journal article·2020-05-31Open access

Gold Nanoparticles for Drug Delivery and Cancer Therapy

Sarkar Siddique, James C. L. Chow

Applied Sciences· Volume 10· Issue 11

Abstract

Nanomaterials are popularly used in drug delivery, disease diagnosis and therapy. Among a number of functionalized nanomaterials such as carbon nanotubes, peptide nanostructures, liposomes and polymers, gold nanoparticles (Au NPs) make excellent drug and anticancer agent carriers in biomedical and cancer therapy application. Recent advances of synthetic technique improved the surface coating of Au NPs with accurate control of particle size, shape and surface chemistry. These make the gold nanomaterials a much easier and safer cancer agent and drug to be applied to the patient’s tumor. Although many studies on Au NPs have been published, more results are in the pipeline due to the rapid development of nanotechnology. The purpose of this review is to assess how the novel nanomaterials fabricated by Au NPs can impact biomedical applications such as drug delivery and cancer therapy. Moreover, this review explores the viability, property and cytotoxicity of various Au NPs.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Gold and Silver Nanoparticles Synthesis and Applications · Nanoparticle-Based Drug Delivery · Graphene and Nanomaterials Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Physics, Ryerson University, Toronto, ON M5B 2K3, Canada

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5B 2K3, Canada

Department of Radiation Oncology, University of Toronto, Toronto, ON M5T 1P5, Canada

References (100+)

