journal article·2019-04-26Open access

Blockchain Technology in Healthcare: A Comprehensive Review and Directions for Future Research

Seyednima Khezr, Md Moniruzzaman, Abdulsalam Yassine, Rachid Benlamri

Applied Sciences· Volume 9· Issue 9

Abstract

One of the most important discoveries and creative developments that is playing a vital role in the professional world today is blockchain technology. Blockchain technology moves in the direction of persistent revolution and change. It is a chain of blocks that covers information and maintains trust between individuals no matter how far they are. In the last couple of years, the upsurge in blockchain technology has obliged scholars and specialists to scrutinize new ways to apply blockchain technology with a wide range of domains. The dramatic increase in blockchain technology has provided many new application opportunities, including healthcare applications. This survey provides a comprehensive review of emerging blockchain-based healthcare technologies and related applications. In this inquiry, we call attention to the open research matters in this fast-growing field, explaining them in some details. We also show the potential of blockchain technology in revolutionizing healthcare industry.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Blockchain Technology Applications and Security · IoT and Edge/Fog Computing · Internet of Things and AI

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Electrical and Computer Engineering, Lakehead University, 955 Oliver Road, Thunder Bay, ON P7B 5E1, Canada

Department of Software Engineering, Lakehead University, 955 Oliver Road, Thunder Bay, ON P7B 5E1, Canada

References (100+)

