Synthesis, characterization, and in vivo evaluation of a bovine bone-derived nano-hydroxyapatite/chitosan composite for bone regeneration
Bibliographic record
Abstract
No abstract is available for this record. The assistant can identify its topic from the title, but cannot infer the study’s results.
Source: Not provided · Quality: missing
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Graphene and Nanomaterials Applications · Magnesium Alloys: Properties and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (34)
Show source-provided references
1. F. Migliorini, La G. Padula, E. Torsiello, F. Spiezia, F. Oliva, N. Maffulli, Strategies for large bone defect reconstruction after trauma, infections or tumour excision: a comprehensive review of the literature. Eur. J. Med. Res. 26(1), 118 (2021)10.1186/s40001-021-00593-9 ↗
2. C. Papakostidis, P.V. Giannoudis, Reconstruction of infected long bone defects: Issues and Challenges. Injury. 54(3), 807–810 (2023)10.1016/j.injury.2023.01.052 ↗
3. K.M. Zekry, N. Yamamoto, K. Hayashi, A. Takeuchi, A.Z.A. Alkhooly, A.S. Abd-Elfattah, H. Tsuchiya, Reconstruction of intercalary bone defect after resection of malignant bone tumor. J. Orthop. Surg. 27(1), 2309499019832970 (2019)10.1177/2309499019832970 ↗
4. F. Marini, F. Giusti, T. Iantomasi, M.L. Brandi, Congenital metabolic bone disorders as a cause of bone fragility. Int. J. Mol. Sci. 22(19), 10281 (2021)10.3390/ijms221910281 ↗
5. K.Y. Chew, G.Y. Tan, B.K. Tan, Delayed autografting in the face and hands: the role of allografts in burn wound bed preparation. JPRAS Open. 45, 480–490 (2025). https://doi.org/10.1016/j.jpra.2025.05.00610.1016/j.jpra.2025.05.006 ↗
6. V. Dănilă, C. Balcoș, A. Armencia, D. Baciu, Processed xenografts, top biomaterials for bone tissue reconstruction. Med. Mater. 4(4), 163–168 (2024)
7. H.T. Cao, V.L. Ha, D.N.T. Mai, In vitro assessment of bovine-derived hydroxyapatite for bone xenografts. J. Mater. Sci. 59(23), 10406–10418 (2024)10.1007/s10853-024-09794-z ↗
8. A.F. Vladu, A. Kaya, M.G. Ficai, A. Ficai, D. Tutuianu, R. Motelica, L. Titorencu, I, Localized Combination Therapy Using Collagen–Hydroxyapatite Bone Grafts for Simultaneous Bone Cancer Inhibition and Tissue Regeneration. Polymers. 17(16), 2239 (2025)10.3390/polym17162239 ↗
9. S. Luthfiyah, B. Soegijono, F.B. Susetyo, H.A. Notonegoro, Comparing properties of bovine bone derived hydroxyapatite and synthetic hydroxyapatite. J. Appl. Sci. Eng. 25(6), 1197–1203 (2022)
10. K. Aoki, H. Ideta, Y. Komatsu, A. Tanaka, M. Kito, M. Okamoto, N. Saito, Bone-regeneration therapy using biodegradable scaffolds: calcium phosphate bioceramics and biodegradable polymers. Bioengineering. 11(2), 180 (2024)10.3390/bioengineering11020180 ↗
11. F.T. Omigbodun, B.I. Oladapo, N. Osa-uwagboe, Exploring the frontier of Polylactic Acid/Hydroxyapatite composites in bone regeneration and their revolutionary biomedical applications–A review. J. Reinf. Plast. Compos. 45(5–6), 1230–1250 (2024). https://doi.org/10.1177/0731684424127804510.1177/07316844241278045 ↗
12. P.J. Piszko, A. Piszko, S. Kiryk, J. Kiryk, T. Horodniczy, N. Struzik, M. Dobrzyński, Bone Regeneration Capabilities of Scaffolds Containing Chitosan and Nanometric Hydroxyapatite—Systematic Review Based on In Vivo Examinations. Biomimetics. 9(8), 503 (2024)10.3390/biomimetics9080503 ↗
13. Z.M. Yao, W.M. Xie, Y. Yang, J.M. Chen, Y. Zhan, X.D. Wu, G.X. Zhang, Chitosan scaffolds for bone applications: A detailed review of main types, features and multifaceted uses. Eur. Cells Mater. 52, 58–79 (2025)10.22203/eCM.v052a05 ↗
14. K. Chen, F. Wang, X. Sun, W. Ge, M. Zhang, L. Wang, G. Wu, 3D-printed zinc oxide nanoparticles modified barium titanate/hydroxyapatite ultrasound-responsive piezoelectric ceramic composite scaffold for treating infected bone defects. Bioactive Mater. 45, 479–495 (2025)10.1016/j.bioactmat.2024.11.015 ↗
15. E.M. Hia, J. Park, I.W. Suh, C.H. Park, Synergistic effects of modified zinc oxide nanoparticle in a hybrid chitosan-gelatin hydrogel for bone regeneration. Int. J. Biol. Macromol. 315, 144490 (2025). https://doi.org/10.1016/j.ijbiomac.2025.14449010.1016/j.ijbiomac.2025.144490 ↗
