Unconventional ions in bioactive glass: Innovative functions and promising therapeutic prospects
Bibliographic record
Abstract
No abstract is available for this record. The assistant can identify its topic from the title, but cannot infer the study’s results.
Source: Not provided · Quality: missing
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Magnesium Oxide Properties and Applications · Recycling and utilization of industrial and municipal waste in materials production
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (100+)
Show source-provided references
1. M.N. Rahaman, D.E. Day, B.S. Bal, Q. Fu, S.B. Jung, L.F. Bonewald, A.P. Tomsia, Bioactive glass in tissue engineering. Acta Biomater. 7, 2355–2373 (2011)10.1016/j.actbio.2011.03.016 ↗
2. J.R. Jones, Review of bioactive glass: from Hench to hybrids. Acta Biomater. 9, 4457–4486 (2013)10.1016/j.actbio.2012.08.023 ↗
3. J.S. Fernandes, P. Gentile, R.A. Pires, R.L. Reis, P.V. Hatton, Multifunctional bioactive glass and glass-ceramic biomaterials with antibacterial properties for repair and regeneration of bone tissue. Acta Biomater. 59, 2–11 (2017)10.1016/j.actbio.2017.06.046 ↗
4. D.S. Brauer, Bioactive glasses—structure and properties. Angew. Chem. Int. Ed. 54, 4160–4181 (2015)10.1002/anie.201405310 ↗
5. P.A. Dash, S. Mohanty, S.K. Nayak, A review on bioactive glass, its modifications and applications in healthcare sectors. J. Non-cryst. Solids. 614, 122404 (2023)10.1016/j.jnoncrysol.2023.122404 ↗
6. D. Zhang, O. Leppäranta, E. Munukka, H. Ylänen, M.K. Viljanen, E. Eerola, M. Hupa, L. Hupa, Antibacterial effects and dissolution behavior of six bioactive glasses, Journal of Biomedical Materials Research Part A: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials. 93, 475–483 (2010)10.1002/jbm.a.32564 ↗
7. N. Lindfors, J. Geurts, L. Drago, J. Arts, V. Juutilainen, P. Hyvönen, A.J. Suda, A. Domenico, S. Artiaco, C. Alizadeh, Antibacterial bioactive glass, S53P4, for chronic bone infections–a multinational study. In L. Drago (Ed.) A Modern Approach to Biofilm-Related Orthopaedic Implant Infections: Advances in Microbiology, Infectious Diseases and Public Health. Springer. 5, 81–92 (2017)10.1007/5584_2016_156 ↗
8. M. Lallukka, M. Miola, Z. Najmi, A. Cochis, S. Spriano, L. Rimondini, E. Verné, Cu-doped bioactive glass with enhanced in vitro bioactivity and antibacterial properties. Ceram. Int. 50, 5091–5103 (2024)10.1016/j.ceramint.2023.11.253 ↗
9. F. Kurtuldu, H. Kaňková, A.M. Beltrán, L. Liverani, D. Galusek, A.R. Boccaccini, Anti-inflammatory and antibacterial activities of cerium-containing mesoporous bioactive glass nanoparticles for drug-free biomedical applications. Mater. Today Bio. 12, 100150 (2021)10.1016/j.mtbio.2021.100150 ↗
10. H. Sun, K. Zheng, T. Zhou, A.R. Boccaccini, Incorporation of zinc into binary SiO2-CaO mesoporous bioactive glass nanoparticles enhances anti-inflammatory and osteogenic activities. Pharmaceutics. 13, 2124 (2021)10.3390/pharmaceutics13122124 ↗