Show source-provided references
1. Martelli, S., and Chow, J.C.L. (2020). Dose Enhancement for the Flattening-Filter-Free and Flattening-Filter Photon Beams in Nanoparticle-Enhanced Radiotherapy: A Monte Carlo Phantom Study. Nanomaterials, 10.10.3390/nano10040637 ↗
2. Imaging dose of cone-beam computed tomography in nanoparticle-enhanced image-guided radiotherapy: A Monte Carlo phantom study10.3934/bioeng.2020001 ↗
3. Chan, M.F. (2018). Monte Carlo Nanodosimetry in Gold Nanoparticle-Enhanced Radiotherapy. Recent Advancements and Applications in Dosimetry, Nova Science Publishers. Chapter 2.
4. Gold nanoparticles as novel agents for cancer therapy10.1259/bjr/59448833 ↗
5. Cancer Nanomedicine: From Drug Delivery to Imaging10.1126/scitranslmed.3005872 ↗
6. Abdulle, A., and Chow, J.C.L. (2019). Contrast Enhancement for Portal Imaging in Nanoparticle-Enhanced Radiotherapy: A Monte Carlo Phantom Evaluation Using Flattening-Filter-Free Photon Beams. Nanomaterials, 9.10.3390/nano9070920 ↗
7. Toxicity and cellular uptake of gold nanoparticles: what we have learned so far?10.1007/s11051-010-9911-8 ↗
8. The new era of nanotechnology, an alternative to change cancer treatment10.2147/DDDT.S142337 ↗
9. Tumor-Agnostic Treatment for Cancer: When How is Better than Where10.1007/s40261-020-00915-5 ↗
10. Kong, F.-Y., Zhang, J.-W., Li, R.-F., Wang, Z.-X., Wang, W.-J., and Wang, W. (2017). Unique Roles of Gold Nanoparticles in Drug Delivery, Targeting and Imaging Applications. Molecules, 22.10.3390/molecules22091445 ↗
11. Martinez, L.M.T., Kharissova, O.V., and Kharisov, B.I. (2017). Application of Nanoparticle Materials in Radiation Therapy. Handbook of Ecomaterials, Springer Nature. Chapter 150.
12. Grumezescu, A.M. (2016). Photon and electron interactions with gold nanoparticles: a Monte Carlo study on gold nanoparticle-enhanced radiotherapy. Nanobiomaterials in Medical Imaging: Applications of nanobiomaterials, Elsevier. Chapter 2.
13. Kharissova, O.V., Torres-Martínez, L.M., and Kharisov, B.I. (2020). Recent Progress of Gold Nanomaterials in Cancer Therapy. Handbook of Nanomaterials and Nanocomposites for Energy and Environmental Applications, Springer Nature.10.1007/978-3-030-11155-7 ↗
14. Positioning metal-organic framework nanoparticles within the context of drug delivery—A comparison with mesoporous silica nanoparticles and dendrimers10.1016/j.biomaterials.2017.01.025 ↗
15. Abbas, M., Alqahtani, M., AlGahtani, A., Kessentini, A., Loukil, H., Parayangat, M., Ijyas, T., and Mohammed, A.W. (2020). Validation of Nanoparticle Response to the Sound Pressure Effect during the Drug-Delivery Process. Polymers, 12.10.3390/polym12010186 ↗
16. Gold nanoparticle research before and after the Brust–Schiffrin method10.1039/C2CC35720H ↗
17. Bai, X., Wang, Y., Song, Z., Feng, Y., Chen, Y., Zhang, D., and Feng, L. (2020). The Basic Properties of Gold Nanoparticles and their Applications in Tumor Diagnosis and Treatment. Int. J. Mol. Sci., 21.10.3390/ijms21072480 ↗
18. Dumur, F., Dumas, E., and Mayer, C. (2020). Functionalization of Gold Nanoparticles by Inorganic Entities. Nanomaterials, 10.10.3390/nano10030548 ↗
19. Renaissance of nuclear medicine through green nanotechnology: functionalized radioactive gold nanoparticles in cancer therapy—My journey from chemistry to saving human lives10.1007/s10967-016-4888-0 ↗
20. Gold nanoparticle-based theranostics: disease diagnostics and treatment using a single nanomaterial10.2147/NDD.S60285 ↗
21. Slepička, P., Kasálková, N.S., Siegel, J., Kolská, Z., and Švorčík, V. (2019). Methods of Gold and Silver Nanoparticles Preparation. Materials, 13.10.3390/ma13010001 ↗
22. Role of ions in the colloidal synthesis of gold nanowires10.1080/14786430601110356 ↗
23. The optical, photothermal, and facile surface chemical properties of gold and silver nanoparticles in biodiagnostics, therapy, and drug delivery10.1007/s00204-014-1245-3 ↗
24. Unique optical properties and applications of hollow gold nanospheres (HGNs)10.1016/j.ccr.2016.01.014 ↗
25. Synthesis of thiol-derivatised gold nanoparticles in a two-phase Liquid?Liquid system10.1039/C39940000801 ↗
26. Zhao, J., and Friedrich, B. (2017). Synthesis of Gold Nanoparticles Via the Chemical Reduction Methods, Shaker.
27. Multimodal drug delivery using gold nanoparticles10.1039/b9nr00112c ↗
28. Turkevich Method for Gold Nanoparticle Synthesis Revisited10.1021/jp061667w ↗
29. Synthesis of polyethyleneimine-stabilized gold nanoparticles for colorimetric sensing of heparin10.1016/j.colsurfa.2012.11.052 ↗
30. Polyethyleneimine-Coated Gold Nanoparticles: Straightforward Preparation of Efficient DNA Delivery Nanocarriers10.1002/asia.201600951 ↗
31. Nanoparticle PEGylation for imaging and therapy10.2217/nnm.11.19 ↗
32. Recent advances in stealth coating of nanoparticle drug delivery systems10.1002/wnan.1157 ↗
33. Recent trends and methodologies in gold nanoparticle synthesis—A prospective review on drug delivery aspect10.1016/j.onano.2017.07.001 ↗