Show source-provided references
1. Michael, J., Cohn, A., and Butcher, J.R. (2019, March 20). BlockChain Technology. Available online: https://www.steptoe.com/images/content/1/7/v3/171269/LIT-FebMar18-Feature-Blockchain.pdf.
2. How the Blockchain Revolution Will Reshape the Consumer Electronics Industry [Future Directions]10.1109/MCE.2017.2684916 ↗
3. Yli-Huumo, J., Ko, D., Choi, S., Park, S., and Smolander, K. (2016). Where is current research on blockchain technology?—A systematic review. PLoS ONE, 11.10.1371/journal.pone.0163477 ↗
4. Yaeger, K., Martini, M., Rasouli, J., and Costa, A. (2019). Emerging Blockchain Technology Solutions for Modern Healthcare Infrastructure. J. Sci. Innov. Med., 2.10.29024/jsim.7 ↗
5. Blockchain Technology: Living in a Decentralized Everything10.1089/cyber.2017.29097.csi ↗
6. Smart contract applications within blockchain technology: A systematic mapping study10.1016/j.tele.2018.10.004 ↗
7. (2019, March 12). Smart Contracts. Available online: https://blockchainhub.net/smart-contracts/.
8. Blockchain technology in the energy sector: A systematic review of challenges and opportunities10.1016/j.rser.2018.10.014 ↗
9. Blockchain Technology in Finance10.1109/MC.2017.3571047 ↗
10. Blockchain and its coming impact on financial services10.1002/jcaf.22179 ↗
11. Pilkington, M. (2016). 11 Blockchain technology: Principles and applications. Research Handbook on Digital Transformations, Edward Elgar.10.4337/9781784717766.00019 ↗
12. A conceptual secure blockchain-based electronic voting system
13. Foroglou, G., and Tsilidou, A.L. (2015, January 14). Further applications of the blockchain. Proceedings of the 12th Student Conference on Managerial Science and Technology, Athens, Greece.
14. Yang, R., Yu, F.R., Si, P., Yang, Z., and Zhang, Y. (2019). Integrated blockchain and edge computing systems: A survey, some research issues and challenges. IEEE Commun. Surv. Tutor.10.1109/COMST.2019.2894727 ↗
15. A Survey of Blockchain Security Issues and Challenges
16. Nakamoto, S. (2008). Bitcoin: A Peer-to-Peer Electronic Cash System, BN Publishing.
17. Rawal, V., Mascarenhas, P., Shah, M., and Kondaka, S.S. (2017). White Paper: Blockchain for Healthcare an Opportunity to Address Many Complex Challenges in Healthcare, CitiusTech.
18. Hitching healthcare to the chain: An introduction to blockchain technology in the healthcare sector10.22215/timreview/1111 ↗
19. Data interchange standards in healthcare it-computable semantic interoperability: Now possible but still difficult. do we really need a better mousetrap?
20. Interoperability in healthcare: Benefits, challenges and resolutions
21. A collaborative mobile edge computing and user solution for service composition in 5G systems10.1002/ett.3446 ↗
22. A continuous diversified vehicular cloud service availability framework for smart cities10.1016/j.comnet.2018.08.023 ↗
23. The next generation of interoperability agents in healthcare10.3390/ijerph110505349 ↗
24. Blockchain Technology for Healthcare: Facilitating the Transition to Patient-Driven Interoperability10.1016/j.csbj.2018.06.003 ↗
25. Zhang, P., White, J., Schmidt, D.C., and Lenz, G. (2017). Applying software patterns to address interoperability in blockchain-based healthcare apps. arXiv.
26. Ancile: Privacy-preserving framework for access control and interoperability of electronic health records using blockchain technology10.1016/j.scs.2018.02.014 ↗
27. Blockchain technology use cases in healthcare10.1016/bs.adcom.2018.03.006 ↗
28. A systematic literature review of blockchain-based applications: Current status, classification and open issues10.1016/j.tele.2018.11.006 ↗
29. Sharma, R. (2018). Blockchain in Healthcare, FCCCO.
30. Mackey, T.K., Kuo, T.T., Gummadi, B., Clauson, K.A., Church, G., Grishin, D., Obbad, K., Barkovich, R., and Palombini, M. (2019). ‘Fit-for-purpose?’—Challenges and opportunities for applications of blockchain technology in the future of healthcare. BMC Med., 17.10.1186/s12916-019-1296-7 ↗
31. Peter, H., and Moser, A. (2017, January 26–27). Blockchain-applications in banking & payment transactions: Results of a survey. Proceedings of the 14th International Scientific Conference Pt, European Financial Systems, Brno, Czech Republic.
32. Zheng, Z., Xie, S., Dai, H.N., and Wang, H. (2016). Blockchain Challenges and Opportunities: A Survey, Inderscience Publishers. Work Paper.
33. Blockchain technology in business and information systems research10.1007/s12599-017-0505-1 ↗
34. Disruption of financial intermediation by FinTech: A review on crowdfunding and blockchain10.1111/acfi.12405 ↗
35. Conoscenti, M., Vetro, A., and De Martin, J.C. (December, January 29). Blockchain for the Internet of Things: A systematic literature review. Proceedings of the 2016 IEEE/ACS 13th International Conference of Computer Systems and Applications (AICCSA), Agadir, Morocco.10.1109/AICCSA.2016.7945805 ↗