11. W. Liu, M. Chen, M. Luo, T. Li, C. Hu, C. Xie, S. Li, T. Leng, J. Tian, P. Xu, Bioactive glass ions hydrogels with antiinflammation antioxidant capacity for treating inflammation-related diseases. Mater. Design. 227, 111669 (2023)10.1016/j.matdes.2023.111669 ↗
12. M. Vitázková, F. Kurtuldu, S. Sajjadi, Z. Neščáková, L. Buňová, A. Zeleňáková, P. Hrubovčák, A. Šoltýsová, Z. Vargas-Osorio, M. Michálek, Magnetic Mesoporous Bioactive Glass Nanocomposite for Enhanced Osteogenesis and Angiogenesis in Bone Tissue Engineering. ACS Appl. Bio Mater. 8, 7145–7160 (2025)10.1021/acsabm.5c00894 ↗
13. J. Jiménez-Holguín, D. Lozano, M. Saiz-Pardo, D. De Pablo, L. Ortega, S. Enciso, B. Fernández-Tomé, I. Díaz-Güemes, F.M. Sánchez-Margallo, M. Portolés, Osteogenic-angiogenic coupled response of cobalt-containing mesoporous bioactive glasses in vivo. Acta Biomater. 176, 445–457 (2024)10.1016/j.actbio.2024.01.003 ↗
14. D. Ege, K. Zheng, A.R. Boccaccini, Borate bioactive glasses (BBG): bone regeneration, wound healing applications, and future directions. ACS Appl. bio Mater. 5, 3608–3622 (2022)10.1021/acsabm.2c00384 ↗
15. S. Homaeigohar, M. Li, A.R. Boccaccini, Bioactive glass-based fibrous wound dressings. Burns trauma. 10, tkac038 (2022)10.1093/burnst/tkac038 ↗
16. M.S. Shaikh, M.A. Fareed, M.S. Zafar, Bioactive glass applications in different periodontal lesions: a narrative review. Coatings. 13, 716 (2023)10.3390/coatings13040716 ↗
17. Z.W. Loh, M.H.M. Zaid, M.M.A. Kechik, Y.W. Fen, K.M. Amin, W.M. Cheong, New formulation calcium-based 45S5 bioactive glass: In vitro assessment in PBS solution for potential dental applications. J. Mater. Res. Technol. 24, 3815–3825 (2023)10.1016/j.jmrt.2023.04.071 ↗
18. R. Borges, L.M. Ferreira, C. Rettori, I.M. Lourenco, A.B. Seabra, F.A. Mueller, E.P. Ferraz, M.M. Marques, M. Miola, F. Baino, Superparamagnetic and highly bioactive SPIONS/bioactive glass nanocomposite and its potential application in magnetic hyperthermia. Biomaterials Adv. 135, 112655 (2022)10.1016/j.msec.2022.112655 ↗
19. Z. Zhang, N. Zhang, X. Li, G. Li, K. Zhang, A. Jing, J. Li, H. Tang, Porous magnetic Fe3O4/bioactive glass–ceramic (CaO-SiO2-P2O5-MgO) scaffold with enhanced self-heating ability for hyperthermia treatment of bone tumor—an in vitro study. J. Aust. Ceram. Soc. 58, 1729–1745 (2022)10.1007/s41779-022-00807-1 ↗
20. K.R. Rust, G.T. Singleton, J. Wilson, P.J. Antonelli, Bioglass middle ear prosthesis: Long-term results. Am. J. Otol. 17, 371–374 (1996)
21. E.J.G. Schepers, P. Ducheyne, Bioactive glass particles of narrow size range for the treatment of oral bone defects: A 1–24 month experiment with several materials and particle sizes and size ranges. J. Rehabil. 24, 171–181 (1997)10.1111/j.1365-2842.1997.tb00311.x ↗
22. J. Wilson, S.B. Low, Bioactive ceramics for periodontal treatment: comparative studies in the Patus monkey. J. Appl. biomaterials: official J. Soc. Biomaterials. 3, 123–129 (1992)10.1002/jab.770030208 ↗
23. J. Turner, A. Nandakumar, N. Anilbhai, A.R. Boccaccini, J.R. Jones, G. Jell, The effect of Si species released from bioactive glasses on cell behaviour: A quantitative review. Acta Biomater. 170, 39–52 (2023)10.1016/j.actbio.2023.09.012 ↗
