journal article·2020-03-15Open access

Classification of Brain Tumors from MRI Images Using a Convolutional Neural Network

Milica M. Badža, Marko Č. Barjaktarović

Applied Sciences· Volume 10· Issue 6

Abstract

The classification of brain tumors is performed by biopsy, which is not usually conducted before definitive brain surgery. The improvement of technology and machine learning can help radiologists in tumor diagnostics without invasive measures. A machine-learning algorithm that has achieved substantial results in image segmentation and classification is the convolutional neural network (CNN). We present a new CNN architecture for brain tumor classification of three tumor types. The developed network is simpler than already-existing pre-trained networks, and it was tested on T1-weighted contrast-enhanced magnetic resonance images. The performance of the network was evaluated using four approaches: combinations of two 10-fold cross-validation methods and two databases. The generalization capability of the network was tested with one of the 10-fold methods, subject-wise cross-validation, and the improvement was tested by using an augmented image database. The best result for the 10-fold cross-validation method was obtained for the record-wise cross-validation for the augmented data set, and, in that case, the accuracy was 96.56%. With good generalization capability and good execution speed, the new developed CNN architecture could be used as an effective decision-support tool for radiologists in medical diagnostics.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Brain Tumor Detection and Classification · Advanced Neural Network Applications · Machine Learning and ELM

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Innovation center, School of Electrical Engineering, University of Belgrade, Bulevar kralja Aleksandra 73, 11000 Belgrade, Serbia

School of Electrical Engineering, University of Belgrade, Bulevar kralja Aleksandra 73, 11000 Belgrade, Serbia

References (50)