36. Dorri, A., Kanhere, S.S., Jurdak, R., and Gauravaram, P. (2017, January 13–17). Blockchain for IoT security and privacy: The case study of a smart home. Proceedings of the 2017 IEEE International Conference on Pervasive Computing and Communications Workshops (PerCom Workshops), Kona, HI, USA.10.1109/PERCOMW.2017.7917634 ↗
37. A blockchain future for internet of things security: A position paper10.1016/j.dcan.2017.10.006 ↗
38. A Review on the Use of Blockchain for the Internet of Things10.1109/ACCESS.2018.2842685 ↗
39. Ferrag, M.A., Derdour, M., Mukherjee, M., Derhab, A., Maglaras, L., and Janicke, H. (2018). Blockchain technologies for the internet of things: Research issues and challenges. IEEE Internet Things J.10.1109/JIOT.2018.2882794 ↗
40. Review of existing peer-to-peer energy trading projects10.1016/j.egypro.2017.03.737 ↗
41. Chitchyan, R., and Murkin, J. (2018). Review of blockchain technology and its expectations: Case of the energy sector. arXiv.
42. Blockchain in government: Benefits and implications of distributed ledger technology for information sharing10.1016/j.giq.2017.09.007 ↗
43. Hou, H. (August, January 31). The application of blockchain technology in E-government in China. Proceedings of the IEEE 2017 26th International Conference on Computer Communication and Networks (ICCCN), Vancouver, BC, Canada.10.1109/ICCCN.2017.8038519 ↗
44. Alketbi, A., Nasir, Q., and Talib, M.A. (2018, January 25–26). Blockchain for government services—Use cases, security benefits and challenges. Proceedings of the IEEE 2018 15th Learning and Technology Conference (L&T), Jeddah, Saudi Arabia.10.1109/LT.2018.8368494 ↗
45. Li, X., Jiang, P., Chen, T., Luo, X., and Wen, Q. (2017). A survey on the security of blockchain systems. Future Gen. Comput. Syst., in press.
46. A survey on security and privacy issues of bitcoin10.1109/COMST.2018.2842460 ↗
47. A survey on security and privacy issues of blockchain technology10.3934/mfc.2018007 ↗
48. Mettler, M. (2016, January 14–16). Blockchain technology in healthcare: The revolution starts here. Proceedings of the 2016 IEEE 18th International Conference on e-Health Networking, Applications and Services (Healthcom), Munich, Germany.10.1109/HealthCom.2016.7749510 ↗
49. Blockchain distributed ledger technologies for biomedical and health care applications10.1093/jamia/ocx068 ↗
50. Stagnaro, C. (2019, April 24). White Paper: Innovative Blockchain Uses in Health Care. Available online: https://www.freedassociates.com/.
51. Hölbl, M., Kompara, M., Kamišalić, A., and Nemec Zlatolas, L. (2018). A Systematic Review of the Use of Blockchain in Healthcare. Symmetry, 10.10.20944/preprints201809.0136.v1 ↗
52. Opportunities for Use of Blockchain Technology in Medicine10.1007/s40258-018-0412-8 ↗
53. Siyal, A., Junejo, A., Zawish, M., Ahmed, K., Khalil, A., and Soursou, G. (2019). Applications of Blockchain Technology in Medicine and Healthcare: Challenges and Future Perspectives. Cryptography, 3.10.3390/cryptography3010003 ↗
54. Blockchain in healthcare applications: Research challenges and opportunities10.1016/j.jnca.2019.02.027 ↗
55. OmniPHR: A distributed architecture model to integrate personal health records10.1016/j.jbi.2017.05.012 ↗
56. Azaria, A., Ekblaw, A., Vieira, T., and Lippman, A. (2016, January 22–24). Medrec: Using blockchain for medical data access and permission management. Proceedings of the 2016 2nd International Conference on Open and Big Data (OBD), Vienna, Austria.10.1109/OBD.2016.11 ↗
57. A secure system for pervasive social network-based healthcare10.1109/ACCESS.2016.2645904 ↗
58. MeDShare: Trust-less medical data sharing among cloud service providers via blockchain10.1109/ACCESS.2017.2730843 ↗
59. Healthcare data gateways: Found healthcare intelligence on blockchain with novel privacy risk control10.1007/s10916-016-0574-6 ↗
60. Saraf, C., and Sabadra, S. (2018, January 11–12). Blockchain platforms: A compendium. Proceedings of the 2018 IEEE International Conference on Innovative Research and Development (ICIRD), Bangkok, Thailand.10.1109/ICIRD.2018.8376323 ↗
61. (2019, March 20). Ethereum. Available online: https://www.ethereum.org/.
62. (2019, March 20). Ripple. Available online: https://ripple.com/.
63. (2019, March 20). Hyperledger. Available online: https://www.hyperledger.org/.
64. Blockchain Applications for Healthcare Data Management10.4258/hir.2019.25.1.51 ↗
65. Panesar, A. (2019). Machine Learning and AI for Healthcare: Big Data for Improved Health Outcomes, Springer.10.1007/978-1-4842-3799-1 ↗
66. Social uses of personal health information within PatientsLikeMe, an online patient community: What can happen when patients have access to one another’s data10.2196/jmir.1053 ↗
67. Castaldo, L., and Cinque, V. (2018). Blockchain-based logging for the cross-border exchange of ehealth data in europe. International ISCIS Security Workshop, Springer.10.1007/978-3-319-95189-8_5 ↗