24. N. Al-Harbi, H. Mohammed, Y. Al-Hadeethi, A.S. Bakry, A. Umar, M.A. Hussein, M.A. Abbassy, K.G. Vaidya, G. Al, E.M. Berakdar, Mkawi, Silica-based bioactive glasses and their applications in hard tissue regeneration: A review, vol. 14 (Pharmaceuticals, 2021), p. 7510.3390/ph14020075 ↗
25. D.M.B. Nogueira, M.P. de Oliveira Rosso, D.V. Buchaim, M.S.R. Zangrando, R.L. Buchaim, Update on the use of 45S5 bioactive glass in the treatment of bone defects in regenerative medicine. World J. Orthop. 15, 204 (2024)10.5312/wjo.v15.i3.204 ↗
26. K. Jurczyk, M.U. Jurczyk, K. Niespodziana, J. Jakubowicz, M. Jurczyk, Titanium–10wt% 45S5 Bioglass nanocomposite for biomedical applications. Mater. Chem. Phys. 131, 540–546 (2011)10.1016/j.matchemphys.2011.10.020 ↗
27. Y. Xiang, J. Du, Effect of Strontium Substitution on the Structure of 45S5 Bioglasses. Chem. Mater. 23, 2703–2717 (2011)10.1021/cm102889q ↗
28. N. Gupta, V.K. Vyas, A. MANdAL, Studies of Substitution Effect of B 2 O 3 on Structure and Properties of 1393 Bioactive Glass. Orient. J. Chem. 37, 1409–1414. (2021) http://dx.doi.org/10.13005/ojc/37061910.13005/ojc/370619 ↗
29. Q. Fu, M.N. Rahaman, H. Fu, X. Liu, Silicate, borosilicate, and borate bioactive glass scaffolds with controllable degradation rate for bone tissue engineering applications. I. Preparation and in vitro degradation. J. biomedical Mater. Res. part. A 95, 164–171 (2010)10.1002/jbm.a.32824 ↗
30. L. Bi, M.N. Rahaman, D.E. Day, Z. Brown, C. Samujh, X. Liu, A. Mohammadkhah, V. Dusevich, J.D. Eick, L.F. Bonewald, Effect of bioactive borate glass microstructure on bone regeneration, angiogenesis, and hydroxyapatite conversion in a rat calvarial defect model. Acta Biomater. 9, 8015–8026 (2013)10.1016/j.actbio.2013.04.043 ↗
31. C. Huang, S. Shi, M. Qin, X. Rong, Z. Ding, X. Fu, W. Zeng, L. Luo, D. Wang, Z. Luo, A Composite Hydrogel Functionalized by Borosilicate Bioactive Glasses and VEGF for Critical-Size Bone Regeneration. Adv. Sci. 11, 2400349 (2024)10.1002/advs.202400349 ↗
32. N. Ramli, E. Sazali, Z.A. Mahraz, S. Ghoshal, S.M. Zain, R. Hisam, N. Malek, A. Syahrom, M. Sahar, F. Noor, Hard tissue repairing potency of mesoporous borosilicate bioactive glass: An in vitro assessment. J. Non-cryst. Solids. 609, 122289 (2023)10.1016/j.jnoncrysol.2023.122289 ↗
33. F. Sharifianjazi, M. Moradi, A. Abouchenari, A.H. Pakseresht, A. Esmaeilkhanian, M. Shokouhimehr, M.S. Asl, Effects of Sr and Mg dopants on biological and mechanical properties of SiO2–CaO–P2O5 bioactive glass. Ceram. Int. 46, 22674–22682 (2020)10.1016/j.ceramint.2020.06.030 ↗
34. D. Almasri, Y. Dahman, Prosthetic joint infections: biofilm formation, management, and the potential of mesoporous bioactive glass as a new treatment option. Pharmaceutics. 15, 1401 (2023)10.3390/pharmaceutics15051401 ↗
35. G. Kaur, O.P. Pandey, K. Singh, D. Homa, B. Scott, G. Pickrell, A review of bioactive glasses: Their structure, properties, fabrication and apatite formation. J. Biomedical Mater. Res. Part. A 102, 254–274 (2014)10.1002/jbm.a.34690 ↗