34. Tuning the size of gold nanoparticles in the citrate reduction by chloride ions10.1039/c2nr30957b ↗
35. Cortez-Lemus, N.A., Licea-Claverie, A., Paraguay-Delgado, F., and Alonso-Nuñez, G. (2015). Gold nanoparticles size design and control by poly(N,N ′-diethylaminoethyl methacrylate). J. Nanomater.10.1155/2015/273814 ↗
36. Gold Nanoparticle Size Controlled by Polymeric Au(I) Thiolate Precursor Size10.1021/ja076333e ↗
37. Halide ion controlled shape dependent gold nanoparticle synthesis with tryptophan as reducing agent: Enhanced fluorescent properties and white light emission10.1016/j.cplett.2009.11.052 ↗
38. Defining Rules for the Shape Evolution of Gold Nanoparticles10.1021/ja305245g ↗
39. Coughlin, A., and West, J. (2012). Gold nanoshells for imaging and photothermal ablation of cancer. Nanomedicine, Elsevier BV.10.1533/9780857096449.2.326 ↗
40. A New Era for Cancer Treatment: Gold-Nanoparticle-Mediated Thermal Therapies10.1002/smll.201000134 ↗
41. Endosomal Confinement of Gold Nanospheres, Nanorods, and Nanoraspberries Governs Their Photothermal Identity and Is Beneficial for Cancer Cell Therapy10.1002/adbi.201900284 ↗
42. 3D Self-Assembled Plasmonic Superstructures of Gold Nanospheres: Synthesis and Characterization at the Single-Particle Level10.1002/smll.201102009 ↗
43. Encapsulation of gold nanoparticles by simian virus 40 capsids10.1039/c1nr10568j ↗
44. Cellular uptake of gold nanoparticles directly cross-linked with carrier peptides by osteosarcoma cells10.1007/s10856-008-3588-x ↗
45. Cellular Uptake of Gold Nanoparticles and Their Movement in 3D Multicellular Tumor Spheroids: Effect of Molecular Weight and Grafting Density of Poly(2-hydroxyl ethyl acrylate)10.1002/mabi.201900221 ↗
46. The Effect of shape on Cellular Uptake of Gold Nanoparticles in the forms of Stars, Rods, and Triangles10.1038/s41598-017-04229-z ↗
47. Shape Matters: Gold Nanoparticle Shape Impacts the Biological Activity of siRNA Delivery10.1021/acs.bioconjchem.9b00004 ↗
48. The effect of particle size on the genotoxicity of gold nanoparticles10.1002/jbm.a.35944 ↗
49. Size-dependent in vivo toxicity of PEG-coated gold nanoparticles10.2147/IJN.S21657 ↗
50. Glomerular barrier behaves as an atomically precise bandpass filter in a sub-nanometer regime10.1038/nnano.2017.170 ↗
51. Polyethylene Glycol-Coated Gold Nanoparticles as DNA and Atorvastatin Delivery Systems and Cytotoxicity Evaluation
52. The Cellular Interactions of PEGylated Gold Nanoparticles: Effect of PEGylation on Cellular Uptake and Cytotoxicity10.1002/ppsc.201300357 ↗
53. Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles10.1016/j.taap.2008.12.023 ↗
54. Biodistribution of PEG-modified gold nanoparticles following intratracheal instillation and intravenous injection10.1016/j.biomaterials.2010.05.009 ↗
55. Doxorubicin-Tethered Responsive Gold Nanoparticles Facilitate Intracellular Drug Delivery for Overcoming Multidrug Resistance in Cancer Cells10.1021/nn200007z ↗
56. Targeted systemic delivery of siRNA to cervical cancer model using cyclic RGD-installed unimer polyion complex-assembled gold nanoparticles10.1016/j.jconrel.2016.08.041 ↗
57. Bin-Jumah, M.N., Al-Abdan, M., Al-Basher, G., and Alarifi, S. (2020). Molecular Mechanism of Cytotoxicity, Genotoxicity, and Anticancer Potential of Green Gold Nanoparticles on Human Liver Normal and Cancerous Cells. Dose-Response, 18.10.1177/1559325820912154 ↗
58. Effect of electrical discharge plasma on cytotoxicity against cancer cells of N,O-carboxymethyl chitosan-stabilized gold nanoparticles10.1016/j.carbpol.2020.116162 ↗
59. Wang, W., Wang, J., and Ding, Y. (2020). Gold nanoparticle-conjugated nanomedicine: design, construction, and structure-efficacy relationship studies. J. Mater. Chem. B.10.1039/C9TB02924A ↗
60. Gold nanoparticle (AuNP)-based drug delivery and molecular imaging for biomedical applications10.1007/s12272-013-0273-5 ↗
61. Doxorubicin-loaded fucoidan capped gold nanoparticles for drug delivery and photoacoustic imaging10.1016/j.ijbiomac.2016.06.007 ↗
62. Designing Aptamer-Gold Nanoparticle-Loaded pH-Sensitive Liposomes Encapsulate Morin for Treating Cancer10.1186/s11671-020-03297-x ↗
63. Photothermal Nanotherapeutics and Nanodiagnostics for Selective Killing of Bacteria Targeted with Gold Nanoparticles10.1529/biophysj.105.061895 ↗
64. Neomycin and gentamicin detection via molecular recognition with cyclam-decorated gold nanoparticles10.1080/10610278.2015.1071819 ↗
65. Development of gentamicin-gold nanospheres for antimicrobial drug delivery to Staphylococcal infected foci10.3109/10717544.2012.746402 ↗
66. Novel Antibody-Engineered Gold Nanoparticles as Targeted Drug Delivery for Primary Mesenchimal Cells Do Not Elicit an Inflammatory Response10.1016/j.healun.2014.01.445 ↗
67. Cyclic Peptide-Capped Gold Nanoparticles as Drug Delivery Systems10.1021/mp300448k ↗
68. Design of fluorophore-loaded human serum albumin nanoparticles for specific targeting of NIH:OVCAR3 ovarian cancer cells10.1088/1361-6528/ab8b90 ↗