68. Hien, D.T.T., Hien, D.H., and Pham, V.H. (2018, January 6–7). A survey on opportunities and challenges of Blockchain technology adoption for revolutionary innovation. Proceedings of the ACM Ninth International Symposium on Information and Communication Technology, Danang City, Vietnam.
69. Liang, X., Zhao, J., Shetty, S., Liu, J., and Li, D. (2017, January 8–13). Integrating blockchain for data sharing and collaboration in mobile healthcare applications. Proceedings of the 2017 IEEE 28th Annual International Symposium on Personal, Indoor, and Mobile Radio Communications (PIMRC), Montreal, QC, Canada.10.1109/PIMRC.2017.8292361 ↗
70. Patel, V. (2018). A framework for secure and decentralized sharing of medical imaging data via blockchain consensus. Health Inform. J.10.1177/1460458218769699 ↗
71. Medblock: Efficient and secure medical data sharing via blockchain10.1007/s10916-018-0993-7 ↗
72. BMPLS: Blockchain-based multi-level privacy-preserving location sharing scheme for telecare medical information systems10.1007/s10916-018-0998-2 ↗
73. Shen, B., Guo, J., and Yang, Y. (2019). MedChain: Efficient Healthcare Data Sharing via Blockchain. Appl. Sci., 9.10.3390/app9061207 ↗
74. Vo, H.T., Kundu, A., and Mohania, M.K. (2018). Research Directions in Blockchain Data Management and Analytics, EDBT.
75. Controllable and trustworthy blockchain-based cloud data management10.1016/j.future.2018.09.019 ↗
76. Blockchain for consent management in the ehealth environment: A nugget for privacy and security challenges
77. Zhang, R., and Liu, L. (2010, January 5–10). Security models and requirements for healthcare application clouds. Proceedings of the 2010 IEEE 3rd International Conference on cloud Computing, Miami, FL, USA.10.1109/CLOUD.2010.62 ↗
78. Secure cloud-based EHR system using attribute-based cryptosystem and blockchain10.1007/s10916-018-0994-6 ↗
79. Privacy-friendly platform for healthcare data in cloud based on blockchain environment10.1016/j.future.2018.12.044 ↗
80. A Proposed Solution and Future Direction for Blockchain-Based Heterogeneous Medicare Data in Cloud Environment10.1007/s10916-018-1007-5 ↗
81. EdgeCare: Leveraging Edge Computing for Collaborative Data Management in Mobile Healthcare Systems10.1109/ACCESS.2019.2898265 ↗
82. A cost-benefit analysis of electronic medical records in primary care10.1016/S0002-9343(03)00057-3 ↗
83. Physicians’ use of electronic medical records: barriers and solutions10.1377/hlthaff.23.2.116 ↗
84. Implementing electronic health records: Key factors in primary care
85. Blockchain-Based Medical Records Secure Storage and Medical Service Framework10.1007/s10916-018-1121-4 ↗
86. Secure attribute-based signature scheme with multiple authorities for Blockchain in electronic health records systems
87. A Medical Records Managing and Securing Blockchain Based System Supported by a Genetic Algorithm and Discrete Wavelet Transform10.1016/j.cogsys.2018.05.004 ↗
88. Rivest, R. (1992). The MD5 Message-Digest Algorithm, RFC Editor. Technical Report.10.17487/rfc1321 ↗
89. Yang, J., Onik, M.M.H., Lee, N.Y., Ahmed, M., and Kim, C.S. (2019). Proof-of-Familiarity: A Privacy-Preserved Blockchain Scheme for Collaborative Medical Decision-Making. Appl. Sci., 9.10.3390/app9071370 ↗
90. Zhang, X., and Poslad, S. (2018, January 20–24). Blockchain support for flexible queries with granular access control to electronic medical records (EMR). Proceedings of the 2018 IEEE International Conference on Communications (ICC), Kansas City, MO, USA.10.1109/ICC.2018.8422883 ↗
91. Zhang, X., Poslad, S., and Ma, Z. (2018, January 9–13). Block-Based Access Control for Blockchain-Based Electronic Medical Records (EMRs) Query in eHealth. Proceedings of the 2018 IEEE Global Communications Conference (GLOBECOM), Abu Dhabi, UAE.10.1109/GLOCOM.2018.8647433 ↗
92. Sharples, M., and Domingue, J. (2016). The blockchain and kudos: A distributed system for educational record, reputation and reward. European Conference on Technology Enhanced Learning, Springer.10.1007/978-3-319-45153-4_48 ↗
93. Devine, P. (2015, January 7–10). Blockchain Learning: Can Crypto-Currency Methods Be Appropriated to Enhance Online Learning?. Proceedings of the ALT Online Winter Conference, Manchester, UK.
94. Blockchain technology: A data framework to improve validity, trust, and accountability of information exchange in health professions education10.1097/ACM.0000000000002326 ↗
95. Benna, I.I. (2019). Optimizing Health, Education and Governance Delivery Through Blockchain. Optimizing Regional Development Through Transformative Urbanization, IGI Global.10.4018/978-1-5225-5448-6 ↗
96. An introduction to the Blockchain and its implications for libraries and medicine10.1080/02763869.2017.1332261 ↗
97. Assessing quality using administrative data10.7326/0003-4819-127-8_Part_2-199710151-00048 ↗
98. Proposing New Blockchain Challenges in eHealth10.1007/s10916-019-1195-7 ↗
99. Electronic health records in ambulatory care—A national survey of physicians10.1056/NEJMsa0802005 ↗
100. A cloud-based approach for interoperable electronic health records (EHRs)10.1109/JBHI.2013.2257818 ↗