36. F. Sharifianjazi, M. Sharifianjazi, M. Irandoost, K. Tavamaishvili, M. Mohabatkhah, M. Montazerian, Advances in Zinc-Containing Bioactive Glasses: A Comprehensive Review. J. Funct. Biomaterials. 15, 258 (2024)10.3390/jfb15090258 ↗
37. H. Madival, A. Rajiv, C. Muniraju, M.S. Reddy, Advancements in Bioactive Glasses: A Comparison of Silicate, Borate, and Phosphate Network Based Materials. Biomedical Mater. Devices. 4, 425–445 (2026)10.1007/s44174-025-00297-2 ↗
38. M. Cannio, D. Bellucci, J.A. Roether, D.N. Boccaccini, V. Cannillo, Bioactive Glass Applications: A Literature Review of Human Clinical Trials, Materials, 14 (2021) 544010.3390/ma14185440 ↗
39. F.H. Laybidi, A. Bahrami, Antibacterial properties of ZnO-containing bioactive glass coatings for biomedical applications. Mater. Lett. 365, 136433 (2024)10.1016/j.matlet.2024.136433 ↗
40. M. Bellantone, H.D. Williams, L.L. Hench, Broad-spectrum bactericidal activity of Ag2O-doped bioactive glass. Antimicrob. Agents Chemother. 46, 1940–1945 (2002)10.1128/AAC.46.6.1940-1945.2002 ↗
41. A. Moghanian, S. Firoozi, M. Tahriri, Characterization, in vitro bioactivity and biological studies of sol-gel synthesized SrO substituted 58S bioactive glass. Ceram. Int. 43, 14880–14890 (2017)10.1016/j.ceramint.2017.08.004 ↗
42. J. Salazar-Martinez, P. Forero-Sossa, J. Henao, A. Giraldo-Betancur, SrO-Containing Bioactive Glasses in the SiO2–CaO–P2O5 System: A Comprehensive Review (ACS Biomaterials Science & Engineering, 2025)
43. A. Zambon, G. Malavasi, A. Pallini, F. Fraulini, G. Lusvardi, Cerium containing bioactive glasses: a review. ACS Biomaterials Sci. Eng. 7, 4388–4401 (2021)10.1021/acsbiomaterials.1c00414 ↗
44. K. Zheng, E. Torre, A. Bari, N. Taccardi, C. Cassinelli, M. Morra, S. Fiorilli, C. Vitale-Brovarone, G. Iviglia, A.R. Boccaccini, Antioxidant mesoporous Ce-doped bioactive glass nanoparticles with anti-inflammatory and pro-osteogenic activities. Mater. Today Bio. 5, 100041 (2020)10.1016/j.mtbio.2020.100041 ↗
45. H.H. Negm, M.A. Abdo, M.S. Sadeq, Impact of Y2O3 on structural, mechanical and nonlinear optical properties of CrO3-Na2O-B2O3 glasses. Optik. 274, 170546 (2023)10.1016/j.ijleo.2023.170546 ↗
46. K.R. Di Bona, S. Love, N.R. Rhodes, D. McAdory, S.H. Sinha, N. Kern, J. Kent, J. Strickland, A. Wilson, J. Beaird, Chromium is not an essential trace element for mammals: effects of a low-chromium diet. J. Biol. Inorg. Chem. 16, 381–390 (2011)10.1007/s00775-010-0734-y ↗
47. P. Bhattacharya, S. Misra, M. Hussain, Nutritional Aspects of Essential Trace Elements in Oral Health and Disease: An Extensive Review. Scientifica (Cairo). 5464373 (2016). https://doi.org/10.1155/2016/546437310.1155/2016/5464373 ↗
48. О. Sushko, R. Iskra, L. Ponkalo, Influence of chromium citrate on oxidative stress in the tissues of muscle and kidney of rats with experimentally induced diabetes. Regul. Mech. Biosystems. 10, 209–214 (2019)10.15421/021931 ↗
