FTIR and Raman Characterization of TiO2 Nanoparticles Coated with Polyethylene Glycol as Carrier for 2-Methoxyestradiol
Source abstract
Abstract
The aim of this study was to prepare a novel targeting drug delivery system for 2-Methoxyestradiol (2ME) in order to improve the clinical application of this antitumor drug. It is based in nanoparticles (NPs) of titanium dioxide (TiO2) coated with polyethylene glycol (PEG) and loaded with 2ME. A complete IR and Raman characterization have been made to confirm the formation of TiO2–PEG–2ME composite. Vibrational modes have been assigned for TiO2, PEG, and 2ME and functionalized TiO2–PEG and TiO2–PEG–2ME. The observed variation in peak position of FTIR and Raman of each for these composites has been elucidated in terms of intermolecular interactions between PEG–2ME and TiO2, obtaining step-by-step the modification processes that were attributed to the conjugation of PEG and 2ME to TiO2 NPs. Modifying TiO2 NPs with PEG loaded with the 2ME drug revealed that the titanium dioxide nanocarrier possesses an effective adsorption capability, and we discuss their potential application as a system of drug delivery.
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Research context
OpenAlex topics: Polymer Nanocomposite Synthesis and Irradiation · Conducting polymers and applications · Nonlinear Optical Materials Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Departamento de Física, Universidad Técnica Federico Santa María, Valparaíso 2340000, Chile
Centro del Desarrollo para la Nanociencia y Nanotecnología-CEDENNA, Universidad de Santiago de Chile, Santiago 8320000, Chile
Laboratorio de Inmunología de la Reproducción, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 8320000, Chile
Instituto de Quimica y Bioquímica, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso 2340000, Chile
Grupo Polímeros, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 8320000, Chile
Funding
Proyecto Basal · Fondecyt Regular · Fondecyt · PIIC, DGIP-UTFSM · ACT1108 · Center for Development of Nanoscience and Nanotechnology, CEDENNA
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