrobial and anticancer agent10.1016/j.jpba.2019.112961 ↗
6. Synthesis and characterization of zinc/iron oxide composite nanoparticles and their antibacterial properties10.1016/j.colsurfa.2010.10.015 ↗
7. Biogenesis of metal nanoparticles and their pharmacological applications: Present status and application prospects10.1007/s40097-018-0267-4 ↗
8. Characterization techniques for nanoparticles: Comparison and complementarity upon studying nanoparticle properties10.1039/C8NR02278J ↗
9. Femtosecond X-ray protein nanocrystallography10.1038/nature09750 ↗
10. Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistribution10.1021/mp800032f ↗
11. Characterization of dendrimers by X-ray photoelectron spectroscopy10.1366/0003702991945524 ↗
12. Following enzyme activity with infrared spectroscopy10.3390/s100402626 ↗
13. Antibacterial properties and toxicity from metallic nanomaterials10.2147/IJN.S134526 ↗
14. Dietary reference intakes: Vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc10.1016/S0002-8223(01)00078-5 ↗
15. Biogenic copper nanoparticles and their applications: A review10.1007/s42452-020-2279-1 ↗
16. 7. Physico-chemical and heavy metals analysis of drinking water and their effect on human health: A Review
17. Bioactivity, mechanism of action, and cytotoxicity of copper-based nanoparticles: A review10.1007/s00253-013-5422-8 ↗
18. Risk–benefit analysis of mineral intakes: Case studies on copper and iron10.1017/S0029665110003873 ↗
19. Biological synthesis of copper nanoparticles and its impact
20. Green synthesis of copper & copper oxide nanoparticles using the extract of seedless dates10.1016/j.heliyon.2019.e03123 ↗
21. Green synthesis of copper nanoparticles using leaf extract of Ageratum houstonianum Mill. and study of their photocatalytic and antibacterial activities10.1088/2632-959X/ab8e99 ↗
22. Edis, Z., Bloukh, S.H., Ashames, A., and Ibrahim, M. (2018). Copper-Based Nanoparticles, their chemistry and Antibacterial properties: A Review. International Conference on Pure and Applied Chemistry, Springer.10.1007/978-3-030-20283-5_24 ↗
23. Oxidation behavior of copper nanoparticles at low temperature10.1016/j.materresbull.2011.08.043 ↗
24. Oxidation of copper nanoparticles in water: Mechanistic insights revealed by oxygen uptake and spectroscopic methods10.1039/c3dt32836h ↗
25. Synthesis of copper nanoparticles and role of pH on particle size control10.1016/j.matpr.2016.04.100 ↗
26. A facile synthesis of monodispersed carbon-encapsulated copper nanoparticles with excellent oxidation resistance from a refluxing-derived precursor10.1246/cl.130064 ↗
27. Green synthesized and characterized copper nanoparticles using various new plants extracts aggravate microbial cell membrane damage after interaction with lipopolysaccharide10.1016/j.ijbiomac.2020.05.198 ↗
28. Rapid synthesis of Au, Ag, and bimetallic Au core-Ag shell nanoparticles using Neem (Azadirachta indica) leaf broth10.1016/j.jcis.2004.03.003 ↗
29. Synthesis, characterization and pharmacological potential of green synthesized copper nanoparticles10.1007/s00449-019-02173-y ↗
30. Green synthesis of copper nanoparticles by Citrus limon fruits extract, characterization and antibacterial activity
31. Biosynthesis of copper nanoparticles; its characterization and efficacy against human pathogenic bacterium10.1016/j.jece.2016.03.046 ↗
32. Green synthesis and characterizations of copper nanoparticles10.1016/j.matchemphys.2019.122283 ↗
33. Green synthesis and characterization of spherical copper nanoparticles as organometallic antibacterial agent10.1002/aoc.3642 ↗
34. Green synthesis of copper nanoparticles using Ginkgo biloba L. leaf extract and their catalytic activity for the Huisgen [3 2] cycloaddition of azides and alkynes at room temperature10.1016/j.jcis.2015.07.004 ↗
35. Biological synthesis of copper nanoparticles using plant extract