49. R. Iskra, R. Fedoruk, Chromium, its properties, transformation, and impact on humans. Physiological Journal. 2022;68(4):89–97. https://doi.org/10.15407/fz68.04.08910.15407/fz68.04.089 ↗
50. G.R. Pokhrel, G. Pokhre, The Effect of Chromium on Human-Health: A Review. BMC J. Sci. Res. 5, 27–35 (2022)10.3126/bmcjsr.v5i1.50669 ↗
51. N. Krishnamacharyulu, G. Jagan Mohini, G. Little Flower, G. Sahaya Baskaran, N. Veeraiah, An in-vitro bioactive, structural and degradation studies on B2O3–SiO2–P2O5–Na2O–CaO glass system incorporated with chromium ions, Materials Today: Proceedings. 5, 26280–26289 (2018)10.1016/j.matpr.2018.08.078 ↗
52. M.A. Madshal, A.M. Abdelghany, M.I. Abdelghany, G. El-Damrawi, Fabrication and in vitro studies on bioactive borate glasses containing dopant chromium sulfate. Ceram. Int. 49, 31591–31597 (2023)10.1016/j.ceramint.2023.07.111 ↗
53. S. Singh, G. Kalia, K. Singh, Effect of intermediate oxide (Y2O3) on thermal, structural and optical properties of lithium borosilicate glasses. J. Mol. Struct. 1086, 239–245 (2015)10.1016/j.molstruc.2015.01.031 ↗
54. L. Placek, T. Keenan, A. Coughlan, A. Wren, Investigating the effect of glass ion release on the cytocompatibility, antibacterial efficacy and antioxidant activity of Y2O3/CeO2 doped SiO2-SrO-Na2O glasses. Biomedical glasses. 4, 32–44 (2018)10.1515/bglass-2018-0004 ↗
55. Y. Say, N. Aslan, S. Cihangir, O. Murat, U. Çaydaş, Y2O3-Doped BioGlass Coatings for Ti-6Al-4V Alloy: Insights into Degradation, Bioactivity, Ion Release, Adhesion, and Corrosion Behavior, Metallurgical and Materials Transactions A. 56, 4172–4188 (2025)10.1007/s11661-025-07896-0 ↗
56. A. Arafat, S.A. Samad, J.J. Titman, A.L. Lewis, E.R. Barney, I. Ahmed, Yttrium doped phosphate-based glasses: structural and degradation analyses. Biomedical glasses. 6, 34–49 (2020)10.1515/bglass-2020-0004 ↗
57. A. Hadush Tesfay, Y.-J. Chou, C.-Y. Tan, F. Fufa Bakare, N.-T. Tsou, E.-W. Huang, S.-J. Shih, Control of dopant distribution in yttrium-doped bioactive glass for selective internal radiotherapy applications using spray pyrolysis. Materials. 12, 986 (2019)10.3390/ma12060986 ↗
58. N.J. Thyparambil, L.C. Gutgesell, C.C. Hurley, L.E. Flowers, D.E. Day, J.A. Semon, Adult stem cell response to doped bioactive borate glass. J. Mater. Science: Mater. Med. 31, 13 (2020)
59. M.H.A. Mhareb, M. Alqahtani, F. Alshahri, Y.S.M. Alajerami, N. Saleh, N. Alonizan, M.I. Sayyed, M.G.B. Ashiq, T. Ghrib, S.I. Al-Dhafar, T. Alayed, M.A. Morsy, The impact of barium oxide on physical, structural, optical, and shielding features of sodium zinc borate glass. J. Non-cryst. Solids. 541, 120090 (2020)10.1016/j.jnoncrysol.2020.120090 ↗
60. V.E. Eremyashev, D.A. Zherebtsov, L.M. Osipova, M.V. Brazhnikov, Effect of Calcium, Barium, and Strontium on the Thermal Properties of Borosilicate Glasses. Glass Ceram. 74, 345–348 (2018)10.1007/s10717-018-9991-y ↗
61. N. Koju, P. Sikder, B. Gaihre, S.B. Bhaduri, Smart Injectable Self-Setting Monetite Based Bioceramics for Orthopedic Applications (in: Materials, 2018), p. 125810.20944/preprints201806.0366.v1 ↗