Show source-provided references
1. (2019, November 05). World Health Organization—Cancer. Available online: https://www.who.int/news-room/fact-sheets/detail/cancer.
2. An Efficient Segmentation Approach for Brain Tumor Detection in MRI10.17485/ijst/2016/v9i47/106448 ↗
3. (2019, November 30). Cancer Treatments Centers of America—Brain Cancer Types. Available online: https://www.cancercenter.com/cancer-types/brain-cancer/types.
4. (2019, November 30). American Association of Neurological Surgeons—Classification of Brain Tumours. Available online: https://www.aans.org/en/Media/Classifications-of-Brain-Tumors.
6. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: A summary10.1007/s00401-016-1545-1 ↗
7. Afshar, P., Plataniotis, K.N., and Mohammadi, A. (2019, January 12–17). Capsule Networks for Brain Tumor Classification Based on MRI Images and Coarse Tumor Boundaries. Proceedings of the ICASSP 2019–2019 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP), Brighton, UK.10.1109/ICASSP.2019.8683759 ↗
8. Byrne, J., Dwivedi, R., and Minks, D. (2014). Tumours of the brain. Nicholson T (ed) Recommendations Cross Sectional Imaging Cancer Management, Royal College of Radiologists. [2nd ed.]. Available online: https://www.rcr.ac.uk/publication/recommendations-cross-sectional-imaging-cancer-management-second-edition.
9. (2019, November 05). Center for Biomedical Image Computing & Analytics (CBICA). Available online: http://braintumorsegmentation.org/.
10. Deep learning with mixed supervision for brain tumor segmentation10.1117/1.JMI.6.3.034002 ↗
11. Big data analysis for brain tumor detection: Deep convolutional neural networks10.1016/j.future.2018.04.065 ↗
12. Amin, J., Sharif, M., Raza, M., and Yasmin, M. (2018). Detection of Brain Tumor based on Features Fusion and Machine Learning. J. Ambient. Intell. Humaniz. Comput., 1–17.10.1007/s12652-018-1092-9 ↗
13. Brain tumor classification from multi-modality MRI using wavelets and machine learning10.1007/s10044-017-0597-8 ↗
14. Pereira, S., Meier, R., Alves, V., Reyes, M., and Silva, C. (2018). Automatic Brain Tumor Grading from MRI Data Using Convolutional Neural Networks and Quality Assessment. Understanding and Interpreting Machine Learning in Medical Image Computing Applications, Springer.10.1007/978-3-030-02628-8_12 ↗
15. 5 Performance Analysis of Machine Learning Classifiers for Brain Tumor MR Images10.33317/ssurj.v1i1.36 ↗
16. Brain Tumor Segmentation Using OTSU Embedded Adaptive Particle Swarm Optimization Method and Convolutional Neural Network
17. Classification using deep learning neural networks for brain tumors10.1016/j.fcij.2017.12.001 ↗
18. Matching shape sequences in video with applications in human movement analysis10.1109/TPAMI.2005.246 ↗
19. A survey on deep learning in medical image analysis10.1016/j.media.2017.07.005 ↗
20. Deep Learning for Brain MRI Segmentation: State of the Art and Future Directions10.1007/s10278-017-9983-4 ↗
21. Cheng, J., Huang, W., Cao, S., Yang, R., Yang, W., Yun, Z., Wang, Z., and Feng, Q. (2015). Enhanced Performance of Brain Tumor Classification via Tumor Region Augmentation and Partition. PLoS ONE, 10.10.1371/journal.pone.0140381 ↗
22. Cheng, J. (2019, September 10). Brain Tumor Dataset. Available online: https://doi.org/10.6084/m9.figshare.1512427.v5.
23. Multi-grade brain tumor classification using deep CNN with extensive data augmentation10.1016/j.jocs.2018.12.003 ↗
24. Performance evaluation of classification algorithms by k-fold and leave-one-out cross validation10.1016/j.patcog.2015.03.009 ↗
25. The need to approximate the use-case in clinical machine learning10.1093/gigascience/gix019 ↗
26. Using and understanding cross-validation strategies. Perspectives on Saeb et al10.1093/gigascience/gix020 ↗
27. Glorot, X., and Bengio, Y. (2010, January 13–15). Understanding the difficulty of training deep feedforward neural networks. Proceedings of the thirteenth international conference on artificial intelligence and statistics, Chia Laguna Resort, Sardinia, Italy.
28. Phaye, S.S.R., Sikka, A., Dhall, A., and Bathula, D. (2018). Dense and Diverse Capsule Networks: Making the Capsules Learn Better. arXiv.
29. Pashaei, A., Ghatee, M., and Sajedi, H. (2019). Convolution neural network joint with mixture of extreme learning machines for feature extraction and classification of accident images. J. Real Time Image Process., 1–16.10.1007/s11554-019-00852-3 ↗
30. A Hybrid Feature Extraction Method With Regularized Extreme Learning Machine for Brain Tumor Classification10.1109/ACCESS.2019.2904145 ↗
31. Pashaei, A., Sajedi, H., and Jazayeri, N. (2018, January 25–26). Brain Tumor Classification via Convolutional Neural Network and Extreme Learning Machines. Proceedings of the 2018 8th International Conference on Computer and Knowledge Engineering (ICCKE), Mashhad, Iran.10.1109/ICCKE.2018.8566571 ↗
32. Afshar, P., Mohammadi, A., and Plataniotis, K.N. (2018, January 7–10). Brain Tumor Type Classification via Capsule Networks. Proceedings of the 2018 25th IEEE International Conference on Image Processing (ICIP), Athens, Greece.10.1109/ICIP.2018.8451379 ↗
33. Kurup, R.V., Sowmya, V., and Soman, K.P. (2019). Effect of Data Pre-processing on Brain Tumor Classification Using Capsulenet. International Conference on Intelligent Computing and Communication Technologies, Springer Science and Business Media LLC.
34. Development of Deep Learning algorithms for Brain Tumor classification using GLCM and Wavelet Packets
35. Multi-Classification of Brain Tumor Images Using Deep Neural Network10.1109/ACCESS.2019.2919122 ↗
36. Kutlu, H., and Avci, E. (2019). A Novel Method for Classifying Liver and Brain Tumors Using Convolutional Neural Networks, Discrete Wavelet Transform and Long Short-Term Memory Networks. Sensors, 19.10.3390/s19091992 ↗
37. Brain tumor classification for MR images using transfer learning and fine-tuning10.1016/j.compmedimag.2019.05.001 ↗
38. Shaikh, M., Kollerathu, V.A., and Krishnamurthi, G. (2019, January 8–11). Recurrent Attention Mechanism Networks for Enhanced Classification of Biomedical Images. Proceedings of the 2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019), Venice, Italy.10.1109/ISBI.2019.8759214 ↗
39. Fernando, T., Denman, S., Aristizabal, D.E.A., Sridharan, S., Laurens, K.R., Johnston, P., and Fookes, C. (2019). Neural Memory Plasticity for Anomaly Detection. arXiv.10.1016/j.neunet.2020.04.011 ↗
40. A Deep Learning-Based Framework for Automatic Brain Tumors Classification Using Transfer Learning10.1007/s00034-019-01246-3 ↗
41. Tripathi, P.C., and Bag, S. (2019). Non-invasively Grading of Brain Tumor Through Noise Robust Textural and Intensity Based Features. Computational Intelligence in Pattern Recognition, Springer Science and Business Media LLC.10.1007/978-981-13-9042-5_45 ↗
42. Ismael, M., and Abdel-Qader, I. (2018, January 3–5). Brain Tumor Classification via Statistical Features and Back-Propagation Neural Network. Proceedings of the 2018 IEEE International Conference on Electro/Information Technology (EIT), Rochester, MI, USA.10.1109/EIT.2018.8500308 ↗
43. Kotia, J., Kotwal, A., and Bharti, R. (2019, January 2–4). Risk Susceptibility of Brain Tumor Classification to Adversarial Attacks. Proceedings of the Advances in Intelligent Systems and Computing, Krakow, Poland.10.1007/978-3-030-31964-9_17 ↗
44. Magnetic resonance imaging-based brain tumor grades classification and grading via convolutional neural networks and genetic algorithms10.1016/j.bbe.2018.10.004 ↗
45. Abiwinanda, N., Hanif, M., Hesaputra, S.T., Handayani, A., and Mengko, T.R. (2018). Brain Tumor Classification Using Convolutional Neural Network. World Congress on Medical Physics and Biomedical Engineering 2018 Prague, Springer.10.1007/978-981-10-9035-6_33 ↗
46. Kaldera, H.N.T.K., Gunasekara, S.R., and Dissanayake, M.B. (April, January 26). Brain tumor Classification and Segmentation using Faster R-CNN. Proceedings of the 2019 Advances in Science and Engineering Technology International Conferences (ASET), Dubai, UAE.10.1109/ICASET.2019.8714263 ↗
47. Feature selection based on hybrid optimization for magnetic resonance imaging brain tumor classification and segmentation
48. (2020, February 03). Portable Ultrasound Enables Anytime, Anywhere Imaging. Available online: https://healthtechmagazine.net/article/2018/07/portable-ultrasound-enables-anytime-anywhere-imaging.
49. Toward Improving Safety in Neurosurgery with an Active Handheld Instrument10.1007/s10439-018-2091-x ↗
50. Fully automatic catheter segmentation in MRI with 3D convolutional neural networks: Application to MRI-guided gynecologic brachytherapy10.1088/1361-6560/ab2f47 ↗