16. B. Chen, P. Yu, W.N. Chan, F. Xie, Y. Zhang, L. Liang, K.F. To, Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets. Signal. Transduct. Target. therapy. 9(1), 6 (2024)10.1038/s41392-023-01679-y ↗
17. M. Aqib, M. Alomar, A. Anwar, K. Naseem, A. Javaid, A. Intisar, I.H. Khan, Synthesis, characterization and antimicrobial analysis of metal-doped (Zn2 + and Ag+) brushite powder for bone regeneration. Mater. Chem. Phys. 320, 129460 (2024)10.1016/j.matchemphys.2024.129460 ↗
18. S.K. Suvarna, D.M. Rassl, D. Neil, Tissue pathways for cardiovascular pathology (The Royal College of Pathologists, 2018)
19. K.S. Han, A. Sathiyaseelan, K. Saravanakumar, M.H. Wang, Wound healing efficacy of biocompatible hydroxyapatite from bovine bone waste for bone tissue engineering application. J. Environ. Chem. Eng. 10(1), 106888 (2022)10.1016/j.jece.2021.106888 ↗
20. Y. Warastuti, J. Setiawan, B. Basril, F. Lukitowati, R.S.A. Koesoemowidodo, Preparation, Synthesis, and Characterization of Hydroxyapatite From (Bovine Bones Through Alkaline Hydrothermal Method, 2025)10.5829/ije.2025.38.12c.06 ↗
21. I.E. Agbozu, O.P. Wategire, Evaluation of Extracted Cow Bone Hydroxyapatite. Sch. Int. J. Chem. Mater. Sci. 8(3), 138–147 (2025)10.36348/sijcms.2025.v08i03.007 ↗
22. I. Irsyam, F. Mahyudin, G. Mastutik, T. Widyawati, F. Zulhendri, H. Rahmadhany, M.A.M. Lubis, In vitro cytotoxicity evaluation of bovine hydroxyapatite–propolis composite on human mesenchymal stem cells. J. Med. Pharm. Chem. Res. 8(5), 1217–1230 (2026)
23. M. Shabeena, G.K. Nagaraja, Y.P. Naveen, Unravelling the bone regeneration capability of polylactic acid nanocomposite films embedded with hydroxyapatite functionalized halloysite nanotubes. New J. Chem. 49(42), 18574–18586 (2025)10.1039/D5NJ01985K ↗
24. M. Abdelbaky, A.M. Abdelghany, A.H. Oraby, M.M. Rashad, Ultraviolet-stimulated photocatalysis of crystal violet using (Gd (2-x) La (x) Zr (2-x) Sn (x) O7) pyrochlore nanoparticles. Appl. Water Sci. 15(7), 168 (2025)10.1007/s13201-025-02492-4 ↗
25. E. Ahmed, H.M. Aly, A.M. Abdelghany, A.A. Ismail, Structure and radiation shielding attitude of hexa-structured borosilicate glasses containing zinc oxide. Appl. Phys. A 131(5), 1–10 (2025)10.1007/s00339-025-08482-2 ↗
26. A.F. Amhare, H. Liu, L. Qiao, H. Deng, J. Han, Elemental influence: The emerging role of zinc, copper, and selenium in osteoarthritis. Nutrients. 17(13), 2069 (2025)10.3390/nu17132069 ↗
27. T. Rolić, M. Yazdani, S. Mandić, S. Distante, Iron metabolism, calcium, magnesium and trace elements: a review. Biol. Trace Elem. Res. 203(4), 2216–2225 (2025)10.1007/s12011-024-04289-z ↗
28. J. Li, Y. Qu, B. Chu, T. Wu, M. Pan, D. Mo, Z. Qian, Research progress on biomaterials with immunomodulatory effects in bone regeneration. Adv. Sci. 12(33), e01209 (2025)10.1002/advs.202501209 ↗
29. E. Ahmed, H.M. Aly, A.M. Abdelghany, A.A. Ismail, Structure and radiation shielding attitude of hexa-structured borosilicate glasses containing zinc oxide. Appl. Phys. A 131(5), 401 (2025)10.1007/s00339-025-08482-2 ↗
30. A. Oryan, S. Alidadi, A. Moshiri, N. Maffulli, Bone regenerative medicine: classic options, novel strategies, and future directions. J. Orthop. Surg, Res. 9(1), 18 (2014)10.1186/1749-799X-9-18 ↗
31. P.V. Giannoudis, H. Dinopoulos, E. Tsiridis, Bone substitutes: an update. Injury. 36(3), S20–S27 (2005)10.1016/j.injury.2005.07.029 ↗
32. D. Buser, Localized ridge augmentation using guided bone regeneration. Craniomaxillofacial reconstructive and corrective bone surgery: principles of internal fixation using the AO/ASIF technique (2002)
33. J.M. Anderson, A. Rodriguez, D.T. Chang, Foreign body reaction to biomaterials. Semin Immunol. 20(2), 86–100 (2008). https://doi.org/10.1016/j.smim.2007.11.00410.1016/j.smim.2007.11.004 ↗
34. M. Bosetti, M. Cannas, The effect of bioactive glasses on bone marrow stromal cells differentiation. Biomaterials. 26(18), 3873–3879 (2005)10.1016/j.biomaterials.2004.09.059 ↗