62. L.B. Nogueira, T.P.R. Campos, Nuclear characterization and investigation of radioactive bioglass seed surfaces for brachytherapy via scanning electron microscopy. J. Solgel Sci. Technol. 58, 251–258 (2011)10.1007/s10971-010-2385-4 ↗
63. L.M.P. Salzedas, M.J.Q. Louzada, De Oliveira Filho, Radiopacity of restorative materials using digital images. J. Appl. Oral Sci. 14, 147–152 (2006)10.1590/S1678-77572006000200015 ↗
64. T.H. Darrah, Inorganic trace element composition of modern human bones: Relation to bone pathology and geographical provenance (University of Rochester, 2008)
65. S. Majumdar, S.K. Hira, H. Tripathi, A.S. Kumar, P.P. Manna, S. Singh, S. Krishnamurthy, Synthesis and characterization of barium-doped bioactive glass with potential anti-inflammatory activity. Ceram. Int. 47, 7143–7158 (2021)10.1016/j.ceramint.2020.11.068 ↗
66. H. Shokrollahi, F. Salimi, A. Doostmohammadi, The fabrication and characterization of barium titanate/akermanite nano-bio-ceramic with a suitable piezoelectric coefficient for bone defect recovery. J. Mech. Behav. Biomed. Mater. 74, 365–370 (2017)10.1016/j.jmbbm.2017.06.024 ↗
67. P. Paliwal, A.S. Kumar, H. Tripathi, S.P. Singh, S.C.U. Patne, S. Krishnamurthy, Pharmacological application of barium containing bioactive glass in gastro-duodenal ulcers. Mater. Sci. Eng., C 92, 424–434 (2018)10.1016/j.msec.2018.06.068 ↗
68. A. Yazdanpanah, F. Moztarzadeh, Synthesis and characterization of Barium–Iron containing magnetic bioactive glasses: The effect of magnetic component on structure and in vitro bioactivity. Colloids Surf., B 176, 27–37 (2019)10.1016/j.colsurfb.2018.12.036 ↗
69. P.K. Pothuganti, A. Bhogi, M.R. Kalimi, P.S. Reniguntla, Structural properties of borobismuthate glasses doped with MnO, Materials Today: Proceedings. 92, 1087–1091 (2023)10.1016/j.matpr.2023.05.131 ↗
70. A. Bhogi, B. Srinivas, P. Papolu, M. Shareefuddin, P. Kistaiah, Effect of Mn2 + ions on spectroscopic and electrical properties of lithium strontium borate glasses. Mater. Chem. Phys. 291, 126698 (2022)10.1016/j.matchemphys.2022.126698 ↗
71. J.H. Beattie, A. Avenell, Trace element nutrition and bone metabolism. Nutr. Res. Rev. 5, 167–188 (1992)10.1079/NRR19920013 ↗
72. A. Surazynski, W. Miltyk, J. Palka, J. Phang, Prolidase-dependent regulation of collagen biosynthesis. Amino acids. 35, 731–738 (2008)10.1007/s00726-008-0051-8 ↗
73. A.S. Hazell, P. Desjardins, R.F. Butterworth, Increased expression of glyceraldehyde-3-phosphate dehydrogenase in cultured astrocytes following exposure to manganese. Neurochem. Int. 35, 11–17 (1999)10.1016/S0197-0186(99)00024-8 ↗
74. Y.-J. Bae, M.-H. Kim, Manganese supplementation improves mineral density of the spine and femur and serum osteocalcin in rats. Biol. Trace Elem. Res. 124, 28–34 (2008)10.1007/s12011-008-8119-6 ↗
75. H.-C.C. Tsai, G.J. Everson, Effect of manganese deficiency on the acid mucopolysaccharides in cartilage of guinea pigs. J. Nutr. 91, 447–452 (1967)10.1093/jn/91.4.447 ↗