36. Assisted green synthesis of copper nanoparticles using Syzygium aromaticum bud extract: Physical, optical and antimicrobial properties10.1016/j.ijleo.2017.10.074 ↗
37. Green synthesis and characterization of copper nanoparticles using Azadirachta indica leaves10.1016/j.matchemphys.2018.04.007 ↗
38. Green synthesis of zerovalent copper nanoparticles for efficient reduction of toxic azo dyes congo red and methyl orange10.1515/gps-2018-0038 ↗
39. Biosynthesis of copper nanoparticles using aqueous Tilia extract: Antimicrobial and anticancer activities10.1016/j.heliyon.2018.e01077 ↗
40. Biogenesis of copper nanoparticles using peel extract of Punica granatum and their antimicrobial activity against opportunistic pathogens10.1080/17518253.2016.1141238 ↗
41. Biological synthesis of copper nanoparticles using Magnolia kobus leaf extract and their antibacterial activity10.1002/jctb.4052 ↗
42. Sonochemical synthesis of amorphous Cu and nanocrystalline Cu2O embedded in a polyaniline matrix10.1039/b005769j ↗
43. Hydrothermal synthesis of copper based nanoparticles: Antimicrobial screening and interaction with DNA10.1016/j.jinorgbio.2013.12.009 ↗
44. Nanoscale twinned copper nanowire formation by direct electrodeposition10.1002/smll.200900746 ↗
45. Effect of copper salts and reducing agents on characteristics and antimicrobial activity of copper nanoparticles10.1016/j.matlet.2014.06.014 ↗
46. New routes to Cu (I)/Cu nanocatalysts for the multicomponent click synthesis of 1,2,3-triazoles10.1039/C2NR32570E ↗
47. Cross-Dehydrogenative Coupling of Tertiary Amines and Terminal Alkynes Catalyzed by Copper Nanoparticles on Zeolite10.1002/adsc.201500787 ↗
48. Synthesis and evaluation of antioxidant and antibacterial behavior of CuO nanoparticles10.1016/j.colsurfb.2012.07.002 ↗
49. Copper nanoparticles mediated by chitosan: Synthesis and characterization via chemical methods10.3390/molecules171214928 ↗
50. Synthesis and evaluation of the structural, optical, and antibacterial properties of copper oxide nanoparticles10.1007/s00339-019-2785-4 ↗
51. Chemical synthesis of copper nanoparticles in aqueous solutions in the presence of anionic surfactant sodium dodecyl sulfate10.1016/j.colsurfa.2018.05.023 ↗
52. Synthesis of copper nanoparticles with various sizes and shapes: Application as a superior non-enzymatic sensor and antibacterial agent10.20964/2016.06.83 ↗
53. Synthesis and optical properties of copper nanoparticles prepared by a chemical reduction method10.1088/2043-6262/2/1/015009 ↗
54. Antimicrobial Effect of Copper Nanoparticles Synthesized by Chemical Method10.3126/ijasbt.v7i4.26295 ↗
55. Synthesis of silver nanoparticles: Chemical, physical and biological methods
56. Strategies to minimize antibiotic resistance10.3390/ijerph10094274 ↗
57. Synthesis, characterization, and antimicrobial properties of copper nanoparticles
58. Copper Nanoparticles as Potential Antimicrobial Agent in Disinfecting Root Canals. A Systematic Review10.4067/S0718-381X2016000300024 ↗
59. Investigations into the antibacterial behavior of copper nanoparticles against Escherichia coli10.1007/s13213-010-0015-6 ↗
60. Copper, an ancient remedy returning to fight microbial, fungal and viral infections
61. Mechanism of antibacterial activity of copper nanoparticles10.1088/0957-4484/25/13/135101 ↗
62. Duval, R.E., Grare, M., and Demoré, B. (2019). Fight against antimicrobial resistance: We always need new antibacterials but for right bacteria. Molecules, 24.10.3390/molecules24173152 ↗
63. Resistance to vancomycin and teicoplanin: An emerging clinical problem10.1128/CMR.3.3.280 ↗
64. Metal nanoparticles: Understanding the mechanisms behind antibacterial activity10.1186/s12951-017-0308-z ↗
65. Ravishankar Rai, V. (2021, November 03). Nanoparticles and Their Potential Application as Antimicrobials. Available online: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.459.8922.