69. Assisted delivery of anti-tumour platinum drugs using DNA-coiling gold nanoparticles bearing lumophores and intercalators: towards a new generation of multimodal nanocarriers with enhanced action10.1039/C9SC02640A ↗
70. De Matteis, V., and Rizzello, L. (2020). Noble Metals and Soft Bio-Inspired Nanoparticles in Retinal Diseases Treatment: A Perspective. Cells, 9.10.3390/cells9030679 ↗
71. Platelet-Like Gold Nanostars for Cancer Therapy: The Ability to Treat Cancer and Evade Immune Reactions10.3389/fbioe.2020.00133 ↗
72. European Journal of Medicinal Chemistry Doxorubicin-loaded oligonucleotide conjugated gold nanoparticles: A promising in vivo drug delivery system for colorectal cancer therapy10.1016/j.ejmech.2017.08.063 ↗
73. The Enhancement Effect of Gold Nanoparticles in Drug Delivery and as Biomarkers of Drug-Resistant Cancer Cells10.1002/cmdc.200600264 ↗
74. Attaching DNA to Gold Nanoparticles With a Protein Corona10.3389/fchem.2020.00121 ↗
75. Terminal PEGylated DNA–Gold Nanoparticle Conjugates Offering High Resistance to Nuclease Degradation and Efficient Intracellular Delivery of DNA Binding Agents10.1021/acsami.5b05228 ↗
76. Multiplexed mRNA Sensing and Combinatorial-Targeted Drug Delivery Using DNA-Gold Nanoparticle Dimers10.1021/acsnano.7b08620 ↗
77. Efficient and synergetic DNA delivery with pyridinium amphiphiles–gold nanoparticle composite systems having different packing parameters10.1039/C5CC05760D ↗
78. Effects of the reaction parameters on the properties of thermosensitive poly(N-isopropylacrylamide) microspheres prepared by precipitation and dispersion polymerization10.1002/pola.21223 ↗
79. Poly( N -isopropylacrylamide)-based nanogels encapsulating gold nanoparticles for DNA delivery10.1016/j.jconrel.2015.05.141 ↗
80. Influence of alkane chain lengths and head groups on tethering of liposome–gold nanoparticle on gold surface for electrochemical DNA sensing and gene delivery10.1016/j.snb.2015.09.031 ↗
81. Development of Dual Functional Nucleic Acid Delivery Nanosystem for DNA Induced Silencing of Bcl-2 Oncogene10.2147/IJN.S236217 ↗
82. Crotamine Cell-Penetrating Nanocarriers: Cancer-Targeting and Potential Biotechnological and/or Medical Applications10.1007/978-1-0716-0319-2_5 ↗
83. Application of a Y-type-DNA-functionalized nanogold probe featuring specific telomerase recognition and doxorubicin release in cancer cells10.1039/C9AN02630D ↗
84. DNA self-assembly of targeted near-infrared-responsive gold nanoparticles for cancer thermo-chemotherapy10.1002/anie.201204018 ↗
85. Synthesis, Characterization and Biocompatibility of a Multifunctional Gold Nanoparticle System for the Delivery of Single-Stranded RNA to Lymphocytes10.17159/0379-4350/2018/v71a1 ↗
86. Efficient RNA delivery by integrin-targeted glutathione responsive polyethyleneimine capped gold nanorods10.1016/j.actbio.2015.05.028 ↗
87. Intranasal delivery of targeted polyfunctional gold-iron oxide nanoparticles loaded with therapeutic microRNAs for combined theranostic multimodality imaging and presensitization of glioblastoma to temozolomide10.1016/j.biomaterials.2019.119342 ↗
88. Nanoparticle Delivery of miR-708 Mimetic Impairs Breast Cancer Metastasis10.1158/1535-7163.MCT-18-0702 ↗
89. Radiation therapy is a treatment to be considered for recurrent epithelial ovarian cancer after chemotherapy10.1177/030089161109700509 ↗
90. Current status and future perspectives of gold nanoparticle vectors for siRNA delivery10.1039/C8TB02484G ↗
91. Multifunctional PEI-entrapped gold nanoparticles enable efficient delivery of therapeutic siRNA into glioblastoma cells10.1016/j.jconrel.2017.03.183 ↗
92. Anisamide-targeted gold nanoparticles for siRNA delivery in prostate cancer - synthesis, physicochemical characterisation and in vitro evaluation10.1039/C6TB00082G ↗
93. Effective melanoma cancer suppression by iontophoretic co-delivery of STAT3 siRNA and imatinib using gold nanoparticles10.1016/j.ijpharm.2017.03.087 ↗
94. Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells10.1016/j.jconrel.2019.01.006 ↗
95. Immobilization of HIV-1 TAT peptide on gold nanoparticles: A feasible approach for siRNA delivery10.1002/jcp.29105 ↗
96. Gold nanoparticle-mediated photothermal therapy: applications and opportunities for multimodal cancer treatment10.1002/wnan.1449 ↗
97. Structural-Engineering Rationales of Gold Nanoparticles for Cancer Theranostics10.1002/adma.201602080 ↗
98. Applications of Inorganic Nanomaterials in Photothermal Therapy Based on Combinational Cancer Treatment10.2147/IJN.S239751 ↗
99. An injectable nanocomposite hydrogel co-constructed with gold nanorods and paclitaxel-loaded nanoparticles for local chemo-photothermal synergetic cancer therapy10.1039/C9TB00120D ↗
100. Gold nanostars for cancer cell-targeted SERS-imaging and NIR light-triggered plasmonic photothermal therapy (PPTT) in the first and second biological windows10.1039/C9TB00061E ↗