76. T.S. Slørdahl, H. Hov, R.U. Holt, V. Baykov, T. Syversen, A. Sundan, A. Waage, M. Børset, Mn2 + regulates myeloma cell adhesion differently than the proadhesive cytokines HGF, IGF-1, and SDF‐1α. Eur. J. Haematol. 81, 437–447 (2008)10.1111/j.1600-0609.2008.01148.x ↗
77. M. Helfrich, S. Nesbitt, P. Lakkakorpi, M. Barnes, S. Bodary, G. Shankar, W. Mason, D. Mendrick, H. Väänänen, M. Horton, β1 integrins and osteoclast function: involvement in collagen recognition and bone resorption. Bone. 19, 317–328 (1996)10.1016/S8756-3282(96)00223-2 ↗
78. B.R. Barrioni, E. Norris, S. Li, P. Naruphontjirakul, J.R. Jones, M.M. Pereira, Osteogenic potential of sol–gel bioactive glasses containing manganese. J. Mater. Science: Mater. Med. 30, 86 (2019)
79. M. Miola, C.V. Brovarone, G. Maina, F. Rossi, L. Bergandi, D. Ghigo, S. Saracino, M. Maggiora, R.A. Canuto, G. Muzio, E. Vernè, vitro study of manganese-doped bioactive glasses for bone regeneration. Mater. Sci. Engineering: C 38, 107–118 (2014)10.1016/j.msec.2014.01.045 ↗
80. F. Westhauser, S. Wilkesmann, Q. Nawaz, S.I. Schmitz, A. Moghaddam, A.R. Boccaccini, Osteogenic properties of manganese-doped mesoporous bioactive glass nanoparticles. J. Biomedical Mater. Res. Part. A 108, 1806–1815 (2020)10.1002/jbm.a.36945 ↗
81. C.-F. Tseng, Y.-C. Fei, Y.-J. Chou, Investigation of in vitro bioactivity and antibacterial activity of manganese-doped spray pyrolyzed bioactive glasses. J. Non-cryst. Solids. 549, 120336 (2020)10.1016/j.jnoncrysol.2020.120336 ↗
82. Q. Nawaz, M.A.U. Rehman, A. Burkovski, J. Schmidt, A.M. Beltrán, A. Shahid, N.K. Alber, W. Peukert, A.R. Boccaccini, Synthesis and characterization of manganese containing mesoporous bioactive glass nanoparticles for biomedical applications. J. Mater. Science: Mater. Med. 29, 64 (2018)
83. F. Bronner, Metals in bone: Aluminum, boron, cadmium, chromium, lanthanum, lead, silicon, and strontium, in: Principles of bone biology (Elsevier, 2008), pp. 515–53110.1016/B978-0-12-373884-4.00044-6 ↗
84. H. Elgharbawy, O. Hemeda, A. Henaish, Exploring the potential of new boron-phosphate bioactive glass doped with lanthanum and zinc oxides for bone regeneration: In vitro study. J. Mol. Struct. 1307, 137958 (2024)10.1016/j.molstruc.2024.137958 ↗
85. H. Jodati, B. Güner, Z. Evis, D. Keskin, A. Tezcaner, Synthesis and characterization of magnesium-lanthanum dual doped bioactive glasses. Ceram. Int. 46, 10503–10511 (2020)10.1016/j.ceramint.2020.01.050 ↗
86. W. Lou, Y. Dong, H. Zhang, Y. Jin, X. Hu, J. Ma, J. Liu, G. Wu, Preparation and characterization of lanthanum-incorporated hydroxyapatite coatings on titanium substrates. Int. J. Mol. Sci. 16, 21070–21086 (2015)10.3390/ijms160921070 ↗
87. X. Wang, L. Yuan, J. Huang, T.L. Zhang, K. Wang, Lanthanum enhances in vitro osteoblast differentiation via pertussis toxin-sensitive gi protein and ERK signaling pathway. J. Cell. Biochem. 105, 1307–1315 (2008)10.1002/jcb.21932 ↗