66. Antimicrobial Nanoparticles: Applications and mechanisms of action10.4038/sljid.v8i1.8167 ↗
67. Characterisation of copper oxide nanoparticles for antimicrobial applications10.1016/j.ijantimicag.2008.12.004 ↗
68. Strain specificity in antimicrobial activity of silver and copper nanoparticles10.1016/j.actbio.2007.11.006 ↗
69. Seed mediated formation of bimetallic nanoparticles by UV Irradiation: A photochemical approach for the preparation of “core–shell” type structures10.1021/nl0100264 ↗
70. Susceptibility constants of Escherichia coli and Bacillus subtilis to silver and copper nanoparticles10.1016/j.scitotenv.2006.11.007 ↗
71. Comparison of Antibacterial Effects of ZnO and CuO Nanoparticles Coated Brackets against Streptococcus Mutans
72. Characterization of copper nanoparticles synthesized by a novel microbiological method10.1007/s11837-010-0171-y ↗
73. Green-synthesized copper nanoparticles as a potential antifungal against plant pathogens10.1039/C9RA03110C ↗
74. Singlet oxygen mediated DNA degradation by copper nanoparticles: Potential towards cytotoxic effect on cancer cells10.1186/1477-3155-9-9 ↗
75. Nanoparticles—A review
76. Ecotoxicological effects and mechanism of CuO nanoparticles to individual organisms10.1016/j.envpol.2016.11.066 ↗
77. Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: The role of particle size, shape and composition10.1002/jat.1385 ↗
78. Impairment of mitochondrial function by particulate matter (PM) and their toxic components: Implications for PM-induced cardiovascular and lung disease10.2741/2142 ↗
79. Sirotkin, A.V., Radosová, M., Tarko, A., Fabova, Z., Martín-García, I., and Alonso, F. (2020). Abatement of the stimulatory effect of copper nanoparticles supported on titania on ovarian cell functions by some plants and phytochemicals. Nanomaterials, 10.10.3390/nano10091859 ↗
80. Liver toxicity assessments in rats following sub-chronic oral exposure to copper nanoparticles10.1186/s12302-019-0214-0 ↗
81. Research strategies for safety evaluation of nanomaterials, part VII: Evaluating consumer exposure to nanoscale materials10.1093/toxsci/kfj129 ↗
82. Copper-based nanoparticles induce high toxicity in leukemic HL60 cells10.1016/j.tiv.2015.05.020 ↗
83. Interplay between autophagy and apoptosis mediated by copper oxide nanoparticles in human breast cancer cells MCF710.1016/j.bbagen.2013.08.011 ↗
84. The newest achievements in synthesis, immobilization and practical applications of antibacterial nanoparticles10.1016/j.cej.2013.05.046 ↗
85. Synthesis of agarose-metal/semiconductor nanoparticles having superior bacteriocidal activity and their simple conversion to metal-carbon composites10.1007/s12039-008-0088-y ↗
86. Colloidal Cu nanoparticles/chitosan composite film obtained by microwaveheating for food package applications10.1007/s00289-008-0031-x ↗
87. Copper (II) ions and copper nanoparticles-loaded chemically modified cotton cellulose fibers with fair antibacterial properties10.1002/app.29890 ↗
88. Kalińska, A., Jaworski, S., Wierzbicki, M., and Gołębiewski, M. (2019). Silver and copper nanoparticles—An alternative in future mastitis treatment and prevention?. Int. J. Mol. Sci., 20.10.3390/ijms20071672 ↗
89. Potential of copper nanoparticles to increase growth and yield of wheat10.24218/jnat.2015.02 ↗
90. Synthesis, characterization, and antifouling potential of functionalized copper nanoparticles10.1021/la800102f ↗