Plant-Derived Bioactives and Oxidative Stress-Related Disorders: A Key Trend towards Healthy Aging and Longevity Promotion
Source abstract
Abstract
Plants and their corresponding botanical preparations have been used for centuries due to their remarkable potential in both the treatment and prevention of oxidative stress-related disorders. Aging and aging-related diseases, like cardiovascular disease, cancer, diabetes, and neurodegenerative disorders, which have increased exponentially, are intrinsically related with redox imbalance and oxidative stress. Hundreds of biologically active constituents are present in each whole plant matrix, providing promissory bioactive effects for human beings. Indeed, the worldwide population has devoted increased attention and preference for the use of medicinal plants for healthy aging and longevity promotion. In fact, plant-derived bioactives present a broad spectrum of biological effects, and their antioxidant, anti-inflammatory, and, more recently, anti-aging effects, are considered to be a hot topic among the medical and scientific communities. Nonetheless, despite the numerous biological effects, it should not be forgotten that some bioactive molecules are prone to oxidation and can even exert pro-oxidant effects. In this sense, the objective of the present review is to provide a detailed overview of plant-derived bioactives in age-related disorders. Specifically, the role of phytochemicals as antioxidants and pro-oxidant agents is carefully addressed, as is their therapeutic relevance in longevity, aging-related disorders, and healthy-aging promotion. Finally, an eye-opening look into the overall evidence of plant compounds related to longevity is presented.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Medicinal Plants and Bioactive Compounds · Phytochemicals and Antioxidant Activities · Genomics, phytochemicals, and oxidative stress
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam 44340847, Iran
CREA—Research Centre for Food and Nutrition, Via Ardeatina, 546-00178 Roma, Italy
Department of Biomedical Sciences, University of Cagliari, 09124 Cagliari, Italy
Department of Biomedical, Surgical and Dental Sciences, Milan State University, 20142 Milan, Italy
Department of Chemistry, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal 576104, India
Department of Biological and Environmental Sciences and Technologies (Di.S.Te.B.A.), University of Salento, 73100 Lecce, Italy
Institute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, 11129 Belgrade, Serbia
Department of Biochemistry, Faculty of Science, University of Yaounde 1, Yaounde 812, Cameroon
Department of Pharmaceutical Chemistry, H.N.B. Garhwal (A Central) University, Srinagar Garhwal, Uttarakhand 246174, India
Department of Biochemistry, Hemvati Nandan Bahuguna Garhwal University (A Central University), Srinagar, Garhwal, Uttarakhand 246174, India
Department Agricultural and Food Engineering, School of Engineering, Holy Spirit University of Kaslik, Jounieh B.P. 446, Lebanon
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
Department of Experimental, Diagnostic and Specialty Medicine-DIMES General Pathology Section, Via San Giacomo, 14, Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy
Department of Agricultural and Environmental Sciences, Milan State University, via G. Celoria 2, 20133 Milan, Italy
Research Group in Community Nutrition and Oxidative Stress, University of Balearic Islands & Health Research Institute of the Balearic Islands (IdISBa), E-07122 Palma, Balearic Islands, Spain
CIBEROBN (Physiopathology of Obesity and Nutrition), University of Balearic Islands, E- 07122 Palma, Balearic Islands, Spain
Department of Nutrition and Dietetics, Faculty of Pharmacy, University of Concepcion, Concepcion 4070386, Chile
Unidad de Desarrollo Tecnológico, Universidad de Concepción UDT, Concepcion 4070386, Chile
Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal
Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal
Department of Medical Parasitology, Kerman University of Medical Sciences, Kerman 7616913555, Iran
Department of Biology and Biotechnology, School of Agriculture of the Polytechnic Institute of Bragança (ESA-IPB), Campus de Santa Apolónia, 5301-854 Bragança, Portugal
CIMO, Mountain Research Center, Polytechnic Institute of Bragança, Campus Santa Apolónia, 5301-855 Bragança, Portugal
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1991953381, Iran
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