88. H. Elgharbawy, O.M. Hemeda, R.M. Shalaby, A.M.A. Henaish, Influence of calcium-to-phosphorous ratio on the bioactivity and surface characteristics of lanthanum-zinc doped bioactive glasses based on boron, phosphorous, and calcium for bone tissue engineering. Ceram. Int. 51, 61180–61194 (2025)10.1016/j.ceramint.2025.10.314 ↗
89. A.M. Ibrahim, A.E. Omar, H.Y. Ahmed, M.M. Farag, Z.M. Al–Rashidy, Al Rashidy, Antibacterial coating based on lanthanum-doped nanobioactive glass/chitosan composite of metal implant for orthopedic applications. Appl. Phys. A 131, 684 (2025)10.1007/s00339-025-08823-1 ↗
90. R. Badraddin, E. Koç, A. Saud, Incorporation of B and La oxides into bioactive glass: in vitro studies for bone regeneration applications. Digest J. Nanomaterials Biostructures (DJNB), 19 (2024)10.15251/DJNB.2024.193.1173 ↗
91. E. Sharifi, A. Bigham, S. Yousefiasl, M. Trovato, M. Ghomi, Y. Esmaeili, P. Samadi, A. Zarrabi, M. Ashrafizadeh, S. Sharifi, Mesoporous bioactive glasses in cancer diagnosis and therapy: stimuli-responsive, toxicity, immunogenicity, and clinical translation. Adv. Sci. 9, 2102678 (2022)10.1002/advs.202102678 ↗
92. Z. Liu, Z. Li, J. Liu, S. Gu, Q. Yuan, J. Ren, X. Qu, Long-circulating Er3+-doped Yb2O3 up-conversion nanoparticle as an in vivo X-Ray CT imaging contrast agent. Biomaterials. 33, 6748–6757 (2012)10.1016/j.biomaterials.2012.06.033 ↗
93. T. Zambanini, R. Borges, P.C. Faria, G.P. Delpino, I.S. Pereira, M.M. Marques, J. Marchi, Dissolution, bioactivity behavior, and cytotoxicity of rare earth-containing bioactive glasses (RE = Gd, Yb). Int. J. Appl. Ceram. Technol. 16, 2028–2039 (2019)10.1111/ijac.13317 ↗
94. A.M. Deliormanlı, S. Oguzlar, M. Zeyrek Ongun, Effects of Eu3+, Gd3 + and Yb3 + substitution on the structural, photoluminescence, and decay properties of silicate-based bioactive glass powders. J. Mater. Res. 37, 622–635 (2022)10.1557/s43578-021-00461-6 ↗
95. M. Yukawa, M. Suzuki-Yasumoto, K. Amano, M. Terai, Distribution of trace elements in the human body determined by neutron activation analysis. Archives Environ. Health: Int. J. 35, 36–44 (1980)10.1080/00039896.1980.10667459 ↗
96. N. Yamagata, The concentration of common cesium and rubidium in human body. J. Radiat. Res. 3, 9–30 (1962)10.1269/jrr.3.9 ↗
97. M. Chen, S. Wu, Y. Tan, R. Li, Y. Liu, Q. Huang, Rubidium-doped titanium surfaces with modulatory effects on MC3T3-E1 cell response and antibacterial capacity against Staphylococcus aureus. Biomed. Mater. 14, 045016 (2019)10.1088/1748-605X/ab2585 ↗
98. Z. Ouyang, Q. Huang, B. Liu, H. Wu, T. Liu, Y. Liu, Rubidium chloride targets Jnk/p38-mediated NF-κB activation to attenuate osteoclastogenesis and facilitate osteoblastogenesis. Front. Pharmacol. 10, 584 (2019)10.3389/fphar.2019.00584 ↗
99. S. Ouyang, K. Zheng, Q. Huang, Y. Liu, A.R. Boccaccini, Synthesis and characterization of rubidium-containing bioactive glass nanoparticles. Mater. Lett. 273, 127920 (2020)10.1016/j.matlet.2020.127920 ↗
100. Y.-. Tan, W.-. Chen, W. Wei, Q.-. Huang, X. He, Rubidium-modified bioactive glass-ceramics with hydroxyapatite crystals for bone regeneration. Trans. Nonferrous Met. Soc. China. 31, 521–532 (2021)10.1016/S1003-6326(21)65514-0 ↗